Search clinical trials for: moderate to severe chronic obstructive pulmonary disease

Total 478729 results

Incyte Corporation

Recruiting

A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Inadequately Controlled Moderate to Severe Asthma

Moderate to Severe Asthma

Korea, Republic of, United States, Spain, Poland, Japan, Canada, Germany, Belgium, Argentina
Assistance Publique - Hôpitaux de Paris

Recruiting

Tadalafil for Severe Pulmonary Hypertension Due to Chronic Obstructive Pulmonary Disease (ERASE PH-COPD)

Chronic Obstructive Pulmonary Disease | Pulmonary Hypertension

France
Fondazione Policlinico Universitario Agostino Gemelli...

Recruiting

Small Airways Disease (SAD) in Severe Asthma as a Novel Endpoint and Distinct Target for Biological Therapy. (SASAB)

Asthma | Small Airway Disease

Italy
Saglik Bilimleri Universitesi

Recruiting

Effect of Home Based Pulmonary Rehabilitation on Exacerbation and Hospital Admission in Severe COPD

COPD Exacerbation

Turkey
IHF GmbH - Institut für Herzinfarktforschung

Not yet recruiting

BENTO - Bronchoscopic Lung Volume Reduction in Severe Emphysema Using Thermoablation

Emphysema or Chronic Obstructive Pulmonary Disease

Germany
University Hospital, Basel, Switzerland

Recruiting

Comparison Between the Non-powered AEON™ Endostapler and Echelon FLEX™ Powered Plus Stapler With Regards to the Closure of Lung Tissue After Lung Resection in the Presence of Severe Lung Emphysema (Stapler)

Lung Resection | Postoperative Air Leak

Switzerland
Kronikgune
Odense University Hospital; Assuta Ashdod Hospital; Maccabi Healthcare Services... and other collaborators

Recruiting

Assessment of the Effectiveness, Socio-economic Impact and Implementation of a Digital Solution for Severe Patients (ADLIFE)

Heart Failure NYHA Class III | Heart Failure NYHA Class IV | Chronic Obstructive Pulmonary Disease Severe

Denmark, Germany, Israel, Spain, Sweden, United Kingdom
Philip Morris Products S.A.

Recruiting

Effect of Switching From Cigarette Smoking to THS on Disease Progression in Mild to Moderate COPD Subjects With Chronic Bronchitis Symptoms.

Smoking | Tobacco Use | COPD

United States, Bulgaria, Czechia, Germany, Japan, Romania, Slovakia, United Kingdom
Assistance Publique - Hôpitaux de Paris
Ministry of Health, France; Xenios AG

Recruiting

CO2 Removal in Severe Acute exacerbatIons of Chronic Obstructive Lung Diseases (CORAIL)

COPD Acute Exacerbation

France
Hasselt University

Recruiting

Functional Strength Training and Neuromuscular Electrical Stimulation in Severe Acute Exacerbations of COPD

Acute Exacerbation of COPD | Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Belgium
University of Crete

Recruiting

Role of Epithelial Barrier Integrity in Biologic Treatment Response of Severe Asthmatics With/Out Chronic Rhinosinusitis With Nasal Polyps (CRSwNP).

Severe Eosinophilic Asthma w/wo CRSwNP

Greece
Guangzhou Institute of Respiratory Disease
Boehringer Ingelheim

Recruiting

Effect of Tiotropium Bromide Combined With Odaterol on Small Airway Remodeling in Patients With Mild to Moderate Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

China
Sanofi
Regeneron Pharmaceuticals

Recruiting

Study Assessing the Long-term Effect of Dupilumab on Prevention of Lung Function Decline in Adult Patients With Uncontrolled Moderate to Severe Asthma (ATLAS)

Asthma

Belgium, Brazil, Romania, United Kingdom, Slovakia, Hungary, Mexico, South Africa, Turkey, Greece, United States, Bulgaria, Canada, India, Ireland, Korea, Republic of, Oman, Puerto Rico, Taiwan, United Arab Emirates, Saudi Arabia
Istituti Clinici Scientifici Maugeri SpA

Recruiting

Treatment With Mepolizumab on Patients With Severe Refractory Eosinophilic Asthma With or Without CRSwNP.

Asthma | Nasal Polyps | Sinusitis Chronic

Italy
Fondazione Policlinico Universitario Agostino Gemelli...

