Search clinical trials for: Phase 2a: Multiple solid tumor types

Total 61461 results

ANRS, Emerging Infectious Diseases
Bristol-Myers Squibb

Completed

Pilot Study to Assess the Efficacy of and Tolerance to a QUadruple Therapy to Treat HIV-HCV Coinfected Patients Previously Null Responders (QUADRIH)

HCV-HIV Co-Infection

France
State University of New York - Downstate Medical...

Recruiting

Phase 2A Pilot C3 Trial of Recurrent/Refractory Metastatic Advanced Pancreatic Cancer (C3)

Pancreatic Cancer Metastatic

United States
Hoffmann-La Roche

Completed

A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) Plus Ribavirin in Hemophiliac Patients With Chronic Hepatitis C.

Hepatitis C, Chronic

Mexico
Heuron Inc.

Completed

Evaluation of Clinical Decision Support System for Large Vessel Occlusion Using Brain CT Images

Ischemic Stroke

Korea, Republic of
Indiana University
Indiana University School of Medicine

Withdrawn

SABR for T1-2a N1 NSCLC

Lung Cancer

United States
Prof. Facchinetti Fabio
Merck Sharp & Dohme LLC

Completed

Menopause is a Critical Factor in Determining Failure of Antiviral Therapy in Women With Chronic Hepatitis C (MEN_EPID)

Chronic Hepatitis C

Italy
Vir Biotechnology, Inc.
Alnylam Pharmaceuticals

Active, not recruiting

Study of VIR-2218 With or Without Pegylated Interferon Alpha-2a for Treatment of Chronic Hepatitis B Virus Infection

Chronic Hepatitis B

Australia, Hong Kong, Korea, Republic of, Malaysia, New Zealand, Thailand
Janssen R&D Ireland

Completed

An Efficacy, Safety, and Tolerability Study of TMC435 in Treatment-naive, Genotype 1 Hepatitis C-infected Patients (QUEST-1)

Hepatitis C

United States, Australia, Ukraine, United Kingdom, Germany, Spain, Mexico, Canada, New Zealand, Russian Federation, Puerto Rico, Romania
National Institute of Diabetes and Digestive and...

Completed

Entecavir/Pegylated Interferon in Immune Tolerant Children With Chronic Hepatitis B Virus (HBV) Infection

Hepatitis B

United States, Canada
Hanlim Pharm. Co., Ltd.

Unknown

Phase 2a Clinical Trial of HL237 for Rheumatoid Arthritis

Rheumatoid Arthritis

Korea, Republic of
Hoffmann-La Roche

Completed

HELPS Study - A Study of Peginterferon Alfa-2a (Pegasys) in Patients With Chronic Hepatitis C (CHC) and End-Stage Renal Disease (ESRD)

Hepatitis C, Chronic

France, Greece, Austria, Turkey, United Arab Emirates, Brazil, Italy, Indonesia
Basilea Pharmaceutica

Completed

Phase 1/2a Study of BAL101553 as 48-hour Infusions in Patients With Advanced Solid Tumors or Recurrent Glioblastoma

Neoplasms

Switzerland
Janssen-Cilag International NV

Completed

An Efficacy and Safety Study of Telaprevir in Patients Infected With Both Chronic Hepatitis C Virus (HCV-1) and Human Immunodeficiency Virus (HIV-1) (INSIGHT)

Chronic Hepatitis C

Australia, France, United Kingdom, Spain, Russian Federation, Brazil, Poland, Sweden
French National Agency for Research on AIDS and...
Hoffmann-La Roche; InterMune

Completed

Interferon Gamma With Peg-Interferon Alpha 2a and Ribavirin in Non Responders Patients With Chronic Hepatitis C

Hepatitis C, Chronic

France
Basilea Pharmaceutica

Completed

Phase 1/2a Study of Oral BAL101553 in Adult Patients With Solid Tumors or Glioblastoma or High-grade Glioma

Neoplasms

Belgium, United Kingdom, Germany, Switzerland
Third Affiliated Hospital, Sun Yat-Sen University
Peking University; Huazhong University of Science and Technology; First People... and other collaborators

Unknown

HBsAg Loss/Seroconversion in Low Replicative Chronic Hepatitis B Virus(HBV) Infection Patients

Chronic Hepatitis B

China
Third Affiliated Hospital, Sun Yat-Sen University
Peking University; Huazhong University of Science and Technology; First People... and other collaborators

Unknown

The Optimizing Treatment of Peginterferon (PEG IFN) Alpha in Chronic Hepatitis B Virus Patients With Low Level HBsAg

