Search clinical trials for: Liver Function

Total 39225 results

Pfizer

Completed

A Study to Compare How the Study Medicine (PF-07923568) is Processed in Participants With Different Levels of Loss of Liver Function to Healthy Participants.

Liver Diseases | Hepatic Impairment

United States
Xuzhou Medical University

Completed

The Impact of Different Exercise Modes on Bile Acid Levels and Liver Function in Patients With Non-alcoholic Fatty Liver Disease

Non-alcoholic Fatty Liver Disease NAFLD

China
TenNor Therapeutics (Suzhou) Limited

Completed

Efficacy and Safety of Rifasutenizol (TNP 2198) in Participants With H. Pylori Infection

H.Pylori Infection

China
Eli Lilly and Company

Completed

A Study of Imlunestrant (LY3484356) in Female Participants With Impaired Liver Function

Hepatic Insufficiency | Healthy

United States
SK Life Science, Inc.

Completed

Safety Study of Cenobamate in Subjects With Normal Hepatic Function and Subjects With Severe Hepatic Impairment

Hepatic Impairment

Poland, Slovakia
Astellas Pharma Global Development, Inc.

Completed

A Study to Investigate the Effect of Mild and Moderate Hepatic Impairment on the Safety and Tolerability of Fezolinetant Compared to Participants With Normal Hepatic Function

Healthy Volunteers | Hepatic Impairment

United States
Ascelia Pharma AB

Completed

Safety and Diagnostic Efficacy of Mangoral in Participants With Focal Liver Lesions and Reduced Kidney Function (SPARKLE)

Severe Renal Impairment | Known or Suspected Focal Liver Lesions

United States, Italy, Germany, Poland, Russian Federation, Sweden, Turkey, Argentina, Colombia, Mexico
Zimmer Biomet

Active, not recruiting

Comprehensive Nano - Post Market Clinical Follow-Up Study

Osteoarthritis | Rheumatoid Arthritis | Avascular Necrosis | Correction of Functional Deformity | Revision

Korea, Republic of, Canada, United Kingdom, Austria
King's College London
King's College Hospital NHS Trust; National Institute for Health Research,...

Terminated

Liver Immunosuppression Free Trial (LIFT)

Transplantation, Liver

United Kingdom
Washington University School of Medicine

Enrolling by invitation

Liver Health and Metabolic Function in People With Obesity

Non-Alcoholic Fatty Liver Disease

United States
RemeGen Co., Ltd.

Active, not recruiting

A Study of RC48-ADC Administered Intravenously to Patients With HER2-Positive Metastatic Breast Cancer With or Without Liver Metastases

Breast Neoplasms | Breast Diseases | HER2-positive Breast Cancer | Capecitabine | HER2 Positive Breast Carcinoma | HER2-positive Advanced Breast With Liver Metastases

China
Postgraduate Institute of Medical Education and...

Completed

Effects of Direct-acting Antiviral Agents on HCV Cognitive Function, and Depression in HCV Related Cirrhosis: A Prospective Clinical Trial

Depression in Chronic Hepatitis C

India
Institut de Recherches Internationales Servier

Completed

A Study of Vorasidenib in Participants With Moderate or Mild Hepatic Impairment and Matched Participants With Normal Hepatic Function

Hepatic Impairment

United States
Tang-Du Hospital

Completed

Liver Resection for Patients With Hepatocellular Carcinoma and Impaired Liver Function

Hepatic Cancer

China
Al B. Benson, III, MD
Celgene Corporation; Big Ten Cancer Research Consortium

Completed

FOLFOX-A in the Treatment of Metastatic or Advanced Unresectable Gastric, Gastro-Esophageal Junction Adenocarcinoma

Gastric Cancer | Gastro-Esophageal Junction Adenocarcinoma

United States
Sanofi

Completed

A Study in Adults to Investigate the Impact of Mild, Moderate, and Severe Hepatic Impairment on Pharmacokinetics of Venglustat Compared to Participants With Normal Hepatic Function

Hepatic Function Abnormal

United States, Germany
Cambridge University Hospitals NHS Foundation Trust
University of Cambridge

Terminated

Molecular Investigation of Genetic Factors in CArDiovascular Diseases Using an BIOresource of Healthy Volunteers (CADBIO)

Cardiovascular Diseases

United Kingdom
Takeda

Completed

A Study of Soticlestat in Adults With Liver Failure Compared to Those With Normal Liver Function

