Search clinical trials for: Challenge Study

Total 119877 results

Baxalta now part of Shire
Baxter Innovations GmbH

Terminated

Early Prophylaxis Immunologic Challenge (EPIC) Study (EPIC)

Hemophilia A

Poland, United States, Bulgaria, Serbia, Canada, Russian Federation, Germany, Netherlands, Lithuania, Czechia, Austria, Spain
University of Maryland, Baltimore
PATH

Terminated

Safety and Efficacy Challenge Study of CVD 1208S, a Live, Attenuated Oral Vaccine to Prevent Shigella: Phase IIb

Shigella

United States
National Institute of Allergy and Infectious Diseases...

Completed

H1N1v Virus Challenge Study in Healthy Subjects

Influenza

United States
Valneva Austria GmbH
Johns Hopkins University; Naval Medical Research Center

Completed

Study Confirming A Human Challenge Model and Investigating The Safety Of VLA1701

Diarrhea | Enterotoxigenic Escherichia Coli Infection

United States
Amsterdam UMC, location VUmc

Terminated

Iressa Re-challenge in Advanced NSCLC EGFR-mutated Patients (IRENE)

Lung Cancer

Netherlands
SecuraBio

Completed

A Phase 2a, Efficacy and Safety Study of Duvelisib in Mild Asthmatic Subjects

Asthma

Germany, United Kingdom
LimmaTech Biologics AG
Johns Hopkins Bloomberg School of Public Health

Completed

Phase 2b Challenge Study With the Bioconjugate Vaccine Flexyn2a

Shigellosis

United States
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

A Prospective, Observational Study On The Effectiveness Of New Antiepileptic Drugs As First Bitherapy In The Daily Clinical Practice

Focal Epilepsy
Alyatec

Completed

Clinical Validation Study in Allergic Conjunctivitis to Birch Pollen During Allergen Challenge in ALYATEC EEC

Allergic Conjunctivitis

France
Bayer

Completed

Study to Find Out if Cream V61-044 Used to Treat Fungal Infections Causes an Allergic Skin Reaction to Sunlight in Healthy Participants

Dermatitis, Photoallergic

United States
University of Zurich
ADR-AC Laboratory, Berne

Completed

Basophile Activation Testing (BAT) in Hazelnut Allergy (Hazelnut BAT Study)

Food Allergy

Switzerland
National Institute of Allergy and Infectious Diseases...

Completed

Mucosal and Systemic Immunity After Viral Challenge of Healthy Volunteers Vaccinated With Inactivated Influenza Vaccine Via the Intranasal Versus Intramuscular Route

Influenza

United States
January, Inc.

Unknown

Sugar Challenge Study

Healthy | Type 2 Diabetes | Pre-Diabetes

United States
AstraZeneca
Parexel

Withdrawn

A Study to Evaluate the Effect of AZD8154 Administered Via Nebulizer Once Daily in Subjects With Mild Allergic Asthma Challenged With an Inhaled Allergen

Asthma

Canada
Shield Therapeutics

Completed

Safety and Efficacy Study of Oral Ferric Iron To Treat Iron Deficiency Anaemia in Quiescent Crohn's Disease (AEGIS-2) (AEGIS-2)

Crohn's Disease | Inflammatory Bowel Disease | Iron Deficiency Anaemia
GlaxoSmithKline
The PATH Malaria Vaccine Initiative (MVI)

Completed

Efficacy, Immunogenicity and Safety Study of GSK Biologicals' Candidate Malaria Vaccine Evaluating Different Dose Schedules in a Sporozoite Challenge Model in Healthy Malaria-naïve Adults

Malaria

United States
GlaxoSmithKline
PATH

Completed

A Study to Evaluate the Efficacy, Immunogenicity and Safety in a Sporozoite Challenge Model of a Fractional Booster Dose of GSK Biologicals' Candidate Malaria Vaccine Administered to Previously Vaccinated Healthy Malaria-naïve Adults

