Search clinical trials for: Cytochrome P450 CYP2D6 genotype

Total 7024 results

Pfizer
Medivation, Inc.

Completed

A Phase 1 Trial To Assess The Safety And Pharmacokinetics Of Single, Ascending, Oral Doses Of Dimebon In Healthy Adults

Healthy Volunteers

Belgium
Johns Hopkins University
National Center for Complementary and Integrative Health (NCCIH)

Completed

Pharmacokinetic Interaction Study of Efavirenz and American Ginseng in Healthy Volunteers

Healthy Volunteers

United States
National Taiwan University Hospital

Withdrawn

Efficacy of Type-5 Phosphodiesterase Inhibitors in Primary and Secondary Pulmonary Hypertension

Primary and Secondary Pulmonary Hypertension

Taiwan
BioCryst Pharmaceuticals

Completed

An Open-label Drug-Drug Interaction Study to Evaluate the Effect of BCX7353 on Cytochrome P450 Enzyme Activity Using Probe Substrates

Hereditary Angioedema

United Kingdom
GlaxoSmithKline

Completed

A Study to Investigate the Effect of GSK1605786 on Hepatic Cytochrome P450, and BCRP and OATP1B1 Transport in Healthy Adult Subjects

Crohn's Disease

United States
ArQule, Inc. (a wholly owned subsidiary of Merck...

Completed

A Study of ARQ 197 in Healthy Volunteers to Assess the Pharmacokinetic (PK) Profile in Extensive and Poor Metabolizers as Defined by Cytochrome P450 2C19 (CYP 2C19) Genotype

Healthy

United States
University of British Columbia

Completed

Pharmacokinetics of Oral Morphine and Pharmacogenomics of CYP2D6 and UGT2B7, in an Urban Pediatric Population Presenting for Elective Surgery

Pain

Canada
National Institute of Diabetes and Digestive and...

Completed

The Effect of Thyroid Hormone on Drug Elimination in Cancer Patients

Thyroid Cancer

United States
ViiV Healthcare

Recruiting

A Study to Investigate Safety, Tolerability, and Pharmacokinetics (PK) of VH4524184 and the Potential for Changes in Cytochrome P450 3A (CYP3A) Activity

HIV Infections

United States
SK Life Science, Inc.

Completed

Assess the Influence of Cenobamate on the PK of Cytochrome P450 (CYP) Probe Drugs as a Means of Predicting Drug-drug Interactions

Healthy

United States
Hartford Hospital
Agency for Healthcare Research and Quality (AHRQ)

Unknown

Pharmacogenetic Decision Support IT System for Psychiatric Hospitalization: RCT (CYP-GUIDES)

Major Depressive Disorder

United States
Novartis Pharmaceuticals
Medicines for Malaria Venture

Completed

Drug-drug Interaction Study of Ganaplacide and Lumefantrine With Itraconazole

Malaria

United Kingdom
Bristol-Myers Squibb

Completed

A Study to Investigate the Effects of Cytochrome P450 1A2 Induction by Ritonavir on BMS-986165 Drug Levels and Effects in Healthy Participants

Healthy Participants

United States
NEMA Research, Inc.

Completed

Prevalence of Potential Cytochrome P450 Pharmacokinetic Incident Drug-Drug Interactions Among Chronic Low Back Pain Patients Taking Opioid Analgesics and Associated Economic Outcomes

Chronic Low Back Pain
National Center for Research Resources (NCRR)

Unknown

The Inhibition of Platelet Antiaggregating Activity of Clopidogrel by Atorvastatin Detected by Erythromycin Breath Test: a Metabolic Inhibition of Hepatic Cytochrome P450-3A

Thrombosis | Hypercholesterolemia

United States
Universidade Estadual Paulista Júlio de Mesquita...
University of Sao Paulo

Completed

Influence of Diabetes on Tramadol Pharmacokinetics

Type 2 Diabetes Mellitus | Type 1 Diabetes Mellitus | Neuropathic Pain

Brazil
Eli Lilly and Company

Active, not recruiting

A Maintenance Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 2)

Ulcerative Colitis

Spain, United States, China, Australia, Austria, Japan, Hungary, Taiwan, Russian Federation, Canada, Korea, Republic of, Italy, Belgium, Poland, Switzerland, Argentina, India, Israel, Latvia, Ukraine, Denmark, Mexico, Romania, Malaysia, Netherland... and more
Astellas Pharma Europe B.V.
Medivation, Inc.

