Search clinical trials for: Iron overload

Total 2670 results

Peking Union Medical College Hospital
Novartis

Unknown

Study of MRI Monitoring in Patients With Aplastic Anemia and Low or Int-1 Risk of MDS Complicated With Iron Overload

Iron Overload | Aplastic Anemia | Dysmyelopoietic Syndromes
Rennes University Hospital

Completed

Effects of Phlebotomy on Insulin Sensitivity in Insulin Resistance-associated Hepatic Iron Overload Patients (SAINPOS)

Insulin Resistance | Iron Overload

France
University of Western Ontario, Canada

Completed

Evaluation of Phlebotomy as a Treatment for Non-alcoholic Fatty Liver Disease

Non-alcoholic Fatty Liver Disease

Canada
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Hemochromatosis and Iron Overload Screening Study (HEIRS)

Iron Overload | Blood Disease | Hemochromatosis
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Statistical Basis for Hemochromatosis Screening

Blood Disease | Hemochromatosis
Novartis Pharmaceuticals

Completed

Observation of Patients With Transfusional Hemosiderosis Treatment With Deferasirox

Transfusional Hemosiderosis

Egypt, Spain, United Kingdom, Jordan
Mayo Clinic

Completed

Evaluation of a New MR Pulse Sequence to Quantify Liver Iron Concentration

Hemochromatosis

United States
University of Rochester
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Hemochromatosis--Genetic Prevalence and Penetrance

Blood Disease | Hemochromatosis
ApoPharma

Completed

Efficacy Study in Removing Excess Iron From the Heart

Hemosiderosis | Thalassemia Major

Greece, Italy
Novartis Pharmaceuticals

Completed

ENTRUST, a 5 Year Surveillance of Children Aged 2 to <6 Years With Transfusional Iron Overload Treated With Deferasirox

Anemia

United States
Sideris Pharmaceuticals

Terminated

Safety and Pharmacokinetic Study of Escalating Doses of SP-420, an Iron Chelator, in Patients With β-Thalassemia

Iron Overload | Beta-Thalassemia

United States, Canada, Lebanon, Thailand, Turkey
University of Campinas, Brazil
Fundação de Amparo à Pesquisa do Estado de São Paulo

Completed

Amlodipine in the Prevention and Treatment of Iron Overload in Patients With Thalassemia Major (AmloThal)

Iron Overload | Thalassemia

Brazil
HaEmek Medical Center, Israel

Completed

Renal Function Among Thalassemia Patients Treated by a Oral Chelator Deferasirox

Iron Overload | Thalassemia

Israel
HaEmek Medical Center, Israel

Completed

Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia

Sickle Cell Disease | Thalassemia

Israel
ApoPharma

Completed

Absorption, Metabolism, and Excretion of a Single Dose of Ferriprox® in Patients With Sickle Cell Disease

Sickle Cell Disease

Canada
Zealand University Hospital

Completed

Iron Overload and Transient Elastography in Patients With Myelodysplastic Syndrome

Myelodysplastic Syndrome

Denmark
Rennes University Hospital
Ministry of Health, France

Completed

Bone Status on Patients With Genetic Hemochromatosis: a 3 Years Descriptive and Evolutionary Study (FEROS)

Genetic Hemochromatosis

France
Assistance Publique - Hôpitaux de Paris

Terminated

Phlebotomy and Risk of Hepatocellular Carcinoma in Patients With Compensated Alcoholic Cirrhosis (CIRROX)

Iron Overload | Alcoholic Cirrhosis

France
Assistance Publique - Hôpitaux de Paris
Novartis

Completed

Multicenter Observational Study on Myocardial Iron Overload in 3 Multitransfused Populations (SUFEMYO)

Sickle Cell Disease | Thalassemia | Myelodysplasia

France
Novartis Pharmaceuticals

Completed

Extension Study of Iron Chelation Therapy With Deferasirox in Patients With Transfusional Iron Overload

Transfusional Iron Overload

Italy
Rennes University Hospital

Terminated

Rare Iron Overloads Except C282Y Homozygosity : Description and Characterization. (HEPCIDEF)

Rare Iron Overloads Except C282Y Homozygosity

France
Genzyme, a Sanofi Company

Completed

Iron Balance Study of DFO and GT56-252 in Patients With Transfusional Iron Overload Secondary to Beta-Thalassemia

Beta-Thalassemia

United States
University of Campinas, Brazil
Fundação de Amparo à Pesquisa do Estado de São Paulo

Completed

Amlodipine Use in the Prevention and Treatment of Iron Overload in Patients With Thalassemia Major (AnloThal)

Thalassemia Major

Brazil
University Hospital, Basel, Switzerland

Completed

Iron Homoeostasis in Inflammation

Inflammation | Bacterial Infections and Mycoses | Anemia, Iron-Deficiency | Iron Overload

Switzerland
Novartis Pharmaceuticals

Completed

Safety and Efficacy of Desferasirox in Chinese Patients With Iron Overload and Aplastic Anemia

Iron Overload

China
Novartis Pharmaceuticals

Completed

Evaluating Use of Deferasirox as Compared to Deferoxamine in Treating Cardiac Iron Overload (CORDELIA)

Transfusional Hemosiderosis | Transfusional Iron Overload

Taiwan, Turkey, Egypt, United Kingdom, Thailand, Canada, China, Italy, Cyprus, Lebanon, United Arab Emirates
Rennes University Hospital

Completed

HEPFER-Evaluation of a New Phenotypic Biological Marker in Genetic Type 1 Hemochromatosis (HEPFER)

Hereditary Hemochromatosis C282Y Homozygous

France
University Health Network, Toronto

Completed

MR Imaging of Diffuse Myocardial Fibrosis in Transfusion-Dependent Anemias (MAFIO)

Thalassemia Major | Chronic Blood Transfusion Related Iron Overload

Canada
Seoul National University Hospital

Completed

Pharmacogenetic Study in Patients Received Iron Chelating Agent

Hemosiderosis

Korea, Republic of
Wolfson Medical Center
Hadassah Medical Organization; Tel-Aviv Sourasky Medical Center; Sheba Medical... and other collaborators

Completed

Evaluation the Effect of Exjade on Oxidative Stress in Low Risk Myelodysplastic Syndrome Patients With Iron Over Load

Myelodysplastic Syndrome

Israel
HealthCore-NERI
National Heart, Lung, and Blood Institute (NHLBI); Thalassemia Clinical Research...

