Search clinical trials for: morphine induced constipation

Total 16530 results

Nova Scotia Health Authority
Dalhousie University

Completed

Effects of a Surgery-induced Peripheral Inflammatory Response on the Blood Brain Barrier

Dissecting Aneurysm of the Thoracic Aorta

Canada
Mundipharma Research GmbH & Co KG

Completed

A Single-arm, Study to Assess the Effect and Tolerability of Standardised Laxative Therapy (SLT) for the Reversal of Opioid-induced Constipation (OIC).

Opioid Induced Constipation

Sweden
University of Vermont

Completed

Methylnaltrexone for Opioid-induced Constipation in Cancer Patients

Neoplasms | Constipation | Opioid-Related Disorders

United States
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Unknown

Study of Methylnaltrexone in Opioid-Induced Constipation Patients

Opioid-induced Constipation

China
Kuopio University Hospital

Completed

Opioid Induced Bowel Dysfunction in Patients Undergoing Spinal Surgery (oksineukir)

Constipation

Finland
Mundipharma SAS

Terminated

Efficacy of Oxycodone/Naloxone(OXN), Versus Oxycodone (OXY), for the Reduction of Intensity of Opioid-induced Constipation in Pain Patients (OXN3505)

Pain | Constipation

France
Cubist Pharmaceuticals LLC
GlaxoSmithKline

Completed

Alvimopan For The Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain

Constipation | Bowel Dysfunction

United States, Australia, Canada, Hungary, Netherlands, Spain, Sweden, France, New Zealand, Norway, South Africa, Switzerland
Cubist Pharmaceuticals LLC
GlaxoSmithKline

Completed

Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain

Constipation | Bowel Dysfunction

United States, Germany, Estonia, Finland, United Kingdom, Canada, Austria, Denmark, Poland, Ireland
Cubist Pharmaceuticals LLC
GlaxoSmithKline

Completed

Study 767905/008 Extension Study: Alvimopan for Treatment of Opioid-Induced Bowel Dysfunction in Cancer Pain Subjects

Cancer | Bowel Dysfunction

United States, France, Canada, Finland, Spain, Pakistan, Poland, Hong Kong, United Kingdom, Peru, New Zealand, Portugal, Russian Federation
Mundipharma AB

Completed

Non-interventional Study Comparing Targiniq and Oxycodone/Laxatives

Pain | Opioid Induced Constipation

Sweden
CAMC Health System

Terminated

Enteral Naloxone Versus a Traditional Bowel Regimen for the Prevention of Opioid Induced Constipation in Trauma Patients

Analgesia | Constipation

United States
AstraZeneca

Completed

Longitudinal Study of Patients With Opioid-Induced Constipation

Patients With Opioid Induced Constipation

Canada, United States
Centre for Addiction and Mental Health
Academic Health Science Centres

Completed

Feasibility Study of Oral Naloxone for Treatment of Methadone-induced Constipation

Constipation

Canada
AstraZeneca
Nektar Therapeutics

Completed

A Phase 2, Double-Blind, Multiple-Dose Escalation Study to Evaluate NKTR-118 (Oral PEG-Naloxol) in Patients With Opioid-Induced Constipation (OIC)

Opioid Induced Constipation (OIC)

United States
AstraZeneca

Completed

Assessment of Efficacy and Safety in Patients With Non-cancer-related Pain and Opioid-induced Constipation

Opioid-Induced Constipation (OIC)

Croatia, Sweden, United States, Czech Republic, Spain, Hungary, United Kingdom, Belgium
AstraZeneca

Completed

Assessment of Efficacy and Safety in Patients With Non-cancer-related Pain and Opioid-induced Constipation

Opioid-Induced Constipation (OIC)

United States, Australia, Slovakia, Germany
AstraZeneca

Terminated

Assessment of Efficacy and Safety in Relieving Opioid-induced Constipation in Patients With Cancer-related Pain

Opioid-Induced Constipation

Croatia, United States, Bulgaria, United Kingdom, Poland, Romania, Belgium, Puerto Rico, Slovakia, Australia, South Africa, Czech Republic, Germany, Spain
Shriners Hospitals for Children

Completed

Methylnaltrexone Use for Opioid-induced Postoperative Constipation

Constipation

United States
Kyungpook National University Hospital

Completed

Prevention of Intrathecal Morphine Induced Pruritus: Comparison of Ondansetron and Palonosetron

Morphine Adverse Reaction

Korea, Republic of
Mundipharma CVA

Completed

A Non-interventional, Observational Study for Targinact® Treatment in Patients With Chronic Severe Pain

Chronic Severe Pain

Belgium
Purdue Pharma LP

Completed

A Study of Oxycodone/Naloxone Controlled-release Tablets (OXN) to Assess Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) in Opioid-experienced Subjects With Moderate to Severe Chronic Low Back Pain

Low Back Pain

United States
Purdue Pharma LP

Completed

Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) for Uncontrolled Moderate - Severe Low Back Pain

Low Back Pain

United States, Poland, Czech Republic, Italy
AstraZeneca

Completed

Assessment of Long-term Safety in Patients With Non-cancer-related Pain and Opioid-induced Constipation

Opioid-Induced Constipation (OIC)

