Search clinical trials for: simvastatin

Total 633 results

Eli Lilly and Company

Withdrawn

A Study of LY3526318 in Healthy Male Japanese Participants

Healthy

Japan
Ain Shams University

Completed

Lepidium Sativum Extract Versus Simvastatin as an Adjunctive Local Delivery Agents to Non-Surgical Periodontal Therapy

Periodontitis

Egypt
National Cancer Institute (NCI)

Completed

Simvastatin in Reducing Pancreatitis in Patients With Recurrent, Acute or Chronic Pancreatitis

Acute Pancreatitis

United States
The University of Hong Kong

Enrolling by invitation

Statin and Bone Health

Diabetes Mellitus, Type 2

Hong Kong
Amgen

Completed

LDL-C Assessment With PCSK9 Monoclonal Antibody Inhibition Combined With Statin Therapy-2 (LAPLACE-2)

Hyperlipidemia

United States, Denmark, France, Italy, Czechia, Taiwan, Switzerland, Korea, Republic of, Germany, Hong Kong, Netherlands, Australia, Belgium, Canada, Hungary, South Africa, Russian Federation, Spain, United Kingdom, Sweden, Mexico
University of Oxford

Completed

7-day Simvastatin and Emotional Processing (SSTEP-HV)

Depression | Inflammation

United Kingdom
University of Texas Southwestern Medical Center
Abhimanyu Garg; Prishant Mishra; Jimin Ren

Completed

7 Tesla MRI Study in Patients With Statin Related Muscle Complaints

Muscle Weakness | Muscle Cramp | Muscle Stiffness | Statin-related Muscle Pain | Muscle Aches

United States
Suez Canal University

Completed

Efficacy of Combination of Biodentine and Simvastatin as a Pulp Capping Materials in Vital Pulpotomy of Primary Molars

Pulpitis - Irreversible

Egypt
Brigham and Women's Hospital

Completed

Effect of Statin Use on Aldosterone Secretion

Healthy Subjects

United States
Hospital do Coracao

Withdrawn

Single Pill to Avert Cardiovascular Events (SPACE)

Cardiovascular Disease

Brazil
Madrigal Pharmaceuticals, Inc.
Celerion

Completed

Drug Interaction Study of MGL-3196 With Rosuvastatin and Simvastatin

Healthy

United States
National Taiwan University Hospital

Completed

Simvastatin Therapy in Patients With Dilated Cardiomyopathy. (SavDCM)

Dilated Cardiomyopathy

Taiwan
University of Cologne
German Federal Ministry of Education and Research

Completed

Statin Recapture Therapy Before Coronary Artery Bypass Grafting (StaRT-CABG)

Coronary Artery Disease

Germany
University College, London
London School of Hygiene and Tropical Medicine; The Leeds Teaching Hospitals... and other collaborators

Active, not recruiting

Multiple Sclerosis-Simvastatin Trial 2 (MS-STAT2)

Secondary Progressive Multiple Sclerosis (SPMS)

United Kingdom
Fundación de investigación HM
Apices Soluciones S.L.

Completed

Study of Ruxolitinib Plus Simvastatin in the Prevention and Treatment of Respiratory Failure of COVID-19. (Ruxo-Sim-20)

Coronavirus Infection

Spain
Postgraduate Medical Institute, Lahore

Completed

Salivary Bmp-2 Levels & Radiographic Measurement Of Bone Density at Extracted Tooth (salivaryBMP2)

Bone Injury

Pakistan
Amarin Pharma Inc.

Completed

Efficacy and Safety of AMR101 (Ethyl Icosapentate) in Patients With Fasting Triglyceride (Tg) Levels ≥ 500 and ≤ 2000 mg/dL (MARINE)

Hypertriglyceridemia

United States, Netherlands, Russian Federation, Ukraine, Denmark, Finland, Germany, India, Italy, Mexico, South Africa
Amarin Pharma Inc.

