Search clinical trials for: Dose Expansion

Total 21393 results

Azienda Sanitaria Ospedaliera
Cardiologia 2 - Emodinamica - Ospedale Maggiore, Novara, Italy

Terminated

Half-Dose Intracoronary Abciximab Bolus Improves the Mortality Outcome Compared to Standard Intravenous Regimen

Myocardial Infarction | Coronary Disease

Italy
Johns Hopkins University
Sunovion

Completed

Mucociliary Clearance in Healthy Subjects: Comparison of Levalbuterol and Racemic Albuterol

Mucociliary Clearance

United States
University of British Columbia
Vancouver Coastal Health Research Institute; 3M

Completed

Safety and Efficacy of Imiquimod Applied in Dose-Cycle for Actinic Keratoses

Actinic Keratoses

Canada
Eyetech Pharmaceuticals
Pfizer

Completed

A Clinical Trial to Explore Safety and Efficacy of Different Doses of Pegaptanib Sodium, Compared to Sham, in Patients With Wet AMD.

Age-Related Macular Degeneration
Royal Adelaide Hospital
University Hospital, Essen; Knoll Pharmaceuticals, Germany (now Abbott)

Completed

Itopride in Functional Dyspepsia:a Dose Finding Study

Functional Dyspepsia

Germany
Hadassah Medical Organization
Jerusalem Institute for Child Development

Unknown

Trial of Low-Dose Naltrexone for Children With Pervasive Developmental Disorder (PDD)

Pervasive Developmental Disorder

Israel
International Centre for Diarrhoeal Disease Research...
Karolinska Institutet

Completed

Zinc Supplementation in Shigella Patients

Testing Effect of Intervention
University of Edinburgh
Pfizer

Completed

Effect of Regular Sildenafil on Blood Pressure and Arterial Function in Hypertension

Hypertension

United Kingdom
Corautus Genetics

Unknown

To Find the Best Dose of pVGI.1(VEGF2) to Benefit Angina Patients When Given With an Experimental Injection Catheter

Angina Pectoris

United States
Celgene Corporation
Prologue Research International

Terminated

Phase I/II Open-Label, Dose Escalation Study To Determine The Maximum Tolerated Dose And To Evaluate The Safety Profile of Lenalidomide (Revlimid® CC-5013) With Liposomal Doxorubicin In Subjects With Advanced Ovarian and Primary Peritoneal Carcinoma

Ovarian Cancer

United States
Université de Sherbrooke
Canadian International Development Agency

Completed

Study of the Management of Vaginal Discharge in West African Using Single Dose Treatments

Candidiasis | Vaginitis | Bacterial Vaginosis

Ghana, Guinea, Togo
Medical University of Vienna

Completed

Effect of High-Dose Prednisolone (Solu Dacortin®) Treatment on Choroidal and Optic Nerve Head Blood Flow in Humans

Regional Blood Flow | Optic Disk

Austria
Halozyme Therapeutics

Completed

A Phase IIIB Dose Comparison Study of Subcutaneous Hydration With and Without Human Recombinant Hyaluronidase (HYLENEX) in Volunteer Subjects

Healthy

United States
University of Wuerzburg

Unknown

VELCADE as Maintenance Treatment in Patients With Multiple Myeloma Following Autologous Peripheral Blood Stem Cell Transplantation (PBSCT)

Multiple Myeloma

Austria, Germany, Italy
Samaritan Pharmaceuticals, Inc

Completed

A Dose Response and Safety Study of Procaine HCl in HIV-Infected Patients

HIV Infections

United States
Hamamatsu University
Maruyama Memorial General Hospital; Seirei Hamamatsu General Hospital; Iwata... and other collaborators

Completed

Study of the Relationship Between rHuEPO Dose, Serum ADPN, and Mortality in Patients Beginning Hemodialysis (HD)

Renal Dialysis
National Institute of Environmental Health Sciences...

Completed

Ozone Exposure and Dose Delivered to Human Lungs

Lung Disease

United States
KK Women's and Children's Hospital
National Healthcare Group, Singapore

Completed

Trial Of Misoprostol And Dinoprostone Vaginal Pessaries for Cervical Priming (TROMAD Study)

Induction of Labour

Singapore
Weill Medical College of Cornell University
Schering-Plough

Completed

Comparison of PEG-Intron and Two Different Doses of Ribavirin for the Treatment of Chronic Hepatitis C In Treatment Naïve Subjects

Chronic Hepatitis C
NeurogesX

Completed

Pilot Study of High-Dose Capsaicin Patches to Treat Postherpetic Neuralgia Pain

Pain | Peripheral Nervous System Diseases | Neuralgia | Herpes Zoster

United States
University of Otago
Australian and New Zealand College of Anaesthetists

Completed

Comparison of Two Different Doses of Paracetamol for Post-Operative Pain Relief

Adult Patients Scheduled for 3rd Molar Teeth Extractions

New Zealand
Agarwal, Pinky, M.D.
GlaxoSmithKline; Colorado Neurology

Unknown

Open Label High Dose Ropinirole (Requip) Study for Patients With Parkinson's Disease

Parkinson's Disease

United States
University of Texas Southwestern Medical Center

Completed

Impact of Low Dose Naloxone on Fentanyl Requirements in Pediatric ICU Patients

Opioid Tolerance

United States
Cell Genesys

Terminated

Intravenous CG7870 in Combination With Docetaxel in Patients With Metastatic Hormone-Refractory Prostate Cancer

Prostate Cancer

United States
Kwong Wah Hospital

Completed

Effects of 2 Different Doses of Pantoprazole on Gastric pH and Recurrent Bleeding in Patients Who Bled From Peptic Ulcers

Peptic Ulcer Hemorrhage

China
City, University of London
Imperial College London

Completed

Patching for Lazy Eye: Trial to Evaluate Daily Patching Amounts

Amblyopia

United Kingdom
Daiichi Sankyo, Inc.

