Search clinical trials for: Plasma Pharmacokinetic

Total 19782 results

Cubist Pharmaceuticals LLC

Completed

Plasma Pharmacokinetics (PK) & Lung Penetration of Ceftolozane/Tazobactam in Participants With Pneumonia (MK-7625A-007)

Pneumonia | Critically Ill
Chelsea and Westminster NHS Foundation Trust
Merck Sharp & Dohme LLC; Imperial College London; University of Liverpool

Completed

Pharmacokinetics of Plasma Doravirine Once Daily Over 72 Hours Following Drug Intake Cessation in Healthy Volunteers

Human Immunodeficiency Virus

United Kingdom
Astellas Pharma Inc

Completed

Comparison of Plasma Concentration Changes Between Two Types of Tablets of FK949E Administration to Patients With Major Depressive Disorder

Major Depressive Disorder

Japan
GlycoMimetics Incorporated

Completed

A Study to Determine the Efficacy, Safety and Pharmacokinetics of GMI-1271 as Adjunct to Standard of Care for the Treatment of Multiple Myeloma

Multiple Myeloma

Ireland, Denmark, United Kingdom, Germany
Galera Therapeutics, Inc.

Completed

Study to Evaluate the Effects of 90 mg Intravenous Infusions of GC4419 on the Single Dose Pharmacokinetics of Dextromethorphan in Healthy Adult Subjects

Healthy

United States
Millennium Pharmaceuticals, Inc.

Completed

Pharmacokinetics Study of Oral Ixazomib (MLN9708) in Relapsed/Refractory Multiple Myeloma and Advanced Solid Tumors Participants With Normal Renal Function or Severe Renal Impairment

Multiple Myeloma | Advanced Solid Tumors

United States, Canada
National Institute of Allergy and Infectious Diseases...

Completed

A Study to Evaluate the Safety, Tolerability and Plasma PK of a Single Oral Dose of Zoliflodacin in Healthy Male and Female Volunteers

Gonorrhoea

United States
Boehringer Ingelheim

Completed

Study to Investigate the Pharmacokinetics (PK) and Pharmacodynamics (PD) of Idarucizumab in Chinese Healthy Male and Female Volunteers Who Had Taken Dabigatran Etexilate and Whose Plasma Concentrations of Dabigatran Were at or Close to Steady State

Healthy Volunteers

China
University Hospital, Grenoble

Completed

Influence of a Combined Pharmacogenetic Score on Through Plasma Voriconazole Concentrations in Haematological Patients (VORIGENE)

Invasive Aspergillosis | Voriconazole | Haematological Cancer Patients

France
St. Jude Children's Research Hospital
Eisai Inc.; Medicines for Malaria Venture; Global Health Innovative Technology...

Completed

First-in-Human Study of an Oral Plasmodium Falciparum Plasma Membrane Protein Inhibitor

Malaria

United States
Fraunhofer-Institute of Toxicology and Experimental...
Federal Institute for Occupational Safety and Health (BAuA)/Germany)

Completed

Pharmacokinetics of Enrofloxacin in Plasma and Urine (EnroHuman)

Healthy

Germany
Astellas Pharma Inc

Completed

Examination of Plasma Concentrations and Safety in Chronic Kidney Disease Patients Undergoing Hemodialysis

Patients on Stable Chronic Maintenance Dialysis Who Are Receiving Hemodialysis Therapy | Pharmacodynamics of ASP7991 | Pharmacokinetics of ASP7991

Japan
Millennium Pharmaceuticals, Inc.

