Search clinical trials for: nucleus accumbens

Total 547 results

Pfizer

Completed

Safety and Immunogenicity of Pneumococcal Conjugate Formulations in Healthy Adults 18 Through 49 Years of Age

Pneumococcal Disease

United States
Millennium Pharmaceuticals, Inc.

Completed

Drug-Drug Interaction Study of TAK-788 and Midazolam in Participants With Advanced Non-small Cell Lung Cancer (NSCLC)

Carcinoma, Non-Small-Cell Lung | Lung Neoplasms

Australia, Singapore, Netherlands
Yale University
Mayo Clinic; National Institute of Neurological Disorders and Stroke (NINDS); Dartmouth-Hitchcock Medical Center

Active, not recruiting

Stimulation of the Thalamus for Arousal Restoral in Temporal Lobe Epilepsy (START)

Epilepsy, Temporal Lobe

United States
Eli Lilly and Company

Completed

A Study of LY3819469 in Participants With Impaired and Normal Renal Function

Healthy | Renal Insufficiency

United States
Rush University Medical Center

Enrolling by invitation

The Course of Hip Flexion Weakness Following LLIF or ALIF

Degenerative Disc Disease | Spondylolisthesis | Herniated Nucleus Pulposus

United States
Glycovax Pharma Inc.
Government of Canada; JSS Medical Research Inc.; Seppic; Avance Clinical Pty Ltd.

Active, not recruiting

Safety and Immunogenicity of Glycovax-002 Vaccine in Healthy Adults

SARS-CoV-2

Australia
Northwell Health
National Institute of Neurological Disorders and Stroke (NINDS); The University...

Completed

Computational Modeling of 60 Hz Subthalamic Nucleus Deep Brain Stimulation for Gait Disorder in Parkinson's Disease

Parkinson Disease

United States
Vaxart

Active, not recruiting

A Study to Determine the Safety and Immunogenicity of Bivalent GI.1 and GII.4 Vaccines in Healthy Volunteers

Norovirus Infections

United States
CanSino Biologics Inc.
Novotech (Australia) Pty Limited

Active, not recruiting

A Study to Evaluate the Safety and Immunogenicity of Recombinant Trivalent Poliomyelitis Vaccine (Sf-RVN Cell) in Healthy Adults

Poliomyelitis

Australia
ModernaTX, Inc.

Completed

A Safety, Reactogenicity, and Immunogenicity Study of mRNA-1045 (Influenza and Respiratory Syncytial Virus [RSV]) or mRNA-1230 (Influenza, RSV, and Severe Acute Respiratory Syndrome Coronavirus 2 [SARS-CoV-2]) Vaccine in Adults 50 to 75 Years Old

Influenza | SARS-CoV-2 | RSV

United Kingdom, Australia, United States
The University of Queensland
Coalition for Epidemic Preparedness Innovations

Completed

A FIRST IN HUMAN TO EVALUATE THE SAFETY AND IMMUNOGENICITY OF SARS-CoV-2 UQSC2 VACCINE IN HEALTHY ADULTS.

COVID-19

Australia
Vanderbilt University Medical Center

Active, not recruiting

Longitudinal Outcomes of DBS in PD

Parkinson Disease

United States
Cochlear

Completed

Innovations in Clinical Care of CE Approved Nucleus Cochlear Implant Recipients

Hearing Loss

Belgium, Australia
Angitia Biopharmaceuticals
Angitia Australia Pty Ltd

Completed

A First-in-Human Study Evaluating AGA2118 in Men and Postmenopausal Women

Osteoporosis

Australia
Sanofi

Completed

A Study in Adults to Investigate the Impact of Mild, Moderate, and Severe Hepatic Impairment on Pharmacokinetics of Venglustat Compared to Participants With Normal Hepatic Function

Hepatic Function Abnormal

United States, Germany
Shanghai Zhimeng Biopharma, Inc.

Completed

A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of CB03-154 in Healthy Participants in Australia

Healthy Volunteers

Australia
University Hospital, Bordeaux

Completed

Optimization of VIM Targeting in Essential Tremor Surgery (Opti-VIM)

Essential Tremor

France
Pfizer

Completed

Renal Impairment Study of PF-06700841

Renal Impairment | Healthy Volunteer

United States
ORIC Pharmaceuticals

Completed

Effect of Food on the Pharmacokinetics of ORIC-114

Food Effect in Healthy Participants

Australia
Alexion Pharmaceuticals, Inc.

Completed

Bioavailability Study of 2 Oral Formulations of ALXN1840

Healthy

Australia
RANI Therapeutics

Completed

Study Evaluating PK of Ustekinumab Administered Orally Via RaniPill™ Capsule

Healthy Volunteers

Australia
NervGen Pharma

Completed

A Phase I Safety Study of NVG-291 in Healthy Adults

Spinal Cord Injury

Australia
Amgen

Completed

A Study to Evaluate the Pharmacokinetics, Safety, and Pharmacodynamics of Olpasiran in Participants With Normal Renal Function and Participants With Various Degrees of Renal Impairment

Renal Impairment

United States
Cochlear

Completed

Evaluation of the Benefits for Overall Health Following Cochlear Implant Treatment in the Elderly Population

Hearing Loss

Spain, Israel, France, Italy
Syneos Health
Dr. Reddy's Laboratories Limited

Completed

Comparative Study of 3 Tocilizumab Products in Normal Healthy Volunteeers

Rheumatoid Arthritis | Giant Cell Arteritis

New Zealand, Australia, India
Venatorx Pharmaceuticals, Inc.
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Ceftibuten/VNRX-7145 in Participants With Varying Degrees of Renal Function

Pharmacokinetics

United States
iN Therapeutics Co., Ltd.

