Search clinical trials for: Endothelin A antagonist

Total 499188 results

Radboud University Medical Center

Completed

ET-blockade and Exercise Induced Blood Flow in T2DM

Type 2 Diabetes Mellitus

Netherlands
Actelion

Completed

Comparison of the Pharmacokinetic Properties of Two Tablet Formulations of Macitentan in Healthy Adults

Healthy Subjects

Czech Republic
Actelion

Withdrawn

Correlation of LONGterm Wrist ACTigraphy Recorded Physical Performance & 6-minute Walk Distance in Patients With Pulmonary Arterial Hypertension (LONGACT)

Pulmonary Arterial Hypertension
United Therapeutics

Completed

Study of Incidence of Respiratory Tract AEs in Patients Treated With Tyvaso® Compared to Other FDA Approved PAH Therapies (Aspire)

Pulmonary Arterial Hypertension

United States
AstraZeneca

Completed

A Phase III Trial of ZD4054 (Zibotentan) (Endothelin A Antagonist) in Hormone Resistant Prostate Cancer With Bone Metastases (ENTHUSE M1)

Prostate Cancer

Sweden, United States, Brazil, Czech Republic, France, Russian Federation, United Kingdom, Germany, China, Hungary, Poland, Finland, Netherlands, Mexico, Hong Kong, Australia, Belgium, Canada, Denmark, Portugal, South Africa, Korea... and more
Monica Levy Andersen

Completed

Mother-caregivers of Children With Duchenne Muscular Dystrophy (DMDK)

Other Diseases or Conditions

Brazil
Berto J Bouma

Unknown

Bosentan Improves Clinical Outcome of Adults With Congenital Heart Disease or Mitral Valve Lesions Who Undergo CArdiac Surgery (BOCA)

Congenital Heart Disease

Netherlands
Actelion

Completed

Effects of the Combination of Bosentan and Sildenafil Versus Sildenafil Monotherapy on Pulmonary Arterial Hypertension (PAH) (Compass-2)

Pulmonary Arterial Hypertension

United States, Denmark, Sweden, Germany, Spain, Brazil, Saudi Arabia, Portugal, Greece, Slovakia, United Kingdom, Czech Republic
Actelion

Completed

Open Label Extension Study in Patients With Idiopathic Pulmonary Fibrosis Who Completed Protocol AC-052-321/ BUILD 3 / NCT00391443 (BUILD OL)

Idiopathic Pulmonary Fibrosis

United States, France, Spain, Korea, Republic of, United Kingdom, Belgium, Japan, Australia, Canada, Czech Republic, Germany, Ireland, Israel, Italy, Switzerland
Actelion

Completed

BUILD 3: Bosentan Use in Interstitial Lung Disease (BUILD 3)

Idiopathic Pulmonary Fibrosis

United States, France, Spain, Korea, Republic of, Canada, United Kingdom, Australia, Belgium, Netherlands, Japan, Germany, Czech Republic, Italy, Switzerland, Austria, Croatia, Ireland, Israel, Serbia
Actelion

Completed

Study of Macitentan (ACT-064992) on Morbidity and Mortality in Patients With Symptomatic Pulmonary Arterial Hypertension (SERAPHIN)

Pulmonary Arterial Hypertension

United States, United Kingdom, Belarus, Argentina, Australia, Austria, Belgium, Bulgaria, Canada, Chile, China, Colombia, Croatia, France, Germany, Hong Kong, Hungary, India, Israel, Italy, Malaysia, Mexico, Netherlands, Norway, Peru, Poland and more
IRCCS Azienda Ospedaliero-Universitaria di Bologna

Terminated

Effects of Bosentan on Respiratory Mechanics

Pulmonary Hypertension

Italy
University of Edinburgh
Encysive Pharmaceuticals

Completed

Role of Endothelin-A (ETA) and Endothelin-B (ETB) Receptors in the Vasodilatory Response to Endothelin-3 (ET-3)

Pulmonary Arterial Hypertension | Vasodilation | Vasoconstriction

United Kingdom
MelCure SA
Universitaire Ziekenhuizen KU Leuven; University of Bern; California Institute...

