Search clinical trials for: Biological Response Modifiers

Total 17374 results

University of Tennessee
University of Tennessee Health Science Center

Completed

A Trial of Gabapentin in Vulvodynia: Biological Correlates of Response

Vulvodynia

United States
Centre for Addiction and Mental Health

Completed

Efficacy and Biological Targets of Response to rTMS Therapy in Youth Depression

Depressive Symptoms

Canada
Istanbul University

Completed

The Effects of Scalp Block on Haemodynamic Response and Postoperative Pain in Posterior Fossa Surgery

Posterior Fossa Tumors
Eskisehir Osmangazi University

Unknown

Effects of Sleep Quality on Melatonin Levels and Inflammatory Response After Major Abdominal Surgery

Sleep Deprivation

Turkey
Medical University of Warsaw

Completed

Cardiac Arrhythmias in Patients Undergoing Kidney Cancer Surgery Depending on the Anaesthesia Method

Kidney Cancer | Anesthesia, Local | Surgery | Arrhythmia, Cardiac

Poland
GlaxoSmithKline

Completed

Study to Evaluate the Persistence of the Cellular and Humoral Immune Response Following Vaccinations With GlaxoSmithKline (GSK) Biologicals' Candidate Vaccines Containing HBsAg and Different Adjuvants in Healthy Adult Volunteers

Hepatitis B

Belgium
University of Roma La Sapienza

Completed

Safety, Immunogenicity And Efficacy Of Vaccination In Military Personnel

Vaccination Failure | Vaccination Adverse Events | Specific Antibody Response

Italy
University of Pennsylvania

Completed

Dose Response Study of Dexamethasone in Combination With Bupivacaine 0.25% (Dex Dose)

Post Surgical Pain

United States
Assiut University

Unknown

Dexmedetomidine Versus Magnesium Sulphate for Caesarean Delivery

Cesarean Section

Egypt
Hoffmann-La Roche

Completed

A Study of Tocilizumab in Participants With Active Rheumatoid Arthritis (RA) and an Inadequate Response to Non-Biological Disease-modifying Anti-rheumatic Drugs (DMARDs)

Rheumatoid Arthritis

Montenegro
Hoffmann-La Roche

Withdrawn

A Study of The Effect of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate on Articular Damage in The Hand in Patients With Moderate to Severe Rheumatoid Arthritis Who Have an Inadequate Response to Non-Biological DMARDs

Rheumatoid Arthritis
GlaxoSmithKline

Completed

Comparison of Monodose and Multidose Presentations of GSK Biologicals' Hepatitis B Vaccine in Terms of Immune Response

Hepatitis B

Belgium
GlaxoSmithKline

Completed

Assess the Immune Response Following Primary Vaccination With GSK Biologicals' Tritanrix™-HepB/Hib-MenAC vs Tritanrix™-HepB/Hiberix™ Given at 6,10 & 14 Wks of Age to Infants Who Received Hepatitis B Vaccine at Birth

Diphtheria; Haemophilus Influenzae Type b; Hepatitis B; Tetanus; Whole Cell Pertussis

South Africa
GlaxoSmithKline

Completed

Assess if Immune Response of GSK Biologicals' Tritanrix™-HepB/Hib-MenAC Given Without or With Hepatitis B Vaccine at Birth is at Least as Good as Tritanrix™-HepB/Hiberix™ Without Hepatitis B Vaccine at Birth, When Given to Healthy Infants

Hepatitis B | Tetanus | Diphtheria | Haemophilus Influenzae Type b | Whole Cell Pertussis

Philippines
GlaxoSmithKline

Completed

Comparison of GSK Biologicals' DTaP-IPV Candidate Vaccine to DTaP and IPV Separately Administered Vaccines in Terms of Immune Response and Safety

Tetanus | Diphtheria | Acellular Pertussis

United States
Iowa State University

Completed

Dose-response Effects of Soybean Oil in Salad Dressing on Carotenoid/Fat-soluble Vitamin Bioavailability in Salad Vegetables

Biological Availability
Mansoura University

Unknown

Spinal for Laparoscopic Cholecystectomy (Sp-Lap)

Laparoscopic Cholecystectomy

Egypt
The Higher Institute of Sport and Physical Education...

