Search clinical trials for: tPA

Total 168 results

University of Malaya

Unknown

Comparing Clinical Application of Innovatedly Made Transpalatal Arch (TPA) From 3D Reconstructed Model and Conventionally Made TPA

Transpalatal Arch (TPA) | Oral Health Related Quality of Life (OHRQoL) | Oral Health Impact Profile Short Version 14 (OHIP 14) | Orthodontic Pain | Three Dimensional (3D) Orthodontic Device

Malaysia
Hui-Sheng Chen

Terminated

Argatroban Plus r-tPA for Posterior Circulation Infarction（AR-PCI）

Argatroban, Rt-PA

China
University of North Carolina, Chapel Hill
Parion Sciences

Completed

Evaluation of Regional Lung Deposition of Inhaled Saline Using the tPAD Device

Lung Diseases

United States
Neuroscience Trials Australia
Melbourne Health; University of Melbourne; Commonwealth Scientific and Industrial... and other collaborators

Completed

Extending the Time for Thrombolysis in Emergency Neurological Deficits (EXTEND)

Stroke

Australia, Finland, New Zealand
Neuroscience Trials Australia
China Medical University Hospital

Completed

EXTEND (International): Extending the Time for Thrombolysis in Emergency Neurological Deficits (International) (EXTEND)

Stroke

Taiwan
The Cleveland Clinic
Health Resources and Services Administration (HRSA)

Completed

Enhancing Donated After Cardiac Death (DCD) Utilization With Thrombolytic Therapy

Liver Transplantation | Kidney Transplantation

United States
Biosuccess Biotech Co., Ltd.

Terminated

Safety and Efficacy Study of PD-616 Plus Cytarabine to Treat Acute Myelogenous Leukemia or Myelodysplastic Syndrome (AML/MDS)

Myelodysplastic Syndrome | Acute Myelogenous Leukemia

United States
Capital Medical University

Unknown

r-tPA Thrombolytic Therapy in Combination With Remote Ischemic Conditioning for Acute Ischemic Stroke Recovery (rtPA-RIC)

Stroke, Acute

China
University Hospital Heidelberg
University Hospital, Essen; University of Erlangen-Nürnberg Medical School; Ruhr... and other collaborators

Terminated

Thrombectomy in Patients Ineligible for iv tPA (THRILL)

Ischemic Stroke

Germany, Austria
University of Louisville
Genentech, Inc.

Terminated

Safety and Efficacy of Tissue Plasminogen Activator (tPA) in Neonates and Infants

Thrombosis

United States
Neuroscience Trials Australia
The Florey Institute of Neuroscience and Mental Health

Completed

Tenecteplase Versus Alteplase Before Endovascular Therapy for Ischemic Stroke (EXTEND-IA TNK)

Ischemic Stroke

Australia, New Zealand
University of Pittsburgh
Parion Sciences

Completed

A Study of Lung Clearance After Hypertonic Saline Delivery Using the tPAD Device

Cystic Fibrosis

United States
University of North Carolina, Chapel Hill

Withdrawn

Novel Therapies for Muco-Obstructive Lung Diseases: Testing the Transnasal Pulmonary Delivery Device in COPD/CB Subjects (tPAD)

COPD | Chronic Bronchitis

United States
Mahidol University

Unknown

Promoting Physical Activity and Break in Office Workers

Physical Activity | Sedentary Lifestyle

Thailand
Andrew D. Barreto, MD
The University of Texas Health Science Center, Houston

Terminated

Randomized Controlled Trial of Argatroban With Tissue Plasminogen Activator (tPA) for Acute Stroke (ARTSS-2)

Ischemic Stroke

United States
Johns Hopkins University
Genentech, Inc.

