Search clinical trials for: maximal tolerated dose

Total 21580 results

Glaxo Wellcome

Completed

The Safety and Effectiveness of Different Dose Levels of 1263W94 in the Treatment of Cytomegalovirus (CMV) of the Eyes in HIV-Infected Patients

HIV Infections | Cytomegalovirus Infections

United States
Chugai Pharma USA

Completed

A Blinded Study Conducted at Multiple Centers Evaluating Various Doses of an Investigational Agent (BO-653) Against Placebo, for Safety and Effectiveness in Preventing Post-Angioplasty Blood Vessel Re-Closure (Restenosis) in Stented Vessels.

Atherosclerosis | Coronary Restenosis | Graft Occlusion, Vascular

United States
Hoechst Marion Roussel

Completed

A Randomized, Double-Blind Active-Controlled, Dose-Ranging Study of the Safety and Efficacy of Chronically Administered MDL 28,574A in the Treatment of HIV-Infected Patients

HIV Infections

United States
National Center for Research Resources (NCRR)
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Phase I/II Study of High-Dose Acyclovir for Central Nervous System or Disseminated Neonatal Herpes Simplex Virus Infection

Herpes Simplex
Fisons

Completed

The Safety and Effectiveness of Pentamidine in the Prevention of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS Who Have Had PCP Before

HIV Infections | Pneumonia, Pneumocystis Carinii

United States
Sandoz

Completed

A Multicenter Placebo-Controlled Dose Titration Study to Evaluate the Efficacy and Safety of Sandostatin (SMS 201-995) in the Treatment of Patients With Acquired Immunodeficiency Related Diarrhea

HIV Infections | Diarrhea

United States
Merck Sharp & Dohme LLC

Completed

A Comparison of Two Dose Levels of Indinavir Combined With Two Nucleoside Analogue Reverse Transcriptase Inhibitors (NRTIs) in HIV-Infected Patients

HIV Infections

United States
Sandoz

Completed

A Phase I/II Trial to Assess the Safety and Tolerance of Escalating Doses of a Human Anti-Cytomegalovirus Monoclonal Antibody (SDZ MSL-109) in Patients With the Acquired Immunodeficiency Syndrome and CMV Retinitis

HIV Infections | Cytomegalovirus Retinitis

United States
Lederle Laboratories

Completed

An Ascending, Single Oral Dose Pharmacokinetic Study of 3'-Deoxy-3'-Fluorothymidine (FLT) in Asymptomatic Human Immunodeficiency Virus (HIV)-Infected Subjects

HIV Infections

United States
National Institute of Allergy and Infectious Diseases...

Completed

A Phase I Randomized Dose/Formulation Comparison Study of SC-52151

HIV Infections

United States
National Center for Research Resources (NCRR)
Tulane University School of Medicine

Completed

Phase III Randomized Study of High Vs Standard Dose of Interferon Alfa for Chronic Hepatitis C

Hepatitis C
Otsuka America Pharmaceutical

Completed

A Study of Multiple Doses of Vesnarinone in Advanced HIV Disease

HIV Infections

United States
Pharmacia and Upjohn

Completed

A Double-Blind, Randomized, Dose Response Study of Three Doses of Delavirdine Mesylate (U-90152S) in Combination With Zidovudine (ZDV) Versus ZDV Alone in HIV-1 Infected Individuals With CD4 Counts of 200-500mm3

HIV Infections

United States, Puerto Rico
Wyeth-Lederle Vaccines

Completed

A Study of GENEVAX-HIV, a Possible Vaccine

HIV Infections | HIV Seronegativity

United States
Wyeth-Lederle Vaccines

Completed

Safety and Effects of Giving a New HIV Vaccine (GENEVAX-HIV) to HIV-Negative Volunteers

HIV Infections | HIV Seronegativity

United States
Glaxo Wellcome

Completed

A Study to Compare the Safety and Effectiveness of Two Dosing Schedules of Lamivudine in Combination With Two Other Anti-HIV Drugs

HIV Infections

United States
PPD

Unknown

Differences Between Women and Men Taking a Combination of Indinavir, Ritonavir, Enteric-Coated Didanosine, and Stavudine Who Previously Took Anti-HIV Drugs

HIV Infections

United States, Puerto Rico
Celgene Corporation

Completed

Compassionate Use Study of Two Dose Levels of Thalidomide in Adults With HIV Wasting Syndrome

HIV Infections | HIV Wasting Syndrome

United States
Eunice Kennedy Shriver National Institute of Child...
National Center for Research Resources (NCRR)

Unknown

Building Better Bones in Children

Osteoporosis

United States
Lederle Laboratories

Completed

A Multi-Center, Open-Label, Ascending, Multiple Oral Dose, Safety, Tolerance and Pharmacokinetic Study of 3'-Deoxy-3'-Fluorothymidine (FLT) in Patients With Acquired Immune Deficiency Syndrome (AIDS) or AIDS-Related Complex (ARC)

HIV Infections

United States
Apollon

Completed

A Phase I Trial of APL 400-003 Vaccine: Safety and Immune Response Evaluations of Multiple Injections at Escalating Doses in Asymptomatic HIV-Infected Patients

HIV Infections

United States
Hoffmann-La Roche

Completed

A Comparison of Three Anti-HIV Drug Combinations Containing Saquinavir Soft Gelatin Capsules Used in HIV-1 Infected Patients

HIV Infections

United States, Puerto Rico, Spain, Germany, Italy, United Kingdom
Gilead Sciences

Unknown

The Safety and Effectiveness of PMPA Prodrug in HIV-Infected Patients

HIV Infections

United States
GMP Endotherapeutics

Completed

Single Dose and 34-Day Tolerance Study of INGAP Peptide in Insulin Deficient Patients

Diabetes Mellitus, Type 2 | Diabetes Mellitus, Type 1

United States
Millennium Pharmaceuticals, Inc.

Terminated

Phase I Dose Escalation Study of VELCADE Plus Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer or Other Solid Tumors

Advanced Non-Small Cell Lung Cancer | Other Solid Tumors
Hoffmann-La Roche

Completed

A Phase IIIB Open-Label, Comparative Study to Evaluate Saquinavir Soft Gel Capsule (SGC) Treatment in Combination With Other Antiretrovirals in HIV-1 Infected Antiretroviral-Naive Patients

HIV Infections

United States
National Center for Research Resources (NCRR)
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

Phase III Randomized, Double-Blind, Placebo-Controlled Study of Antenatal Thyrotropin-Releasing Hormone in Pregnant Women With Threatened Premature Delivery

Respiratory Distress Syndrome
VaxGen

Completed

Effectiveness of an HIV Vaccine in HIV-Negative Adults in North America Who Are at Risk of HIV Infection

HIV Infections | HIV Seronegativity

United States, Canada, Netherlands, Puerto Rico
Eunice Kennedy Shriver National Institute of Child...
Children's Hospital of Philadelphia

Completed

Study of Antenatal Thyrotropin-Releasing Hormone in Women in Premature Labor to Prevent Lung Disease in Preterm Infants

Respiratory Distress Syndrome
Medical Research Laboratories International

Terminated

Implitapide in Patients With Homozygous Familial Hypercholesterolemia (HoFH) on Maximal Concurrent Lipid-Lowering Therapy

Familial Hypercholesterolemia

Israel, Netherlands, United States, Canada, Norway

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