Search clinical trials for: Phase IIa

Total 19326 results

H. Lee Moffitt Cancer Center and Research Institute
Genentech, Inc.

Completed

Phase I/IIa Trial of Gemcitabine Plus Trastuzumab and Pertuzumab in Previously Treated Metastatic HER2+ Breast Cancer

Breast Cancer

United States
BioLineRx, Ltd.

Completed

Phase IIA Open Label Study to Evaluate Efficacy and Safety of BL-8040 Followed by (hATG), Cyclosporine and Methyprednisolone in Adult Subjects With Aplastic Anemia or Hypoplastic Myelodysplastic Syndrome

Aplastic Anemia | Hypoplastic Myelodysplastic Syndrome

United States
Apellis Pharmaceuticals, Inc.

Completed

A Phase IIa Study to Assess the Safety, Efficacy, and Pharmacokinetics of Subcutaneously Administered Pegcetacoplan (APL-2) in Subjects With PNH

PNH

Serbia, Bulgaria
Bioverativ Therapeutics Inc.
Swedish Orphan Biovitrum; Syntonix Pharmaceuticals, Inc.

Completed

Phase I/IIa Study of FIXFc in Hemophilia B Patients

Hemophilia B

United States
Barbara Ann Karmanos Cancer Institute
National Cancer Institute (NCI)

Terminated

Dasatinib for Immune Modulation After Donor Stem Cell Transplant for Hematologic Malignancies

Myeloid Leukemia | Multiple Myeloma | Hodgkin's Lymphoma | Non-Hodgkin's Lymphoma | Myelodysplastic Syndrome | Lymphoid Leukemia

United States
MedSIR

Completed

POEM STUDY: A Phase IIa Trial in Endometrial Carcinoma With Temsirolimus (POEM)

Carcinoma, Endometrioid | mTOR Protein

Spain
Fore Biotherapeutics

Terminated

Phase I/IIa Study to Evaluate the Safety, PK, PD, and Preliminary Efficacy of PLX8394 in Patients With Advanced Cancers.

Melanoma | Colorectal Cancer | Cholangiocarcinoma | Non-small Cell Lung Cancer | Histiocytosis | Thyroid Cancer | Hairy Cell Leukemia

United States
Advanced Accelerator Applications

Terminated

99mTc-rhAnnexin V-128 a Phase I/IIa Study in Patients With Rheumatoid Arthritis (RA) or Ankylosing Spondylitis (AS)

Rheumatoid Arthritis | Ankylosing Spondylitis

Switzerland
RHEACELL GmbH & Co. KG
FGK Clinical Research GmbH; Ticeba GmbH; Granzer Regulatory Consulting & Services

Completed

Allogeneic ABCB5-positive Stem Cells for Treatment of DFU "Malum Perforans"

Diabetic Neuropathic Ulcer

Germany
RHEACELL GmbH & Co. KG
FGK Clinical Research GmbH; Ticeba GmbH; Granzer Regulatory Consulting & Services

Completed

Allogeneic ABCB5-positive Stem Cells for Treatment of CVU

Skin Ulcer Venous Stasis Chronic

Germany
RHEACELL GmbH & Co. KG
FGK Clinical Research GmbH; Ticeba GmbH; Granzer Regulatory Consulting & Services

Terminated

Clinical Trial to Investigate Efficacy and Safety of the IMP in Patients With Non Healing Wounds Originating From Ulcers

Skin Ulcer Venous Stasis Chronic

Germany
RHEACELL GmbH & Co. KG
FGK Clinical Research GmbH; Ticeba GmbH; Granzer Regulatory Consulting & Services

Terminated

Allogeneic ABCB5-positive Stem Cells for Treatment of PAOD

Peripheral Arterial Occlusive Disease

Germany, Austria, Czechia, Poland, United Kingdom
COL George Peoples, MD, FACS

Completed

Phase I/IIa Trial of Folate Binding Protein Vaccine in Ovarian Cancer

Ovarian Cancer | Endometrial Cancer | Peritoneal Cancer | Fallopian Cancer

United States
TheraVasc Inc.

Completed

Phase IIa: Safety, PK, & Tolerability of Sodium Nitrite in Patients With Peripheral Arterial Disease-SONIC

Peripheral Arterial Disease

United States
Taiho Pharmaceutical Co., Ltd.

