Search clinical trials for: Maximum tolerated dose

Total 21316 results

Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Single Ascending Dose Study of the Safety, Tolerability, and Pharmacokinetics of GAP-134 Administered Intravenously

Arrhythmia

United States
Azevan Pharmaceuticals

Completed

Multiple Dose Safety Study of SRX251 Capsules in Healthy Volunteers

Healthy

United States
Tel-Aviv Sourasky Medical Center

Unknown

Low-Dose Risperidone Treatment for Subjects Suffering From Borderline Personality Disorder

Borderlone Personality Disorder

Israel
Weill Medical College of Cornell University
National Institute of Allergy and Infectious Diseases (NIAID)

Terminated

Safety Study of Low Dose Interleukin 2 (IL-2) Plus PEG-IFN/RBV In Chronic Hepatitis C Virus Genotype I

Hepatitis C

United States
NeurogesX

Completed

NGX-4010 for the Treatment of Postherpetic Neuralgia

Pain | Peripheral Nervous System Diseases | Neuralgia | Herpes Zoster | Shingles

United States
NeurogesX

Completed

Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy

HIV Infections | Pain | Peripheral Nervous System Diseases

United States
NeurogesX

Terminated

Study of NGX-4010 for Treatment of Painful HIV-Associated Neuropathy

HIV Infections | Pain | Peripheral Nervous System Diseases

United States
NeurogesX

Completed

Controlled Study of NGX-4010 for the Treatment of Postherpetic Neuralgia

Pain | Peripheral Nervous System Diseases | Neuralgia | Herpes Zoster

United States
National Cancer Institute (NCI)

Completed

Antimetabolite Induction, High-Dose Alkylating Agent Consolidation and Retroviral Transduction of the MDR1 Gene Into Peripheral Blood Progenitor Cells Followed by Intensification Therapy With Sequential Paclitaxel and Doxorubicin for Stage 4 Breast Cancer

Breast Neoplasms | Neoplasm Metastasis

United States
National Institutes of Health Clinical Center (CC)

Completed

The Early Reversibility of Rocuronium After Different Doses of Neostigmine

Paralysis

United States
National Institute of Mental Health (NIMH)

Completed

Positron Emission Tomography Imaging of Dopamine Receptors Using the Tracer [11C]NNC-112

Healthy

United States
Eunice Kennedy Shriver National Institute of Child...

Completed

Dose Response Relationship for Single Doses of Corticotropin Releasing Hormone (CRH) in Normal Volunteers and in Patients With Adrenal Insufficiency

Healthy | Cushing's Syndrome | Adrenal Gland Hyperfunction | Adrenal Gland Hypofunction

United States
National Institute of Neurological Disorders and...

Completed

Intravenous Immunoglobulin (IVIg) for the Treatment of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

Demyelinating Diseases | Paraproteinemias

United States
National Cancer Institute (NCI)

Completed

Phase I Study of Continuous Hyperthermic Peritoneal Perfusion (CHPP) With Escalating Dose I.P. Platinum for Gastrointestinal Peritoneal Carcinomatosis

Stomach Neoplasms | Peritoneal Neoplasms

United States
National Cancer Institute (NCI)

Completed

New Therapeutic Strategies for Patients With Ewing's Sarcoma Family of Tumors, High Risk Rhabdomyosarcoma, and Neuroblastoma

Neuroblastoma | Rhabdomyosarcoma | Ewing's Sarcoma

United States
National Institute of Neurological Disorders and...

Completed

Treatment of Parkinson's Disease With a Transdermal Skin Patch

Parkinson Disease

United States
National Cancer Institute (NCI)

Completed

A Pilot Study to Investigate the Clinical Utility of the Peregrine Monte Carlo Dose Calculation System for Radiation Therapy Treatment Planning

Neoplasm

United States
National Cancer Institute (NCI)

Completed

A Phase I Study of Isolated Hepatic Portal and Arterial Perfusion (IHP) With Escalating Dose Melphalan for Primary or Metastatic Unresectable Cancers of the Liver

Neoplasm Metastasis | Liver Neoplasms

United States
National Institute of Neurological Disorders and...

