Search clinical trials for: Simvastatine

Total 599 results

University of Guadalajara

Completed

Statins for Oxidative Stress and Mitochondrial Function in Diabetic Polyneuropathy

Oxidative Stress | Diabetic Polyneuropathy

Mexico
Organon and Co

Completed

To Evaluate the Lipid-Lowering Efficacy and Safety of Simvastatin 40 Mg Tablet In Patients With Hypercholesterolemia (0733-264)

Hypercholesterolemia

Taiwan
Pakistan Institute of Living and Learning
King's College London

Completed

Simvastatin as an Augmentation Treatment for Treatment Resistant Depression: Randomized Controlled Trial. (DepSTAT)

Major Depressive Disorder | Treatment Resistant Depression

Pakistan
Takeda

Completed

Efficacy of Lapaquistat Acetate Alone or Combined With Simvastatin in Subjects With Hypercholesterolemia

Hypercholesterolemia

United States, Canada
Pfizer

Completed

A Clinical Trial Comparing Torcetrapib/Atorvastatin To Simvastatin In Subjects With High Cholesterol.

Dyslipidemia | Hypercholesterolemia | Hyperlipidemia

United States
Cedars-Sinai Medical Center
Roswell Park Cancer Institute

Completed

Cellular Effect of Cholesterol-Lowering Prior to Prostate Removal

Prostate Cancer

United States
Organon and Co
Merck Sharp & Dohme LLC

Terminated

Effect of Ezetimibe Plus Simvastatin on Flow-Mediated Brachial Artery Vasoactivity in Subjects With Primary Hypercholesterolemia (Study P03336)

Atherosclerosis | Hypercholesterolemia
Organon and Co
Merck Sharp & Dohme LLC

Completed

Comparison of Ezetimibe Plus Simvastatin Versus Ezetimibe or Simvastatin Alone in Subjects With Primary Hypercholesterolemia (Study P03757)(COMPLETED)

Hypercholesterolemia
Tehran University of Medical Sciences

Completed

Simvastatin in Relapsing Remitting Multiple Sclerosis (RRMS) Patients Using Avonex Compared to Placebo (irmsrct)

Relapsing Remitting Multiple Sclerosis

Iran, Islamic Republic of
Organon and Co

Completed

MK0653A (Ezetimibe (+) Simvastatin) Compared to an Approved Drug (Atorvastatin) for the Treatment of High Cholesterol (0653A-051)(COMPLETED)

Hypercholesterolemia
Complexa, Inc.

Completed

A Study of the PK Interaction of CXA-10 With Pravastatin and Vytorin® in Healthy Males (DDI)

Acute Kidney Injury

United States
Merck Sharp & Dohme LLC

Completed

Lipid Efficacy Study (0524B-022)(COMPLETED)

Primary Hypercholesterolemia | Mixed Hyperlipidemia
Johns Hopkins University
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

Effects of Simvastatin on Uterine Leiomyoma Size

Leiomyoma | Fibroid Uterus | Leiomyoma, Uterine | Fibroid Tumor | Fibromyoma

United States
Organon and Co
Merck Sharp & Dohme LLC

Completed

Ezetimibe Plus Simvastatin Versus Simvastatin in Untreated Subjects With High Cholesterol (P03435)

Atherosclerosis | Hypercholesterolaemia
Ain Shams University

Completed

Simvastatin Effect on Radiation Therapy of Brain Metastases

Brain Metastases

Egypt
Pfizer

Terminated

A Clinical Trial Comparing Torcetrapib/Atorvastatin To Simvastatin In Subjects With High Cholesterol (A5091031).

Dyslipidemia | Hypercholesterolemia | Hyperlipidemia

United States
Anna Cruceta

Recruiting

Efficacy of Simvastatin in Alcoholic Liver Fibrosis (SIMFIB)

Liver Fibrosis | Alcohol Abuse

Spain
Indonesia University

Recruiting

The Role of Simvastatin in The Epithelial-Mesenchymal Transition Process of Breast Cancer

Triple Negative Breast Cancer | Chemotherapy Effect | Simvastatin Adverse Reaction

Indonesia
Washington University School of Medicine

Completed

Statins and Cerebral Blood Flow in Subarachnoid Hemorrhage (SAH)

Subarachnoid Hemorrhage

United States
Takeda

Completed

Efficacy of Lapaquistat Acetate and Simvastatin in Subjects With Primary Dyslipidemia.

Hypercholesterolemia

Poland, United Kingdom, Germany, South Africa, Finland, Estonia, Czech Republic
Seoul National University Hospital
Merck Sharp & Dohme LLC

Unknown

Study to Compare the Effect of Vytorin (Simvastatin/Ezetimibe) 10/20mg Versus Atorvastatin 20mg on ApoB/ApoA1 Ratio in Subjects With Diabetes

Type 2 Diabetes Mellitus Without Insulin Treatment

Korea, Republic of
Canadian Network for Observational Drug Effect...
Canadian Institutes of Health Research (CIHR); Drug Safety and Effectiveness...

Completed

High Potency Statins and Acute Kidney Injury

Hypercholesterolemia

Canada
Samsung Medical Center

Completed

Trial of Simvastatin and Gemcitabine in Pancreatic Cancer Patients

Pancreatic Cancer

Korea, Republic of
Nicolaus Copernicus University

Completed

The Evaluation of Vitiligous Lesions Repigmentation After the Administration of Atorvastatin Calcium Salt and Simvastatin-acid Sodium Salt in Patients With Active Vitiligo (EVRAAS)

Non-segmental Vitiligo

Poland
Organon and Co
Schering-Plough

Completed

A Research Study to Evaluate MK0653 (Ezetimibe) and Simvastatin, Given Together and Alone, on Intestinal Absorption of Cholesterol (0653-050)(COMPLETED)

Cholesterol
Organon and Co

Completed

An Investigational Drug on Clinical Outcomes in Patients With Aortic Stenosis (Narrowing of the Major Blood Vessel of the Heart)(MK-0653A-043 AM4)(COMPLETED)

Aortic Stenosis
Merck Sharp & Dohme LLC

Completed

Ezetrol Post-Marketing Study

Hyperlipidemia
Government Dental College and Research Institute...

