Clinical Trials Sponsored by Threshold Pharmaceuticals

Total 19744 results

Hallym University Medical Center
Pfizer; HK inno.N Corporation; Handok Inc.; Jeil Pharmaceutical Co., Ltd.

Completed

S-1, Oxaliplatin, and Irinotecan for Advanced Gastrointestinal Cancer

Gastrointestinal Neoplasms

Korea, Republic of
Kyunghee University Medical Center
Kyung Hee University Hospital at Gangdong; Hamsoa Pharmaceutical Co., Ltd.

Completed

A 12 Week, Phase II Trial to Evaluate the Efficacy and Safety of WIN-34B in Patients With Osteoarthritis of the Knee

Osteoarthritis, Knee

Korea, Republic of
Research in Real-Life Ltd
Teva Branded Pharmaceutical Products R&D, Inc.; i3 Research

Completed

Real-world Effectiveness and Cost-effectiveness of Qvar Versus FP, a US Study (USQvarAsthma)

Asthma

United Kingdom
Chengdu University of Traditional Chinese Medicine
Chongqing Taiji Group of Fuling pharmaceutical Co., LTD

Completed

Multicentre, Randomized, Controlled Trial of Qideng Mingmu Capsule in The Treatment of Diabetic Retinopathy

Diabetic Retinopathy | Diabetic Eye Problems | Retinal Disorders

China
Seoul National University Hospital
Seoul National University Bundang Hospital; Dong-A Pharmaceutical Co., Ltd.

Unknown

A Randomized Trial of Udenafil Therapy in Patients With Heart Failure With Preserved Ejection Fraction [ULTIMATE-HFpEF]

Diastolic Heart Failure

Korea, Republic of
Tel-Aviv Sourasky Medical Center
Teva Branded Pharmaceutical Products R&D, Inc.; Medtronic - MITG

Unknown

A Double Blind Placebo Control Study to Assess the Safety,Tolerability and Efficacy of Copaxone in Crohn's Disease (Cop1CD)

Crohns Disease

Israel
University of Cologne
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; German Hodgkin...

Terminated

Study of Bortezomib (Velcade) in Combination With Dexamethasone to Treat Patients With Relapsed Hodgkin's Lymphoma

Hodgkin Disease

Germany
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

Study of the Pharmacokinetics of Isavuconazole in Healthy Non-Elderly and Elderly Male and Female Subjects

Healthy Volunteers | Pharmacokinetics of Isavuconazole | Safety and Tolerability in Elderly

United States
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

Drug Interaction Study of Isavuconazole and Digoxin

Healthy Volunteers | Pharmacokinetics of Isavuconazole | Pharmacokinetics of Digoxin

United States
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

Drug Interaction Study of the Effect of Ketoconazole at Steady State on the Pharmacokinetics of a Single Dose of Isavuconazole in Healthy Adult Subjects

Healthy Adult Volunteers | Pharmacokinetics of Isavuconazole | Pharmacokinetics of Ketoconazole

United States
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

Drug Interaction Study of Multiple Doses of Isavuconazole and a Single Dose of Bupropion

Healthy Volunteers | Pharmacokinetics of Isavuconazole | Pharmacokinetics of Bupropion

United States
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

Drug Interaction Study of Multiple Doses of Isavuconazole and Single Dose of Dextromethorphan in Healthy Adult Subjects

Healthy Adult Volunteers | Pharmacokinetics of Isavuconazole | Pharmacokinetics of Dextromethorphan

United States
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

Drug-drug Interaction Study Between Lopinavir/Ritonavir and Isavuconazole

Healthy Volunteers | Pharmacokinetics of Isavuconazole | Pharmacokinetics of Lopinavir/Ritonavir

United States
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

A Study to Evaluate the Effect of Multiple Doses of Esomeprazole on the Pharmacokinetics of Isavuconazole

Healthy Subjects | Pharmacokinetics of Isavuconazole

United States
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

A Study to Evaluate the Pharmacokinetics of BAL8728 After a Single Dose of Pyridinylmethyl-14C-Labeled Isavuconazonium Sulfate in Healthy Male Subjects

Healthy Subjects | Pharmacokinetics of 14C-labeled Isavuconazonium Sulfate

United States
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

Study to Evaluate the Pharmacokinetics of 14C-labeled Isavuconazole Following a Single Oral Dose of 14C-labeled Prodrug Isavuconazonium Sulfate (BAL8557) in Healthy Male Subjects

Healthy Subjects | Pharmacokinetics of 14C-labeled Isavuconazole

United States
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

A Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of a Single Dose of Sirolimus in Healthy Subjects

Healthy Subjects | Pharmacokinetics of Isavuconazole | Pharmacokinetics of Sirolimus

United States
Foundation for the National Institutes of Health
Eli Lilly and Company; National Institute of Diabetes and Digestive and Kidney... and other collaborators

Unknown

Dynamic Responsiveness of Insulin Secretory Parameters To Sitagliptin and Glimeperide Administration in Type 2 DM