Terminated

Proof of Concept Study With an Endothelin Receptor B Inhibitor (BQ-788) for Human Melanoma

Melanoma
Actelion

Terminated

Persistent Pulmonary Hypertension of the Newborn (FUTURE 4)

Persistent Pulmonary Hypertension of the Newborn

United States, Australia, Belgium, Czech Republic, France, Germany, Korea, Republic of, Poland, Russian Federation, Singapore, Switzerland, United Kingdom
Actelion

Completed

Open-label Study With Bosentan in Interstitial Lung Disease (BUILD 2 OL)

Interstitial Lung Disease | Scleroderma

United States, Korea, Republic of, Israel, France, United Kingdom, Netherlands, Switzerland, Germany, Canada, Italy, Sweden
Actelion

Completed

Effect of Bosentan in Patients With Metastatic Melanoma Treated With Dacarbazine (DTIC)

Melanoma

Australia
Actelion

Completed

Pulmonary Artery Remodelling With Bosentan

Hypertension, Pulmonary

Australia
Universitair Ziekenhuis Brussel

Completed

Transcranial Doppler in Multiple Sclerosis (TRADOMS)

Multiple Sclerosis

Belgium
University Hospital, Rouen

Completed

Role of Endothelin-1 in Flow-mediated Dilatation (Endothelin)

Healthy Conditions

France
Pfizer

Terminated

Study Looking at Combination Therapy (Sitaxsentan+Sildenafil) Vs. Monotherapy (Sitaxsentan Alone) SR-PAAS -Sitaxsentan Efficacy And Safety Trial With A Randomized Prospective Assessment Of Adding Sildenafil

Pulmonary Arterial Hypertension | Pulmonary Hypertension

United States, Bulgaria, Argentina, Chile, China, Colombia, Czech Republic, India, Malaysia, Mexico, Peru, Romania, Russian Federation, Serbia, South Africa, Thailand, Turkey, Ukraine
Pfizer

Terminated

Sitaxsentan Efficacy And Safety Trial With A Randomized Prospective Assessment Of Adding Sildenafil (SR-PAAS)

Pulmonary Arterial Hypertension | Pulmonary Hypertension

United States, Bulgaria, Argentina, Chile, China, Colombia, Costa Rica, Czech Republic, Dominican Republic, Guatemala, India, Malaysia, Mexico, Peru, Philippines, Romania, Russian Federation, Saudi Arabia, Serbia, Slovakia, South... and more
Pfizer

Withdrawn

Drug Interaction Between Ritonavir And Sitaxsentan

Pulmonary Arterial Hypertension
Pfizer

Withdrawn

Effect Of Rifampin On Pharmacokinetics Of Sitaxsentan

Pulmonary Arterial Hypertension
University of California, Los Angeles
Actelion

Completed

Endothelin Blockade in Patients With Single Ventricle Physiology

Congenital Heart Disease

United States
Actelion

Completed

Macitentan for the Treatment of Digital Ulcers in Systemic Sclerosis Patients (DUAL-1)

Systemic Sclerosis | Ulcers

Canada, United States, Belarus, Hungary, Croatia, Australia, Denmark, Ukraine, Bulgaria, Chile, Colombia, Czech Republic, Finland, Germany, India, Italy, Poland, Russian Federation
Christoph Hehrlein
Actelion

Unknown

Prognostic Influence of Light Rheography Measurement of Patients With Secondary Raynaud Syndrome With Ulcers on Hands (Anti-Vasospasm)

Raynaud's Phenomenon | Skin Necrosis

Germany
Actelion

Withdrawn

Safety and Tolerability Study of Macitentan in Patients With Idiopathic Pulmonary Fibrosis (MUSIC OL)

Idiopathic Pulmonary Fibrosis
K.Lance Gould
Gilead Sciences

Completed

Darusentan Effect on PET Uptake Heterogeneity (Darusentan)

Coronary Artery Disease | Endothelial Dysfunction

United States
Mayo Clinic

Completed

Role of Endothelin in Microvascular Dysfunction Following PCI for NSTEMI (BQ-123)

Myocardial Reperfusion Injury

United States
University Teaching Hospital Hall in Tirol

Completed

Safety and Efficacy of Bosentan in Patients With Diastolic Heart Failure and Secondary Pulmonary Hypertension (BADDHY)

Hypertension, Pulmonary | Heart Failure, Diastolic

Austria
University Hospital, Grenoble
Institut National de la Santé Et de la Recherche Médicale, France; Actelion

Completed

Preventive Effects of Bosentan on the Systemic Cardiovascular Consequence of Sleep Apnea (BOSAS)

Hypertension | Obstructive Sleep Apnea

France
Gilead Sciences

Terminated

ARTEMIS-PH - Study of Ambrisentan in Subjects With Pulmonary Hypertension Associated With Idiopathic Pulmonary Fibrosis (ARTEMIS-PH)