Completed

A Study to Evaluate How Daily Dosing With Enzalutamide Affects the Metabolism of Caffeine and Dextromethorphan in Men With Prostate Cancer

Prostate Cancer | Pharmacokinetics of Dextromethorphan | Pharmacokinetics of Caffeine

Moldova, Republic of
University of Florida

Completed

Integrating Pharmacogenomic Testing Into a Child Psychiatry Clinic (PGX)

Obsessive Compulsive Disorder | Anxiety | Major Depressive Disorder

United States
Boehringer Ingelheim

Completed

The Effect of BI 187004 on the Pharmacokinetics of Cytochrome P450 Substrates (Caffeine, Warfarin, Omeprazole, Metoprolol and Midazolam) and a P Glycoprotein Substrate (Digoxin)

Healthy

Germany
Nutrition 21, Inc.

Completed

Efficacy and Safety Study of Chromium Picolinate + Biotin on Glucose and Cholesterol Control in T2DM

Diabetes Mellitus, Type 2
Sunnybrook Health Sciences Centre

Completed

A Genetic and Perfusion Study of Response to Cognitive Enhancers in Lewy Body Disease

Lewy Body Disease

Canada
Tufts University
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Withdrawn

Effect of Ethanol and Genetic Polymorphisms on Bupropion Metabolism

Depression | Alcohol Drinking | Smoking Cessation | Attention Deficit Disorder

United States
Moleac Pte Ltd.
Moleac Australia Pty Ltd

Completed

Drug-Drug Interaction Study of MLC1501 Using Cocktail of Drugs Acting as Sensitive Clinical Probes/Substrates of Cytochrome P450 Isoenzymes and Transporters in Healthy Subjects

Stroke

Australia
University of Guadalajara

Completed

Effect of Aerobic Training and Ginkgo Biloba on Lipids Levels in HIV-positive Patients Undergoing Antiretroviral Treatment

Human Immunodeficiency Virus

Mexico
Amgen

Terminated

Safety and Efficacy of Therapies for Metastatic Castration-resistant Prostate Cancer (mCRPC)

Metastatic Castration-resistant Prostate Cancer

United States, Sweden, Spain, United Kingdom, Australia, Denmark
Celgene

Recruiting

A Study to Evaluate the Effect of Cytochrome P450 (CYP) 3A Inhibitor (Itraconazole) and Inducer (Rifampin) on the Drug Levels of Golcadomide (BMS-986369) in Healthy Participants

Healthy Volunteers

United States
Janssen Research & Development, LLC

Suspended

A Study to Evaluate the Effect of Ustekinumab on Cytochrome P450 Enzyme Activities Following Induction and Maintenance Dosing in Participants With Active Crohn's Disease or Ulcerative Colitis

Crohn Disease | Ulcerative Colitis

Germany, United States, Belgium, United Kingdom
Janssen-Cilag International NV

Completed

A Study in Healthy Participants to Evaluate the Effects of Multiple Doses of JNJ-55308942 on Cytochrome P450 Substrate Activity and on the Pharmacokinetics of Levonorgestrel/Ethinyl Estradiol

Healthy

Belgium
National Cancer Institute (NCI)

Completed

A Phase I/II Trial of BMS-247550 for Treatment of Patients With Recurrent High-Grade Gliomas

Adult Anaplastic Astrocytoma | Adult Giant Cell Glioblastoma | Adult Gliosarcoma | Recurrent Adult Brain Tumor

United States
Thomas Jefferson University
Bristol-Myers Squibb

Completed

Drug Interaction Study of Apixaban With Cyclosporine and Tacrolimus (ACT)

Healthy | Venous Thromboembolism | Pharmacokinetics

United States
Aragon Pharmaceuticals, Inc.