Completed

Effect of AMR101 (Ethyl Icosapentate) on Triglyceride (Tg) Levels in Patients on Statins With High Tg Levels (≥ 200 and < 500 mg/dL) (ANCHOR)

Hypertriglyceridemia

United States
Aurinia Pharmaceuticals Inc.

Completed

Drug-Drug Interaction Study to Investigate Effects of Voclosporin on Pharmacokinetics of Simvastatin (Statin-DDI)

Drug-drug Interaction

United States
Amarin Pharma Inc.

Completed

A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High-Risk Patients With Hypertriglyceridemia and on Statin (REDUCE-IT)

Cardiovascular Diseases

United States, Australia, Canada, India, Netherlands, New Zealand, Poland, Romania, Russian Federation, South Africa, Ukraine
National Cancer Center, Korea
Boehringer Ingelheim

Completed

BIBW 2992 Plus Simvastatin vs. BIBW 2992 in Previously Treated Patients With Advanced Non-adenocarcinomatous NSCLC

Non-small Cell Lung Cancer

Korea, Republic of
National Cancer Center, Korea

Active, not recruiting

Irinotecan/Cisplatin With or Without Simvastatin in Chemo-naive Patients With Extensive Disease-small Cell Lung Cancer

Small Cell Lung Carcinoma

Korea, Republic of
Sanofi
Regeneron Pharmaceuticals

Completed

Safety, Tolerability, and Effect of Alirocumab in High Cardiovascular Risk Patients With Severe Hypercholesterolemia Not Adequately Controlled With Conventional Lipid-modifying Therapies (ODYSSEY APPRISE)

Hypercholesterolemia

France, Belgium, Austria, Canada, Czechia, Denmark, Finland, Germany, Greece, Hungary, Poland, Romania, Slovakia, Slovenia, Spain, Switzerland
VA Office of Research and Development

Completed

Integrating Pharmacogenetics In Clinical Care (I-PICC)

Cardiovascular Disease

United States
Organon and Co

Completed

Vytorin As Strategy To Reduce Dislipidemia In Adults (0653A-148)

Hyperlipidemia
Organon and Co

Withdrawn

A Study to Evaluate the Efficacy and Safety of Vytorin Versus Standard Treatment of Other Statins in Moderate, Moderately High and High Risk Participants (MK-0653A-406) (VYCTORY)

Dyslipidemia
Organon and Co

Completed

Aggrastat to Zocor (AtoZ) - the Use of Two Approved Drugs to Treat Patients Who Have Experienced Chest Pain or a Heart Attack (0733-180)

Acute Coronary Syndrome
Organon and Co

Completed

EASEGO Study: Doubling of Atorvastatin/Simvastatin or INEGY in Patients With Hypercholesterolemia and Coronary Artery Disease(CAD)(0653A-089)

Atherosclerosis
Brigham and Women's Hospital
Patient-Centered Outcomes Research Institute; McGill University; VA Boston Healthcare...

Active, not recruiting

Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes Study (CER-4-T2D)

Type2 Diabetes | Renal Disease | Cardiovascular Events

United States
Organon and Co

Completed

Effect Of Ezetimibe Coadministration With Simvastatin In A Middle Eastern Population: A Prospective, Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial (0653-151)

Hypercholesterolemia
Organon and Co

Completed

A Study Comparing Ezetimibe Plus Simvastatin Versus Simvastatin Alone in Patients at Risk for Heart Disease (0653-023)(COMPLETED)

Coronary Disease
Organon and Co
Schering-Plough

Completed

A Research Study to Evaluate MK0653 (Ezetimibe) and Simvastatin, Given Together and Alone, on Intestinal Absorption of Cholesterol (0653-050)(COMPLETED)

Cholesterol
Organon and Co

Completed

Study To Assess The Efficacy Of A Cholesterol Lowering Drug On Top Of Statins In Patients After Myocardial Infarction (MI)(0653A-150)

Cardiovascular Disorder
Organon and Co

Completed

Eze/Simva Switch Study in Diabetics (0653A-807)