Chronic Hepatitis B

China
Hoffmann-La Roche

Completed

PROPHESYS 3: Observational Study on Predictors of Response in Patients With Treatment-naïve Chronic Hepatitis C Initiated on Treatment With Pegasys (Peginterferon Alfa-2a) or Peginterferon-alfa-2b

Hepatitis C, Chronic

United States, Puerto Rico
Hoffmann-La Roche

Completed

A Study of Combination Treatment With Peginterferon Alfa-2a (Pegasys) Plus Ribavirin (Copegus) in Participants With Chronic Hepatitis C

Hepatitis C, Chronic

Czechia, Slovakia
University of Vermont

Withdrawn

Peginterferon and Ribavirin, With or Without Telaprevir, for Genotype 1 Hepatitis C and IL28B CC Polymorphism

Hepatitis C

United States
Hoffmann-La Roche

Completed

A Study of Sustained Virological Response in Relation to IL28-b Expression in Treatment-Naïve Patients With Chronic Hepatitis C Genotype 1 on Combination Treatment With Pegasys (Peginterferon Alfa-2a) and Copegus (Ribavirin)

Hepatitis C, Chronic

Brazil
Janssen R&D Ireland

Completed

A Study to Assess the Safety, Tolerability and Efficacy of TMC435 Along With Pegylated Interferon Alpha-2a (Pegasys) and Ribavirin (Copegus) Triple Therapy in Chronic Hepatitis C Genotype-1 Infected Patients Co-infected With Human Immunodeficiency Virus-Type 1

Hepatitis C Virus Genotype-1

United States, France, United Kingdom, Germany, Spain, Portugal, Canada, Puerto Rico
The Wistar Institute
National Institute of Allergy and Infectious Diseases (NIAID); Hoffmann-La... and other collaborators

Completed

Antiviral Activity of Peg-IFN-Alpha-2A in Chronic HIV-1 Infection

HIV Infections

United States
Hoffmann-La Roche

Completed

A Study to Collect Blood Biomarker Samples From Participants With Chronic Hepatitis B (CHB) Who Received Treatment With Pegasys (Peginterferon Alfa-2a) ± Nucleoside/Nucleotide Analogue

Hepatitis B, Chronic

Thailand, China, Italy, United Kingdom, Korea, Republic of, Taiwan, Austria, Bulgaria, Germany, New Zealand, France, Poland, Portugal, Romania, Greece
Henan Provincial People's Hospital

Unknown

A Study to Evaluate Addition of Peginterferon Alfa-2a to Chronic Hepatitis B (CHB) Patients Treated With NAs

Chronic Hepatitis B

China
Hoffmann-La Roche

Completed

A Study of Peginterferon Alfa-2a (Pegasys) and Ribavirin (Copegus) Combination Therapy in Participants With Chronic Hepatitis C (CHC) and Various Degrees of Renal Impairment

Hepatitis C, Chronic

Sweden, New Zealand, United States, France, Brazil
Hoffmann-La Roche

Completed

POTENTE Study: A Study of Early Virological Response in Naive Patients With Chronic Hepatitis C, Genotype 2 or 3, Treated With PEGASYS (Peginterferon Alfa-2a (40KD)) Plus Copegus (Ribavirin).

Hepatitis C, Chronic

Brazil
Hoffmann-La Roche

Completed

PROPHESYS 2: An Observational Study on Predictors of Response in Treatment-naïve Patients With Chronic Hepatitis C Treated With Pegasys (Peginterferon Alfa-2a) or Peginterferon-alfa-2b

Hepatitis C, Chronic

Belgium, Ireland, Italy, United Kingdom
IRCCS San Raffaele
Hoffmann-La Roche; Abbott

Unknown

Lopinavir/Ritonavir Monotherapy Versus Standard Highly Active Antiretroviral Therapy (HAART) in HIV/HCV Coinfected Patients Starting Treatment With Anti-Hepatitis C Virus (HCV) Therapy

HIV Infections | Hepatitis C

Italy
Servier Bio-Innovation LLC
Institut de Recherches Internationales Servier

Recruiting

S095035 in Adult Participants With Advanced or Metastatic Solid Tumors With Deletion of the Methylthioadenosine Phosphorylase (MTAP) Gene

MTAP-deleted Solid Tumors

Australia, United States
Pfizer

Completed

A Trial In Diabetic Patients To Assess Effect Of CE-326,597 On Glucose Control And Body Weight

Weight Management | Treatment Of Obesity

Canada, United States, Bulgaria, Spain, Mexico, India, Puerto Rico
Janssen Pharmaceutical K.K.

