Search clinical trials for: placebo controlled study

Total 159395 results

Hospices Civils de Lyon

Active, not recruiting

Multicenter, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Fluconazole in Hypercalcicuric Patients With Increased 1.25(OH) 2D Levels (FLUCOLITH)

Nephrolithiasis | Hypercalciuria | Nephrocalcinosis

France
Organon and Co

Completed

Multicenter, Double-blind, Randomized, Placebo-controlled Study of Mometasone Furoate Nasal Spray in Pediatric Subjects With Perennial Allergic Rhinitis (Study P06332)

Rhinitis, Allergic, Perennial
Yale University
National Institute of Mental Health (NIMH); Heffter Research Institute

Active, not recruiting

Efficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study.

Obsessive-Compulsive Disorder

United States
Organon and Co

Completed

Fixed Dose Efficacy and Safety Study of Asenapine for the Treatment of Schizophrenia in Adolescents (P05896)

Schizophrenia, Paranoid | Schizophrenia, Disorganized | Schizophrenia, Undifferentiated
Escient Pharmaceuticals, Inc

Active, not recruiting

Phase 2a, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of EP262 in Subjects With Atopic Dermatitis (EASE)

Atopic Dermatitis

United States, Canada
Novartis Pharmaceuticals

Completed

A Phase 3 Study of Efficacy and Safety of Remibrutinib in the Treatment of CSU in Adults Inadequately Controlled by H1- Antihistamines (REMIX-2)

Chronic Spontaneous Urticaria

United States, India, Malaysia, Taiwan, Poland, United Kingdom, China, Thailand, Switzerland, Germany, Vietnam, Brazil, Russian Federation, Slovakia, Denmark, Canada, South Africa, Austria
Opella Healthcare Group SAS, a Sanofi Company

Completed

A Placebo-controlled Study of 2-day Pre-treatment With Fexofenadine in Seasonal Allergic Rhinitis (FEXPRESAR)

Seasonal Allergic Rhinitis

Canada
Novartis Pharmaceuticals

Completed

A Phase 3 Study of Efficacy and Safety of Remibrutinib in the Treatment of CSU in Adults Inadequately Controlled by H1 Antihistamines (REMIX-1)

Chronic Spontaneous Urticaria

United States, Hungary, Taiwan, Spain, Italy, Korea, Republic of, Australia, France, Bulgaria, Czechia, Turkey, India, Argentina, Mexico, Japan, Colombia, Russian Federation, Puerto Rico, Singapore
Pfizer

Completed

A 2-Year Phase 3 Study Of CP-690,550 In Patients With Active Rheumatoid Arthritis On Background Methotrexate

Arthritis, Rheumatoid

United States, Colombia, Korea, Republic of, Brazil, Taiwan, Mexico, India, Japan, Australia, Bulgaria, Ukraine, Canada, Poland, Czechia, Greece
University of Toronto
Centre for Addiction and Mental Health; Lotte & John Hecht Memorial Foundation

Completed

A Placebo Controlled Study of Homeopathic Treatment of Children and Youth With ADHD

Attention Deficit Hyperactivity Disorder

Canada
Eli Lilly and Company
Incyte Corporation

Completed

A Long-term Study of Baricitinib (LY3009104) With Topical Corticosteroids in Adults With Moderate to Severe Atopic Dermatitis That Are Not Controlled With Cyclosporine or for Those Who Cannot Take Oral Cyclosporine Because it is Not Medically Advisable (BREEZE-AD4)

Atopic Dermatitis

Belgium, Netherlands, Japan, Spain, Switzerland, United Kingdom, Germany, France, Austria, Russian Federation, Poland, Italy, Brazil, Finland
The University of Texas Health Science Center,...

Withdrawn

A Prospective, Randomized, Placebo-Controlled Pilot Study to Characterize the Intestinal Microbiome and to Evaluate the Safety and Fecal Microbiome Changes Following Administration of Lyophilized PRIM-DJ2727 or Placebo Given Orally in Subjects With Nonalcoholic Fatty Liver Disease

Nonalcoholic Fatty Liver Disease (NAFLD) With History of Diabetes Melitus
HighTide Biopharma Pty Ltd
Shenzhen HighTide Biopharmaceutical Ltd.