Malaria

United States
Central Adelaide Local Health Network Incorporated
Vaxine Pty Ltd

Unknown

Study of Sting Challenge and Serological Responses to Jack Jumper Venom Immunotherapy With Inulin as Adjuvant (Jumpvax) (Jumpvax)

Immunotherapy | Ant Sting

Australia
GlaxoSmithKline

Completed

Phase 2a, AMP Challenge, Dose Escalation Study to Assess the Dose Response for Topical Efficacy and Systemic Activity in Asthmatic Subjects

Asthma

United Kingdom, Germany
GlaxoSmithKline

Completed

A Study to Evaluate the Efficacy, Safety and Immunogenicity of a Vaccine Designed to Protect Against Infection With Shigella Sonnei in Healthy Adults

Dysentery, Bacillary

United States
Aga Khan University
The Hospital for Sick Children; Grand Challenges Canada

Completed

The Prevention of Rh Disease of Newborns in Pakistan

Rhesus Disease | Anti-D (Rh) Antibodies Affecting Care of Mother

Pakistan
Radboud University Medical Center
The PATH Malaria Vaccine Initiative (MVI); QIMR Berghofer Medical Research...

Completed

Controlled Human Malaria Infection Model for Evaluation of Transmission-blocking Interventions - Study 2 (CHMI-trans2)

Transmission | Malaria,Falciparum | Controlled Human Malaria Infection | Gametocytes

Netherlands
University Hospital, Strasbourg, France

Terminated

Comparative Study of Pathophysiological Mechanisms and Bronchial Response in Occupational Asthma to Wheat Flour and Quaternary Ammonium Compounds During Standardized Bronchial Provocation Tests

Occupational Asthma

France
McMaster University
AllerGen NCE Inc.

Unknown

Canadian Peanut Thresholds Study

Peanut Allergy

Canada
Andrew Steer
National Health and Medical Research Council, Australia; Queen Fabiola Children... and other collaborators

Completed

Controlled Human Infection for Vaccination Against Streptococcus Pyogenes (CHIVAS)

Bacterial Infections | Gram-Positive Bacterial Infections | Strep Throat | Streptococcus Pharyngitis | Streptococcus Pyogenes Pharyngitis | Streptococcus Pyogenes Infection | Group A Streptococcus: B Hemolytic Pharyngitis | Group A Streptococcal Infection

Australia
U.S. Army Medical Research and Development Command
Naval Medical Research Center

Withdrawn

A Clinical Trial to Evaluate Plasmodium Falciparum 7G8 and NF54 Challenge Strains (PfSPZ) in a Head-to-head Comparative Study - (ECG-CHMI) (ECG-CHMI)

Plasmodium Falciparum
Medicines for Malaria Venture
Q-Pharm Pty Limited; Clinical Network Services (CNS) Pty Ltd; QIMR Berghofer...

Completed

SJ733 Induced Blood Stage Malaria Challenge Study (SJ733IBSMCS)

Plasmodium Falciparum Malaria

Australia
Celltrion

Completed

A Study to Evaluate the Efficacy and Safety of CT-P27 in an Influenza Challenge Model

Influenza A

United Kingdom
University Hospital, Grenoble
Bristol-Myers Squibb

Completed

Efficacy of Re-challenge With Immune-Checkpoints Inhibitors in Advanced Non-Small-Cell Lung Cancer Patients: a Retrospective Observational Study (RE-CHALLENGE)

Non Small Cell Lung Cancer

France
Eli Lilly and Company

Completed

An Observational Study to Understand Challenges Associated With Progression of Insulin Therapy in Type 2 Diabetes (MOSAIc)

Diabetes Mellitus, Type 2

United States, Argentina, Brazil, Canada, China, Germany, India, Israel, Italy, Japan, Korea, Republic of, Mexico, Puerto Rico, Russian Federation, Saudi Arabia, Spain, Turkey, United Arab Emirates, United Kingdom
University of Southampton
Public Health England; University Hospital Southampton NHS Foundation Trust

Unknown

Bordetella Pertussis Colonisation Challenge Study (Periscope)

Whooping Cough

United Kingdom
Celgene

Completed

A Study to Evaluate Gluten Challenge on Immune Responses in Subjects With Celiac Disease

Celiac Disease

United States
Janssen Research & Development, LLC

Completed

A Study Exploring the Use of Vaccine and Antigen Challenges for Immune Monitoring in Healthy Participants

Healthy

Belgium
Janssen BioPharma, Inc.