Healthy Volunteers | Hepatic Impairment

United States, Hungary
Reata, a wholly owned subsidiary of Biogen

Completed

A Pharmacokinetic Study of Omaveloxolone in Subjects With Hepatic Impairment and Normal Hepatic Function

Hepatic Impairment

United States
Reata, a wholly owned subsidiary of Biogen

Completed

Single-Dose, Open-Label Pharmacokinetic Study of Bardoxolone Methyl in Subjects With Mild, Moderate, and Severe Hepatic Impairment and Normal Hepatic Function

Healthy | Hepatic Impairment

United States
Baylor Research Institute

Active, not recruiting

Quantitative Liver Function Tests Using Cholates

End Stage Liver Disease

United States
Canadian Cancer Trials Group
Queen's University, Belfast; Survivorship Research Group

Active, not recruiting

Health Education Materials With/Out a Physical Activity Program for Patients Who Have Undergone Treatment for High-Risk Stage II or Stage III Colon Cancer (CHALLENGE)

Depression | Fatigue | Colorectal Cancer | Sleep Disorders | Cognitive/Functional Effects | Anxiety Disorder | Psychosocial Effects of Cancer and Its Treatment | Excercise

Canada, United States, Australia, France, Korea, Republic of, United Kingdom
ChemoCentryx

Completed

A Phase 3 Clinical Trial of CCX168 (Avacopan) in Patients With ANCA-Associated Vasculitis (ADVOCATE)

ANCA-Associated Vasculitis

United States, Australia, Belgium, Canada, France, Italy, Japan, Netherlands, Spain, United Kingdom, Austria, Czechia, Denmark, Germany, Hungary, Ireland, New Zealand, Norway, Sweden, Switzerland
Guangxi Medical University

Completed

Effect of Smoked Plum and Chewing Gum on Postoperative Bowel Function Following Hepatic Resection (SP/GC-HCC)

Liver Cancer

China
VA Office of Research and Development
Oregon Health and Science University; Portland VA Medical Center

Completed

HCV and Co-morbid Alcohol Use Disorders: A Translational Investigation of Antiviral Therapy Outcomes on CNS Function

Hepatitis C | Alcohol Use Disorder

United States
Suzhou Zelgen Biopharmaceuticals Co.,Ltd

Completed

Pharmacokinetics Of Jaktinib In Subjects With Hepatic Impairment And Normal Hepatic Function

Hepatic Insufficiency | Healthy Subjects

China
Rivus Pharmaceuticals, Inc.

Withdrawn

Ph 2a Study of HU6 on Energy Metabolism, Muscle and Liver Substrate Metabolism, and Mitochondrial Function in Subjects Who Are Overweight or Obese With Type 2 Diabetes

Obesity | Diabete Type 2

United States
Eli Lilly and Company
Loxo Oncology, Inc.

Completed

Study of Pirtobrutinib (LOXO-305) in Participants With Impaired Liver Function and Healthy Participants

Hepatic Insufficiency | Healthy

United States
University of Pittsburgh

Suspended

A Sleep Intervention for Cancer Patients and Their Caregivers

Intervention | Control

United States
Dompé Farmaceutici S.p.A

Completed

Study to Assess Efficacy & Safety of Reparixin in Pancreatic Islet Transplantation (REP0211)

Islet Transplantation in Diabetes Mellitus Type 1

United States, Czechia, Italy, Sweden, United Kingdom
University of Nebraska
National Cancer Institute (NCI)

Completed

Capecitabine, Epirubicin, and Carboplatin in Treating Patients With Progressive, Unresectable, or Metastatic Cancer

Gastric Cancer | Unspecified Adult Solid Tumor, Protocol Specific | Liver Cancer | Gallbladder Cancer | Extrahepatic Bile Duct Cancer

United States
Institut für Klinische Krebsforschung IKF GmbH...
Johann Wolfgang Goethe University Hospital, Prof. Dr. med. Trojan

Active, not recruiting

Dose Escalation Study of Cabozantinib for Advanced HCC Patients With Preserved Liver Function

Hepatocellular Carcinoma (HCC) | Second Line Treatment

Germany
Sagimet Biosciences Inc.

Completed

A Phase I Pharmacokinetic Study of TVB-2640 (Denifanstat) in Subjects With Mild, Moderate, or Severe Hepatic Impairment Compared to Subjects With Normal Hepatic Function

Cirrhosis | Hepatic Impairment | Non-alcoholic Steatohepatitis

United States, Hungary
Endeavor Biomedicines, Inc.

