Search clinical trials for: metabolites

Total 318 results

Centro De Investigación Y De Estudios Avanzados...
Centro de Estudios Cardiometabólicos S.C. (CESCAM); Inulina y Miel de Agave...

Completed

Gastrointestinal Tolerability to Agavins and Impact on Host-gut Microbiota-metabolism Interactions Modulation

Healthy | Obesity

Mexico
Klinikum Nürnberg

Unknown

Determination of Drugs and Their Metabolites in Hospitalized Patients

Neoplasms

Germany
Celgene

Completed

Drug Interaction Study of the Effect on Cyclosporine on Ozanimod and Major Active Metabolites

Healthy Volunteers

United States
Shenzhen People's Hospital

Unknown

Functional Study of Metabolites in Patients With Aortic Dissection

Aortic Dissection

China
Fraunhofer-Institute of Toxicology and Experimental...

Completed

Characterization of the Inhibitory Effects of Fevipiprant (QAW039) on Activation of Eosinophils and ILC2 Cells by Prostaglandin D2 Metabolites (18-03 EONOV)

Atopic Asthma

Germany
Hospital Universitario Dr. Jose E. Gonzalez
Instituto de Información e Investigación en Salud Mental A. C.

Unknown

Brain Hippocampal Volume Relationship With Anxious Symptoms in Major Depressive Patients

Anxiety Disorders | Major Depressive Disorder

Mexico
Northumbria University
Quorn

Completed

The Effects of Replacing Red and Processed Meat With Quorn on Biomarkers of Gut Health (MYCOMEAT)

Colorectal Cancer

United Kingdom
Perosphere Pharmaceuticals Inc, a wholly owned...
World Wide Clinical Trials Early Phase Services, LLC

Completed

An Open-label, Single-dose, Non-randomized Study of IV 14C-labeled PER977 in Healthy Male Subjects

Healthy

United States
Xiangya Hospital of Central South University

Unknown

Effects of Sulforaphane on Cognitive Function in Patients With Frontal Brain Damage

Frontal Lobe Dysfunction
Universitaire Ziekenhuizen KU Leuven

Completed

AXOS and Microbial Metabolites in CKD

Chronic Kidney Disease

Belgium
Universitaire Ziekenhuizen KU Leuven

Withdrawn

The Colonic Transit Time: a Modifiable Determinant of Intestinal Production and Uptake of Microbial Metabolites?

Constipation

Belgium
Universitaire Ziekenhuizen KU Leuven

Unknown

Intestinal Transport of Microbial Metabolites in Chronic Kidney Disease

Chronic Kidney Disease

Belgium
Corcept Therapeutics

Completed

Study in Healthy Subjects to Determine the Effect of an Inhibitor on Exposure to Relacorilant and Its Metabolites

Healthy

United States
Eisai Inc.
Purdue Pharma LP

Completed

Study to Evaluate the Pharmacokinetics of Lemborexant (E2006) and Its Metabolites in Subjects With Mild and Moderate Hepatic Impairment Compared to Healthy Subjects

Hepatic Impairment

United States
Eisai Inc.
Purdue Pharma LP

Completed

Study to Evaluate the Pharmacokinetics of Lemborexant (E2006) and Its Metabolites in Subjects With Normal Renal Function or With Severe Renal Impairment

Renal Impairment

United States
Glac Biotech Co., Ltd

Completed

Double-blind Clinical Trials of Probiotic Products in Oral Health.

Probiotics | Oral Health | Probiotic Metabolites

Taiwan
Laval University

Completed

Investigation of Microbiome-Derived Metabolite Production in Response to a Mediterranean Diet (META)

Food Habits

Canada
Astellas Pharma Europe B.V.
FibroGen

Completed

A Phase 1 Study of Roxadustat in Subjects With Different Degrees of Renal Function

Impaired Renal Function | Normal Renal Function

Germany, United Kingdom
Fytexia

Completed

Mangoselect®: Characterization, Pharmacokinetics and Bioavailability of Xanthone Metabolites

Dietary Modification

Spain
Imperial College London

Completed

Application of New Technologies and Tools to Nutrition Research (NutriTech)

Obesity | Diabetes

United Kingdom
Universiti Putra Malaysia

Unknown

Postprandial Metabolites of Meal Challenge Test in Diabetes State

Type2 Diabetes | Postprandial Hyperglycemia

Malaysia
Biocodex

Completed

Pharmacokinetic Study of Stiripentol and Its Metabolites After Multiple Dose Oral Administration in Healthy Male Volunteers

Healthy Volunteers

Belgium
University of Pennsylvania

Completed

Mechanisms of Action of Acetaminophen

Myocardial Infarction | Arthritis

United States
Merck Sharp & Dohme LLC

Completed

A Study to Evaluate the Effects of Extended Release (ER) Niacin/Laropiprant, Laropiprant, ER Niacin, and Placebo on Urinary Prostanoid Metabolites in Subjects With High Cholesterol (0524A-075)(COMPLETED)

Hypercholesterolemia
First Affiliated Hospital of Chongqing Medical...

Unknown

Efficacy and Safety of Short-term Postoperative Anticoagulant Therapy to Prevente Thrombosis in Arterovenous Fistula (EASOAT)

Thrombosis

China
Pfizer

Completed

A Study to Assess Pharmacokinetics of PF-04965842 and Its Metabolites and Effect of Probenecid in Healthy Participants

Healthy

United States
Sun Yat-sen University
First Affiliated Hospital, Sun Yat-Sen University; Sun Yat-Sen Memorial Hospital...