United States
AstraZeneca

Completed

Assessing a Stool Symptom Screener in Patients With Chronic Opioid-Induced Constipation

Opioid-induced Constipation
AstraZeneca

Completed

Study in Healthy Volunteers to Investigate the Effects of Diltiazem on the Pharmacokinetics of Naloxegol

Drug Induced Constipation

United States
AstraZeneca

Completed

Study in Healthy Volunteers to Investigate the Effects of Rifampin on the Pharmacokinetics of NKTR-118

Drug Induced Constipation

United States
AstraZeneca

Completed

Open Label, Healthy Volunteers, Bioequivalence Study With Naloxegol

Opioid Induced Constipation

United Kingdom
University Hospital, Clermont-Ferrand

Completed

Comparison of Sufentanil and Remifentanil Infusion During General Anaesthesia for Removal of Wisdom Teeth in Ambulatory Surgery (SUF-REM-DDS)

Tooth Extractions

France
University Hospital, Strasbourg, France

Unknown

Evaluation of Oral Morphine Gel in Oral Mucositis Induced by Chemotherapy in Children and Young Adults (MorphinOgel)

Cancer

France
University of Tennessee
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Nicotine Patch and Bupropion to Reduce Smoking Rates in Younger, Low-Income, and Minority Individuals

Tobacco Use Disorder

United States
University of Florida
National Institutes of Health (NIH)

Completed

Pharmacotoxicology of Trichloroethylene Metabolites

Healthy

United States
Albany Medical College

Completed

The Effects of Patient Features on Opioid Induced End-Tidal CO2 (Capno)

Opioid Use During Medical Care

United States
Danish University of Pharmaceutical Sciences
Copenhagen University Hospital, Denmark

Completed

Topical Morphine for Stomatitis-related Pain Induced by Chemotherapy

Pain | Mucositis

Denmark
University Hospital, Geneva

Completed

Milk-induced Gastrointestinal Symptoms in Infants

Gastrointestinal Symptoms in Young Infants

Switzerland
S.L.A. Pharma AG

Completed

Naloxone SR Capsules in Patients With Opioid Induced Constipation

Chronic Pain | Opioid Induced Constipation

Germany, United Kingdom
Mundipharma CVA

Unknown

A Non-interventional, Observational Study for Quality of Life (Overall Health Assessment) in Patients With Chronic Severe Pain During Targinact® Treatment

Chronic Severe Pain

Belgium
Mundipharma CVA

Completed

A Non-interventional, Observational Study for Targinact® Treatment in Patients With Severe Pain.

Severe Pain

Belgium
Federal University of Minas Gerais
Santa Casa de Misericórdia de Belo Horizonte

Completed

Sedation to Electroencephalography With Dexmedetomidine or Chloral Hydrate

Other Conditions of Brain

Brazil
Prince of Songkla University

Completed

Gabapentin for Prophylaxis Intrathecal Morphine-Induced Pruritus

Pruritus

Thailand
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Unknown

Study of Opioid Immunosuppressive Effects

Opioid Abuse or Dependence
Shirley Ryan AbilityLab
Takeda Pharmaceuticals North America, Inc.

Completed

Lubiprostone (Amitiza®) Vs. Standard Care in Opioid-induced Constipation After Surgery in Inpatient Rehabilitation

Constipation

United States
Orexigen Therapeutics, Inc

Completed

A Study of Naltrexone SR/ Bupropion SR in Overweight and Obese Subjects Who Are Nicotine-Dependent

Obesity | Overweight | Nicotine Dependence

United States
Alkermes, Inc.

Completed

ALK37-007: Evaluation of Safety and Efficacy of ALKS 37 (RDC-1036) in Adults With Opioid-induced Constipation (OIC)

OIC

United States
Alkermes, Inc.

Completed

ALK37-005: A Study of ALKS 37 (RDC-1036) in Adults With Opioid-induced Constipation (OIC)

Opioid-induced Constipation

United States
Pfizer

Completed

Abuse Potential Assessment of Intranasally Administered EMBEDA Compared To Morphine Sulfate Controlled Release And Placebo

Chronic Pain | Analgesia | Opioid-related Disorders | Narcotic Abuse
Pfizer

Completed

Abuse Potential of Orally Administered Crushed Embeda Compared to Crushed Controlled-Release Morphine and Placebo in Non-Dependent Recreational Opioid Users

Nondependent Opioid Abuse, Episodic

United States
University Medicine Greifswald

Completed

Effects of Methylnaltrexone in Comparison to Naloxone on Loperamide-induced Delay of the Oro-cecal, Whole-gut and Colon Transit Time.

Intestinal Obstruction

Germany
Novartis

Terminated

Safety and Efficacy of Tegaserod in Opioid-induced Constipation in Patients With Non-cancer Pain.

Opioid-induced Constipation

United States
National Institute of General Medical Sciences...

Completed

Opiate-Induced Tolerance & Hyperalgesia in Pain Patients

Chronic Low Back Pain | Opioid-induced Hyperalgesia

United States
Novartis

Terminated

Safety and Efficacy of Tegaserod in Opioid-induced Constipation in Patients With Non-cancer Pain.

Opioid-induced Constipation

United States, China, Egypt, Singapore, Taiwan, Venezuela

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