Recruiting

Small Airways Disease (SAD) in Severe Asthma as a Novel Endpoint and Distinct Target for Mepolizumab (SASAM Study) (SASAM)

Asthma | Small Airway Disease

Italy
Hopital Foch
Air Liquide SA

Recruiting

Exploration of the VOLATOLOM in the Stable Severe COPD (Chronic Obstructive Pulmonary Disease) (VOC-BPCO)

Chronic Obstructive Pulmonary Disease Severe

France
Vastra Gotaland Region

Recruiting

Multidisciplinary Management of Severe COPD

Copd | COPD Exacerbation

Sweden
Li Xuyan

Recruiting

ECCO2R in the Treatment of Acute Exacerbation of COPD With Severe Hypercapnia

Lung Diseases, Obstructive

China
Hopital Foch
Air Liquide SA

Recruiting

Volatolom Variation in Severe COPD During Hospitalization for Exacerbation and After Hospitalization (VOC-BPCO-Exa) (VOC-BPCO-Exa)

Chronic Obstructive Pulmonary Disease Exacerbation

France
Isabelle Opitz, Professor, MD

Recruiting

Surgical Compared to Bronchoscopic Lung Volume Reduction in Patients With Severe Emphysema (SINCERE)

Emphysema

Belgium, Switzerland, Denmark, Austria
Canandaigua VA Medical Center

Recruiting

Manual Therapy in Addition to Pulmonary Rehabilitation in Moderate Chronic Obstructive Pulmonary Disease.

Chronic Obstructive Pulmonary Disease Moderate

United States
Fred Hutchinson Cancer Center
AstraZeneca

Recruiting

Acalabrutinib for the Treatment of Chronic Graft Versus Host Disease

Hematopoietic and Lymphoid Cell Neoplasm | Recurrent Moderate-Severe Chronic Graft Versus Host Disease

United States
Versailles Hospital

Recruiting

Comparison of Corticosteroids vs Placebo on Duration of Ventilatory Support During Severe Acute Exacerbations of COPD Patients in the ICU (Corticop)

Chronic Obstructive Pulmonary Disease

France
Johns Hopkins University
Patient-Centered Outcomes Research Institute; University of Illinois at Chicago

Recruiting

Roflumilast or Azithromycin to Prevent COPD Exacerbations (RELIANCE) (RELIANCE)

Chronic Bronchitis | Chronic Obstructive Pulmonary Disease Severe

United States
Hospital de Clinicas de Porto Alegre
Universidade Federal do Rio de Janeiro; Pontifícia Universidade Católica do...

Recruiting

Cell Therapy Associated With Endobronchial Valve (CEL&VAL)

Chronic Obstructive Pulmonary Disease Severe

Brazil
ADIR Association

Recruiting

6-minute Stepper Test and Pulmonary Rehabilitation in Patients With Severe to Very Severe Chronicle Obstructive Pulmonary Disease (6STaR-2)

Chronic Obstructive Pulmonary Disease | Pulmonary Rehabilitation | 6-minute Stepper Test

France
Yonsei University

Not yet recruiting

Low- and Moderate-intensity Statin and Clinical Outcome of Primary Prevention in Individuals Aged >75 Years: the SCOPE-75 RCT Study

Healthy Elderly Individuals With High LDL-cholesterol or Risk of Cardiovascular Disease

Korea, Republic of
Cairo University

Active, not recruiting

Chest Mobility Exercises Versus Proprioceptive Neuromuscular Facilitation in Patients With COPD

Chronic Obstructive Pulmonary Disease Moderate

Egypt
University Medical Center Groningen

Completed

The Identification of Phenotypes in Patients With Severe Chronic Obstructive Pulmonary Disease (Groningen Severe COPD Cohort)

Severe COPD
Cliniques universitaires Saint-Luc- Université...

Completed

Breathing Control Exercises in Patients With Chronic Obstructive Pulmonary Disease.

Severe Chronic Obstructive Pulmonary Disease

Belgium
Imperial College London

Withdrawn

Endotoxin and Inflammatory Markers in Healthy Non-Smokers and Current Smokers Including Patients With Chronic Obstructive Pulmonary Disease (COPD)

Chronic Obstructive Pulmonary Disease

United Kingdom
Guy's and St Thomas' NHS Foundation Trust

Suspended

Efficacy of an Advanced Auto-titrating NIV in COPD

Chronic Obstructive Pulmonary Disease Severe

United Kingdom
Pulmonx Corporation

Active, not recruiting

Fissure Closure With the AeriSeal System for CONVERTing Collateral Ventilation Status (CONVERT) (CONVERT)

Emphysema | COPD | Severe Emphysema

United Kingdom, France, Netherlands, Germany, Australia, Italy, Switzerland
RAPT Therapeutics, Inc.

