Search clinical trials for: pathogenic mechanisms

Total 96227 results

University Health Network, Toronto
Canadian Venous Thromboembolism Clinical Trials and Outcomes Research (CanVECTOR)...

Not yet recruiting

TRanEXamic Acid to Decrease Heavy Menstrual Bleeding in Individuals Anticoagulated for Venous Thromboembolism Pilot Study (T-REX HMB)

Venous Thromboembolism | Venous Thromboses | Anticoagulants and Bleeding Disorders | Heavy Menstrual Bleeding
Bruce Cree
Kyverna Therapeutics

Recruiting

A Study of KYV-101, a CD19 CAR T Cell Therapy, in Participants With Treatment Refractory Progressive Multiple Sclerosis

Progressive Multiple Sclerosis

United States
Iffat Anwar Medical Complex

Recruiting

Assessment of Different Clinical Techniques to Treat Patients With Chronic Low Back Pain (CLBP)

Chronic Low Back Pain (CLBP)

Pakistan
University Health Network, Toronto

Not yet recruiting

A Study of High Dose Radiation Therapy for Locally Advanced Pancreatic Cancer That Responded to Initial Chemotherapy Treatment (ABLATE)

Locally Advanced Pancreatic Adenocarcinoma
University of Pennsylvania

Not yet recruiting

Letrozole and Misoprostol for Early Pregnancy Loss Management: A Prospective Pilot Cohort Study (LeMi)

Miscarriage | Early Pregnancy Loss | Miscarriage in First Trimester

United States
Cancer Institute and Hospital, Chinese Academy...

Not yet recruiting

Gumarontinib Combined With 3rd EGFR-TKI in Patients With Non-small Cell Lung Cancer.

Non-small Cell Lung Cancer
Shanghai Zhongshan Hospital

Not yet recruiting

IndObufen Versus asPirin After Coronary Drug-eluting Stent implantaTION in Elderly Patients With Acute Coronary Syndrome (OPTION2)

Coronary Artery Disease
Bayer

Not yet recruiting

A Study to Learn More About How Well BAY 2927088 Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Human Epidermal Growth Factor Receptor 2 (HER2) (SOHO-02)

Advanced Non-small Cell Lung Cancer | HER2 Mutation

United States, Korea, Republic of, Belgium, China, Hong Kong, Japan, Taiwan, Denmark, Germany, Israel, Poland, Italy, United Kingdom, Bulgaria, Czechia, Portugal, Switzerland, Greece, Turkey, Romania, Sweden, France, Singapore, Mexico, ... and more
University of California, San Francisco

Not yet recruiting

Platelet Rich Plasma Injections In Young And Old Human Subjects (PRP-KOBE)

Osteoarthritis | Musculoskeletal Disorders | Articular Cartilage

United States
CSPC Ouyi Pharmaceutical Co., Ltd.

Not yet recruiting

Safety and Efficacy Study of Pilocarpine HCl Ophthalmic Solution in Participants With Presbyopia

Presbyopia
Second Affiliated Hospital of Wenzhou Medical University
Jinhua Municipal Central Hospital; Taizhou Hospital; Taizhou Hospital of Zhejiang... and other collaborators

Not yet recruiting

Anesthesia and Perioperative Neurocognitive Disorders in the Elderly Patients Undergoing Hip Fracture Surgery Platform Trial (ANDES Platform Trial) (ANDES platform)

Cognitive Impairment | Dementia | Hip Fractures | Anesthesia | Cognitive Decline

China
Central Hospital, Nancy, France

Not yet recruiting

PET Biomarker Study for Antidepressant Response Prediction in Major Depressive Disorder (TEPDEP)

Major Depressive Disorder
Assaf-Harofeh Medical Center

Not yet recruiting

Effect of Regional Anesthesia or Intravenous Infusion of Lidocaine on Morphine Use After Scoliosis Repair Surgery

Scoliosis

Israel
Corporacion Parc Tauli

Not yet recruiting

Preoperative Chemoradiotherapy and Transanal Endoscopic Microsurgery Versus Ttransanal Endoscopic Microsurgery in T1 N0, M0 Rectal Cancer (TAUTEM-T1 Study) (TAUTEM-T1)

Rectal Cancer Stage I
Maria Sklodowska-Curie National Research Institute...

