Search clinical trials for: Genetic mutations

Total 19615 results

Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Active, not recruiting

Genetics Study of Tissue Collected From Patients With Acute Myeloid Leukemia

Leukemia

United States
Novartis Pharmaceuticals

Completed

Study to Investigate Safety, Pharmacokinetic (PK), Pharmacodynamic (PD) and Clinical Activity of Trametinib in Subjects With Cancer or Plexiform Neurofibromas and Trametinib in Combination With Dabrafenib in Subjects With Cancers Harboring V600 Mutations

Cancer

France, Australia, United States, Canada, United Kingdom
Assistance Publique - Hôpitaux de Paris
Bristol-Myers Squibb

Terminated

Tumor Mutational Burden in Lung Cancer Patients (MUBULUC)

Non Small Cell Lung Cancer | Non-small Cell Lung Cancer Stage IV | Non Small Cell Lung Cancer Stage III | Non-Small Cell Carcinoma of Lung

France
Columbia University
Cold Spring Harbor Laboratory

Completed

Pancreatic Intraepithelial Neoplasia (PanIN) and the Association With Recurrence of Pancreatic Adenocarcinoma

Pancreatic Cancer

United States
TRPHARM
Klinar CRO; Damagen Genetic Diagnostic Center

Enrolling by invitation

A Study on the Prevalence of Mutation of Cerebrotendinous Xanthomatosis (CTX) (F-GENE)

Xanthomatosis, Cerebrotendinous

Turkey
NYU Langone Health
Genzyme, a Sanofi Company

Completed

Genzyme Osteopenia/Osteoporosis Study

Gaucher Disease

United States
National Cancer Institute (NCI)

Terminated

Parental Irradiation of Ukrainian Cleanup Workers and Evacuees and Germline Mutations in Their Offspring (Trio Study)

Genetics

Ukraine
European Organisation for Research and Treatment...

Active, not recruiting

Genetics of EGFR (Epidermal Growth Factor Receptor) Mutation Study (GEM)

EGFR Mutation Positive Non Small Cell Lung Cancer

United Kingdom
Hellenic Cooperative Oncology Group

Completed

Germline Mutations in Pancreatic Adenocarcinoma (PaMPA)

Pancreatic Cancer | Hereditary Cancer | Predisposition, Genetic | Germline Mutation Abnormality

Greece
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Terminated

Targeted Therapy in Treating Patients With Incurable Non-Small Cell Lung Cancer With Genetic Mutations

Recurrent Non-Small Cell Lung Carcinoma | Stage IV Non-Small Cell Lung Cancer | EGFR Activating Mutation

United States
Nantes University Hospital

Terminated

Genetic Study of Familial Forms of Non-atopic Asthma (GANA)

Non-atopic Asthma | Genetic Study

France
Columbia University
Mayo Clinic

Completed

Stool Testing for Pancreatic Cancer

Pancreatic Cancer

United States
National Cancer Institute (NCI)

Completed

A Pilot Study of Metformin in Patients With a Diagnosis of Li-Fraumeni Syndrome

Li-Fraumeni Syndrome

United States
Assiut University

Unknown

Clinical Characteristic and MEFV Gene Mutations in Patient With Juvenile Onest Systemic Lupus Erythematosus

SLE (Systemic Lupus)
Vertex Pharmaceuticals Incorporated

Completed

Observational Study of Outcomes in Cystic Fibrosis Patients With Selected Gating Mutations on a CFTR Allele (The VOCAL Study) (VOCAL)

Cystic Fibrosis

Netherlands, Italy, United Kingdom
Vertex Pharmaceuticals Incorporated

Terminated

Study to Evaluate the Safety and Efficacy of CTP-656 in Patients With Cystic Fibrosis With CFTR Gating Mutations

Cystic Fibrosis

United States
IRCCS San Raffaele

Unknown

Evaluation of Clinical, Radiomics and Molecular Features of Lung Metastasis in PDAC Patients (LUMACA Trial) (LUMACA)