Completed

A First-In-Human Study of Orally Administered JNJ-64417184 to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses, and the Antiviral Activity of Multiple Doses in a Respiratory Syncytial Virus (RSV) Challenge Study in Healthy Participants

Healthy

United Kingdom
GlaxoSmithKline

Completed

A Study to Evaluate Persistence of Hepatitis B Antibodies, Immunogenicity and Safety of Engerix™-B Kinder Challenge Dose, in Adolescents Vaccinated With Four Doses of Infanrix™ Hexa During Infancy

Hepatitis B

Germany
WCCT Global
National Institutes of Health (NIH); Stanford University

Completed

Single Ascending Dose Challenge Study to Determine Safety and Reactogenicity of an Influenza Challenge Virus

Influenza
Teva Pharmaceuticals USA

Completed

Pravastatin Sodium 40 mg Tablets Food Challenge Study

Healthy

Canada
National Institute of Allergy and Infectious Diseases...

Completed

Influenza A H3N2 Human Challenge Study in Healthy Adult Volunteers

Determine Minimally to Moderately Infective Dose (MMID) of Influenza A H3N2

United States
Amgen

Completed

A Study to Evaluate the Efficacy and Safety of AMG 714 in Adult Patients With Celiac Disease

Celiac Disease

Finland
Braeburn Pharmaceuticals

Completed

A Multiple Dose Opioid Challenge Study

Moderate or Severe Opioid Use Disorder

United States
University of Southampton
University Hospital Southampton NHS Foundation Trust

Completed

Defining the Immune Response to Nasopharyngeal Colonisation by the Commensal Neisseria Lactamica (Lac-7)

Meningitis, Bacterial

United Kingdom
Hvivo
GlaxoSmithKline

Completed

RSV Study in Adults 60 to 75 Years of Age

RSV Infection

United Kingdom
Massachusetts General Hospital
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

High Threshold Peanut Challenge Study (PAID-UP)

Peanut Allergy
Partners in Health
Grand Challenges Canada

Completed

The Pediatric Development Clinic Study (PDC)

Pregnancy, Puerperium and Perinatal Conditions

Rwanda
Peking University Third Hospital

Completed

Study on The Oral Immune Tolerance of CMPA Infants Using Amino Acid Formula

Cow's Milk Protein Allergy
University of Wisconsin, Madison
National Heart, Lung, and Blood Institute (NHLBI); Pharmaxis

Completed

Mannitol Bronchoprovocation Challenge Ancillary Study/ACRN

Asthma

United States
GlaxoSmithKline

Completed

Lipopolysaccharide (LPS) or Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Challenge Study on Healthy Subjects

Arthritis, Rheumatoid

United Kingdom
Inha University Hospital
Otsuka Pharmaceutical Development & Commercialization, Inc.

Unknown

Efficacy Study of Cilostazol and Aspirin on Cerebral Small Vessel Disease (Challenge)

Cerebral Small Vessel Disease

Korea, Republic of
GlaxoSmithKline

Completed

Crossover Study Comparing Fluticasone Furoate (FF)/Vilanterol (VI) Once Daily Versus Fluticasone Propionate (FP) Twice Daily in Subjects With Asthma and Exercise-Induced Bronchoconstriction (EIB)

Asthma

United States, Canada
GlaxoSmithKline
Walter Reed Army Institute of Research (WRAIR); The PATH Malaria Vaccine Initiative...

Completed

Efficacy, Safety and Immunogenicity Study of GlaxoSmithKline(GSK) Biologicals' Candidate Malaria Vaccine 257049 in the Sporozoite Challenge Model in Healthy Malaria-naïve Adults

Malaria

United States

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