Clinical Trials Sponsored by TNO

Total 1883 results

TO Pharmaceuticals

Withdrawn

A Trial to Assess the Efficacy and Safety of Medical Grade Cannabis in Children Diagnosed With Autism Spectrum Disorder

Autistic Disorder

Israel
TO Pharmaceuticals

Completed

The Effect of Cannabis on Dementia Related Agitation and Aggression

Agitation Related to Dementia

Israel
TO Pharmaceuticals

Withdrawn

Study to Investigate the Efficacy and Safety of Cannabis Oil for the Treatment of Subjects With Hidradenitis Suppurativa

Hidradenitis Suppurativa

Israel
Can Tho Stroke International Services Hospital

Recruiting

Rescue Carotid Stenting in Tandem Occlusions: 4-year Experience From a Comprehensive Stroke Centre

Acute Stroke | Ischemic Stroke, Acute

Vietnam
Can Tho Stroke International Services Hospital

Recruiting

Intracranial Stenting in Non-acute Symptomatic Ischemic Stroke (INSIS)

Arterial Occlusive Diseases | Ischemic Stroke | Intracranial Arterial Diseases | Intracranial Arteriosclerosis

Vietnam
Tao Zhang

Recruiting

Efficacy and Safety of Toripalimab Combined With Docetaxel or Nab-paclitaxel in Patients With Advanced Gastric Cancer

Gastric Cancer Stage IV

China
Jin-tao Zhang

Unknown

Mental Imagery Tasks to Reduce Internet Gaming Disorder (IGD) Cravings

Internet Gaming Disorder

China
Gao Tao

Completed

Indicators Predicting Surgery in Acute Severe Ulcerative Colitis(ASUC)

Surgery | Ulcerative Colitis Acute
Medical University Innsbruck
TNI Medical AG

Unknown

STIT-2: Evaluation of Safety and Efficacy of Short-time TNI® Treatment in Patients With COPD and Hypercapnia (STIT-2)

COPD | Hypercapnia

Austria, Germany, Switzerland
RTI International
No Means No Worldwide

Completed

The No Means No South Africa Evaluation Study

Sexual Violence | Gender-based Violence

South Africa
Can Tho Stroke International Services Hospital

Recruiting

Tandem Occlusions After Emergent Stenting in Acute Ischemic Stroke (TOESIS)

Acute Stroke | Ischemic Stroke, Acute

Vietnam
Treadwell Therapeutics, Inc
TIO Discovery Engine

Recruiting

Safety and Efficacy Study of CFI-402411 in Subjects With Advanced Solid Malignancies

Advanced Solid Malignancies

United States, Hong Kong, Canada
Can Tho Stroke International Services Hospital

Completed

Rescue Stenting in the Severe Atherosclerotic Stenosis After the Failure of Intravenous Thrombolysis (RESFIT)

Thrombosis | Stent Stenosis | Ischemic Stroke, Acute

Vietnam
Can Tho Stroke International Services Hospital

Completed

Rescue Intracranial Stenting in Acute Ischemic Stroke (RISIS)

Ischemic Stroke | Intracranial Hemorrhages | Stroke, Ischemic | Stent Stenosis | Acute Stroke | Cerebral Ischemia | Intracranial Atherosclerosis | Stent Occlusion | Thrombotic Stroke, Acute

Vietnam
Gilead Sciences
Ono Pharmaceutical Co. Ltd

Completed

Study to Evaluate the Safety and Tolerability of Tirabrutinib (ONO/GS-4059) Given as Monotherapy in Participants With Relapsed/Refractory NHL and CLL

Chronic Lymphocytic Leukaemia | Non Hodgkins Lymphoma

United Kingdom, France
University of Leipzig
TNI Medical AG

Completed

Effectiveness of TNI vs. BiPAP in Chronic Global Insufficiency in COPD Patients (TIBICO)

COPD Chronic Obstructive Pulmonary Disease

Germany
Ono Pharmaceutical Co. Ltd
MSD K.K.

Completed

MK-0431/ONO-5435 Phase III Clinical Trial-Rapid-acting Insulin Secretagogue Add-on Study in Patients With Type 2 Diabetes

Type 2 Diabetes

Japan
Rabin Medical Center
Ono Academic College

Unknown

Force Feedback Joystick in Upper Limb Rehabilitation Following Stroke

Stroke

Israel
Wageningen University
University Medical Center Groningen; Cereal Partners Worldwide; TNO; Nederlands... and other collaborators

Completed

Improving Resilience With Whole Grain Wheat (Graandioos)

Healthy | Metabolism

Netherlands
Can Tho Stroke International Services Hospital

Completed

Emergent Stenting In Acute Vertebrobasilar Occlusions (ESVO)

Acute Stroke | Ischemic Stroke, Acute | Vertebro Basilar Ischemia

Vietnam
HNO-Praxis Alte Post
Aerin Medical

Completed

Evaluate the Effectiveness of the Vivaer ARC Stylus for Nasal Breathing

Nasal Obstruction, Bilateral

Germany
Yale University
Ono Pharmaceutical Co. Ltd

Withdrawn

The Utility of Camostat Mesylate in Patients With COVID-19 Associated Coagulopathy (CAC) and Cardiovascular Complications

COVID-19 | Coagulopathy | Cardiovascular Complication
Gilead Sciences
Ono Pharmaceutical Co. Ltd

Completed

Study to Evaluate Safety and Pharmacokinetics of GS-4059 (Tirabrutinib) in Healthy Volunteers and Participants With Rheumatoid Arthritis (RA)

Rheumatoid Arthritis

United States
Gao Tao

Unknown

Damage Control Surgery in Acute Mesenteric Ischemia

Damage Control

China
TNO
Wageningen University and Research; Google LLC.; Jumbo Supermarkten Bv.; Noldus...