Diabetes Mellitus, Type 2
Organon and Co

Terminated

Vytorin Treating Uncontrolled Lipids (VyTUL) Study (0653A-122)

Cardiovascular Diseases | Diabetes Mellitus
Organon and Co

Completed

Study Evaluating the Efficacy and Safety of Simvastatin Alone Compared With Simvastatin Plus Ezetimibe in Type 2 Diabetic Patients (0653-021)(COMPLETED)

Diabetes Mellitus, Type 2
Organon and Co
Merck Sharp & Dohme LLC

Completed

Ezetimibe Plus Simvastatin Versus Simvastatin Alone in African-American Subjects With Primary Hypercholesterolemia (P03377)

Atherosclerosis | Hypercholesterolemia
Organon and Co
Merck Frosst Canada Ltd.

Terminated

Ezetimibe Plus Simvastatin Versus Simvastatin in Patients With Hypercholesterolemia and Coronary Risk Factors (P03405)

Atherosclerosis | Hypercholesterolemia
Organon and Co

Completed

Safety and Tolerability Study of Ezetimibe (SCH 058235/MK-0653) Plus Atorvastatin or Simvastatin in Homozygous Familial Hypercholesterolemia (P01417/MK-0653-019)

Hypercholesterolemia
Organon and Co
Merck Sharp & Dohme LLC

Completed

Ezetimibe Plus Simvastatin Versus Simvastatin in Untreated Subjects With High Cholesterol (P03435)

Atherosclerosis | Hypercholesterolaemia
Organon and Co

Completed

To Evaluate the Lipid-Lowering Efficacy and Safety of Simvastatin 40 Mg Tablet In Patients With Hypercholesterolemia (0733-264)

Hypercholesterolemia

Taiwan
Organon and Co
Merck Sharp & Dohme LLC

Terminated

Effect of Ezetimibe Plus Simvastatin on Flow-Mediated Brachial Artery Vasoactivity in Subjects With Primary Hypercholesterolemia (Study P03336)

Atherosclerosis | Hypercholesterolemia
Organon and Co
Merck Sharp & Dohme LLC

Completed

Effect of Ezetimibe Plus Simvastatin Versus Simvastatin Alone on Atherosclerosis in the Carotid Artery (ENHANCE)(P02578) (ENHANCE)

Atherosclerosis | Hypercholesterolemia | Hyperlipoproteinemia Type II
Organon and Co

Completed

A Crossover Study to Evaluate the Efficacy of Simvastatin in Elevating HDL-C Levels in Patients With Type 2 Diabetes (0733-216)(COMPLETED)

HDL Cholesterol
Organon and Co

Completed

A Study to Evaluate Ezetimibe in Korean Patients With Primary Hypercholesterolemia (0653-042)

Hypercholerolemia
Organon and Co
Merck Sharp & Dohme LLC

Completed

Comparison of Co-administration of Ezetimibe Plus Simvastatin Versus Simvastatin Alone in Primary Hypercholesterolemia (P03476)

Atherosclerosis | Hypercholesterolemia | Coronary Heart Disease
Organon and Co
Merck Sharp & Dohme LLC

Completed

Assessment of Interaction Between Vytorin and Niaspan in Healthy Subjects (P04955AM2)

Hypercholesterolemia | Hyperlipidemia
Organon and Co

Completed

A 12 Week Study of MK0653A in Patients Who Have Been Hospitalized for a Possible Heart Problem (0653A-808)

Hypercholesterolemia
Organon and Co
Merck Sharp & Dohme LLC

Completed

Comparison of Ezetimibe Plus Simvastatin Versus Ezetimibe or Simvastatin Alone in Subjects With Primary Hypercholesterolemia (Study P03757)(COMPLETED)

Hypercholesterolemia
Organon and Co

Completed

A Study to Evaluate an Investigational Drug in Patients With Mixed Hyperlipidemia (0653A-071)(COMPLETED)

Hypercholesterolemia | Hypertriglyceridemia | Hyperlipidemia

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