Pancreas Adenocarcinoma

Italy
Tel-Aviv Sourasky Medical Center
Tel Aviv University

Unknown

Azithromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis (FAP)

Familial Adenomatous Polyposis

Israel
University Hospital, Rouen

Completed

Targeted Next-generation Sequencing Panel for Identification of Germline Mutations in Early Onset Cancers With Sporadic or Hereditary Presentation (PANEL)

Breast Cancer | Colorectal Cancer | Ovarian Cancer | Pediatric Cancers | Multiple Primary Malignant Tumours

France
Imperial College London Diabetes Centre

Unknown

Genetic Causes of Hypercholesterolaemia in the Emirati Population

Familial Hypercholesterolemia

United Arab Emirates
Nantes University Hospital

Completed

Prospective Multicenter Study on the Identification of Genetic Abnormalities Predisposing to Vasospasm From a Privileged Model: the Primary Raynaud's Phenomenon (RAY-GENE)

Primary Raynaud's Phenomenon (PR) | Genetic Mutations Causing PR | Study of Patients and Their Relatives (With or Without Primary PR)

France
Regeneron Pharmaceuticals
Sanofi

Completed

A Study of Alirocumab in Participants With Autosomal Dominant Hypercholesterolemia (ADH) and Gain-of-Function Mutations (GOFm) of the Proprotein Convertase Subtilisin Kexin 9 (PCSK9) Gene or Loss-of-Function Mutations (LOFm) of the Apolipoprotein (Apo) B Gene

Hypercholesterolemia

France, United States
University of Copenhagen

Completed

GLP-1 Response and Effect in Individuals With Obesity Causing Genetic Mutations

Obesity

Denmark
German Breast Group
AstraZeneca

Completed

Assessing the Efficacy of Paclitaxel and Olaparib in Comparison to Paclitaxel / Carboplatin Followed by Epirubicin/Cyclophosphamide as Neoadjuvant Chemotherapy in Patients With HER2-negative Early Breast Cancer and Homologous Recombination Deficiency (GeparOla)

Breast Cancer | Triple Negative Breast Neoplasms | HRpos Breast Neoplasms | BRCA 1 /2 and / or HRD

Germany
Fudan University

Unknown

Next-generation Sequencing of Colorectal Cancer Somatic Cells to Guide Genetic Susceptibility Gene Mutations Screening.

Hereditary Colorectal Cancer

China
Medical University Innsbruck

Unknown

Characterization of Two Novel Mutations in the Apob Gene

Familial Hypobetalipoproteinaemia - Heterozygous Form | Low-LDL-syndrome

Austria
Igentify Ltd
Sheba Medical Center

Unknown

The Use of Digital Genetic Counselor (DGC) for BRCA1/2 Mutation Carrier Testing

BRCA Mutations
M.D. Anderson Cancer Center

Unknown

The Molecular Predisposition to Hereditary Nonpolyposis Colon Cancer (HNPCC)

Kidney Cancer | Colorectal Cancer | Bladder Cancer | Skin Cancer | Endometrial Cancer | Uterus Cancer

United States
M.D. Anderson Cancer Center

Terminated

Metformin in Non Small Cell Lung Cancer (NSCLC)

Lung Cancer

United States
National Institute on Deafness and Other Communication...

Terminated

Genetic Analysis of Human Hereditary Hearing Impairment

Partial Hearing Loss

United States
Memorial Sloan Kettering Cancer Center

Completed

Decision-making Regarding Prophylactic Mastectomy and Oophorectomy in Women Seeking Genetic Counseling and Testing for BRCA1/2 Mutations

Breast Cancer | Ovarian Cancer

United States
National Cancer Institute (NCI)

Completed

Frequency of EGFR Mutations in Latinos/Hispanics With Non-Small Cell Lung Cancer

Non-Small-Cell Lung Carcinoma

United States, Mexico, Bolivia, Peru, Venezuela
Eloxx Pharmaceuticals, Inc.