Active, not recruiting

A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function Mutations

Solid Tumors With PTCH1 Loss-of-function Mutations

United States
University of Alabama at Birmingham
National Institutes of Health (NIH); Mereo BioPharma

Completed

Alvelestat (MPH966) for the Treatment of ALpha-1 ANTitrypsin Deficiency (ATALANTa)

Emphysema or COPD | Alpha-1 Antitrypsin Deficiency (AATD) | Pi*ZZ, Pi*SZ, Pi*Null, Another Rare Phenotype/Genotype Known to be Associated With Either Low or Functionally Impaired AAT Including F or I Mutations

United States
Philips Clinical & Medical Affairs Global

Enrolling by invitation

Distal Evaluation of Functional Performance With Intravascular Sensors to Assess the Narrowing Effect: Guided Physiologic Stenting (DEFINE GPS)

Coronary Artery Disease | Ischemic Heart Disease

United States, Netherlands, Denmark, Sweden, Canada, Israel, United Kingdom, Spain, Australia, Germany, Switzerland, Austria, Belgium, France, Portugal, Mexico
Radboud University Medical Center
Erasmus Medical Center; ViiV Healthcare; Elisabeth-TweeSteden Ziekenhuis; Onze...

Completed

2000 HIV Human Functional Genomics Partnership Program (2000HIV)

HIV Infections

Netherlands
Novo Nordisk A/S

Completed

A Research Study Looking Into Blood and Urine Levels of the Medicine NNC0194-0499 in the Body and How Well it is Tolerated in Participants With Reduced Kidney Function and Normal Kidney Function

Non-alcoholic Steatohepatitis (NASH)

Germany
Boehringer Ingelheim

Completed

A Pharmacokinetic Study to Assess Nevirapine [Viramune] Levels in HIV Infected Patients With Impaired Hepatic Functions

Hepatic Insufficiency | HIV Infections

France, United States, Spain
University of Liverpool
University of Southampton; Liverpool University Hospitals NHS Foundation Trust and other collaborators

Active, not recruiting

AGILE (Early Phase Platform Trial for COVID-19)

Covid19

United Kingdom, South Africa
Royal North Shore Hospital

Active, not recruiting

Liver Function Investigation With SPECT (LiverINSPECT)

Liver Cancer, Adult

Australia
Copenhagen University Hospital, Hvidovre

Completed

Is There an Association Between Chronic Pancreatitis and Pulmonary Function (RespPanc)

Healthy | Respiratory Insufficiency | Chronic Pancreatitis | Cirrhosis, Liver | Lung Function Decreased

Denmark
Sheffield Teaching Hospitals NHS Foundation Trust
University of Sheffield; University of Liverpool

Completed

Muscle in Obesity: Imaging, Function and microRNA

Muscle Function

United Kingdom
University of Pittsburgh
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); National...

Active, not recruiting

The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes (TRIABETES)

Obesity | Type 2 Diabetes Mellitus

United States
Millennium Pharmaceuticals, Inc.

Completed

A Study to Evaluate Pharmacokinetics (PK) and Safety of Oral Mobocertinib in Participants With Moderate or Severe Hepatic Impairment (HI) and Normal Hepatic Function

Healthy Volunteers | Hepatic Impairment

United States
Vanderbilt University Medical Center

Enrolling by invitation

Physiologic and Functional Adaptations of Insulin Sensitive Tissues

Liver Diseases | Obesity | Diabetes | Insulin Resistance | Bariatric Surgery Candidate | Roux-en-y Gastric Bypass

United States
Fujian Akeylink Biotechnology Co., Ltd.

Completed

Pharmacokinetics and Safety of GST-HG171 Tablets in Subjects With Impaired and Normal Liver Function

COVID-19 Pneumonia

China
Shanghai Vinnerna Biosciences Co., Ltd.
Sponsor GmbH

Completed

A Study in Subjects With Liver Function Injury and Subjects With Normal Liver Function

Subjects With Liver Function Injury | Normal Liver Function Subject

China
Northwestern University
National Heart, Lung, and Blood Institute (NHLBI); American Society for Transplantation

Withdrawn

Mechanism of Hypertension Treatments in Liver Transplant Recipients (BLOCK LTR-HTN)

High Blood Pressure | Liver Transplant | Renal Function Abnormal

United States
Liverpool John Moores University

Completed

Can Exercise Training Reduce the Frequency and Severity of Hot Flushes Associated With Breast Cancer Treatment?

Breast Cancer

United Kingdom

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