Suspended

Phase 2 Study to Evaluate RPT193 in Adults With Moderate to Severe T2-high Asthma

Asthma

United States, Bulgaria, Czechia, Poland
Dong Yang
Jilin University

Enrolling by invitation

Comparison of Aerosol Inhalation and Intravenous Glucocorticoid in the Treatment of Severe AECOPD

Acute Exacerbation of Chronic Obstructive Pulmonary Disease

China
Nordsjaellands Hospital
Rigshospitalet, Denmark; University of Copenhagen

Completed

Multidimensional Individualized Nutritional Therapy for Individuals With Severe COPD (MINDNUT)

Chronic Obstructive Pulmonary Disease

Denmark
Meridigen Biotech Co., Ltd.

Active, not recruiting

Mesenchymal Stem Cells for The Treatment of Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease Moderate

Taiwan
University Medical Center Groningen

Completed

Evaluation of the Free Flow Medical Lung Tensioning Device System for the Treatment of Severe Emphysema (EFFORT)

Emphysema or COPD

Netherlands, Germany
Pharmacyclics LLC.
Janssen Research & Development, LLC

Active, not recruiting

Phase 1/2 Dose Finding and Safety Study of Ibrutinib in Pediatric Subjects With Chronic Graft Versus Host Disease (cGVHD)

Chronic Graft Versus Host Disease

United States, Spain, Korea, Republic of, Australia, Austria, Canada, France, Germany, Israel, Italy, Netherlands, Russian Federation, United Kingdom
Stanford University
Varian, a Siemens Healthineers Company

Active, not recruiting

Lung Volume Reduction for Severe Emphysema by Stereotactic Ablative Radiation Therapy

Emphysema

United States
Boston Scientific Corporation
PneumRx, Inc.

Completed

Study of PneumRx Endobronchial Coil System in Treatment of Subjects With Severe Emphysema (ELEVATE)

Emphysema

United Kingdom, France, Germany, Netherlands, Italy, Austria
Sanofi
Regeneron Pharmaceuticals

Active, not recruiting

The Effect of Dupilumab on Lung Inflammation and Related Changes in Airway Volumes Detectable by Functional Respiratory Imaging in Patients With Moderate-severe Asthma (VESTIGE)

Asthma

Portugal, Ukraine, Spain, Taiwan, Sweden, United States, Bulgaria, Denmark, France, Italy, Romania, Saudi Arabia, United Kingdom
University Medical Center Groningen
Maastricht University Medical Center; Center of Expertise for Chronic Organ...

Completed

A Trial on the Effects of Bronchoscopic Lung Volume Reduction in Severe Emphysema. (SOLVE)

Emphysema

Netherlands
Saglik Bilimleri Universitesi

Completed

The Effectiveness Pulmonary Telerehabilitation and Cognitive Telerehabilitation in COPD Patients

Quality of Life | Fatigue | Muscle Weakness | Pulmonary Disease | COPD | Respiratory Disease | Dyspnea | Muscle Strength | Functional Capacity | Severe Chronic Obstructive Pulmonary Disease | Motor Imagery | Muscle; Accessory

Turkey
Joon Young Choi
Seoul St. Mary's Hospital; Hallym University Medical Center; Konkuk University...

Completed

Exacerbations and Their Outcomes International (EXACOS International)

COPD | Exacerbation Copd

Korea, Republic of
Ionis Pharmaceuticals, Inc.

Terminated

A Study to Assess the Safety, Tolerability, and Efficacy of ION-827359 in Participants With Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD) With Chronic Bronchitis (CB)

Chronic Obstructive Pulmonary Disease | Chronic Bronchitis

Germany, Czechia, Hungary, United Kingdom
Ankara University

Completed

Are Comorbidities Related to Frequent Severe Exacerbations of AECOPD

Chronic Obstructive Lung Disease | Acute Exacerbation of COPD | Comorbidities and Coexisting Conditions

Turkey
Heidelberg University

Completed

Implantation of Endobronchial Valves Versus Intrabronchial Valves in Patients With Severe Heterogeneous Emphysema

Pulmonary Emphysema

Germany
Genentech, Inc.

Terminated

A Study to Assess the Impact of Omalizumab on Exercise Capacity, Physical Activity, and Sleep Quality in Participants With Moderate to Severe Allergic Asthma (EDURO)

Moderate-to-severe Allergic Asthma

United States
Hospital Galdakao-Usansolo
Hospital General Universitario Gregorio Marañon; Hospital Donostia; Hospital... and other collaborators

Completed

COPD Readmissions Prediction- ReCOPD Project (ReCOPD)

Pulmonary Disease, Chronic Obstructive, Severe Early-Onset

Spain

Search clinical trials for: moderate to severe chronic obstructive pulmonary disease

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