Completed

Effect of Talampanel (an AMPA Receptor Blocker) on Brain Activity

Healthy

United States
National Cancer Institute (NCI)

Completed

A Phase I Study of Isolated Hepatic Perfusion With Escalating Dose Melphalan Followed by Postoperative Hepatic Arterial Floxuridine and Leucovorin for Metastatic Unresectable Colorectal Cancers of the Liver

Neoplasm Metastasis | Colorectal Neoplasm | Liver Neoplasm

United States
National Cancer Institute (NCI)

Completed

A Pilot Trial of AC (Adriamycin, Cyclophosphamide) Chemotherapy With G-CSF (Granulocyte Colony-Stimulating Factor) Followed by Infusional Taxol (Paclitaxel) as Adjuvant Treatment for High Risk Stage II and Stage III Breast Cancer Patients

Breast Cancer | Breast Neoplasms

United States
National Institute of Neurological Disorders and...

Completed

Intravenousimmunoglobulin (IVIg) for the Treatment of Inflammatory Myopathies

Dermatomyositis | Polymyositis | Inclusion Body Myositis

United States
National Institute of Neurological Disorders and...

Completed

High-Dose Intravenous Immunoglobulin to Treat Cerebellar Degeneration

Spinocerebellar Degenerations

United States
National Cancer Institute (NCI)

Completed

Feasibility Study of Interleukin 1-Alpha With Ifosfamide, CBDCA, and Etoposide With Autologous Bone Marrow Transplant in Metastatic Carcinoma and Lymphoma

Lymphoma | Testicular Neoplasms | Breast Neoplasms | Neoplasm Metastasis

United States
National Cancer Institute (NCI)

Completed

Phase I-II Multiple-Dose Safety and Efficacy Study of a Selective Inhibitor of Cyclooxygenase - 2 (SC-58635) in Hereditary Non-Polyposis Colorectal Cancer (HNPCC) Patients and Carriers

Colorectal Neoplasm | Hereditary Nonpolyposis

United States
National Institute of Dental and Craniofacial Research...

Completed

Local Flurbiprofen to Treat Pain Following Wisdom Tooth Extraction

Pain

United States
National Cancer Institute (NCI)

Completed

Autologous T-Cell Transplantation and the Immunotherapy of Residual Disease in Breast Cancer: Pilot Study of Vaccine-Driven T-Cell Expansion in Patients Treated With Dose-Intensive Chemotherapy

Neoplasm Metastasis | Breast Neoplasm

United States
National Cancer Institute (NCI)

Completed

A Randomized, Double-Blind, Placebo Controlled Trial Evaluating the Impact of Nystatin on the Development of Oral Irritation in Patients Receiving High Dose Intravenous Interleukin-2

Gastrointestinal Diseases | Candidiasis, Oral | Stomatitis

United States
National Cancer Institute (NCI)

Completed

Effect of Preoperative Chemotherapy on Axillary Lymph Node Metastases in Stage II Breast Cancer: A Prospective Randomized Trial

Neoplasm Metastasis | Breast Neoplasm

United States
National Cancer Institute (NCI)

Completed

A Multimodality Treatment Approach to Patients With Inflammatory Cancer of the Breast and Locally Advanced Non-Inflammatory Stage III Breast Cancer and Stage IV Breast Cancer

Breast Neoplasms | Neoplasm Metastasis

United States
National Cancer Institute (NCI)

Completed

Phase I Trial of FLAC (5-Fluorouracil, Leucovorin, Adriamycin, Cytoxan) Plus GM-CSF (Granulocyte-Macrophage Colony Stimulating Factor) Plus Dose Escalation of IL-3 (Interleukin-3) in Metastatic Breast Cancer

Breast Neoplasms | Neoplasm Metastasis

United States
National Cancer Institute (NCI)

