Search clinical trials for: repeat dose

Total 22107 results

GlaxoSmithKline

Terminated

First-time-in-Human (FTIH) Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single (in Both Fed and Fasted States) or Repeat Doses of GSK3358699

Arthritis, Rheumatoid

United Kingdom
Boston Pharmaceuticals

Completed

Study to Determine the Single and Repeat Dose Pharmacokinetics, Food Effect, Proton Pump Inhibitor (PPI) Drug Interaction, Safety and Tolerability of Oral Prototype Formulations of BOS172767 in Healthy Subjects

Healthy Subjects

United Kingdom
Boston Pharmaceuticals

Completed

Study to Determine the Relative Bioavailability, Single and Repeat Dose Pharmacokinetics, Safety and Tolerability of BOS172767 Enantiomers in Healthy Subjects

Healthy Participants

United Kingdom
Leiden University Medical Center
Swiss Tropical & Public Health Institute; Centre Suisse de Recherches Scientifiques...

Completed

Repeated Doses of Praziquantel in Schistosomiasis Treatment (RePST) (RePST)

Schistosomiasis

Côte D'Ivoire
GlaxoSmithKline

Terminated

A Safety and Tolerability Study of Otelixizumab in Thyroid Eye Disease

Graves Ophthalmopathy

United Kingdom
GlaxoSmithKline
Wake Forrest Baptist Health

Terminated

An Exploratory Study on the Effects of Repeat Doses of Albiglutide Compared to Exenatide on Gastric Myoelectrical Activity and Gastric Emptying in Type 2 Diabetes Mellitus Subjects

Diabetes Mellitus, Type 2

United States
GlaxoSmithKline

Completed

A Two-part Study to Compare a Tablet and Capsule Formulation of GSK2838232 With and Without Food, and to Assess the Safety and Drug Levels of Repeated Once-daily Doses of GSK2838232 Without Ritonavir

HIV Infections | Infection, Human Immunodeficiency Virus

United States
GlaxoSmithKline

Terminated

Repeat Dose Study of GSK3772847 in Participants With Moderate to Severe Asthma With Allergic Fungal Airway Disease (AFAD)

Asthma

France, Netherlands, Russian Federation, United Kingdom
Unity Biotechnology, Inc.

Completed

A Study of Single and Repeat Dose Administration of UBX0101 in Patients With Osteoarthritis of the Knee

Knee Osteoarthritis

United States
Iconic Therapeutics, Inc.

Completed

Study Evaluating Single and Repeated Intravitreal Doses of ICON-1 in Patients With Uveal Melanoma

Uveal Melanoma | Choroid Neoplasm

United States
Fondazione del Piemonte per l'Oncologia

Completed

Study of Efficacy and Safety of Laparoscopic Intra-abdominal Chemotherapy (PIPAC) Performed in Patients With Peritoneal Carcinomatosis From Colorectal, Ovarian, Gastric Cancer and Primary Peritoneal Tumors (PI-CaP)

Peritoneal Carcinomatosis

Italy
Pfizer

Completed

Study to Evaluate the Effect of Repeat-Dose Rifampin on the Pharmacokinetics (PK) of PF-06651600

Healthy Volunteers

Belgium
Jonsson Comprehensive Cancer Center

Completed

Docetaxel and Trastuzumab With or Without Carboplatin in Treating Women With HER2-Positive Breast Cancer

Breast Cancer

United States
Medy-Tox

Completed

The Efficacy and Safety of Repeat-dose Potenfill for Temporary Penile Enhancement

Penile Enhancement | Penile Girth Enhancement

Korea, Republic of
GlaxoSmithKline

Completed

First Time in Human (FTIH) Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Single and Repeat Doses of GSK3439171A in Healthy Subjects and to Assess Food Effect

Muscular Dystrophies

United States
GlaxoSmithKline

Completed

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of Repeat Doses of GSK2982772 in Subjects With Psoriasis

Psoriasis

Canada
Chiesi Farmaceutici S.p.A.