Completed

Blood Glucose, Cognition and Wellbeing @ Work

Healthy | PreDiabetes

Netherlands
TAO An

Recruiting

Home-based Psychoeducation for Older Adults With Frailty: A Randomised Controlled Trial

Frailty | Well-Being, Psychological

Hong Kong
Bristol-Myers Squibb
Ono Pharmaceutical Co. Ltd

Recruiting

A Study to Evaluate Treatment Preferences for Japanese Participants With Muscle-invasive Urothelial Carcinoma of the Bladder (SNUGGLE)

Urinary Bladder Neoplasms

United States
Bristol-Myers Squibb
Ono Pharmaceutical Co. Ltd

Recruiting

A Study of Nivolumab, Nivolumab Plus Ipilimumab, or Investigator's Choice Chemotherapy for the Treatment of Participants With Deficient Mismatch Repair (dMMR)/Microsatellite Instability High (MSI-H) Metastatic Colorectal Cancer (mCRC) (CheckMate 8HW)

Metastatic Colorectal Cancer

United States, Belgium, China, Canada, Denmark, France, Norway, Romania, Spain, United Kingdom, Austria, Brazil, Germany, Netherlands, Argentina, Czechia, Ireland, Italy, Turkey, Chile, Greece, Puerto Rico, Australia, Japan
Bristol-Myers Squibb
Ono Pharmaceutical Co. Ltd

Completed

An Investigational Immuno-therapy Study of Nivolumab Compared to Sorafenib as a First Treatment in Patients With Advanced Hepatocellular Carcinoma

Hepatocellular Carcinoma

United States, Australia, Austria, Belgium, Canada, China, Czechia, France, Germany, Hong Kong, Israel, Italy, Japan, Korea, Republic of, Poland, Russian Federation, Singapore, Spain, Sweden, Switzerland, Taiwan, United Kingdom
Bristol-Myers Squibb
Ono Pharmaceutical Co. Ltd

Active, not recruiting

An Investigational Immuno-therapy Study of Nivolumab, Compared to Placebo, in Patients With Bladder or Upper Urinary Tract Cancer, Following Surgery to Remove the Cancer (CheckMate 274)

Various Advanced Cancer

United States, Argentina, Australia, Austria, Belgium, Brazil, Canada, Chile, China, Colombia, Denmark, France, Germany, Greece, Ireland, Israel, Italy, Japan, Korea, Republic of, Mexico, Netherlands, Peru, Poland, Romania, Russian Federation and more
Bristol-Myers Squibb
Ono Pharmaceutical Co. Ltd

Active, not recruiting

An Immuno-therapy Study to Evaluate the Effectiveness, Safety and Tolerability of Nivolumab or Nivolumab in Combination With Other Agents in Patients With Advanced Liver Cancer (CheckMate040)

Hepatocellular Carcinoma

United States, Singapore, Spain, United Kingdom, Germany, Italy, Canada, France, Hong Kong, Japan, Korea, Republic of, Puerto Rico, Taiwan
Bristol-Myers Squibb
Ono Pharmaceutical Co. Ltd

Active, not recruiting

A Study to Evaluate Efficacy in Subjects With Esophageal Cancer Treated With Nivolumab and Ipilimumab or Nivolumab Combined With Fluorouracil Plus Cisplatin Versus Fluorouracil Plus Cisplatin (CheckMate 648)

Various Advanced Cancer

United States, Japan, Argentina, Australia, Austria, Brazil, Canada, Chile, China, Colombia, Czechia, Denmark, France, Hong Kong, Italy, Korea, Republic of, Mexico, Peru, Poland, Portugal, Romania, Russian Federation, Singapore, Spain, ... and more
Bristol-Myers Squibb
Ono Pharmaceutical Co. Ltd

Active, not recruiting

A Neoadjuvant Study of Nivolumab Plus Ipilimumab or Nivolumab Plus Chemotherapy Versus Chemotherapy Alone in Early Stage Non-Small Cell Lung Cancer (NSCLC) (CheckMate 816)

Non Small Cell Lung Cancer

United States, China, Hungary, Brazil, Argentina, Canada, France, Greece, Italy, Japan, Korea, Republic of, Romania, Spain, Taiwan, Turkey
Bristol-Myers Squibb
Ono Pharmaceutical Co. Ltd