Completed

Phase 1 Pharmacokinetic Study of Oral Ixazomib Plus Lenalidomide and Dexamethasone in Adult Asian Participants With Relapsed and/or Refractory Multiple Myeloma

Multiple Myeloma

Hong Kong, Korea, Republic of, Singapore
Medical College of Wisconsin

Completed

Pharmacokinetic Study of Propylene Glycol-Free Melphalan HCl for Myeloablative Conditioning in Multiple Myeloma Patients Undergoing Autologous Transplantation

Multiple Myeloma

United States
Xueding Wang
Sun Yat-sen University

Unknown

A Retrospective Pharmacokinetics and Pharmacogenomics Research of Imatinib in Gastrointestinal Stromal Tumor Treatment

Gastrointestinal Stromal Tumors | Somatic Mutation | Plasma Concentration | Germline Mutation

China
Pfizer

Completed

A Study To Understand Safety And Plasma Concentrations Of PF-06669571 During And Following The Oral Administration Of Single And Multiple Doses Of PF-06669571 In Healthy Volunteers Under Fasted And Fed Conditions

Healthy

United States
Milton S. Hershey Medical Center

Completed

Pharmacokinetics of Nicotine Film in Smokers

Smoking Cessation

United States
North Dakota State University
Neuropsychiatric Research Institute, Fargo, North Dakota

Terminated

Mechanistic Investigation Of Intestinal Cytochrome p450 3A4 Following Roux-en-Y Surgery And Its Effect on Plasma Concentrations of Buspirone

Gastric Bypass
AcelRx Pharmaceuticals, Inc.

Completed

Pharmacokinetics of Sufentanil Sublingual Microtablet 30 mcg and 15 mcg in Healthy Subjects

Healthy

United States
National Institute on Drug Abuse (NIDA)

Completed

Oral Fluid, Plasma and Whole Pharmacokinetics and Stability Following Smoked Cannabis

Cannabis Use | Drug Abuse

United States
Universitaire Ziekenhuizen KU Leuven

Completed

Evaluation of the Dosing Regimen of Vancomycin in Pediatric Patients

Gram-Positive Bacterial Infections

Belgium
R.J. Reynolds Vapor Company
Celerion; RAI Services Company

Completed

Comparison of Nicotine Plasma Concentrations and Subjective Effects for Three Menthol Electronic Cigarettes vs Combustible Menthol Cigarettes and Nicotine Gum

Smoking

United States
R.J. Reynolds Vapor Company
Celerion; RAI Services Company

Completed

Comparison of Nicotine Plasma Concentrations and Subjective Effects for Three Electronic Cigarettes vs Combustible Cigarettes and Nicotine Gum

Smoking

United States
Depomed

Completed

Open Label Crossover Study Pharmacokinetics (PK) Study in Healthy Volunteers Receiving Various Forms of Fentanyl

Healthy
Octapharma

Completed

Pharmacokinetic, Efficacy, and Safety Study of Octafibrin Compared to Haemocomplettan/Riastap

Congenital Fibrinogen Deficiency | Afibrinogenemia

Iran, Islamic Republic of, United States, Bulgaria, India, Switzerland, United Kingdom
Galera Therapeutics, Inc.
Syneos Health

Completed

A Study Designed to Compare the Safety and Pharmacokinetics of Intravenously Administered Superoxide Dismutase Mimetic GC4711 and GC4419 in Healthy Volunteers

Healthy | Healthy Volunteers

Australia
Thierry Buclin

Completed

Lumefantrine in Venous Plasma Versus Dried Capillary Blood Spot

Malaria

Switzerland
Entasis Therapeutics
Clinartis

Completed

Study to Determine and Compare Plasma and Intrapulmonary Concentrations of ETX2514 and Sulbactam in Healthy Subjects

Healthy

United States
Millennium Pharmaceuticals, Inc.

Completed

Pharmacokinetics Study of Oral IXAZOMIB in Participants With Advanced Nonhematologic Malignancies or Lymphoma

Lymphoma | Nonhematologic Malignancies

United States
Endo Pharmaceuticals

Completed

A Pharmacokinetic Study of AA4500 (XIAFLEX™, Proposed Name) in Subjects With Dupuytren's Contracture

Dupuytren's Contracture

United States
Aciex Therapeutics, Inc.

Completed

A Single-Center, Open-Label, Study of the Plasma Pharmacokinetics and Safety of AC-170 0.24%

Healthy

United States
Pfizer

Completed

Study to Assess the Concentration of Avibactam and Ceftazidime in Epithelial Lining Fluid and Plasma

Healthy

United Kingdom
University of Nebraska

Completed

Measurement of Plasma and Intracellular Concentrations of Raltegravir

HIV

United States
Centaurus Biopharma Co., Ltd.