Completed

A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Dose in Healthy Volunteers, Repeat Doses in Asthmatic Patients and of Single Dose in COPD Patients of CHF6366

Chronic Obstructive Pulmonary Disease | Asthma

United Kingdom
Loma Linda University
Sarah Capalla; Ebony HIllery; Kaushik Mukherjee; Timothy Lee

Withdrawn

Low Dose Ketamine Infusion for the Treatment of Resistant Depression

Depression

United States
H. Lundbeck A/S

Completed

Effects of Repeated Doses of Foliglurax on Drug Metabolizing Enzymes in Healthy Subjects

Healthy

France
Prometic Biotherapeutics, Inc.
Vanderbilt University Medical Center; Cedars-Sinai Medical Center; Indiana Hemophilia...

No longer available

A Single-patient Study of Repeat-dose Administration of Prometic Plasminogen (Human) Intravenous

Hypoplasminogenemia
Chiesi Farmaceutici S.p.A.

Terminated

A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Repeat Doses of CHF6297 in Healthy Subjects and Patients With COPD (CHF6297 FIH)

Chronic Obstructive Pulmonary Disease

United Kingdom
Novus Therapeutics, Inc

Completed

Evaluation of Safety of Repeated Doses of OP0201 Metered Dose Inhaler Compared to Placebo in Healthy Adult Volunteers

Healthy Adult Volunteers

United States
Yonsei University

Completed

The Optimal Dose of Sevoflurane Via Anaconda® in Post-operative Patient Underwent Head & Neck Surgery

Patients Who Needs Sedation After Head & Neck Surgery

Korea, Republic of
ViiV Healthcare
GlaxoSmithKline

Completed

Dose Ranging Study of GSK1265744 Plus Nucleoside Reverse Transcriptase Inhibitors for Induction of Human Immunodeficiency Virus-1 (HIV-1) Virologic Suppression Followed by Virologic Suppression Maintenance by GSK1265744 Plus Rilpivirine

HIV Infections | Infection, Human Immunodeficiency Virus

United States, Canada
University Tunis El Manar

Completed

Cortisol Level After Repeated Doses of Etomidate

Adrenocortical Abnormality

Tunisia
Pfizer

Completed

Study to Assess Pharmacokinetics, Safety and Tolerability of PF-04965842 in Chinese Healthy Participants

HEALTHY

China
Kristina Gemzell Danielsson

Terminated

Repeated Doses of Misoprostol for Medical Treatment of Missed Miscarriage

Missed Abortion

Sweden
Eli Lilly and Company
Locemia Solutions ULC

Terminated

A Study of Single and Repeated Doses of Glucagon Administered to Participants With Diabetes

Diabetes Mellitus, Type 2 | Diabetes Mellitus, Type 1

Canada
GlaxoSmithKline

Completed

A Phase 3a, Repeat Dose, Open-label, Long-term Safety Study of Mepolizumab in Asthmatic Subjects

Asthma

United States, Argentina, Australia, Canada, France, Germany, Japan, Netherlands, Poland, Russian Federation, Spain, Ukraine, Belgium, Chile, Korea, Republic of, Czechia, Italy, United Kingdom
Biogen

Completed

Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Repeated Doses of PF-04958242 in Healthy Volunteers

Schizophrenia

United States
University of Pennsylvania
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Evaluate the Tolerability and Therapeutic Effects of Repeated Doses of Autologous T Cells With VRX496 in HIV

HIV

United States
Academisch Medisch Centrum - Universiteit van Amsterdam...

Completed

Regorafenib in Combination With Paclitaxel in Advanced Oesophagogastric Carcinoma (REPEAT)

Stomach Neoplasms | Neoplasm Metastasis | Esophageal Neoplasms

Netherlands
OPKO Health, Inc.

