Search clinical trials for: safety and tolerability

Total 474727 results

Eli Lilly and Company

Recruiting

A Study of LY3537982 in Chinese Participants With Advanced Solid Tumors

Advanced Solid Tumors

China
Gilgamesh Pharmaceuticals

Recruiting

A Phase 2a Study to Evaluate the Safety and Tolerability of GM-2505 in Patients With MDD

Major Depressive Disorder

United Kingdom
ReCode Therapeutics

Recruiting

A Phase 1 Study Evaluating Safety and Tolerability of RCT2100 in Healthy Participants

Cystic Fibrosis

New Zealand
Wang Min
Lanyue Biotech (Hangzhou) Co., Ltd.

Recruiting

A Clinical Study Evaluating the Safety, Tolerability and Initial Efficacy of SKG0106 Intravitreal Injection in Diabetic Macular Edema (DME) Patients

Diabetic Macular Edema

China
Ascendo Biotechnology Co., Ltd.

Not yet recruiting

Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ASD141

Metastatic Solid Tumor
Clarity Health Technologies, Inc
SymmetryScience Group, Inc.

Recruiting

The Feasibility, Safety and Tolerability of VR-based Audiovisual Stimulation (CAD)

Alzheimer Disease | Healthy Aging

United States
Alyssum Therapeutics
CBCC Global Research

Recruiting

Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmocodynamics and Preliminary Antitumor Activity of AT-1965 in Patients With Advanced, Refractory or Recurrent Solid Tumors

Solid Tumor

United States
Wuhan Optics Valley Vcanbiopharma Co., Ltd.

Recruiting

Safety, Tolerability and Efficacy of VUM02 Injection in Treatment of Idiopathic Pulmonary Fibrosis (IPF) (DEVIF-I)

Idiopathic Pulmonary Fibrosis

China
Research Institute for Physical Chemical Problems...
The state institution N. N. Alexandrov National Cancer Centre of Belarus; Unitary...

Not yet recruiting

An Open Prospective Randomized Clinical Study of the Effectiveness, Tolerability and Safety of a Single Intraperitoneal Use of the Drug "Prospidelong, Powder for the Preparation of a Gel for Topical Use, 1000 mg in Vials, Package No. 1" in Patients With Disseminated Gastric Cancer, Phase I-II (ИНТЕЛОН-02)

Gastric Cancer With Peritoneal Dissemination

Belarus
Rousselot BVBA

Not yet recruiting

An Open Label, Dose-escalation Study, Assessing the Safety and Tolerability of a Collagen Peptide

Tolerance

United States
Intra-Cellular Therapies, Inc.

Recruiting

Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia or Bipolar Disorder

Schizophrenia | Bipolar Disorder

United States
CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co....

Not yet recruiting

A Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SYH2053

Hyperlipemia
Abbisko Therapeutics Co, Ltd

Recruiting

A Study to Assess Safety, Tolerability, and Pharmacokinetics of ABSK112 in Patients With Non-Small Cell Lung Cancer

Non-Small Cell Lung Cancer

China, United States
Vesper Biotechnologies ApS

Recruiting

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of VES001 in Healthy Participants (SORT-IN-1)

Dementia, Frontotemporal

Netherlands
Chipscreen Biosciences, Ltd.

Not yet recruiting

A Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetic, Pharmacodynamic Profiles and Food Effect of CS32582 Capsules

Healthy

China
EnnovaBio Australia Pharmaceuticals Pty Ltd

Not yet recruiting

A First-in-Human SAD/MAD Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ENC1018 in Healthy Adult Subjects

Healthy
Kynexis B.V.
Parexel

Recruiting

A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of KYN-5356 in Healthy Subjects Aged 18 to 55 Years

Schizophrenia | Cognitive Dysfunction

United States
Shanghai Vitalgen BioPharma Co., Ltd.

Recruiting

A Study to Evaluate the Tolerability, Safety and Efficacy of VGM-R02b

Glutaric Acidemia Type I | Glutaric Aciduria Type I

China
iN Therapeutics Co., Ltd.

Recruiting

A MAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers and PHN Patients.