Completed

A Study of Nivolumab + Chemotherapy or Nivolumab + Ipilimumab Versus Chemotherapy in Non-Small Cell Lung Cancer (NSCLC) Participants With Epidermal Growth Factor Receptor (EGFR) Mutation Who Failed 1L or 2L EGFR Tyrosine Kinase Inhibitor (TKI) Therapy (CheckMate722)

Non-Small-Cell Lung Carcinoma

United States, China, Taiwan, Spain, Korea, Republic of, France, Canada, Hong Kong, Japan, Singapore
Bristol-Myers Squibb
Ono Pharmaceutical Co. Ltd

Completed

Effectiveness Study of Nivolumab Compared to Chemotherapy in Patients With Relapsed Small-cell Lung Cancer (CheckMate331)

Lung Cancer

United States, Belgium, Brazil, China, Denmark, Italy, Japan, Norway, Romania, Spain, Australia, Austria, Chile, Czechia, France, Germany, Greece, Hungary, Israel, Korea, Republic of, Poland, Russian Federation, Switzerland, Taiwan, United...
Bristol-Myers Squibb
Ono Pharmaceutical Co. Ltd

Completed

Study of Nivolumab Combined With Ipilimumab Versus Pemetrexed and Cisplatin or Carboplatin as First Line Therapy in Unresectable Pleural Mesothelioma Patients (CheckMate743)

Mesothelioma

Brazil, United States, China, Italy, Australia, Belgium, Chile, Colombia, France, Germany, Greece, Japan, Mexico, Netherlands, Poland, Romania, Russian Federation, South Africa, Switzerland, Turkey, United Kingdom
Bristol-Myers Squibb
Ono Pharma USA Inc

Completed

Safety and Effectiveness of Nivolumab in Recurring Kidney Cancer Participants

Kidney Cancer | Renal Cancer

Japan
Roxanne Teo

Completed

Endourological Management of Stones During COVID19

COVID-19 | Urolithiasis

Singapore
Bristol-Myers Squibb
Ono Pharmaceutical Co. Ltd

Active, not recruiting

Long-Term Outcomes With Abatacept In Biologic Treatment-Naive Rheumatoid Arthritis Patients In Japanese Clinical Practice Settings

Rheumatoid Arthritis

Japan
Bristol-Myers Squibb
Ono Pharmaceutical Co. Ltd

Completed

Nivolumab or Nivolumab Plus Cisplatin, in Combination With Radiotherapy in Patients With Cisplatin-ineligible or Eligible Locally Advanced Squamous Cell Head and Neck Cancer

Squamous Cell Carcinoma of the Head and Neck

United States, Italy, Japan, Spain, Taiwan, Korea, Republic of, France, Poland, Russian Federation, Turkey
Samsung Medical Center
Ono Pharmaceutical Co. Ltd

Unknown

Neoadjuvant Nivolumab for Operable Esophageal Carcinoma

Esophageal Squamous Cell Carcinoma

Korea, Republic of
Bristol-Myers Squibb
Ono Pharmaceutical Co. Ltd

Completed

Study of Urelumab in Subjects With Advanced and/or Metastatic Malignant Tumors

Malignant Tumors

Japan
Bristol-Myers Squibb
Ono Pharmaceutical Co. Ltd

Completed

A Real-World Study of Ipilimumab Treatment After Nivolumab Treatment in Melanoma in Japan

Melanoma

Japan
Bristol-Myers Squibb
Ono Pharmaceutical Co. Ltd

Completed

Survey on Long-Term Use of ORENCIA® Intravenous Infusion 250mg

Rheumatoid Arthritis
Novartis Pharmaceuticals
Ono Pharmaceutical Co. Ltd

Completed

Efficacy, Safety and Tolerability of Rivastigmine Patch in Patients With Mild to Moderate Alzheimer's Disease Switched From Cholinesterase Inhibitors

Alzheimer's Disease

Japan
Ono Pharmaceutical Co. Ltd
Astellas Pharma Inc

Completed

Controlled Study of ONO-5920 in Patients With Involutional Osteoporosis in Japan

Involutional Osteoporosis
Taichung Veterans General Hospital
Ton General Hospital

Unknown

Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion

Tuberculosis | Empyema | Malignant Pleural Effusion | Tuberculous Pleurisy

China
TAO An

Completed

Home-based Psychoeducation for Older Adults With Frailty: A Feasibility Trial

Frailty | Well-Being, Psychological

Hong Kong
Ono Pharmaceutical Co. Ltd
Bristol-Myers Squibb

Completed

Study of Adjuvant ONO-4538 With Resected Gastric Cancer

Gastric Cancer

China, Japan, Korea, Republic of, Taiwan
Bristol-Myers Squibb
Ono Pharmaceutical Co. Ltd

Completed

A Study of BMS-986207 Given Alone and in Combination With Nivolumab or With Nivolumab and Ipilimumab in Advanced Solid Tumors

Broad Solid Tumor

United States, Argentina, Australia, Canada, Chile, Japan, Romania, Singapore

Clinical Trials Sponsored by TNO

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Cambodia

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Rare Diseases

Drug Interventions

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