Idiopathic Pulmonary Fibrosis | Pulmonary Hypertension

United States, Germany, United Kingdom, Australia, Canada, Italy, Austria
Air Force Military Medical University, China

Unknown

Study of Bosentan in the Treatment of Stable Severe Chronic Obstructive Pulmonary Disease Patients (BTCOPD)

Chronic Obstructive Pulmonary Disease (COPD)

China
Gilead Sciences

Completed

DORADO - Fixed Doses of Darusentan as Compared to Placebo in Resistant Hypertension

Hypertension

United States, Spain, Germany, Argentina, Denmark, Brazil, Canada, France, Sweden, United Kingdom, Italy
Gilead Sciences

Completed

DORADO-AC - Optimized Doses of Darusentan as Compared to an Active Control in Resistant Hypertension (Darusentan)

Hypertension

United States, Spain, Argentina, Australia, Belgium, Brazil, Denmark, France, Germany, New Zealand
Gilead Sciences

Terminated

DORADO-EX: Long-Term Safety Extension Study to the Phase 3 DORADO Study (Protocol DAR-311) of Darusentan in Resistant Hypertension (Darusentan)

Hypertension

United States, Sweden, Argentina, Denmark, Brazil, Canada, France, United Kingdom
Universitaire Ziekenhuizen KU Leuven

Completed

Bosentan for Mild Pulmonary Vascular Disease in Asd Patients. (BOMPA)

Heart Septal Defects, Atrial

Belgium
Air Force Military Medical University, China

Unknown

Study of the Initial Combination of Bosentan With Iloprost in the Treatment of Pulmonary Hypertension Patients (BIPH)

Pulmonary Arterial Hypertension

China
Actelion

Completed

Macitentan Use in an Idiopathic Pulmonary Fibrosis Clinical Study (MUSIC)

Idiopathic Pulmonary Fibrosis

United States, Israel, Spain, Australia, France, Canada, Turkey, Germany, Italy, South Africa, Slovenia, Sweden
Gilead Sciences

Terminated

Study of Cicletanine for Pulmonary Arterial Hypertension (PAH)

Pulmonary Arterial Hypertension

United States, Israel, Australia, Canada, Mexico, Spain, Belgium, Austria, Germany, United Kingdom
Actelion

Completed

Study to Assess the Effect of Macitentan on the Electrocardiogram (ECG) in Healthy Male and Female Subjects

Healthy

Germany
Dong-A Pharmaceutical Co., Ltd.
Dong-A ST Co., Ltd.

Unknown

Clinical Trial to Investigate the Pharmacokinetic Drug Interaction Between Udenafil and Bosentan After Oral Administration

Healthy Volunteers

Korea, Republic of
Actelion

Completed

Bosentan in Systemic Sclerosis (HOME)

Systemic Sclerosis | Digital Ulcers

Netherlands
Gilead Sciences

Terminated

DORADO-AC-EX - A Long-Term Safety Extension Study to the Phase 3 DORADOC-AC Study (Protocol DAR-312) of Darusentan in Resistant Hypertension (Darusentan)

Hypertension

United States, Argentina, Australia, Brazil
AbbVie (prior sponsor, Abbott)

Completed

A Prospective, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate Efficacy and Safety of Atrasentan, Including Thoracic Bioimpedance, in Type 2 Diabetic Subjects With Nephropathy

Diabetic Nephropathy | Chronic Kidney Disease

United States
TC Erciyes University

Completed

The Effects of Dexmedetomidine on Early Stage Renal Functions in Pediatric Patients

Renal Function Disorder | Hemodynamic Instability
AbbVie (prior sponsor, Abbott)

Completed

Evaluate the Efficacy and Safety of Once Daily Administration of Atrasentan Tablets (Low and High) Compared to Placebo in Reducing Residual Albuminuria in Type 2 Diabetic Patients With Nephropathy Who Are Treated With the Maximum Tolerated Labeled Dose of a Renin Angiotensin System (RAS) Inhibitor (RADAR)

Diabetic Nephropathy | Chronic Kidney Disease

United States, Canada, Puerto Rico, Taiwan
Actelion

Completed

Combination Therapy in Pulmonary Arterial Hypertension (COMPASS 3)

Pulmonary Arterial Hypertension

United States
Center for Health, Exercise and Sport Sciences,...

Completed

Characterization and Detection of Prolonged Endothelin Receptors Antagonists Administration (ERAATH)

Pulmonary Hypertension

Serbia

Search clinical trials for: Endothelin A antagonist

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