Completed

Safety of Intravenous Thrombolytics in Stroke on Awakening (SAIL-ON)

Stroke

United States
University of California, Los Angeles
National Institute of Neurological Disorders and Stroke (NINDS)

Terminated

Hypothermia in Acute Stroke With Thrombolysis Imaging Evaluation of Revascularization (HASTIER)

Acute Ischemic Stroke

United States
University of California, San Diego
The University of Texas Health Science Center, Houston; National Institute...

Terminated

The Intravascular Cooling in the Treatment of Stroke 2/3 Trial (ICTuS2/3)

Stroke, Acute

United States, Austria, Switzerland
Medical College of Wisconsin

Terminated

Improving Patient Access to Stroke Therapy Study (IMPACT)

Ischemic Stroke | Transient Ischemic Attack

United States
Grifols Therapeutics LLC

Completed

A Study of Intra-thrombus Plasmin (Human) In Acute Peripheral Arterial Occlusion

Acute Peripheral Arterial Occlusion

United States, Peru, Belgium, Bulgaria, Czech Republic, Germany, India, Poland, Romania, Serbia, Slovakia, Spain
Ocular Therapeutix, Inc.

Completed

Multi-Arm Feasibility Study Evaluating OTX-TP Compared to Timolol in Treatment of Subjects With Open Angle Glaucoma

Glaucoma

South Africa
Capital Medical University

Unknown

Protective Effects of Normobaric Hyperoxia on Blood Brain Barrier in Patients With Acute Ischemic Stroke

Stroke, Acute
University Hospital, Caen

Unknown

Interest of Thromboelastography (ROTEM) as a Biomarker of Revascularisation in Stroke (ROTEMPredict)

Stroke

France
Hadassah Medical Organization

Withdrawn

Study of Aspirin and TPA in Acute Ischemic Stroke

Acute Ischemic Stroke

Israel
Charite University, Berlin, Germany

Completed

Comparison of Pre-hospital and In-hospital Iv-tPA Stroke Treatment

Ischemic Stroke

Germany
East Carolina University

Completed

Telephone Physical Activity Intervention in Obese Youth (TPAI)

Obesity

United States
University of Windsor
The Kidney Foundation of Canada

Unknown

Trial to Compare 1.0 Versus 2.0 mg Alteplase (tPA) Dosing in Restoring Hemodialysis Catheter Function

Kidney Disease

Canada
Thomas Jefferson University
Genentech, Inc.

Unknown

Quality of Life After Stroke Using a Telemedicine-based Stroke Network (STROKE TeleQOL)

Stroke

United States
Children's Mercy Hospital Kansas City

Withdrawn

Empyema Treated With tPA & DNAse

Empyema

United States
Fundacion para la Investigacion Biomedica del Hospital...

Completed

Efficacy and Security of an Endovascular Treatment as First Choice Procedure Compared With a Standard Intravenous Thrombolytic Therapy Treatment for Patients With Acute Ischemic Stroke Within 4.5 Hours After Onset (FUN-TPA)

Acute Ischaemic Stroke

Spain
Sunnybrook Health Sciences Centre
University Health Network, Toronto; Unity Health Toronto

Completed

The CLOQS Trial - Countdown Lights to Optimize Quality in Stroke (CLOQS)

Acute Stroke

Canada
D-Pharm Ltd.

Unknown

A Study of the Safety, Imaging and Clinical Outcomes of THR-18 in Acute Stroke Subjects Treated With tPA

Ischemic Stroke

Moldova, Republic of
Rush University Medical Center

Withdrawn

Effect of Intraventricular tPA Following Aneurysmal Subarachnoid Hemorrhage

Subarachnoid Hemorrhage | Cerebral Vasospasm | Cerebral Aneurysm | Hydrocephalus

United States
Rutgers, The State University of New Jersey
National Cancer Institute (NCI); Rutgers Cancer Institute of New Jersey; Biosuccess...

Terminated

Phase II Study of TPA Plus Dexamethasone & CMT in Hematologic Malignancies

Leukemia

United States
Instituto de Cardiologia do Rio Grande do Sul
Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Brazil; Conselho...