Completed

A Phase 2 Study of Berberine Ursodeoxycholate (HTD1801) in Patients With Type 2 Diabetes Inadequately Controlled With Diet and Exercise

Type 2 Diabetes Mellitus

China
Icahn School of Medicine at Mount Sinai
National Institute of Neurological Disorders and Stroke (NINDS)

Enrolling by invitation

A Controlled Trial of Growth Hormone in Phelan-McDermid Syndrome and Idiopathic Autism

Autism Spectrum Disorder (ASD) | Phelan-McDermid Syndrome

United States
Almirall, S.A.

Completed

A Study of Lebrikizumab in Combination With Topical Corticosteroids in Participants Having Atopic Dermatitis (AD) That Are Not Adequately Controlled or Non-eligible for Cyclosporine

Eczema | Dermatitis, Atopic

Austria, Belgium, France, Germany, Netherlands, Poland, Spain, United Kingdom
University of California, San Diego

Completed

Pulsed Electromagnetic Fields for Postoperative Analgesia: A Randomized, Triple-Masked, Sham-Controlled Pilot Study

Postoperative Pain, Acute

United States
Eusol Biotech Co., Ltd.

Suspended

A Multicenter, Randomized, Double-blind, Placebo-controlled Phase 3 Study to Evaluate the Safety and Efficacy of ES135 in Subjects With Spinal Cord Injury

Spinal Cord Injuries

Taiwan
IrsiCaixa
José Moltó Marhuenda, PhD, MD; Beatriz Mothe Pujadas PhD,MD; Susana Benet Garrabé... and other collaborators

Completed

A Phase I, Randomized, Double-Blind, Placebo-Controlled Safety, Tolerability and Immunogenicity Study of Candidate HIV-1 Vaccines ChAdOx1.HTI and MVA.HTI With Recombinant HIV-1 Envelope Protein ConM SOSIP.v7 gp140 Vaccine, Adjuvanted With MPLA Liposomes in ART-Suppressed HIV-1 Positive Individuals

HIV Infection

Spain
GlaxoSmithKline
Iqvia Pty Ltd

Completed

Placebo-controlled Efficacy and Safety Study of GSK3511294 (Depemokimab) in Participants With Severe Asthma With an Eosinophilic Phenotype (SWIFT-1)

Asthma

United States, France, Germany, Poland, Spain, Italy, United Kingdom, China, Canada, Czechia, Russian Federation, Ireland
James J. Irrgang
Brooke Army Medical Center; Wake Forest University

Terminated

Phase 1/2 Prospective Double-Blind Placebo-Controlled Randomized Clinical Trial of Losartan to Treat Grade II & III Hamstring Strains

Hamstring Injury

United States
AstraZeneca
Iqvia Pty Ltd

Completed

Phase III Double-blind, Placebo-controlled Study of AZD7442 for Pre-exposure Prophylaxis of COVID-19 in Adult. (PROVENT)

COVID-19

United States, Belgium, France, Spain, United Kingdom
CureVac

Completed

A Phase 2b/3, Randomized, Observer-Blinded, Placebo-Controlled, Multicenter Clinical Study Evaluating the Efficacy and Safety of Investigational SARS-CoV-2 mRNA Vaccine CVnCoV in Adults 18 Years of Age and Older

Covid19 | SARS-CoV-2

Belgium, Spain, Germany, Argentina, Colombia, Dominican Republic, Mexico, Netherlands, Panama, Peru
Kyowa Kirin, Inc.

Completed

12-Week, Double-Blind, Placebo-Controlled, Randomized Study of the Efficacy of 40 mg/Day KW-6002 in Parkinson's Disease Patients on Levodopa/Carbidopa

Parkinson's Disease

United States
Kyowa Kirin, Inc.