Completed

Comparative Evaluation Of 1.2% Atorvastatin and 1.2% Simvastatin Gel Local Drug Delivery And Redelivery In Chronic Periodontitis Subjects With Diabetes Mellitus: A Randomized Controlled Clinical Trial.

Chronic Periodontitis Wth Diabetes Mellitus

India
National Cancer Center, Korea
Boehringer Ingelheim

Completed

BIBW 2992 Plus Simvastatin vs. BIBW 2992 in Previously Treated Patients With Advanced Non-adenocarcinomatous NSCLC

Non-small Cell Lung Cancer

Korea, Republic of
Seoul National University Hospital

Completed

Evaluate the Effects of the Environmental Change in Intestine by Antibiotics on the Pharmacokinetic Characteristics of Simvastatin in Healthy Male Volunteers

Simvastatin Pharmacokinetics and Gut Microbiome

Korea, Republic of
Government Dental College and Research Institute...

Completed

Platelet Rich Fibrin Combined With Simvastatin for Treatment of Intrabony Defect in Chronic Periodontitis

Three Wall Intrabony Defects in Chronic Periodontitis

India
paresh Dandona

Terminated

Anti-inflammatory Effects of Simvastatin

Inflammation | Atherosclerosis | Hypercholesterolemia

United States
National Cancer Center, Korea

Active, not recruiting

Irinotecan/Cisplatin With or Without Simvastatin in Chemo-naive Patients With Extensive Disease-small Cell Lung Cancer

Small Cell Lung Carcinoma

Korea, Republic of
University of California, San Diego
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Effects of Statin Medications on Mental Processes, Behavior, and Serotonin Levels

Dyslipidemias

United States
Medical College of Wisconsin

Completed

Effect of Diabetes Mellitus on Cholesterol Metabolism

Type 2 Diabetes Mellitus | Hypercholesterolemia | Type 1 Diabetes Mellitus

United States
Organon and Co

Completed

A 12 Week Study of MK0653A in Patients Who Have Been Hospitalized for a Possible Heart Problem (0653A-808)

Hypercholesterolemia
Canadian Network for Observational Drug Effect...
Canadian Institutes of Health Research (CIHR); Drug Safety and Effectiveness...

Completed

High Potency Statins and the Risk of Diabetes (Statins-DM)

Cardiovascular Disease | Diabetes Mellitus, Type 2
Fundación Lindavista del Corazón AC

Terminated

Left Ventricular Hypertrophy Reduction With Statins in Hypertensives Patients (MK0653A-168)

Hypertension
Abbott

Completed

An Open-Label Study to Compare the Lipid Effects of Niacin ER and Simvastatin (NS) to Atorvastatin in Subjects With Hyperlipidemia or Mixed Dyslipidemia (SUPREME) (SUPREME)

Hyperlipidemia | Mixed Dyslipidemia

United States
Thammasat University

Completed

Efficacy of High and Low-Dose Simvastatin on Vascular Oxidative Stress and Neurological Outcome in Patients With AIS

Ischemic Stroke
Organon and Co

Completed

Ezetimibe Plus (+) Simvastatin Versus Atorvastatin Comparative Study (0653A-092)(COMPLETED)

Hypercholesterolemia
Organon and Co

Completed

A Multicenter, Randomized, Open Label Study to Evaluate the Lipid Lowering Efficacy and Safety of Vytorin® 10/20 vs. Atorvastatin 10mg in Hypercholesterolemia Patients With Metabolic Syndrome in Korea (0653A-129)(COMPLETED)

Hypercholesterolemia
Chinese University of Hong Kong

Completed

Genome-wide Analysis of Lipid-lowering Efficacy and Drug Level of Simvastatin and Rosuvastatin

Hypercholesterolemia

Hong Kong
Novartis Pharmaceuticals

Completed

Safety, Pharmacokinetics and Pharmacodynamics of LGT209 in Healthy Volunteers With Elevated Cholesterol and in Hypercholesterolemic Patients Treated With Statins

Hypercholesterolemia | LDL Cholesterol

United States
Lund University

Recruiting

Treatment of Graves´Ophthalmopathy With Simvastatin (GO-S)

Graves Ophthalmopathy | Thyroid Associated Ophthalmopathy | Thyroid Associated Orbitopathy

Sweden
Mitsubishi Tanabe Pharma Corporation

Completed

A Study to Investigate the Effect of MT-8554 on the Pharmacokinetics of Simvastatin and Rosuvastatin in Healthy Subjects

Healthy

United Kingdom
Mahidol University

Completed

The Effects of Simvastatin on Th17 Cytokines and Th17 Polarizing Cytokine in COPD Patients

COPD

Thailand
Institute of Liver and Biliary Sciences, India

Recruiting

To Study the Safety and Efficacy of Simvastatin in Patients With Hepatopulmonary Syndrome in Cirrhosis.

Liver Cirrhosis

India
Poznan University of Medical Sciences
Yale University

Unknown

Simvastatin and Metformin Therapy in PCOS Women. Prospective Randomised Trial.

Polycystic Ovary Syndrome

Poland
Organon and Co

Completed

Vytorin (10/20 Or 10/40) Compared to Atorvastatin (10 mg or 20 mg) in Patients With Coronary Artery Disease (0653A-126)(COMPLETED)

Hypercholesterolemia

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