Completed

A Comparison of the Effect of Olmesartan Medoxomil, Losartan Potassium, and Atenolol on the Ability of Overweight Patients With High Blood Pressure to Respond to Insulin

Hypertension | Metabolic Syndrome | Insulin Resistance

United States
National Taiwan University Hospital

Completed

Minimal Erythema Dose of UV-B in Normal Population of Taiwan

Human Volunteers

Taiwan
St George Hospital, Australia

Unknown

Boost Use in Breast Conservation Radiotherapy

Breast Neoplasms

Australia
Gustave Roussy, Cancer Campus, Grand Paris

Unknown

Randomized Trial Of Platelet Transfusion Policies After Blood Stem Cells Transplantation In Young Children: Reduction Of Number Of Single Platelet Concentrate Donors Per Child

Children Treated With High-Dose Chemotherapy (HDC) Followed by Haematopoietic Stem Cell Transplantation (HSCT)

France
Herlev Hospital

Unknown

Low-Dose Endotoxemia and the Acute Phase Response

Sepsis | Endotoxemia

Denmark
Chiron Corporation

Unknown

Kinetic of Immune Memory Response After Re-Vaccination With Meningococcal Vaccine

Meningococcal Disease; Meningococcal Meningitis

United Kingdom
University Hospital, Angers

Unknown

High Dose Hyperoncotic Serum Albumin for the Treatment of the Acute Phase of Severe Head Injury

Severe Head Injury

France
National Taiwan University Hospital

Unknown

Establishing Novel Detection Techniques for Various Genetic-Related Diseases by Applying DHPLC Platform.

Colon Cancer | Spinal Muscular Atrophy | Neonatal Hyperbilirubinemia

Taiwan
Poitiers University Hospital
Novartis; Ministry of Health, France

Terminated

Safety and Efficacy of Imatinib in Combination With High Dose Chemotherapy for Acute Phase Chronic Myelogenous Patients

Chronic Myeloid Leukemia

France
Gilead Sciences

Completed

Study Safety/Efficacy of AmBisome Loading Dose Regimen Versus Standard AmBisome Regimen for Initial Treatment

Invasive Aspergillosis | Other Fungal Infections
Hoffmann-La Roche
Trimeris

Completed

A Study to Compare Three Doses of T-20 When Given in Combination With Abacavir, Amprenavir, Ritonavir, and Efavirenz to HIV-Infected Adults

HIV Infections

United States
Zeneus Pharma

Unknown

Myocet, Docetaxel & Trastuzumab as 1st Line Treatment of Patients With HER-2/Neu Positive Metastatic Breast Cancer

Metastatic Breast Cancer

Italy
Celgene Corporation
Prologue Research International

Terminated

Phase I Open-Label, Dose Escalation Study To Determine The Maximum Tolerated Dose And To Evaluate The Safety Profile Of Lenalidomide (Revlimid®, CC-5013) With Pemetrexed In Subjects With Advanced Non-Small Cell Lung Cancer

Non-Small Cell Lung Cancer

United States
Groupe Hospitalier Pitie-Salpetriere
Bristol-Myers Squibb

Unknown

Evaluation of Viral Efficacy and Safety of a Reduced Dose of Stavudine (d4T): THE PHOENIX STUDY

HIV

France
ARI Research Cell
World Health Organization

Completed

Efficacy of Single Versus Double Dose of Oral Amoxicillin for Non-Severe Pneumonia in Children

Pneumonia

Pakistan
Khon Kaen University
National Research Council of Thailand

Completed

Once-Daily Amikacin Plus Cloxacillin in Febrile Neutropenic Children

Cancer | Neutropenia | Fever
Albert Schweitzer Hospital

Completed

Treatment of Malaria With Quinine Plus Sulfadoxine-Pyrimethamine

Malaria

Gabon
Hopital A Michallon
Central Hospital, Nancy, France; University Hospital, Grenoble

Terminated

Plasma Ribavirin Assay During Combination Therapy for Chronic Hepatitis C

Chronic Hepatitis C

France
Boehringer Ingelheim

Completed

Dose Ranging Trial of Tipranavir/Ritonavir in Treatment-Experienced HIV Infected Individuals

HIV Infections

United States, Puerto Rico
Association Européenne de Recherche en Oncologie
Amgen; Aventis Pharmaceuticals

Completed

Randomized Phase II Trial of Dose Dense Docetaxel in N+ Breast Cancer

Node Positive Breast Cancer
Sunnybrook Health Sciences Centre
The Physicians' Services Incorporated Foundation

Completed

A Study of The Effectiveness of N-Acetylcysteine in Kidney Protection Following Cardiopulmonary Bypass

Renal Insufficiency | Heart Disease
Daiichi Sankyo, Inc.

Completed

An Examination of the Safety and Blood Pressure Lowering Effect of Increasing Doses of Benicar® and Benicar® HCT in Patients With Hypertension

Hypertension

United States
Gustave Roussy, Cancer Campus, Grand Paris

Completed

Comparison of High-Dose Methotrexate (HDM) Plus Doxorubicin to HDM Plus Etoposide-Ifosfamide in Osteosarcoma Children

Osteosarcoma | Localised High Grade Osteosarcoma of the Limbs

France
Bandim Health Project

Completed

Different Doses of Vitamin A and Childhood Morbidity and Mortality

Mortality | Morbidity

Guinea-Bissau

3

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