Completed

A Study to Assess the Effectiveness, Safety, and Pharmacokinetics of TMC435 in Combination With Peginterferon Alfa-2a and Ribavirin in Hepatitis-C Infected Patients (DRAGON)

Hepatitis C, Chronic

Japan
Eli Lilly and Company
Rigel Pharmaceuticals

Recruiting

An Adaptive Phase 2a/2b Study of LY3871801 in Adult Participants With Rheumatoid Arthritis

Rheumatoid Arthritis

United States, France, United Kingdom, Argentina, Mexico, India, Czechia, Germany, Slovakia
Joel Neal

Terminated

Phase 2a Desipramine in Small Cell Lung Cancer and Other High-Grade Neuroendocrine Tumors

Neuroendocrine Tumors | Small Cell Lung Cancer (SCLC)

United States
Ohio State University
ACADIA Pharmaceuticals Inc.

Not yet recruiting

Pimavanserin and Aggression and Social Cognition.

Intermittent Explosive Disorder

United States
H. Lee Moffitt Cancer Center and Research Institute
San Diego State University; University of Minnesota; University of Arizona

Completed

Emotional Support Messages Following a Cancer Diagnosis

Anxiety | Psychological Stress

United States
Ardea Biosciences, Inc.

Completed

Phase 2a RDEA3170 and Allopurinol Combination Study in Gout Subjects

Gout

United States
Bristol-Myers Squibb

Completed

Study of BMS-650032 With Peginterferon Alfa-2a Plus Ribavirin

Hepatitis C Virus

France, Spain, United Kingdom, United States, Germany, Italy, Argentina, Ireland
Ironwood Pharmaceuticals, Inc.

Terminated

Phase 2a Study of IW-9179 to Treat Functional Dyspepsia

Dyspepsia | Functional Gastrointestinal Disorders

Belgium, Netherlands
Hoffmann-La Roche

Completed

A Study of Peginterferon Alfa-2a (Pegasys) When Administered in Combination With Ribavirin in Patients With Chronic Hepatitis C (CHC)

Hepatitis C, Chronic

Austria
Jacobio Pharmaceuticals Co., Ltd.

Recruiting

Phase 1/2a Study of JAB-21822 Plus JAB-3312 in Patients With Advanced Solid Tumors Harboring KRAS p.G12C Mutation

Colorectal Cancer | Non-small Cell Lung Cancer | Pancreatic Ductal Carcinoma | KRAS P.G12C

China
Vertex Pharmaceuticals Incorporated
ViroChem Pharma

Completed

Pharmacokinetics of Multiple Ascending Doses of VCH-222 in Subjects With Chronic Hepatitis C Infection

Hepatitis C

Canada, United States, Argentina, Puerto Rico
Aspen Neuroscience
California Institute for Regenerative Medicine (CIRM)

Enrolling by invitation

Phase 1/2a Study of ANPD001 in Parkinson Disease (ASPIRO)

Parkinson Disease

United States
Hepagene (Shanghai) Co., Ltd.

Active, not recruiting

Phase 2a Study of HPG1860 in Subjects With NASH (RISE)

NASH - Nonalcoholic Steatohepatitis

United States
Foundation for Liver Research

Completed

48 Weeks Combination Therapy for Patients With HBeAg-negative Chronic Hepatitis B Virus (HBV) Infection

Hepatitis B

Netherlands
Candel Therapeutics, Inc.

Completed

Phase 2a Study of CAN-2409 With Standard Radiation Therapy for Malignant Glioma (BrTK02)

Glioblastoma Multiforme | High Grade Glioma | Malignant Glioma | Anaplastic Astrocytoma

United States
LimmaTech Biologics AG
Wellcome Trust; Naval Medical Research Center

Completed

Safety and Tolerability of a Bioconjugate Vaccine Against Shigella Flexneri 2a

Shigellosis

United States
Chinese University of Hong Kong

Completed

An Open-label Trial of 48-week Peginterferon Alfa-2a (PEGASYS) to Assess the Sustained Response of Chronic Hepatitis B Patients With HBeAg Seroconversion on Nucleot(s)Ide Analogue Therapy

Chronic Hepaititis B

Hong Kong
Hutchison Medipharma Limited
Sun Yat-sen University; Fudan University

Completed

A Phase Ib Study of Fruquintinib in 3rd Line mCRC

Colorectal Cancer

China
Oramed, Ltd.
Integrium

Completed

A Prospective, Randomized, Double-blind, Placebo Controlled Study to Assess the Impact of ORMD-0801 (Insulin Capsules) on the Exogenous Insulin Requirements of Type 1 Diabetics

Diabetes Mellitus Type 1

United States

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