Search clinical trials for: Multiple-ascending dose

Total 20964 results

Fudan University

Completed

Radiation Dose Escalation Study for Advanced Liver Cancer

Hepatocellular Carcinoma
Hamamatsu University

Completed

Low-Dose Nedaplatin (CDGP:Cis-Diammine-Glycolatoplatinum)/5-FU Combined With Radiation for Esophageal Cancer

Esophageal Cancer | Squamous Cell Carcinoma

Japan
Anza Therapeutics, Inc.

Terminated

Study of Safety and Tolerability of Multiple Intravenous Doses of ANZ-521 in Adults With Chronic Hepatitis C Virus

Chronic Hepatitis C

United States
Odense University Hospital

Unknown

Positron Emission Tomography (PET)/Computed Tomography (CT) and Roentgen in Lung Cancer: Evaluation of Patients in General Practice (PROLOG)

Lung Cancer

Denmark
Vertex Pharmaceuticals Incorporated

Completed

Single and Multiple Dose Escalation Study of VX-509 in Healthy Subjects

Healthy

United States
Southeast University, China
Nanjing Medical University

Unknown

Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS)

Acute Respiratory Distress Syndrome | Adrenal Insufficiency
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating the Safety and Tolerability of NSA-789

Healthy

United States
LEO Pharma

Terminated

Efficacy and Safety of 3 Doses of HL10 Given at Fixed Time Intervals Compared to Standard Therapy

Acute Respiratory Distress Syndrome | Acute Lung Injury

Denmark, Belgium, Austria, Canada, Finland, France, Germany, Netherlands, Norway, Spain, Sweden, United Kingdom
University Hospital Tuebingen

Completed

Darbepoetin Alfa in Patients With "Poor Prognosis" Germ Cell Tumor Treated With High-Dose Chemotherapy (HD-VIP)

Dysgerminoma

Germany
University of Cincinnati
Allergan

Terminated

Botulinum Toxin Type A (Botox) in the Management of Levodopa-Induced Peak-Dose Dyskinesias in Parkinson's Disease

Parkinson Disease

United States
Hannover Medical School
Hoffmann-La Roche

Completed

Exchange of Azathioprine by Mycophenolatmofetile and Cyclosporine A Dose Reduction After Heart Transplantation

Heart Transplantation

Germany
University of Southern Denmark

Unknown

Paroxetines Effect on Tramadols Metabolism and Pharmakodynamics: a Dose Response Study

Depression | Pain
Hannover Medical School
Hoffmann-La Roche

Completed

Withdrawal of Steroids, Cyclosporine A Dose Reduction and Switch to Mycophenolatmofetile After Heart Transplantation

Heart Transplantation

Germany
Samsung Medical Center

Completed

The Comparison of Effects Between Increased Dose of Clopidogrel and Addition of Cilostazol (4C-DES)

Clopidogrel Non-Responsiveness

Korea, Republic of
Erasmus Medical Center
Hoffmann-La Roche

Completed

Fixed Dose MMF vs Concentration Controlled MMF After Renal Transplantation

De Novo Renal Transplant Recipient.

France, Spain, Taiwan, Denmark, Australia, United Kingdom, Germany, Canada, Belgium, China, Sweden, Netherlands, Austria, Brazil, Estonia, Lithuania, Norway, Poland, Venezuela
Pfizer

Withdrawn

A Dose-Ranging, Multicenter Polysomnography Trial of PD 0200390 in Elderly Subjects With Primary Insomnia

Insomnia
Clinical Trial Agency of HIV Study Group

Completed

VENICE Study Nevirapine Full Dose/Dose Escalation (VENICE)

HIV Infections

Spain
MediQuest Therapeutics

Unknown

Dose Response and Safety Study of Topical Methotrexate for the Treatment of Fingernail Psoriasis

Fingernail Psoriasis

United Kingdom
Pfizer

Completed

CPG 7909 Injection in Non-Small Cell Lung Cancer

Carcinoma, Non-Small Cell Lung

United States, Canada, Germany
Heinrich-Heine University, Duesseldorf

Unknown

Combination Chemotherapy With or Without Darbepoetin Alfa in Treating Women With Stage III Breast Cancer

Breast Cancer

Germany
GERCOR - Multidisciplinary Oncology Cooperative...

Unknown

Celecoxib or Observation After Radiation Therapy and Chemotherapy in Treating Patients With Stage II or Stage III Non-Small Cell Lung Cancer

Lung Cancer

France
Sanofi

Completed

Dose-Ranging Study Evaluating AVE2268 in Patients With Type 2 Diabetes Not Adequately Controlled by a Metformin Treatment

Type 2 Diabetes Mellitus

France, Poland, Germany, Italy, Netherlands, Belgium, Denmark, Chile, South Africa, Australia, Argentina
Institute of Cancer Research, United Kingdom

Unknown

Combination Chemotherapy in Treating Women With Resected Breast Cancer

Breast Cancer

United Kingdom, Belgium
Far Eastern Memorial Hospital

Unknown

An Effective and Well-Tolerated Regimen of Docetaxel Plus High-Dose 5-Fluorouracil and Leucovorin(HDFL)to Treat Inoperable Advanced or Metastatic Gastric Cancer

Stomach Neoplasms

Taiwan
Sun Yat-sen University

Unknown

Low-Dose Thalidomide as Adjuvant Therapy After Radiofrequency Ablation for Hepatocellular Carcinoma (LDT-RFA)

Hepatocellular Carcinoma | Liver Cancer

China
Dana-Farber Cancer Institute
National Cancer Institute (NCI)

Unknown

Combination Chemotherapy in Treating Patients With Stage IIB, Stage III, or Stage IV Cancer of the Nasopharynx

Head and Neck Cancer

United States
Daiichi Sankyo Co., Ltd.