Completed

A Pilot Trial of Sequential Chemotherapy With Antimetabolite Induction, High-Dose Alkylating Agent Consolidation With Peripheral Blood Progenitor Cell Support, and Intensification With Paclitaxel and Doxorubicin for Patients With High-Risk Breast Cancer

Breast Cancer | Breast Neoplasms

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Higher-Dose Ezetimibe to Treat Homozygous Sitosterolemia

Heart Diseases | Metabolism, Inborn Errors

United States
National Cancer Institute (NCI)

Completed

Therapeutic Drug Monitoring and Viral Resistance Testing in the Treatment of HIV-Infected Children

HIV Infections

United States
National Cancer Institute (NCI)

Completed

A Pharmacokinetic and Pharmacodynamic Study of Vincristine in Children With Leukemia

Leukemia | Acute Lymphocytic Leukemia

United States
National Cancer Institute (NCI)

Completed

Clinical Evaluation of a Laser Heated, Fiberoptic-Coupled Radiation Dose Verification System

Neoplasm

United States
Charite University, Berlin, Germany
Schering-Plough

Terminated

Effect of Different Iloprost Doses on Symptoms in Systemic Sclerosis (ILODOSE)

Systemic Sclerosis

Germany
University Medicine Greifswald

Completed

Pharmacokinetic Drug Interaction Between Ezetimibe and Tacrolimus After Single Dose Administration in Healthy Subjects

Hypercholesterolemia | Pharmacokinetics | Immunosuppression | Drug Interactions

Germany
University Medicine Greifswald

Completed

Pharmacokinetic Drug Interaction Between Ezetimibe and Sirolimus After Single Dose Administration in Healthy Subjects

Hypercholesterolemia | Pharmacokinetics | Immunosuppression | Drug Interactions

Germany
Solvay Pharmaceuticals

Completed

Analgesic Effectiveness of Three Different Doses of a New Formulation of Lamaline in a Model of Painful Knee (Gonarthrosis)

Knee Osteoarthritis

France
Targeted Genetics Corporation

Completed

Phase 1 Dose Escalation Study of Intra-Articular Administration of tgAAC94

Rheumatoid Arthritis

Canada, United States
Myrexis Inc.

Completed

Multiple Dose Study of MPC-6827 in Subjects With Refractory Brain Metastases

Brain Neoplasms

United States
Myrexis Inc.

Completed

Phase 1, Multiple Dose Study of MPC-6827 in Subjects With Refractory Solid Tumors

Refractory Solid Tumors

United States
Millennium Pharmaceuticals, Inc.

Completed

Phase I/II Dose Escalation Study of VELCADE® and Docetaxel in Patients With Advanced Androgen-Independent Prostate Cancer

Prostatic Neoplasms

United States
Ariston Pharmaceuticals, Inc.

Unknown

Efficacy and Safety Clinical Trial of Intranasal AST-726 for the Prevention of Migraine

Migraine | Migraine Disorders | Migraine Headache | Migraine Without Aura | Migraine With Aura

Finland, Netherlands, United Kingdom
Pfizer
Sanofi

Completed

US Inhaled Insulin Dose Titration Study

Diabetes Mellitus, Type 2

United States
Rabin Medical Center

Unknown

Administration of High Dose Thiotepa and Melphalan With Autologous Hematopoietic Stem Cell Transplant in Children and Adolescents With Solid Tumors

Central Nervous System Tumors | Tumors

Israel
NovaCardia, Inc.
Merck Sharp & Dohme LLC

Completed

Dose Escalation Study of KW-3902 on Diuresis in Subjects With Congestive Heart Failure (CHF).

Heart Failure, Congestive

United States
Erimos Pharmaceuticals

Completed

Dose Escalation Study of EM-1421 for the Treatment of Recurrent or Refractory Solid Tumors

Cancer

United States
Hellenic Oncology Research Group
University Hospital of Crete

Completed

Randomized Phase III Trial Comparing Sequential Administration of FE75C Followed by Docetaxel Versus Paclitaxel as Adjuvant Chemotherapy in Axillary Lymph Node (+) Breast Cancer

Breast Cancer

Greece

3

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