Completed

A SAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers

Pain | Osteoarthritis

Australia
Pfizer

Completed

Dose Escalation Study of PF-07209326 in Healthy Participants and Participants With Sickle Cell Disease

Healthy | Sickle Cell Anemia

United States
Pfizer

Terminated

A Clinical Trial of the Study Medicine (PF-07081532) in People With Diabetes and Kidney Dysfunction

Renal Impairment | Type 2 Diabetes

United States
Kinoxis Therapeutics Pty Ltd
National Institute on Drug Abuse (NIDA)

Completed

A Phase 1 Study Investigating the Safety, Tolerability and Pharmacokinetics of KNX100 in Healthy Volunteers (KTX101)

Opioid-use Disorder | Healthy Volunteer Study

Australia
Yangshengtang Co., Ltd
Syneos Health

Completed

Phase 1 Study of 162, a Novel Neutralizing Antibody Targeting Hepatitis B Surface Antigen, in Healthy Adult Subjects

Chronic Hepatitis B

Australia
St. Joseph's Hospital and Medical Center, Phoenix

Terminated

DBS of Posterior Subthalamic Area (PSA) and Ventral Intermediate Nucleus (VIM) in Essential Tremor (ET)

Essential Tremor

United States
St. Joseph's Hospital and Medical Center, Phoenix
Arizona State University

Enrolling by invitation

Deep Brain Stimulation (DBS) of the Pedunculopontine Nucleus (PPN) (PPNGB01)

Parkinson Disease

United States
Response Pharmaceuticals

Completed

Effect of RDX-002 on Postprandial Triglycerides in Subjects Treated With Olanzapine

Drug-induced Weight Gain

United States
Pfizer

Completed

Safety and Immunogenicity of RSVpreF Coadministered With SIIV in Adults ≥65 Years of Age

Respiratory Syncytial Virus

Australia
K2M, Inc.
Stryker Nordic

Terminated

RHINE™ Cervical Disc Clinical Study: A Prospective Observational Study for Patients Requiring 1-2 Level C-spine Surgery

Radiculopathy | Myelopathy | Spondylosis | Herniated Nucleus Pulposus
Hoffmann-La Roche

Completed

A Study in Healthy Male Subjects to Investigate the Comparability of Pharmacokinetics of the Fixed-Dose Combination of Pertuzumab and Trastuzumab Administered Subcutaneously Using a Handheld Syringe or Using the On-Body Delivery System

Healthy Male Subjects

Australia, New Zealand
Mirati Therapeutics Inc.

Completed

A Study to Evaluate the Effect of Mild, Moderate, and Severe Hepatic Impairment on Pharmacokinetics of Sitravatinib

Hepatic Impairment

United States
Pieris Australia Pty Ltd

Completed

Study of Single and Multiple Doses of PRS-220 Administered by Oral Inhalation in Healthy Subjects

Healthy

Australia
Theratocular Biotek Co.
Novotech (Australia) Pty Limited

Active, not recruiting

A Study to Investigate the Effect of IOP-lowering With TO-O-1001 Eye Drops in Healthy Subjects and in Patients With Open-Angle Glaucoma or Ocular Hypertension

Ocular Hypertension | Open Angle Glaucoma

Australia
Enspire DBS Therapy, Inc.

Completed

Electrical Stimulation of the Dentate Nucleus for Upper Extremity Hemiparesis Due to Ischemic Stroke (EDEN)

Stroke

United States
mAbxience Research S.L.

Completed

Pharmacokinetic Study Comparing MB05 (Proposed Palivizumab Biosimilar), EU-sourced Synagis® and US-sourced Synagis® in Healthy Volunteers.

Healthy Volunteers

Australia, New Zealand
Eli Lilly and Company

Completed

A Study of LY3437943 in Healthy Participants and Participants With Impaired Renal Function

Healthy | Renal Insufficiency

United States
Huahui Health

Completed

A Study to Assess the Safety, Tolerability and Pharmacokinetics of Inhaled HH-120 Aerosol in Healthy Volunteers

COVID-19 Respiratory Infection

Australia
Chen Ling
Prince of Wales Hospital, Shatin, Hong Kong; Shenzhen Second People's Hospital

Completed

Early Versus Late Application of STN DBS to PD Patients With Motor Complications (ELASS)

Parkinson Disease

China
BeBetter Med Inc

Completed

Study of Orally Administered BEBT-503 in Healthy Subjects

Healthy Subjects

Australia
Autobahn Therapeutics, Inc.
Novotech (Australia) Pty Limited

Completed

SAD/MAD of ABX-002-1902 Investigating the Safety, Pharmacokinetics/Pharmacodynamics of in Healthy Subjects

MDD

Australia
Vedic Lifesciences Pvt. Ltd.

Completed

To Evaluate the Efficacy and Safety of Collavant n2 in Individuals With Osteoarthritis of the Knee

Osteoarthritis, Knee

India
Sonnet BioTherapeutics

Completed

Study of SON-1010 (IL12-FHAB) in Healthy Adults

Healthy Adult

Australia
Pfizer

Completed

Study to Estimate the Effects of Hepatic Impairment on the Pharmacokinetics (PK) of PF-07321332

Hepatic Impairment

United States

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