Not yet recruiting

177Lu-PSMA as a Systemic Adjuvant Treatment in Patients With High and Very High Risk Prostate Cancer (PSMA-ADJUVO)

Prostate Cancer
Boston Children's Hospital

Not yet recruiting

Lidocaine Versus Bupivacaine in Orthognathic Surgery

Pain, Postoperative | Numbness | Temperature Sensation | Perception of Touch
Westlake Eye Specialists
Sengi

Recruiting

Effect of Netarsudil vs Brimonidine in NTG Patients on Latanoprost

Normal Tension Glaucoma

United States
Rigshospitalet, Denmark
Aarhus University Hospital Skejby

Recruiting

The Nordic Aortic Valve Intervention Trial 4 (NOTION-4) (NOTION-4)

Heart Diseases | Cardiovascular Diseases | Aortic Valve Stenosis | Heart Valve Diseases | Valve Disease, Aortic

Denmark
New Approaches to Neuroblastoma Therapy Consortium
Nationwide Children's Hospital; United Therapeutics; Children's Neuroblastoma...

Not yet recruiting

NANT 2021-01 Phase II STING (Sequential Temozolomide, Irinotecan, NK Cells and GD2 mAb) Trial

Neuroblastoma

United States
University of Colorado, Denver

Recruiting

Prochlorperazine Maleate Versus Placebo for the Prophylaxis of Acute Mountain Sickness

Acute Mountain Sickness

United States
Fundación de Investigación Biomédica - Hospital...
Hospital Universitario Ramon y Cajal; Universidad Autonoma de Madrid; Hospital... and other collaborators

Not yet recruiting

Cerebral and Anti-inflammatory Response Through Exercise - Mechanisms In Depressive Disorders (CARE-MIND)

Inflammatory Response | Major Depressive Disorder

Spain
Ohio State University

Not yet recruiting

Changes in Eye Shape With Myopia Management Interventions

Myopia
Montefiore Medical Center

Not yet recruiting

The Effect of Local and Systemic Tranexamic Acid on Edema and Ecchymosis in Orbital Surgery

Orbital Edema | Orbital Ecchymosis

United States
Institute of Hematology & Blood Diseases Hospital...

Recruiting

Selinexor、Venetoclax and Azactidine in the Treatment of ND AML Patients Who Are Not Eligible for Intense Chemotherapy

Acute Myeloid Leukemia, Adult

China
Merck Sharp & Dohme LLC

Not yet recruiting

A Study to Evaluate the Efficacy and Safety of MK-0616 Compared With Ezetimibe or Bempedoic Acid or Ezetimibe and Bempedoic Acid in Adults With Hypercholesterolemia (MK-0616-018)

Hypercholesterolemia
Ruijin Hospital

Not yet recruiting

CMV-specific T Cell Immunity Test Indicated Prophylaxis of Letermovir After All-HSCT

Hematologic Malignancy
Zhujiang Hospital

Recruiting

Effect of Henagliflozein on Hepatic Fat Content in Patients With T2DM and NAFLD (HHTN)

Nonalcoholic Fatty Liver Disease | Type2 Diabetes Mellitus

China
Chinese University of Hong Kong
University of Palermo; University of Malaya; Singapore General Hospital; University... and other collaborators

Not yet recruiting

Non-selective Beta-blocker in Compensated Advanced Chronic Liver Disease (BB_cACLD)

Portal Hypertension | Advanced Chronic Liver Disease | Hepatic Decompensation
Fudan University

Recruiting

Apatinib Combined With cdk4/6i in First-line Treatment for HR+/HER2- SNF4 Subtype Breast Cancer

Advanced Breast Cancer | HR+/HER2- Breast Cancer

China
Changchun GeneScience Pharmaceutical Co., Ltd.

Not yet recruiting

Safety, Efficacy and Pharmacokinetic Behavior of Leuprolide Injectable Emulsion for Premenopausal Breast Cancer Subjects.