Pain | Osteoarthritis | Chronic Pain | Neuropathic Pain | Post Herpetic Neuralgia

Australia
Juno Therapeutics, Inc., a Bristol-Myers Squibb...
Celgene Corporation

Recruiting

A Study to Evaluate the Safety, Tolerability, Efficacy, and Drug Levels of CC-97540 in Participants With Relapsing Forms of Multiple Sclerosis or Progressive Forms of Multiple Sclerosis

Multiple Sclerosis

United States, Spain, Germany, Belgium, France, United Kingdom, Italy
AstraZeneca
Parexel

Not yet recruiting

A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD1705 in Participants With Dyslipidemia

Cardiovascular

United States
JKT Biopharma Co., Ltd.

Recruiting

The Safety, Tolerability, Pharmacokinetics and Food Effects of SHEN211 Tablet in Healthy Subjects

Phase 1

China
EuBiologics Co.,Ltd

Recruiting

Phase I, First-In Human Study to Evaluate Safety and Tolerability of EuRSV in Healthy Adults Aged Between 19 Years and 80 Years (EuRSV)

Respiratory Syncytial Virus Infections | Respiratory Syncytial Virus (RSV)

Korea, Republic of
Luye Pharma Group Ltd.

Recruiting

Safety, Tolerability and Pharmacokinetic of Multiple-ascending Doses of LPM3770164 in Healthy Subjects

Tardive Dyskinesia | Huntington Disease

China
Changchun Intellicrown Pharmaceutical Co. LTD

Recruiting

To Evaluate the Safety, Tolerability, Pharmacokinetics and Food Effects of IMM-H014 in Healthy Subjects

Nonalcoholic Steatohepatitis (NASH)

China
Sichuan University

Recruiting

Safety and Tolerability of LDRT+Sugemalimab+Chemotherapy+Olaparib for First-Line Treatment of SLFN-11 Positive ES-SCLC

Lung Cancer | Extensive-stage Small-cell Lung Cancer

China
Incyte Corporation

Recruiting

A Study to Evaluate the Safety and Tolerability of Maximal Use Ruxolitinib Cream

Prurigo Nodularis

United States
Incyte Corporation

Recruiting

A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of INCB160058 When Administered Orally to Healthy Adult Participant

Healthy Participants

Australia
CellinCells

Recruiting

Safety and Tolerability of Autologous Adipose-derived Mesenchymal Stem Cells Therapy in Adults With Atrophic Scars

Atrophic Scar

Korea, Republic of
Hemab ApS

Recruiting

A Phase 1/2 Study to Investigate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of HMB-001 in Glanzmann Thrombasthenia

Glanzmann Thrombasthenia

United States, Belgium, France, Italy, Netherlands, United Kingdom
Children's Hospital of Fudan University

Not yet recruiting

Evaluation of the Safety, Tolerability and Efficacy of a Gene Therapy Drug for the Treatment of Pediatric Fabry Disease

Fabry Disease

China
Sanofi
Regeneron Pharmaceuticals

Recruiting

A Study to Investigate Long-term Safety and Tolerability of Itepekimab in Participants With COPD (AERIFY-4)

Chronic Obstructive Pulmonary Disease

United States, Argentina, Bulgaria, Chile, China, Czechia, Hungary, Israel, Poland, Taiwan, Canada, Portugal, United Kingdom, Korea, Republic of, Japan, Slovakia, South Africa
Aeovian Pharmaceuticals, Inc.

Recruiting

Assessment of the Safety, Tolerability and Pharmacokinetics of AV078 in Healthy Volunteers

Healthy Participants

Australia
ADARx Pharmaceuticals, Inc.
ADARx Australia Pty Ltd

Recruiting

Safety, Tolerability, PK and PD of ADX-850 in Participants With Hypertension

Hypertension | Hypertension,Essential

Australia
Aplagon Oy
TRACER Europe BV

Recruiting

Safety, Tolerability, and Biodistribution of [89Zr]Zr-DFO-APAC in Subjects With PAOD/CLI and Healthy Volunteers (Acronyms: 89Zr = Zirconium-89, DFO = Desferrioxamine, APAC = AntiPlatelet AntiCoagulant, PET/CT = Positron Emission Tomography/Computed Tomography) (CHASE)

Peripheral Arterial Occlusive Disease | Critical Limb Ischemia

Netherlands
Changchun GeneScience Pharmaceutical Co., Ltd.
Syneos Health

Recruiting

A Study to Assess Safety and Tolerability of GS1-144 in Healthy Volunteers

Vasomotor Symptoms | Adult Healthy Volunteers

Australia
PepGen Inc

Recruiting

Safety, Tolerability, PK, and PD Study of PGN-EDODM1 in Participants With Myotonic Dystrophy Type 1 (FREEDOM-DM1)

Myotonic Dystrophy 1

United States, Canada
Maria Sklodowska-Curie National Research Institute...