Terminated

Safety, Tolerability, Pharmacokinetics of ELX-02 in Healthy Adult Volunteers

Genetic Diseases | Nonsense Mutations
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Genetic Mutations and Environmental Exposure in Young Patients With Retinoblastoma and in Their Parents and Young Healthy Unrelated Volunteers

Intraocular Retinoblastoma | Recurrent Retinoblastoma | Extraocular Retinoblastoma

United States, Canada, Puerto Rico
Sunnybrook Health Sciences Centre
Queen's University; Ontario Molecular Pathology Research Network

Unknown

Mutational Analysis as a Prognostic and Predictive Marker of Cardiovascular (CVD) Disease in Patients With Myelodysplasia

Cardiovascular Diseases | Inflammation | MDS

Canada
Scripps Health
J. Craig Venter Institute

Completed

Biomarker Monitoring in TP53 Mutation Carriers

Li-Fraumeni Syndrome | Hereditary Cancer Syndromes | TP53 Gene Germline Mutation Carrier

United States
University of Alabama at Birmingham

Completed

Evaluation of Ivacaftor in Patients Using Ataluren for Nonsense Mutations

Cystic Fibrosis

United States
Medical University of Vienna

Unknown

Genetic Risk Factors and Acquired Oncogenic Mutations of Melanoma (M3)

Melanoma

Austria
University Hospital, Lille

Completed

Search for New Genetic Mutations Major Effect in Crohn's Disease (MC-WES)

Crohn Disease

France
Cerenis Therapeutics, SA

Terminated

CER-001 Therapy as a Novel Approach to Treat Genetic Orphan Diseases (TANGO)

Familial Hypoalphalipoproteinemia

France, United States, Belgium, Canada, Israel, Italy, Netherlands
Allife Medical Science and Technology Co., Ltd.

Unknown

iHSCs With the Gene Correction of HBB Intervent Subjests With β-thalassemia Mutations

Thalassemia
National Institute of Neurological Disorders and...

Completed

Effect of Vorinostat on Nervous System Hemangioblastomas in Von Hippel-Lindau Disease (Missense Mutation Only)

Von Hippel-Lindau Disease

United States
Danish Headache Center
Maastricht University Medical Center

Completed

Classical Trigeminal Neuralgia and Sodium Channel Mutations

Trigeminal Neuralgia
University of Rochester

Completed

Evaluate the Effectiveness of an Experimental Urethane Dimethacrylate Resin Based Dental Composite Material

Dental Caries | Restorative Material

United States
Medical University of South Carolina
Vertex Pharmaceuticals Incorporated

Completed

An Efficacy and Safety Study of Ivacaftor in Patients With Cystic Fibrosis and Two Splicing Mutations

Cystic Fibrosis
Emory University

Completed

Characterization of Laboratory Response to DDAVP in Adult Hemophilia A Carriers

Hemophilia A

United States
National Cancer Institute (NCI)

Completed

Veliparib in Treating Patients With Malignant Solid Tumors That Do Not Respond to Previous Therapy

Recurrent Fallopian Tube Carcinoma | Recurrent Ovarian Carcinoma | Recurrent Primary Peritoneal Carcinoma | Breast Carcinoma | Ovarian Carcinoma | Pancreatic Carcinoma | Prostate Carcinoma | Recurrent Breast Carcinoma | Estrogen Receptor Negative | HER2/Neu Negative | Progesterone Receptor Negative | Triple-Negative... and other conditions

United States
National Taiwan University Hospital

Unknown

Screening of IDH1 and IDH2 Gene Mutations in Adult Acute Myeloid Leukemia for Possible Targeted Therapy

Acute Myeloid Leukemia

Taiwan
Pathway Genomics

Completed

Utility of Plasma Circulating Tumor DNA (ctDNA) in Asymptomatic Subjects for the Detection of Neoplastic Disease (H1000)

Neoplasms | Mutation

United States
National Cancer Institute (NCI)

Completed

Genetic Susceptibility to Factor VIII Inhibitors

Hemophilia

Sweden

Search clinical trials for: Genetic mutations

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