Completed

A Phase IIa Study of TAS-205 for Duchenne Muscular Dystrophy

Duchenne Muscular Dystrophy

Japan
MGB Biopharma Limited
Syneos Health

Completed

Study to Assess Safety, Tolerability and Efficacy of Incremental Doses of MGB-BP-3 in Patients With CDAD

Clostridium Difficile Infection

Canada, United States
Singapore General Hospital
Duke-NUS Graduate Medical School; 60 Degrees Pharmaceuticals LLC

Withdrawn

Celgosivir or Modipafant as Treatment for Adult Participants With Uncomplicated Dengue Fever in Singapore

Dengue Fever

Singapore
University of Pennsylvania

Completed

Phase I/IIA Study of CART19 Cells for Patients With Chemotherapy Resistant or Refractory CD19+ Leukemia and Lymphoma (Pedi CART19)

B Cell Lymphoma | B Cell Leukemia

United States
Yale University
Peter MacCallum Cancer Centre, Australia

Terminated

An Open Label, International, Multi-centre, Phase I/IIa Study of Lenalidomide (Revlimid) and Romidepsin (Istodax) for Relapsed /Refractory Hodgkin Lymphoma, Mature T-cell Lymphoma and Multiple Myeloma. (RId Study) (RID)

Multiple Myeloma | Hodgkin's Lymphoma | Mature T-cell Lymphoma

United States
ImaginAb, Inc.

Completed

Phase I/IIA Study of PET Imaging With 89Zr-Df-IAB2M in Metastatic Prostate Cancer (IAB2M)

Metastatic Prostate Cancer

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Tacrolimus and Mycophenolate Mofetil in Preventing Graft-Versus-Host Disease in Patients Who Have Undergone Total-Body Irradiation With or Without Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant for Hematologic Cancer

Primary Myelofibrosis | Polycythemia Vera | Essential Thrombocythemia | Stage I Multiple Myeloma | Stage II Multiple Myeloma | Stage III Multiple Myeloma | Recurrent Adult Acute Myeloid Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell... and other conditions

United States, Italy
Goethe University
LOEWE CGT

Completed

Cell Therapy by Autologous BMC for Large Bone Defect Repair (BMC2012)

Humerus Fracture Displaced Proximal

Germany
University of Florida
Prana Therapeutics

Withdrawn

Phase I/IIa Study of Pharmacokinetics and Safety of Epidiferphane™ and Taxanes in Breast Cancer Patients

Breast Cancer
Aeras
Statens Serum Institut

Completed

A Phase I/IIa AERAS-456 in HIV-Negative Adults With & Without Latent Tuberculosis Infection (C-035-456)

Latent Tuberculosis | Latent Tuberculosis Bacteriology and Histology Unknown

South Africa
Italfarmaco

Completed

Phase IIA Study of the HDAC Inhibitor ITF2357 in Patients With JAK-2 V617F Positive Chronic Myeloproliferative Diseases

Myeloproliferative Diseases

Italy
HaEmek Medical Center, Israel

Unknown

A Phase - IIa - IIb, Trial to Study the Safety, Tolerability and Efficacy of Memantine as a Long-term Treatment of SCD (MeMAGEN)

Sickle Cell Disease

Israel
University of Maryland, Baltimore

Completed

Preoperative Accelerated Partial Breast Irradiation (APBI) for Women With Stage I and Select IIA Breast Cancer (GCC 0919)

Breast Cancer

United States
Yale University
Alzheimer's Therapeutic Research Institute

Completed

A Phase IIa Multi-Center Study of 18F-FDG PET, Safety, and Tolerability of AZD0530 in Mild Alzheimer's Disease

Alzheimer's Disease

United States, Canada
Bristol-Myers Squibb
Cardioxyl Pharmaceuticals, Inc

Completed

A Dose Ranging Phase IIa Study of 6 Hour Intravenous Dosages of CXL-1427 in Patients Hospitalized With Heart Failure

Heart Failure | Decompensated Heart Failure | Acute Heart Failure

United States, Germany, Jordan, Poland, Russian Federation
Bayer

Completed

A Randomized Phase IIa Efficacy and Safety Study of Radium-223 Dichloride With Abiraterone Acetate or Enzalutamide in Metastatic Castration-resistant Prostate Cancer (CRPC)

Prostatic Neoplasms

United States
Hoffmann-La Roche

Completed

A Phase IIa Study of Intravenous Rituximab in Pediatric Participants With Severe Granulomatosis With Polyangiitis (Wegener's) or Microscopic Polyangiitis

Granulomatosis With Polyangiitis

United States, Canada, United Kingdom, Germany, Italy, Serbia, Turkey, France
AstraZeneca
Parexel

Completed

Efficacy, Pharmacokinetics (PK), Safety and Tolerability Study of Inhaled AZD8871

Chronic Obstructive Pulmonary Disease COPD

Germany, United Kingdom
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Completed

A Phase II Study of Anlotinib in MTC Patients (ALTN/MTC)

Tumor

China
Tesaro, Inc.