Breast Cancer Subjects

China
Jonsson Comprehensive Cancer Center

Not yet recruiting

PH Weighted Chemical Exchange Saturation Transfer MRI-Based Surgical Resection to Improve Survival in Patients With Glioblastoma

Glioblastoma

United States
Nanfang Hospital, Southern Medical University

Recruiting

Research on the Mechanisms of Treatment Non-response in Inflammatory Bowel Disease Based on Multi-omics Technology

Inflammatory Bowel Diseases

China
University of North Carolina, Chapel Hill
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Not yet recruiting

Dose Optimization of Caffeine for HIE

Hypoxic-Ischemic Encephalopathy

United States
Peking University First Hospital

Recruiting

Fractional Flow Reserve-guided Stenting Versus Medical Therapy in Atherosclerosis Renal Artery Stenosis (FAIR)

Renal Artery Stenosis Atherosclerotic | Secondary Hypertension Renal Arterial

China
Academisch Medisch Centrum - Universiteit van Amsterdam...
Universitair Medical Centrum Groningen

Not yet recruiting

Head-to-Head Comparison of All Botulinum Neurotoxin Type A Products for Glabellar Rhytides

Wrinkle
Pfizer

Not yet recruiting

A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation.

Carcinoma, Non-Small-Cell Lung | Colorectal Neoplasms | Carcinoma, Pancreatic Ductal
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Humanized CD19-Specific CAR T Cells for the Treatment of Patients With Positive Relapsed or Refractory CD19 Positive B-Cell Acute Lymphoblastic Leukemia

Recurrent Acute Lymphoblastic Leukemia | Refractory Acute Lymphoblastic Leukemia

United States
Shanghai Zhongshan Hospital

Not yet recruiting

Combining Chemoradiotherapy With Sintilimab in First-Line ICC

ICC

China
BioNTech SE

Not yet recruiting

Safety, Preliminary Effectiveness of BNT327, an Investigational Therapy for Patients With Small-cell Lung Cancer in Combination With Chemotherapy

Small-cell Lung Cancer | Extensive-stage Small-cell Lung Cancer
BioNTech SE

Not yet recruiting

Safety and Preliminary Effectiveness of BNT327, an Investigational Therapy for Breast Cancer, When Given in Combination With Chemotherapy

Triple Negative Breast Cancer | Locally Advanced Breast Cancer
University of Maryland, Baltimore

Not yet recruiting

Effect of RECK in Posterior Spinal Fusion

Degenerative Disc Disease | Degenerative Spondylolisthesis | Degenerative Lumbar Spinal Stenosis | Degenerative Disease

United States
Universitas Diponegoro
Dr. Kariadi General Hospital Medical Center

Recruiting

Biomarkers & Infection After Prophylactic Antibiotic in Cardiac Implantable Electronic Device Implantation (BI-PACED)

Heart Block | Biomarkers | Antibiotic Prophylaxis | CIED Related Infection | CIED-related Infections

Indonesia
Mersin Medicalpark Hastanesi

Recruiting

Does Verapamil Given Orally Prevent Radial Artery Spasm During Transradial Coronary Angiography

Radial Artery Spasm

Turkey
Shandong University
Chinese PLA General Hospital

Not yet recruiting

Observational Study on the Sensitivity of Neoadjuvant Immunotherapy in Early Triple-Negative Breast Cancer

Triple Negative Breast Cancer | Sensitivity | Neoadjuvant Immunotherapy
Sichuan Kelun Pharmaceutical Research Institute...

Recruiting

A Study of SKB264 in Combination With Pembrolizumab Versus Pembrolizumab in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Non-Small Cell Lung Cancer

China
D. Bradley Welling, MD, PhD
Nobelpharma

Not yet recruiting

In-office Repair of Chronic Tympanic Membrane Perforations

Chronic Tympanic Membrane Perforation

United States
University of Milan
Kolfarma s.r.l. - Italy; Fondazione Telethon

Recruiting

Targeting the Gut to Improve Seizure Control in CDKL5 Deficiency Disorder (CDD) (NUTRIENT)

CDKL5

Italy
AstraZeneca

Not yet recruiting

Volrustomig Priming Regimens Exploratory Phase II Platform Study (eVOLVE-01)

Non-small Cell Lung Cancer
Ohio State University Comprehensive Cancer Center

Recruiting

Manipulating E-Cigarette Nicotine to Promote Public Health

Tobacco-Related Carcinoma

United States
Sichuan Baili Pharmaceutical Co., Ltd.
Baili-Bio (Chengdu) Pharmaceutical Co., Ltd.

Not yet recruiting

A Study of BL-M07D1, BL-M07D1+Pertuzumab and BL-M07D1+Pertuzumab+Docetaxel in Patients With Unresectable Locally Advanced or Metastatic HER2-positive Breast Cancer

HER2-positive Breast Cancer

China

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