Completed

Treatment of Periodontal Disease in Patients With Acute Myocardial Infarction (TPAMI)

Periodontitis

Brazil
Academy Military Medical Science, China
Sun Yat-sen University

Unknown

Therapy of Preconditioned Autologous BMMSCs for Patients With Ischemic Heart Disease (TPAABPIHD)

Myocardial Infarction | Acute Myocardial Infarction | Ischemic Cardiomyopathy
Neuroscience Trials Australia

Terminated

Extending the Time for Thrombolysis in Emergency Neurological Deficits - Intra-Arterial (EXTEND-IA)

Ischemic Stroke

Australia, New Zealand
Cerevast Therapeutics, Inc.

Terminated

Phase 3, Randomized, Placebo-Controlled, Double-Blinded Trial of the Combined Lysis of Thrombus With Ultrasound and Systemic Tissue Plasminogen Activator (tPA) for Emergent Revascularization in Acute Ischemic Stroke (CLOTBUST-ER)

Acute Ischemic Stroke

United States
University of Virginia
National Institute of Neurological Disorders and Stroke (NINDS)

Terminated

Study of Tenecteplase (TNK) in Acute Ischemic Stroke (TNK-S2B)

Stroke

United States
D-Pharm Ltd.

Completed

THR-18's Pharmacokinetics and Pharmacodynamics in Subjects With Acute Ischemic Stroke Treated With tPA

Stroke, Acute

Ukraine
Children's Mercy Hospital Kansas City

Completed

Treatment of Abdominal Abscesses With or Without Fibrinolysis

Abdominal Abscess | Tissue Plasminogen Activator

United States
The Second Artillery General Hospital
Hunan Rui Kang Tong technology development co., LTD

Unknown

Mechanical Opening Device Implantation Following Intravenous r-tPA for Recanalization in Acute Ischemic Stroke

Ischemic Cerebrovascular Accident
University Hospital, Lille
Institut National de la Santé Et de la Recherche Médicale, France

Completed

Outcome of Patients Treated by iv Rt-PA for Cerebral Ischaemia According to the Ratio Sc-tPA/Tc-tPA (OPHELIE)

Stroke, Acute | Drug Toxicity

France
The University of Texas Health Science Center,...

Completed

Argatroban Stroke Treatment - A Pilot Safety Study

Ischemic Stroke

United States
Richard Chang, M.D.
National Institutes of Health Clinical Center (CC)

Completed

Low-Dose Alteplase to Treat Blood Clots in Deep Leg Veins

Acute Deep Venous Thrombosis of the Lower Extremity

United States
Boehringer Ingelheim

Completed

Full Dose Tenecteplase (TNK-tPA) Together With Heparin Sodium, Full Dose Tenecteplase With Enoxaparin, Half Dose Tenecteplase Together With Abciximab and Heparin Sodium in Patients With Acute Myocardial Infarction (AMI) (ASSENT 3)

Myocardial Infarction
Boehringer Ingelheim

Completed

A Study to Investigate the Procoagulant Effect of Tenecteplase (TNK-tPA), Alteplase (Rt-PA) and Streptokinase (SK) Administered to Patients With Acute Myocardial Infarction (AMI)

Myocardial Infarction
Georgetown University
Johns Hopkins University; University of Alabama at Birmingham; University of... and other collaborators

Completed

Acute Stroke Program of Interventions Addressing Racial and Ethnic Disparities (ASPIRE)

Stroke

United States
University Health Network, Toronto

Terminated

Safety and Effectiveness of tPA in Intra-abdominal Abscesses

Abscess

Canada
Boehringer Ingelheim

Completed

Trial to Compare the Efficacy and Safety of a Single Bolus of TNK-tPA (Tenecteplase, Metalyse®) With Accelerated Infusion of Rt-PA (Alteplase, Actilyse®) in Asian Patients With Acute Myocardial Infarction

Myocardial Infarction

China, Korea, Republic of, Hong Kong

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