Completed

12-Week, Double-Blind, Placebo-Controlled Study of 20 and 60 mg/Day Istradefylline in Parkinson's Disease Patients on Levodopa/Carbodopa

Parkinson's Disease

United States
University Medical Center Groningen
AstraZeneca

Completed

Decentralized N=1 Study: A Feasible Approach to Evaluate Individual Therapy Response to Dapagliflozin. (@HOME)

Diabetes Mellitus, Type 2 | Diabetes Mellitus | Diabetes | Diabetes Complications | Chronic Kidney Diseases | Proteinuria | Albuminuria | CKD | Chronic Kidney Disease Due to Type 2 Diabetes Mellitus | Diabetes Mellitus Type 2 With Proteinuria

Netherlands
Taiwan Liposome Company

Completed

Phase IIa, Randomized, Double Blinded, Placebo Controlled, Dose Finding Study for TLC599 in OA Patients

Osteoarthritis of the Knee

Taiwan, Australia
Teva Branded Pharmaceutical Products R&D, Inc.

Active, not recruiting

A Randomized, Double-Blind, Placebo-Controlled Study With an Open-Label, Long-Term Safety Phase to Evaluate the Efficacy and Safety of TV-44749 in Adults With Schizophrenia (SOLARIS)

Schizophrenia

United States, Bulgaria, China, Romania, Turkey
Soleno Therapeutics, Inc.

Completed

Open-Label Extension Study of DCCR in PWS Followed by Double-Blind, Placebo-Controlled, Randomized Withdrawal Period

Prader-Willi Syndrome

United States, United Kingdom
Dompé Farmaceutici S.p.A

Completed

A Phase 2, Multicentre, Randomized, Double-blind, Placebo-controlled Study in Patients With New-onset Type 1 Diabetes

Diabetes Mellitus, Insulin-Dependent

Germany, Belgium, Italy
Rigshospitalet, Denmark
Odense University Hospital; University of Copenhagen; Imperial College London; University... and other collaborators

Active, not recruiting

Epigenetics, Vitamin C, and Abnormal Blood Cell Formation - Vitamin C in Patients With Low-Risk Myeloid Malignancies (EVITA)

Myelodysplastic Syndromes | Cytopenia | Chronic Myelomonocytic Leukemia-1

Denmark, United States
AstraZeneca

Completed

A Phase II, Randomized, Double-blind, Placebo-controlled Study to Assess MEDI3506 in Participants With COPD and Chronic Bronchitis (FRONTIER-4)

Chronic Obstructive Pulmonary Disease (COPD) | Chronic Bronchitis

United States, Canada, Denmark, Spain, United Kingdom, Taiwan, New Zealand, Australia, Germany, Israel, South Africa, Czechia, Hungary, Poland, Netherlands
TJ Biopharma Co., Ltd.

Terminated

A Study to Evaluate the Safety, Tolerability, and PK Profile of Single and Multiple Doses TJ202 in Patient With Systemic Lupus Erythematosus

Systemic Lupus Erythematosus (SLE)

China
CytoDyn, Inc.
Amarex Clinical Research

Completed

Double Blind, Placebo Controlled Study of Safety and Efficacy of Leronlimab in Patients With "Long" COVID-19

Coronavirus Disease 2019

United States
Eli Lilly and Company

Active, not recruiting

A Study to Evaluate Tirzepatide (LY3298176) in Pediatric and Adolescent Participants With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin or Basal Insulin or Both (SURPASS-PEDS)

Glucose Metabolism Disorders | Diabetes Mellitus, Type 2 | Diabetes Mellitus | Endocrine System Diseases | Type2 Diabetes | Metabolic Disease | T2DM (Type 2 Diabetes Mellitus) | T2D

United States, India, Australia, United Kingdom, Mexico, Brazil, Israel, France, Italy
Denovo Biopharma LLC

Completed

A Biomarker-Guided, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients With Treatment-Resistant Depression (ENLIGHTEN)

Treatment Resistant Depression

United States, Canada
Precision Life Sciences Group
Medelis Inc.