Completed

A Phase I/IIa Open-Label, Dose Escalation and Cohort Expansion Trial of Oral TSR-011 in Patients With Advanced Solid Tumors and Lymphomas

Solid Tumors | Lymphomas

United Kingdom, United States, Taiwan, Spain, Poland
Biogen

Completed

A Phase IIa Withdrawal Study of CNV1014802 in Patients With Trigeminal Neuralgia

Trigeminal Neuralgia

United Kingdom
Sichuan J.Z. Bio-chemical Science and Technology...
Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Unknown

Phase Ib/IIa Studies of Chlorogenic Acid for Injection for Safety and Efficacy of Advanced Lung Cancer

Advanced Lung Cancer

China
Sichuan Haisco Pharmaceutical Group Co., Ltd

Completed

A Phase IIa Study Investigating the Tolerance, Efficacy and Safety of HSK3486

Induction of General Anaesthesia

China
AzurRx SAS

Completed

A Phase IIa Study With Escalating Dose of MS1819-SD

Chronic Pancreatitis | Distal Pancreatectomy

Australia, New Zealand, France
GlaxoSmithKline

Completed

A Phase IIA FF/VI Study to Measure FeNO in Asthmatic Patients.

Asthma

New Zealand
Taiwan Liposome Company

Terminated

A Dose-escalation Study of Lipotecan® Plus Radiotherapy in Locally Advanced Hepatocellular Carcinoma

Carcinoma, Hepatocellular

Taiwan
GlaxoSmithKline

Completed

A Phase I/IIa, First Time in Human, Study of GSK2636771 in Subjects With Advanced Solid Tumors With Phosphatase and Tensin Homolog (PTEN) Deficiency

Cancer

Korea, Republic of, United States, United Kingdom
Case Comprehensive Cancer Center
National Cancer Institute (NCI)

Terminated

Preoperative Folfirinox for Resectable Pancreatic Adenocarcinoma - A Phase II Study

Pancreatic Adenocarcinoma | Resectable Pancreatic Cancer | Stage III Pancreatic Cancer | Stage IIA Pancreatic Cancer | Stage IIB Pancreatic Cancer | Stage IA Pancreatic Cancer | Stage IB Pancreatic Cancer | Poorly Differentiated Malignant Neoplasm | Undifferentiated Pancreatic Carcinoma

United States
AstraZeneca

Completed

A Phase IIa Study to Investigate the Efficacy and Safety of AZD7624 in Chronic Obstructive Pulmonary Disease (COPD) Patients While on Maintenance Therapy

Chronic Obstructive Pulmonary Disease COPD

United States, Netherlands, Argentina, South Africa, Chile, Peru
Shionogi

Completed

A Phase Ib/IIa, Double-Blind, Randomized Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of S-777469 in Subjects With Atopic Dermatitis

Atopic Dermatitis

United States
Myelo Therapeutics GmbH

Completed

Efficacy and Safety Phase IIa Study of Myelo001 in Chemotherapy-Induced Neutropenia (MyeloConcept)

Breast Cancer | Myelosuppression | Chemotherapy-Induced Neutropenia

Germany
Uppsala University
Karolinska University Hospital; Uppsala University Hospital; AFA Insurance; Swedish...

Completed

CD19-targeting 3rd Generation CAR T Cells for Refractory B Cell Malignancy - a Phase I/IIa Trial.

B Cell Lymphoma | B Cell Leukemia

Sweden
Bayer

Terminated

Phase IIa Study of Copanlisib in Relapsed or Refractory Mantle Cell Lymphoma (MCL)

Lymphoma, Mantle-Cell

United States
Horizon Pharma USA, Inc.

Completed

Phase IIa Study of Fomepizole for Acetaldehyde Toxicity After Ethanol Exposure in Subjects With Altered Ethanol Metabolism

Aldehyde Dehydrogenase-2 (ALDH2) Deficiency

United States
CleveXel Pharma

Completed

Efficacy Phase IIa Study of CVXL-0107 in Advanced Parkinson's Disease

Idiopathic Parkinson Disease

France
Alexion Pharmaceuticals

Terminated

Phase IIa Trial of ALXN1007 for the Treatment of Non-criteria Manifestations of Antiphospholipid Syndrome

Antiphospholipid (aPL)-Positive

United States, Italy, Brazil, France, Japan, United Kingdom

Search clinical trials for: Phase IIa

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