Not yet recruiting

The Evaluation of the Effectiveness, Safety and Tolerability of Treatment, Using a PSMA-Lu177, in Patients With ACC- an Open, Non-commercial Clinical Trial (LuRM_ACC/2023)

Adenoid Cystic Carcinoma

Poland
JHM BioPharma (Tonghua) Co. , Ltd.

Recruiting

A Phase I/II, Randomized, Double-blind, Placebo, and Active Controlled Clinical Study to Evaluate the Safety, Tolerability, Immunogenicity, and Preliminary Efficacy of JHM03 in Subjects With Moderate to Severe Glabellar Lines

Moderate to Severe Glabellar Lines

China
Second Affiliated Hospital of Soochow University
Shanghai Regenelead Therapies Co., Ltd.

Recruiting

A Study on the Safety and Tolerability of RGL-193 in Patients With Advanced Parkinson's Disease

Advanced Parkinson's Disease

China
Innovent Biologics (Suzhou) Co. Ltd.

Recruiting

A Study to Investigate the Safety, Tolerability and Pharmacokinetics of IBI356 in Healthy Participants and in Atopic Dermatitis Patients

Healthy Participants | Atopic Dermatitis Patients

China
selectION Therapeutics GmbH
FGK Clinical Research GmbH

Recruiting

A Study to Evaluate the Safety and Tolerability, and the Efficacy of Si-544 in Adults With Psoriasis Vulgaris or Psoriatic Arthritis

Psoriasis Vulgaris | Psoriatic Arthritis

Germany
Curon Biopharmaceutical (Shanghai) Co.,Ltd

Recruiting

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of CN201

Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

China
Changchun GeneScience Pharmaceutical Co., Ltd.
West China Hospital

Not yet recruiting

A Randomized, Double-blind, Placebo-controlled Phase II Clinical Study to Evaluate the Safety, Tolerability, Efficacy, and Pharmacokinetic Profile of Genakumab Injection in Patients With Connective Tissue Disease-associated Interstitial Lung Disease

Systemic Sclerosis Associated Interstitial Lung Disease | Rheumatoid Arthritis Associated Interstitial Lung Disease (RA-ILD) | Systemic Sclerosis Associated Interstitial Lung Disease (SSc-ILD)

China
GlaxoSmithKline

Not yet recruiting

A First Time in Human Study to Evaluate the Safety and Tolerability of GSK3996401 Following Dosing With GSK4347859 in Healthy Participants

Systemic Lupus Erythematosus

United Kingdom
AstraZeneca

Recruiting

A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors (CYCAD-1)

ER+ HER2- Advanced Breast Cancer | High-grade Serous Ovarian Cancer (HGSOC)

United States, United Kingdom, Korea, Republic of, Australia, Spain
Vividion Therapeutics, Inc.

Recruiting

A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-130850 in Participants With Advanced Solid and Hematologic Tumors

Advanced Solid Tumors | Advanced Hematologic Tumors

United States, Spain, Australia
Jiangsu Simcere Pharmaceutical Co., Ltd.
Shanghai Xianxiang Medical Technology Co., Ltd.

Recruiting

A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of SIM0237 Alone or in Combination With BCG in NMIBC

Non-Muscle-Invasive Bladder Cancer (NMIBC)

China
Wave Life Sciences Ltd.

Recruiting

A Phase 1 Research Study to Evaluate Safety, Tolerability, and Pharmacokinetics of WVE-006 in Healthy Participants With Wild-type AAT Expression (RestorAATion-1) (RestorAATion-1)

Alpha-1 Antitrypsin Deficiency

United Kingdom
NeuroSense Therapeutics Ltd.

Recruiting

A Phase 2, Randomized, Prospective Double-Blind, Single-Center, Placebo-controlled Study to Evaluate Safety, Tolerability, Target Engagement, and Efficacy of PrimeC in Patients With Mild to Moderate Alzheimer's Disease. (RoAD)

Alzheimer Disease

Israel

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