Completed

Pomegranate Improve Biological Recovery Kinetics in Elite Weightlifter

Healthy

Tunisia
Central Hospital, Nancy, France
Diagnostica Stago

Unknown

Characterization of Hemostatic Disordres in Septic Shock: Searching for Biological Markers (COASEPT)

Septic Shock
Chimei Medical Center

Completed

Biological Markers to Identify Early Sepsis and Acute Lung Injury

Sepsis | Acute Lung Injury

Taiwan
Samsung Medical Center

Unknown

Development of Pharmacogenomic Method to Predict Antidepressant Responsiveness (PG)

Depression | Antidepressant Drug Adverse Reaction

Korea, Republic of
Centre Hospitalier Universitaire de Saint Etienne
Groupe de Recherche sur la Thrombose

Completed

Evaluation of the Biological Response to Clopidogrel in Patients With Ischemic Stroke (AAPIX)

Brain Ischemia | Ischemic Attack

France
University of Pennsylvania

Withdrawn

Presurgical Therapy With Lapatinib to Explore Molecular Determinants of Response to EGFR/erbB2 Targeted Therapy

Breast Cancer

United States
Neil Roy Connelly, MD

Withdrawn

Parturient Controlled Epidural Analgesia (PCEA) With or Without a Basal Infusion for Early Labor

Labor Pain

United States
ANRS, Emerging Infectious Diseases

Completed

X-linked Biological Response to HIV Sensing: the ANRS EP 53 Study (X LIBRIS)

Hiv Infection

France
National Cancer Institute (NCI)

Withdrawn

BL22 Immunotoxin in Treating Patients With Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia

Lymphoma | Leukemia

United States
University of Bath
Biotechnology and Biological Sciences Research Council; Unilever R&D

Completed

Metabolic and Immune System Responses to a Mixed Meal

Inflammation

United Kingdom
Centre Hospitalier Universitaire de Nīmes

Completed

Prospective Validation of Clini-biological Parameters Including Initial Hemostasis, Which Improve the Prediction of Death at 1 Month Among Patients With Septic Shock (SEPSICOAG)

Shock, Septic

France
GlaxoSmithKline

Withdrawn

Safety and Immune Response of One-Dose of Candidate H1N1 Influenza Vaccine GSK2340274A in Adults

Influenza
Brugmann University Hospital

Completed

Effect of Anti-Inflammatory Agents on Biological Responses to Endotoxin Inhalation in Healthy Subjects

Innate Immunity
Hoffmann-La Roche

Completed

An Extension to Study MA21573, Evaluating Tocilizumab in Patients With Active Rheumatoid Arthritis and an Inadequate Response to Current Non-Biological DMARDs and/or Anti-tumor Necrosis Factor (TNF) Therapy

Rheumatoid Arthritis

Czech Republic, France, Italy, Spain, United Kingdom, Canada, Portugal, Netherlands, Poland, Australia, Saudi Arabia, Romania, Hungary, Greece
University of Missouri, Kansas City
United States Department of Defense

Completed

Biological Response of Trauma Patients to Standard Trauma Resuscitation Therapy

Hemorrhagic Shock

United States
Laboratorios Leti, S.L.

Completed

Biological Potency of the Cat Epithelial Allergenic Extracts

Cat Allergy (Disorder)

Spain
Universidad Nacional de Rosario

Completed

Biological Response of Stage IV Knee Osteoarthritis to Serial 12.5% Dextrose

Knee Osteoarthritis

Argentina
Centre Hospitalier Universitaire de Saint Etienne

Terminated

Serum CA9 Level as Biological Marker of the Treatment Response in Metastatic Renal Cell Cancer (CA9CRM)