Type 2 Diabetes
Foundation for the National Institutes of Health
Eli Lilly and Company; National Institute of Diabetes and Digestive and Kidney... and other collaborators

Completed

Outpatient Characterization of the Variability of Insulin Secretory Parameters in the Meal Tolerance and the Maximal Stimulation Tests of Subjects With Type 2 Diabetes Mellitus

Type 2 Diabetes

United States
Foundation for the National Institutes of Health
Eli Lilly and Company; National Institute of Diabetes and Digestive and Kidney... and other collaborators

Completed

Characterization of the Variability Of Insulin Secretory Parameters in the Meal Tolerance and the Maximal Stimulation Tests of Subjects With Prediabetes

Type 2 Diabetes

United States
Foundation for the National Institutes of Health
Eli Lilly and Company; National Institute of Diabetes and Digestive and Kidney... and other collaborators

Completed

Characterization of the Variability of Insulin Secretory Parameters in the Meal Tolerance and the Maximal Stimulation Tests of Subjects With Type 2 Diabetes Mellitus

Type 2 Diabetes

United States
National Institute on Drug Abuse (NIDA)
Technical Resources International, Inc.; Promentis Pharmaceuticals, Inc.; Altasciences...

Not yet recruiting

SXC-2023 Cocaine Interaction Study

Cocaine Use Disorder

United States
Peter MacCallum Cancer Centre, Australia
Sanofi; Regeneron Pharmaceuticals; Monash University; University of Adelaide; University...

Recruiting

Deep sequencIng in Cutaneous Squamous CEll caRciNomas (DISCERN)

Neoplasms | Cutaneous Squamous Cell Carcinoma of the Head and Neck | Non-melanoma Skin Cancer | Cutaneous Squamous Cell Carcinoma

Australia
Institute of Cancer Research, United Kingdom
Merck Sharp & Dohme LLC; Cancer Research UK; Astex Pharmaceuticals, Inc.

Recruiting

ASTEROID: A Trial of ASTX660 in Combination With Pembrolizumab (ASTEROID)

Cervical Cancer | Triple Negative Breast Cancer | Advanced Cancer

United Kingdom
Emory University
National Cancer Institute (NCI); National Institutes of Health (NIH); Telix Pharmaceuticals...

Active, not recruiting

Fluciclovine F18 or Ga68-PSMA PET/CT to Enhance Prostate Cancer Outcomes

Prostate Adenocarcinoma

United States
Kathy Miller
Pfizer; Astex Pharmaceuticals, Inc.; Van Andel Institute Stand Up to Cancer Team

Completed

Study of ASTX727 Plus Talazoparib in Patients With Triple Negative or Hormone Resistant/HER2-negative Metastatic Breast Cancer

Metastatic Breast Cancer | Triple Negative Breast Cancer | Hormone Receptor Positive Tumor

United States
Armata Pharmaceuticals, Inc.
Agility Clinical, Inc.; Vantage Data Designs, Inc.; E Squared Trials and Registries...

Completed

A Study to Evaluate the Microbiology, Safety and Tolerability of C16G2 Dental Strip Application

Dental Caries

United States
Jaeb Center for Health Research
National Eye Institute (NEI); National Institutes of Health (NIH); Regeneron...

Completed

Anti-VEGF vs. Prompt Vitrectomy for VH From PDR (AB)

Proliferative Diabetic Retinopathy | Vitreous Hemorrhage

United States, Canada
Duke University
National Institute of Allergy and Infectious Diseases (NIAID); The Miriam Hospital and other collaborators

Completed

Optical Imaging and User Perception Study of Vaginal Gel

Characterize Gel Distribution in the Vagina | Study Women's Sensory Perceptions and Preferences of Gel

United States
Dana-Farber Cancer Institute
Beth Israel Deaconess Medical Center; Brigham and Women's Hospital; Millennium...

Completed

Bortezomib (Velcade) in Waldenstrom's Macroglobulinemia

Lymphoplasmacytic Lymphoma | Waldenstrom's Macroglobulinemia

United States
Abela Pharmaceuticals, Inc.
Ohio State University; University of California, Irvine; Dr. Mahajan's Hospital...

Unknown

Controlled Trial of ABELADRUG200 in Closed, Severe Head Injury (ABELADRUG200)

Severe Head Trauma

United States
Synta Pharmaceuticals Corp.
National Institute of Allergy and Infectious Diseases (NIAID); National Institutes...

Completed

Study of STA-5326 Mesylate in Patients With Moderate to Severe Crohn's Disease

Crohn's Disease

United States
Foundation for the National Institutes of Health
Eli Lilly and Company; National Institute of Diabetes and Digestive and Kidney... and other collaborators

Completed

Characterization of the Variability of Insulin Secretory Parameters in the Meal Tolerance and the Maximal Stimulation Tests of Healthy Subjects

Type 2 Diabetes

United States
The First Affiliated Hospital with Nanjing Medical...
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Recruiting

A Novel Ferumoxytol-enhanced Cardiac Magnetic Resonance Imaging for the Detection of Intracardiac Thrombus

Heart Aneurysm

China
Duk-Woo Park, MD
CardioVascular Research Foundation, Korea; Daewoong Pharmaceutical Co. LTD.