Completed

Placebo and Active Comparator Controlled Dose Response Study of Rivoglitazone in Type 2 Diabetes (RAISE)

Type 2 Diabetes

China
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study to Determine the Effect of a High-Fat Meal on the Relative Bioavailability and Pharmacokinetics of a Single Dose of Bosutinib Administered Orally to Healthy Subjects

Healthy Subjects

United States
Guangzhou Mental Hospital
First Affiliated Hospital of Jinan University; Second Affiliated Hospital of... and other collaborators

Unknown

A Study to Evaluate the Efficacy and Safety of Flexible Dose of Quetiapine Fumarate (Seroquel) Switching From Other Drugs in the Treatment of Acute Manic Patients With Bipolar Disorder

Bipolar Disorder

China
Nantes University Hospital

Terminated

Anti-Proteinuric Response to ACEI, ARB and Diuretics Combination.

Heavy Proteinuria

France
Main Line Health
Merck Sharp & Dohme LLC; Drexel University College of Medicine

Unknown

Oral Aprepitant and Lower Dose Dexamethasone Versus Aprepitant Alone for Preventing Postoperative Nausea and Vomiting (PONV) After Elective Laparoscopic Surgeries

Nausea | Vomiting

United States
Eisai Inc.

Suspended

A Dose Escalation Study of E7107 Administered Intravenously on Days 1 and 8 Every 21 Days to Patients With Solid Tumors

Cancer

United States
University of Aarhus
Aarhus University Hospital; Rigshospitalet, Denmark

Completed

Adjuvant Low Dose Total Body Irradiation in Elderly Patients With Diffuse Large B-Cell Lymphoma

Non Hodgkin's Lymphoma
Siemens Molecular Imaging

Completed

An Exploratory, Open Label, Single Center Study of [F-18]HX4 (HX4)

Head and Neck Cancer

United States
Nantes University Hospital

Completed

High-Dose Imatinib for Relapsed/Refractory c-Kit Positive Acute Myelogenous Leukemia (AML)

AML

France
Solvay Pharmaceuticals

Completed

Ascending Dose Tolerability/Safety of SLV308 for the Treatment of Parkinson's Disease

Parkinson's Disease

Bulgaria, Malta, Serbia
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating the Safety, Tolerability and Activity of One Dose of PAZ-417 Given to Healthy Japanese Subjects

Healthy | Alzheimer Disease

Japan
Hospital Carlos III, Madrid

Unknown

Phase IV Study to Evaluate the Efficacy/Safety to Extend Treatment and High Dose of Ribavirin in co-Infected Patients (PERICO)

Chronic Hepatitis C

Spain
All India Institute of Medical Sciences, New Delhi

Terminated

Efficacy Study of Glyceryl-Trinitrate Patch and Parecoxib (Valdecoxib) for the Prevention of Pancreatitis After Endoscopic Retrograde Cholangiopancreatography (ERCP)

Pancreatitis | ERCP

India
Keogh Institute for Medical Research

Unknown

Efficacy and Safety Study of Combined Oral and Injection Therapy for Erectile Dysfunction

Erectile Dysfunction

Australia
BeerYaakov Mental Health Center

Unknown

Tolerability And Efficacy Of High Dose Escitalopram In The Treatment Of Patients Suffering From Schizophrenia And Obsessive-Compulsive Disorder (OCD) - An Open Label Study

Schizophrenia | OCD

Israel
Fudan University

Unknown

Induction Chemotherapy Followed by Concurrent Chemoradiotherapy for Nasopharyngeal Carcinoma (NPC) (TPF for NPC)

Nasopharyngeal Carcinoma

China
Teva Pharmaceuticals USA

Completed

Risperidone 1 mg Tablets Dosed in Healthy Subjects Under Fed Conditions

Healthy

Canada
Ruhr University of Bochum

Completed

Medium-Dose UVA1 Versus Narrow-Band UVB in Atopic Dermatitis

Atopic Dermatitis

Germany
Bristol-Myers Squibb

Completed

A Phase I Study to Determine Absorption, Distribution, Metabolism, and Elimination of a Single Radiolabeled Dose of Brivanib (BMS-582664)

Tumors

United States
University of Brasilia
Ministry of Health, Brazil

Completed

Safety and Efficacy of Low-Dose Pentavalent Antimony for Treatment of Cutaneous Leishmaniasis (Lowdosesb)

Cutaneous Leishmaniasis

Brazil
Poniard Pharmaceuticals

Unknown

A Study of Picoplatin and Docetaxel in Subjects With Prostate Cancer

Hormone Refractory Prostate Cancer

Russian Federation
Chakshu Research, Inc.

Unknown

Dose-Ranging Study of an Ophthalamic Solution in Patients With Loss of Visual Function Due to Age-Related Nuclear Cataract

Nuclear Cataract

Nepal
Sanofi

Completed

An Eight-Week Study Evaluating the Efficacy of Two Fixed Doses (250 mg Twice Daily and 100 mg Twice Daily) of SSR149415 in Patients With Major Depressive Disorder (LENA)

Depressive Disorder

Canada, Russian Federation, Bulgaria, Mexico, Argentina, Chile, Croatia
Bayer

Completed

Study to Evaluate the Effect of Renal Function on the Single-Dose Pharmacokinetics of BAY 43-9006

Kidney Diseases

3

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