Metastatic Renal Cell Carcinoma | Metastatic Kidney Cancer

France
Nanfang Hospital of Southern Medical University
The First Affiliated Hospital of Nanchang University; Xiangya Hospital of Central... and other collaborators

Unknown

Treatment Response and Prognosis in Glioma Patients: Q Cell and Its Biological Characteristics

Glioblastoma | Malignant Glioma

China
Barbara Ann Karmanos Cancer Institute
National Cancer Institute (NCI)

Withdrawn

Monoclonal Antibody Therapy in Treating Patients With Advanced Solid Tumors

Unspecified Adult Solid Tumor, Protocol Specific
University of Manitoba
Health Sciences Centre Foundation, Manitoba; St. Boniface Hospital

Completed

The Effects of High Spinal Anesthesia on Heart Function, Stress Response and Pain Control in Aortic Valve Surgery

Aortic Stenosis

Canada
Radiation Therapy Oncology Group
National Cancer Institute (NCI)

Withdrawn

Combination Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Primary or Recurrent Sarcoma

Recurrent Adult Soft Tissue Sarcoma | Stage III Adult Soft Tissue Sarcoma | Stage IVA Adult Soft Tissue Sarcoma | Stage IIB Adult Soft Tissue Sarcoma | Stage IIC Adult Soft Tissue Sarcoma

United States, Canada
National Cancer Institute (NCI)
Pfizer

Completed

Phase II Study of Axitinib (AG-013736) With Evaluation of the VEGF-Pathway in Metastatic, Recurrent or Primary Unresectable Adrenocortical Cancer

Adrenal Cortex Neoplasms

United States
Osservatorio Epidemiologico GISEA

Unknown

Evaluation Effects of Treatment With IL-6R Inhibitor on Clinical Response and Biomarkers in Patients With Rheumatoid Arthritis (RA) Not Responding to DMARDs and/or a First Biological Agent.

Rheumatoid Arthritis (RA)

Italy
National Cancer Institute (NCI)

Completed

Primary Chemotherapy With Docetaxel-Capecitabine and Doxorubicin-Cyclophosphamide in Breast Cancer

Breast Cancer | Breast Neoplasm

United States
National Institute of Allergy and Infectious Diseases...
Autoimmunity Centers of Excellence

Terminated

Rituximab for the Treatment of Early Rheumatoid Arthritis (RA)

Rheumatoid Arthritis

United States
Biomedical Development Corporation
National Heart, Lung, and Blood Institute (NHLBI); University of Texas

Completed

Dose-Response Study of Iocide Oral Rinse

Gingivitis

United States
Clalit Health Services

Unknown

Efficacy and Safety of Adalimumab for the Induction of Clinical Response in Ulcerative Colitis

Ulcerative Colitis

Israel
McGill University Health Centre/Research Institute...

Unknown

The Effect of Insulin on Protein Metabolism After Cardiac Surgery

Cardiac Surgery

Canada
Minneapolis Veterans Affairs Medical Center

Completed

Effect of Pasta on Blood Glucose Response in Normal Subjects

Metabolic Syndrome | Type 2 Diabetes | Blood Glucose Concentration

United States
Abbott
Group Data Management Biostatistics

Completed

Quality of Life Outcomes of HUMIRA in Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA), Ankylosing Spondylitis (AS) After Unsustainable Response to Biologicals and Disease Modifying Antirheumatic Drugs

Rheumatoid Arthritis | Psoriatic Arthritis | Ankylosing Spondylitis

Austria
University of Nottingham

Completed

Biological Modulation of Bacterial QSSMs, Innate and Adaptive Immunity by Antibiotics, Probiotics and Prebiotics in Healthy Individuals

Sepsis | Probiotics | Prebiotics | Quorum Sensing

United Kingdom
National Center for Genome Resources
National Institute of Allergy and Infectious Diseases (NIAID); Pfizer; Hoffmann-La... and other collaborators

Unknown

Observational Study of Sepsis and Pneumonia to Develop Diagnostic Tests

Sepsis | Shock, Septic | Community Acquired Pneumonia | Sepsis Syndrome | Septicemia

United States

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