Not yet recruiting

ENAVOgliflozin Outcome Trial in Patients With Severe Aortic Stenosis After Transcatheter Aortic Valve Replacement (ENAVO-TAVR)

Aortic Valve Stenosis

Korea, Republic of
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Jiangsu Hengrui Pharmaceutical Co., Ltd.

Recruiting

TACE Combined With Camrelizumab and Apatinib in the Treatment of Advanced Liver Cancer

Hepatocellular Carcinoma

China
The First Affiliated Hospital with Nanjing Medical...
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Recruiting

Assessment of Renal Vasculature and Function With Ferumoxytol-enhanced Magnetic Resonance Imaging

Chronic Kidney Diseases

China
Hunan Cancer Hospital
Fuzhou Pulmonary Hospital of Fujian; Chia Tai Tianqing Pharmaceutical Group...

Recruiting

Anlotinib Plus Penpulimab for the Treatment of Sensitive Relapsed Small-Cell Lung Cancer

Small Cell Lung Cancer

China
Anhui Shi, MD
Peking University Cancer Hospital & Institute; Chia Tai Tianqing Pharmaceutical...

Completed

Anlotinib After Chemoradiotherapy in Stage III Non-Small-Cell Lung Cancer（ALTER-L029） (ALTER-L029)

Non-Small Cell Lung Cancer Stage III

China
University Health Network, Toronto
Celgene Corporation; Otsuka Pharmaceutical Development & Commercialization,... and other collaborators

Completed

Busulfan & Melphalan Conditioning for Autologous Stem Cell Transplant (ASCT) and Lenalidomide Maintenance (BuMelMCRN001)

Multiple Myeloma

Canada
Hangzhou ACEA Pharmaceutical Research Co., Ltd.
Guangdong Provincial People's Hospital; Acea Bio (Hangzhou) Co., Ltd.

Active, not recruiting

Safety, Pharmacokinetic and Preliminary Efficacy Study of AC0010 in Patients With EGFR T790M Positive NSCLC

Metastatic Non-small Cell Lung Cancer

China
Dongzhimen Hospital, Beijing
Beijing Union pharmaceutical factory II; Beijing Compete Medical Technology...

Completed

Efficacy and Safety of TMBCZG in Mild to Moderate Vascular Dementia

Vascular Dementia

China
Zhejiang Cancer Hospital
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Innovent Biologics (Suzhou)...

Unknown

The Efficacy and Safety of Antinib Hydrochloride Combined With Sindilumab in Advanced NSCLC Patients

NSCLC

China
Andrew Ko
Eli Lilly and Company; Taiho Pharmaceutical Co., Ltd.

Terminated

Gemcitabine and S-1 for Locally Advanced Unresectable or Metastatic Pancreatic Cancer

Pancreatic Cancer

United States
Rigshospitalet, Denmark
University of Texas Southwestern Medical Center; Groupe Hospitalier Pitie-Salpetriere and other collaborators

Completed

The Effect of Triheptanoin in Adults With McArdle Disease (Glycogen Storage Disease Type V)

Glycogen Storage Disease Type V

Denmark
Hangzhou ACEA Pharmaceutical Research Co., Ltd.
Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Withdrawn

A Study Comparing AC0010 and Chemotherapy in Patients With Advanced NSCLC Who Have Progressed Following Prior EGFR TKI

NSCLC

China
The Affiliated Nanjing Drum Tower Hospital of Nanjing...
Xian-Janssen Pharmaceutical Ltd.

Not yet recruiting

Adjutant Apalutamide Plus ADT in Post-RP Patients With High Risk of Recurrence (ARES Study) (ARES)

Prostate Cancer | Biochemical Recurrence | High Risk

China
Shanghai Henlius Biotech
Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd.; HeNan Sincere...

Recruiting

Evaluate the Efficacy and Safety of Azvudine in Preventing SARS-Cov-2 Infection in Household Contacts of Covid-19

SARS-CoV-2 Infection

Malaysia, Philippines
The First Affiliated Hospital with Nanjing Medical...
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Recruiting

XELOX Combined With Anlotinib and Penpulimab vs XELOX as Adjuvant Therapy in ctDNA Positive Gastric and Esophagogastric Junction Adenocarcinoma (EXPLORING)

Digestive System Diseases | Gastrointestinal Diseases | Carcinoma | Gastrointestinal Neoplasms | Stomach Cancer | Gastric Cancer | Gastroesophageal-junction Cancer

China
Peking Union Medical College Hospital
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Xinda Biopharmaceutical Group

Not yet recruiting

Sintilimab Combined With Anlotinib Therapy for Initially Unresectable Non-small Cell Lung Cancer

Carcinoma, Non-Small-Cell Lung

Clinical Trials Sponsored by Threshold Pharmaceuticals

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