Unknown

Study of Safety,Efficacy and Pharmacokinetics of CT-1530 in Patients With Relapsed or Refractory B Cell Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, and Waldenstrom's Macroglobulinemia

Chronic Lymphocytic Leukemia | Waldenstrom's Macroglobulinemia | Diffuse Large B Cell Lymphoma | Relapsed or Refractory B Cell Non-Hodgkin Lymphoma | Mantle Zone Lymphoma Refractory/Recurrent | Follicle Centre Lymphoma Diffuse

China
Nantes University Hospital

Completed

Tissue and Plasma Pharmacokinetics of Cefazolin in Antibiotic Prophylaxis in Bariatric Surgery (Cefasleeve)

Bariatric Surgery

France
National Cancer Institute (NCI)

Completed

Characterization of the Pharmacokinetics of Oral Selenium Compounds in Humans Before and Following Supplementation

Cancer

United States
GlaxoSmithKline

Completed

Study to Evaluate the Pharmacokinetics and Safety of GSK2336805 in Subjects With Hepatic Impairment and Healthy Matched Control Subjects

Hepatitis C

United States
GlaxoSmithKline

Completed

To Evaluate Plasma and Pulmonary Pharmacokinetics of GSK2140944

Infections, Bacterial

United States
University Hospital, Toulouse

Completed

Study of the Influence of Plasma Exchange on the Pharmacokinetics of Rituximab (PK-rituximab)

Autoimmune Diseases | Renal Transplant

France
Amgen

Completed

Study of the Pharmacokinetics and Safety of Carfilzomib in Patients With Multiple Myeloma and Renal Disease

End-stage Renal Disease | Relapsed Multiple Myeloma

United States, Australia, Canada
Amgen

Completed

Study of the Safety and Pharmacokinetics of Carfilzomib in Patients With Relapsed and Refractory Multiple Myeloma and Varying Degrees of Renal Function

Renal Insufficiency | Multiple Myeloma

United States
Groupe Hospitalier Pitie-Salpetriere

Completed

Pharmacokinetic Study of Antibiotics in Patients Assisted by Extracorporeal Membrane Oxygenation (PHARMECMO) (PHARMECMO)

Sepsis | Extracorporeal Membrane Oxygenation | Intensive Care Unit | Antibiotics
Merck Sharp & Dohme LLC

Completed

A Study to Evaluate the Pharmacokinetic Effect of SCH 503034 (Boceprevir) on Methadone or Buprenorphine/Naloxone Plasma Concentrations (P08123)

Hepatitis C Virus
MerLion Pharmaceuticals GmbH

Completed

Pharmacokinetic Profile in Plasma and Epithelial Lining Fluid of Finafloxacin

Safety and Tolerability

United States
Astellas Pharma Inc

Completed

Study to Evaluate the Effect of Multiple-dose of Fluvoxamine on the Plasma Concentration of Quetiapine (FK949E) in Healthy Male Volunteers

Healthy | Pharmacokinetics of Quetiapine

Japan
Ohio State University Comprehensive Cancer Center
Bayer

Completed

CHOP and Campath-1H in Previously Untreated Aggressive T/NK-Cell Lymphomas

Non-Hodgkin's Lymphoma

United States
Genentech, Inc.

Completed

A Study of the Safety and Pharmacokinetics of MFGR1877S in Patients With Relapsed or Refractory t(4;14)-Positive Multiple Myeloma

Multiple Myeloma

United States, Canada
University of Virginia
The University of Queensland

Completed

Pharmacokinetics of Bolus Versus Continuous Cefazolin Infusion in Patients Undergoing Major Surgery

Plasma Concentration of Antibiotics

United States
Poitiers University Hospital

Completed

Pharmacokinetics of Lenalidomide (Revlimid®) in Patients With Multiple Myeloma and Impaired Renal Function

Multiple Myeloma | Impaired Renal Function

France
Chong Kun Dang Pharmaceutical

Completed

Safety and Pharmacokinetic Profile of CKD-581 (CKD-581)

Lymphoma | Multiple Myeloma

Korea, Republic of

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