Unknown

To Explore the Diversity of Intestinal Flora in Patients With Advanced HCC Combin ed With Anti-PD-1 and Targeted Drug Therapy and the Correlation Between Metabolites and Therapeutic Effect

Advanced Hepatocellular Carcinoma
GlaxoSmithKline

Terminated

Assessment of the Pharmacokinetics of GSK1278863 and Metabolites in Normal Subjects and Subjects With Renal Impairment

Anaemia

United States
National Cancer Institute (NCI)

Completed

A Pilot Study of 1H-Nuclear Magnetic Resonance Spectroscopic Imaging in Pediatric Patients With Primary and Metastatic Brain Tumors

Brain Cancer | Brain Neoplasm | Brain Tumor, Primary

United States
Northumbria University
International Nut and Dried Fruit Council

Completed

Effects of Consumption of Nut Components on Cognitive Function, Intestinal Microbial Communities and Markers of Health

Cognitive Function | Intestinal Microbiota | Urinary Metabolites

United Kingdom
Pfizer

Completed

Single Dose Study With Unlabeled Dose and 14C-labeled Microdose of PF-06700841 in Healthy Male Subjects

Healthy Male Subjects

Netherlands
Intersci Research Association, Austria

Unknown

Urinary Steroid Metabolites in Autism

Autism Spectrum Disorder | Autism

Austria
Celgene

Completed

Extension Study to Further Evaluate the Safety, Pharmacodynamics and Pharmacokinetics of Ozanimod and Active Metabolites

Healthy Volunteers

United States
Cassiopea SpA

Completed

A Study to Investigate the Effects of Cortexolone 17α-propionate (and Its Metabolites) on Healthy Volunteers' Heart

Healthy Volunteers

United Kingdom
Karina Vejrum Sørensen

Unknown

Effect of Dietary Oils as G-protein-coupled Receptor Agonists on Glucose Tolerance

Obesity | Type 2 Diabetes Mellitus

Denmark
Société des Produits Nestlé (SPN)
Ecole Polytechnique Fédérale de Lausanne

Completed

Phosphate Metabolites in Brain of Humans Aged 50+

Basic Science

Switzerland
Shanghai Ninth People's Hospital Affiliated to...

Unknown

A Study of Apatinib Plus Tegafur Gimeracil Oteracil in Recurrent/Metastatic Head and Neck Cancers

Head and Neck Squamous Cell Carcinoma

China
University Hospital, Bordeaux
ANRS, Emerging Infectious Diseases; Sidaction; Centre National de la Recherche...

Completed

Inflammasome Activation Via Circulating Metabolites (InflammoVIH)

Human Immunodeficiency Virus

France
USDA Grand Forks Human Nutrition Research Center

Completed

Dietary Fat, Eicosanoids and Breast Cancer Risk

Breast Cancer

United States
GlaxoSmithKline

Terminated

Dabrafenib/Trametinib, BRAF or BRAF AND MEK Pre-op With BRAF and MEK Post-op, Phase IIB, Melanoma With Brain Mets,Biomarkers and Metabolites

Melanoma and Brain Metastases

United States, Australia
Shanghai Changzheng Hospital

Completed

A Study of PAD Followed by Autologous Stem Cell Transplantation (ASCT) to Treat Newly Diagnosed Multiple Myeloma

Multiple Myeloma

China
Maastricht University Medical Center

Completed

Increasing Ferulic Acid Bioavailability in Bran

Healthy Males

Netherlands
Wei Jiang
Wuzhou Red Cross Hospital; Laibin People's Hospital; Guangxi Naxishan Hospital; People's Hospital of Baise and other collaborators

Unknown

Adjuvant Treatment of Apatinib in Nasopharyngeal Carcinoma

Nasopharyngeal Carcinoma

China
University of Washington
National Institute of General Medical Sciences (NIGMS)

Completed

The Effects of Multiple Dose Fluoxetine and Metabolites on CYP1A2, CYP2C19, CYP2D6 and CYP3A4 Activity (FLUOXETINE)

Healthy Volunteers | Drug-Drug Interaction
Fazer Group
Nokia Technologies Oy; Nightingale Health Oy; Tekes - the Finnish Funding Agency... and other collaborators

Completed

Dietary Intervention With Brain-friendly Diet (BRAVE)

Cognitive Performance | Physiological Stress | LDL Cholesterol

Finland
Tartu University Hospital

Completed

Remote Ischemic Preconditioning as a Method Against Subclinical Renal Injury and Contrast-induced Nephropathy

Atherosclerosis | Stable Angina | Peripheral Artery Disease | Contrast-induced Nephropathy

Estonia
Huazhong University of Science and Technology

Unknown

The Effect of n-3 PUFA Plant Oil Intake on Human Metabolism (PUFA)

Hyperlipidemias

China
USDA Beltsville Human Nutrition Research Center

Completed

Novel Metabolites of Beta-Carotene and Lycopene

Healthy

United States
University of Pennsylvania

Completed

Diet and Stool Metabolites in Fecal Incontinence

Fecal Incontinence

United States
Huazhong University of Science and Technology

Unknown

The Effect of Vaccinium Myrtillus L. Extract Intake on Human Metabolism

Healthy

China

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