Suspended

Phase 3 Randomized, Double-blind, Controlled Study of ICT-107 in Glioblastoma

Glioblastoma Multiforme

United States, Canada, Austria
University of British Columbia
Johnson & Johnson Consumer Inc. (J&JCI); Genome British Columbia

Active, not recruiting

Epigenetic Health Benefits of Budesonide (Project Ace)

Environmental Exposure | Epigenetic Effects of Intranasal Steroids

Canada
Central South University

Completed

A Double-blind, Placebo-controlled Study of Antidepressant Augmentation With Agomelatine

Major Depressive Disorder

China
Technische Universität Dresden
Novartis

Terminated

A Randomized Placebo-controlled Phase 2 Study of Decitabine With or Without Eltrombopag in AML Patients (DELTA)

Acute Myeloid Leukemia

Germany
Sumitomo Pharma America, Inc.

Completed

A Clinical Study That Will Assess the Effect of SEP-363856 or Prior Antipsychotic (PA) Standard of Care on Body-weight Associated Parameters in Subjects With Schizophrenia

Schizophrenia

United States
Novartis Pharmaceuticals

Completed

A Phase III Study of and Efficacy of Ligelizumab in the Treatment of CSU in Adolescents and Adults Inadequately Controlled With H1-antihistamines.

Chronic Spontaneous Urticaria

United States, Poland, Spain, Belgium, Germany, Russian Federation, Taiwan, Netherlands, Italy, Australia, France, Israel, Lebanon, Slovakia, India, Japan, Estonia, Philippines, Mexico, Argentina, United Kingdom, Vietnam, Brazil, Romania and more
University of Southern California

Completed

Nattokinase Atherothrombotic Prevention Study (NAPS)

Prevention of Subclinical Atherosclerosis Progression | Prevention of Cognitive Decline

United States
GlaxoSmithKline

Terminated

Effects of Intravenous GSK3858279 on a Battery of Evoked Pain Tests in Healthy Volunteers

Pain

Netherlands
Zhejiang University

Completed

Double-blind and Placebo-controlled Study on Intervention Effect of Medium and Long Chain Fatty Acid Triglyceride on Glycolipid Homeostasis in Patients With Metabolic Syndrome and Mechanisms

Metabolic Syndrome

China
Rabin Medical Center
NG Solutions Ltd

Active, not recruiting

Double Blind, Randomized, Placebo Controlled Pilot Study to Evaluate the Effect of Nutritional Supplementation on Physical Activity Performance of Young Soccer Players

Growth | Nutritional Supplementation

Israel
Skye Bioscience, Inc.

Completed

Phase 2, Placebo-Controlled, Study Assessing the Safety and Ocular Efficacy of SBI-100 Ophthalmic Emulsion in Patients With Elevated Eye Pressure

Primary Open Angle Glaucoma | Ocular Hypertension

United States
Rivus Pharmaceuticals, Inc.

Active, not recruiting

Exploratory Ph 2A, Double-Blind, Placebo-Controlled Dose Escalation Study of Safety, Tolerability, PD, & PK of HU6 for Subjects With Obese HFpEF (HFpEF)

Heart Failure With Preserved Ejection Fraction

United States
East Sussex Hospitals NHS Trust
Medtronic; Eastbourne Cardiology Research Charity Fund

Completed

A Randomized Sham-controlled Study of Pulmonary Vein Isolation in Symptomatic Atrial Fibrillation (SHAM-PVI)

Atrial Fibrillation

United Kingdom
Enlivex Therapeutics Ltd.

Terminated

A Phase 2b Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study, Evaluating Efficacy and Safety of Allocetra-OTS in Patients With Severe or Critical COVID-19 With Associated Acute Respiratory Distress Syndrome (ARDS)

Covid19

Israel
Odense University Hospital

Active, not recruiting

The DANish COronary DEcalcification (DANCODE) Trial (DANCODE)

Coronary Artery Disease

Denmark

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