Completed

Thalassemia (Cooley's Anemia) Clinical Research Network (TCRN)

Hematologic Diseases | Iron Overload | Hypertension, Pulmonary | Osteoporosis | Thalassemia | Beta-Thalassemia | Anemia, Cooley's

United States, Canada
University Hospital, Clermont-Ferrand
Institut National de la Recherche Agronomique

Unknown

MEPHISTO (Macrophage Phenotype In Metabolic Syndrome With Iron Overload) (MEPHISTO)

Metabolic Syndrome X | Dysmetabolic Iron Overload Syndrome

France
Sanquin Research & Blood Bank Divisions
Radboud University Medical Center; Maastricht University Medical Center; Atrium... and other collaborators

Unknown

Erythrocytapheresis Versus Phlebotomy as Maintenance Therapy in Hereditary Hemochromatosis (HH) Patients

Hereditary Hemochromatosis

Netherlands
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Evaluation of Subcutaneous Desferrioxamine as Treatment for Transfusional Hemochromatosis

Hematologic Diseases | Iron Overload | Hemoglobinopathies | Thalassemia | Beta-Thalassemia | Hemochromatosis | Anemia (Iron-Loading)
Novartis Pharmaceuticals

Completed

Efficacy and Safety of Deferasirox in Non-transfusion Dependent Thalassemia Patients With Iron Overload and a One Year Open-label Extension Study (THALASSA)

Non-transfusion Dependent Thalassemia

Greece, Taiwan, Italy, United Kingdom, Lebanon, Turkey, Malaysia, Thailand, United States
University of Campania "Luigi Vanvitelli"

Completed

Retrospective Evaluation of Adult and Pediatric Transfusion-dependent Patients Treated With Deferasirox Therapy

Iron Overload
ApoPharma

Completed

Active Drug Surveillance Program of Ferriprox Use

Transfusional Iron Overload

Egypt, Cyprus, Oman, Saudi Arabia, Turkey
Dana-Farber Cancer Institute
Brigham and Women's Hospital

Terminated

Deferoxamine for Iron Overload Before Allogeneic Stem Cell Transplantation

Acute Myeloid Leukemia | Acute Lymphoblastic Leukemia | Myelodysplastic Syndrome

United States
Dana-Farber Cancer Institute

Completed

Observational Study of Iron Overload in Stem Cell Transplantation

Acute Myeloid Leukemia | Acute Lymphoblastic Leukemia | Myelodysplastic Syndrome

United States
St. Jude Children's Research Hospital
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Stroke With Transfusions Changing to Hydroxyurea

Hematologic Diseases | Anemia, Sickle Cell | Cerebrovascular Accident | Hemochromatosis

United States
Lipomed

Completed

Study With Deferiprone and/or Desferrioxamine in Iron Overloaded Patients

Hemochromatosis

Egypt, Turkey
Rennes University Hospital
Ministry of Health, France

Completed

Cytochrome P450 2E1 and Iron Overload

Insulin Resistance | Iron Overload

France
Novartis Pharmaceuticals

Completed

Open-Label Single-Arm Pilot Study in Adult Allogeneic Hematopoietic Stem Cell Transplant Recipients With Transfusional Iron Overload

Iron Overload

Spain
Novartis Pharmaceuticals

Completed

Safety & Efficacy of ICL670 vs. Deferoxamine in Beta-thalassemia Patients With Iron Overload Due to Blood Transfusions

Beta-Thalassemia

United States
FerroKin BioSciences, Inc.

Completed

Safety and Pharmacokinetic Study of Escalating Multiple Doses of an Iron Chelator in Patients With Iron Overload

Beta-thalassemia | Transfusional Iron Overload

United States, Australia, Thailand
Children's Hospital of Philadelphia
ApoPharma

Approved for marketing

Compassionate Use of Deferiprone for Patients With Thalassemia and Iron-Induced Heart Disease

Iron Overload

United States
Ain Shams University

Unknown

Study Of Efficacy,Safety of Combined Deferasirox and Deferiprone Versus Combined Deferiprone and Desferal In Conditions of Iron Overload

Sickle Cell Disease | Beta-thalassemia Major | Iron Hemosiderosis

Egypt
Maastricht University Medical Center
Annadal stichting

Unknown

Proton Pump Inhibitors in the Prevention of Iron Reaccumulation in Patient With Hereditary Hemochromatosis (He-ppi)

Hemochromatosis

Netherlands, Belgium
Neurim Pharmaceuticals Ltd.

Completed

Investigation of Melatonin and Zolpidem Effect on Postural Instability in Healthy Adult Subjects

Postural Instability

France
Lipomed

Completed

Study Using Deferiprone Alone or in Combination With Desferrioxamine in Iron Overloaded Transfusion-dependent Patients

Hemochromatosis

Switzerland

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