Completed

A Study in Type 2 Diabetic Patients With Repeated Doses of E1 in Combination With G1

Type 2 Diabetes

United States
OPKO Health, Inc.

Completed

A Study in Type 1 Diabetic Patients With Repeated Doses of E1 in Combination With G1

Type 1 Diabetes

United States
Eli Lilly and Company
Locemia Solutions ULC

Completed

A Study of Single or Repeated Doses of Glucagon in Participants With Diabetes

Diabetes Mellitus, Type 2 | Diabetes Mellitus, Type 1

Canada
GlaxoSmithKline

Completed

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of Single and Repeated Doses of Topical GSK1278863

Wound Healing

United States
Health Decisions
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Unknown

28-Day Repeat-Dose, Dose Escalation Study of 11-β Methyl Nortestosterone Dodecylcarbonate (11β-MNTDC) in Healthy Men (CCN014A)

Healthy Men | Male Contraception

United States
GlaxoSmithKline
Nucleus Network Ltd

Completed

Safety, Tolerability and Preliminary Pharmacokinetics (PK) and Pharmacodynamics (PD) of Single and Repeat Oral Doses of GSK3008356 in Healthy and Obese Subjects

Healthy Volunteers

Australia
GlaxoSmithKline

Completed

Safety, Tolerability and Pharmacokinetics of Single and Repeat Doses of GSK2292767 in Healthy Participants Who Smoke Cigarettes

Asthma

United Kingdom
Pfizer

Completed

A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Repeat Doses of PF-06372865 in Healthy Subjects

Healthy Volunteers

United States
University of Minnesota
Parkinson's Disease Society of the United Kingdom

Completed

Repeated-Dose Oral N-acetylcysteine for the Treatment of Parkinson's Disease

Parkinson Disease

United States
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Effects of a Single-Dose and Repeat-Administration of Intranasal Esketamine on On-Road Driving in Participants With Major Depressive Disorder (DriveSaFe2)

Depressive Disorder, Major

Netherlands
ImmuPharma

Completed

Study of Repeated Administration of a 200-mcg Dose of IPP-201101 Plus Standard of Care in Patients With Systemic Lupus Erythematosus (IP-006)

Lupus Erythematosus, Systemic

United States, Puerto Rico, France, Mauritius, Czechia, Germany, Hungary
Inmunova S.A.
Hospital Italiano de Buenos Aires

Completed

Anti-Shiga Toxin Hyperimmune Equine Immunoglobulin F(ab')2 Fragment (INM004) in Healthy Volunteers

Healthy Volunteers

Argentina
IlDong Pharmaceutical Co Ltd
Asan Medical Center

Terminated

Dose-escalation, Repeated and Single Oral Dosing Study

Acute Coronary Syndrome
Tulane University Health Sciences Center

Completed

Trichomonas Vaginalis Repeat Infections Among HIV Negative Women

Vaginitis Trichomonal or Due to Trichomonas

United States
Daiichi Sankyo, Inc.

Completed

Effect of Repeated Doses of DS-8500a on Pharmacokinetics of Rosuvastatin in Healthy Volunteers

Drug Pharmacokinetics in Healthy Volunteers

United States
Yale University

Completed

Study of High-dose Influenza Vaccine Efficacy by Repeated Dosing IN Gammopathy Patients (SHIVERING 2)

Multiple Myeloma | Influenza | Waldenstrom's Macroglobulinemia | MGUS | Plasma Cell Disorders

United States
Severance Hospital
Armed Forces Capital Hospital, Republic of Korea

Completed

Optimal Sevoflurane Concentration for Intubation in Combination of Clincal Remifentanil Doses

Postoperative Pain

Korea, Republic of
GlaxoSmithKline

Terminated

A Three-part Study to Determine the Safety, Tolerability and Pharmacokinetics of GSK1322322 in Healthy Volunteers and Healthy Male Japanese Subjects

Infections, Bacterial

United States

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