Recruiting

A Study to Evaluate the Effect of Multiple Doses of JNJ-56021927 on the Pharmacokinetics of Multiple Cytochrome P450 and Transporter Substrates in Participants With Castration-Resistant Prostate Cancer

Prostatic Neoplasms, Castration-Resistant

Moldova, Republic of, Spain
Novartis Pharmaceuticals

Completed

Pharmacokinetic, Safety, and Efficacy Effects of Oral LBH589 on Dextromethorphan in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer or Malignant Pleural Mesothelioma

Carcinoma, Non-Small-Cell Lung | Mesothelioma

United States, Canada
Genuine Research Center, Egypt
Eva Pharma

Completed

Bioequivalence Study of Ivermectin From Revemact 6 mg Tablets (Man. by EVA Pharma for Horus for Pharmaceutical Industries, Egypt) and Stromectol 2*3 mg Tablets (Merck Sharp & Dohme B.V., Haarlem, The Netherlands)

Healthy

Egypt
Merck KGaA, Darmstadt, Germany

Completed

A Prospective, Multi-centric Observational Study to Determine the Mono-bifollicular Development in Infertile Women Subjected to Ovulation Induction With Follitropin α (P450)

Ovulation Induction

Spain
National Institute of Environmental Health Sciences...

Completed

Blood Vessel Study

Cardiovascular Disease

United States
Medco Health Solutions, Inc.
Mayo Clinic; International Business Machines (IBM); Laboratory Corporation of... and other collaborators

Completed

The Clinical and Economic Impact of Pharmacogenomic Testing for Tamoxifen Metabolism in Postmenopausal Women Receiving Tamoxifen for Prevention of Recurrent Breast Cancer (MHSLabCorp1)

Breast Neoplasms | Tamoxifen

United States
Holland Bloorview Kids Rehabilitation Hospital
The Hospital for Sick Children

Enrolling by invitation

Fluoxetine in KCNC1-related Disorder

Rare Diseases | Genetic Disease | KCNC1 Related Disorder

Canada
Nantes University Hospital

Completed

OPAL: "Opiates and PhArmacoLogy" (OPAL)

Substance Use Disorder

France
Theravance Biopharma

Completed

A Fixed-Sequence, Two-Period, Open-Label Drug-Drug Interaction Study to Assess the Effect of an Inhibitor of Cytochrome P450 Isoenzyme 3A4 and Permeability Glycoprotein 1 on the Pharmacokinetics of TD-1211

Healthy

United States
University of Texas Southwestern Medical Center

Completed

Fluoxetine in Pulmonary Arterial Hypertension (PAH) Trial (PAH)

Pulmonary Arterial Hypertension

United States
National Cancer Institute (NCI)

Active, not recruiting

Endoxifen in Adults With Hormone Receptor Positive Solid Tumors

Hormone Receptor-Positive Breast | Gynecologic | Desmoid | Hormone Receptor-Positive Neoplasms

United States
VA Office of Research and Development

Completed

Monoamine Transporters Genotypes: Risk of PTSD and Related Comorbidities (MTG)

PTSD

United States
Boston University
National Institute of Mental Health (NIMH)

Completed

Fluoxetine vs EMDR to Treat Post-Traumatic Stress Disorder (PTSD)

Stress Disorders, Post-Traumatic

United States
National Institute of Mental Health (NIMH)
Icahn School of Medicine at Mount Sinai

Completed

Study of Fluoxetine in Patients With Depersonalization Disorder

Depersonalization Disorder

United States
University of Turku
KELA; Finnish State Grant

Completed

Fluoxetine vs. Brief Psychotherapy for Major Depression

Major Depressive Disorder
Amgen

Completed

Safety, Tolerability, Pharmacokinetics, and Efficacy of Acapatamab in Subjects With mCRPC

Prostate Cancer | Metastatic Castration-resistant Prostate Cancer

United States, Belgium, Austria, Singapore, Australia, Netherlands, France, Japan, Taiwan, Canada
Vanderbilt University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

Hypoglycemia Associated Autonomic Failure in Type 1 DM

Type 1 Diabetes

United States
Roseli Shavitt
University of Pernambuco

Completed

Developing Adaptive Treatment Strategies for Children and Adolescents With Obsessive-compulsive Disorder. (SMART)

Obsessive-Compulsive Disorder

Brazil
University of Pittsburgh
National Institute of Mental Health (NIMH)

Completed

PET Imaging Study of Recovered Anorexics

Anorexia Nervosa

United States

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