Search clinical trials for: To determine whether lixivaptan administration at supratherapeutic or therapeutic doses results in t

Total 498735 results

Istanbul University - Cerrahpasa (IUC)

Completed

Superselective Intra-arterial Chemotherapy Treatment for Retinoblastoma- 5 Year Results From Turkey

Retinoblastoma

Turkey
Ohio State University Comprehensive Cancer Center

Completed

Light Sedation or Intubated General Anesthesia in Patients With Brain Cancer Undergoing Craniotomy

Adult Brain Tumor

United States
Centrexion Therapeutics

Completed

The Effect of Injection Site Cooling on Pain Experienced After the Administration of CNTX-4975-05 Into the Knee

Osteoarthritis, Knee

United Kingdom
Pfizer

Terminated

A Four-Way Cross-Over Study To Compare The Plasma Concentrations Of PF-02413873 After Oral Administration Of Several Doses As Suspension And As Tablets.

Healthy

Singapore
Akebia Therapeutics

Completed

Effect of AKB-6548 on Cardiac Repolarization Intervals in Healthy Volunteers

Healthy Volunteers

United States
Medical University of Warsaw

Completed

Liver Function After Intravenous Methylprednisolone Administration

Liver Diseases | Liver Failure | Graves Ophthalmopathy | Graves Disease | Acute Liver Failure | Acute Liver Injury | Liver Dysfunction | Glucocorticoids Toxicity | Liver Injury | Liver Insufficiency | Acute Liver Injury, Drug Induced | Methylprednisolone Adverse Reaction | Dysthyroid Orbitopathy | Dysthyroid Ophthalmopathy
Gilead Sciences

Completed

Gilead Sustained Virologic Response (SVR) Registry

Hepatitis C, Chronic

United States, Spain, Netherlands, France, Australia, Canada, Italy, Germany, New Zealand, Belgium, Sweden, United Kingdom, Estonia, Puerto Rico, Austria, Poland, Czechia
Cognoptix, Inc.

Unknown

Aftobetin-HCl and Fluorescence Detection Measured by Sapphire II to Determine the Number and Timing of Administrations

Mild Cognitive Impairment | Alzheimer's Disease

United States
Boehringer Ingelheim

Completed

Evaluation of Dual Therapy With Dabigatran vs. Triple Therapy With Warfarin in Patients With AF That Undergo a PCI With Stenting (REDUAL-PCI)

Atrial Fibrillation | Percutaneous Coronary Intervention

Canada, United States, Spain, Korea, Republic of, Australia, Germany, Taiwan, Hong Kong, Thailand, United Kingdom, Turkey, Netherlands, Ireland, Hungary, Croatia, Colombia, Israel, Singapore, Italy, New Zealand, Greece, Mexico, Norway, Swed... and more
Edge Therapeutics Inc

Terminated

Safety/Pharmacokinetic Study Comparing Intracisternal EG-1962 to Standard of Care Enteral Nimodipine in Adults With aSAH

Subarachnoid Hemorrhage, Aneurysmal

United States, Canada
Sidney Kimmel Comprehensive Cancer Center at Johns...
National Cancer Institute (NCI); National Institutes of Health (NIH)

Completed

Therapeutic Vaccination for Patients With HPV16+ Cervical Intraepithelial Neoplasia (CIN2/3)

HPV16 Positive | Cervical Intraepithelial Neoplasia (CIN 2/3)

United States
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Completed

Healing Touch or Guided Imagery In Treating Pain, Fatigue, Nausea, and Anxiety in Patients Undergoing Chemotherapy

Pain | Fatigue | Malignant Neoplasm | Anxiety Disorder | Nausea and Vomiting

United States
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Completed

Measuring Stress in Women With Newly Diagnosed Stage I, Stage II, or Stage III Breast Cancer or Ductal Carcinoma In Situ of the Breast

Depression | Breast Cancer | Anxiety Disorder | Psychosocial Effects of Cancer and Its Treatment

United States
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Completed

Massage Therapy Given by Caregiver in Treating Quality of Life of Young Patients Undergoing Treatment for Cancer

Unspecified Childhood Solid Tumor, Protocol Specific | Primary Myelofibrosis | Polycythemia Vera | Essential Thrombocythemia | Stage I Multiple Myeloma | Stage II Multiple Myeloma | Stage III Multiple Myeloma | Chronic Myelomonocytic Leukemia | Juvenile Myelomonocytic Leukemia | Burkitt Lymphoma | Secondary... and other conditions

United States
Bristol-Myers Squibb
Pfizer

Completed

A Phase III Study of Apixaban in Patients With Atrial Fibrillation (AVERROES)

Atrial Fibrillation

Australia, China, France, Germany, India, Korea, Republic of, Poland, Russian Federation, Sweden, United States, Hong Kong, Spain, Argentina, Brazil, Canada, Mexico, Colombia, South Africa, Austria, Belgium, Israel, Singapore, Taiwan, Ital... and more
Melinta Therapeutics, Inc.
Department of Health and Human Services

Completed

Efficacy/Safety of Meropenem-Vaborbactam Compared to Piperacillin-Tazobactam in Adults With cUTI and AP

Acute Pyelonephritis | Urinary Tract Infection Complicated

Italy, Spain, Greece, Peru, United States, Bulgaria, Slovenia, Hungary, Romania, Brazil, Slovakia, Czechia, Ukraine, Taiwan, Belarus, Poland, Korea, Republic of
Corcept Therapeutics

Completed

Study in Healthy Subjects to Determine the Effect of Relacorilant on Exposure to Probe Substrates for Cytochrome P450s

Healthy

United States
Gilead Sciences

Completed

A Gilead Sequence Registry of Subjects Who Did Not Achieve Sustained Virologic Response

Hepatitis C, Chronic

United States, Spain, Australia, Netherlands, Italy, New Zealand, Germany, United Kingdom, France, Sweden, Canada, Estonia, Poland, Puerto Rico, Austria, Czechia
University of Pittsburgh
Health Resources and Services Administration (HRSA)

Completed

Monitoring Organ Donors to Increase Transplantation Results (MOnIToR) (MOnIToR)

Transplantation

United States
St Stephens Aids Trust
Bristol-Myers Squibb

Terminated

Pharmacokinetic Effect of Evotaz/Microgynon Co-administration

HIV

United Kingdom
Wake Forest University Health Sciences

Withdrawn

Phenylephrine Dose and Mode of Administration for Spinal Anesthesia Induced Hypotension

Complications; Cesarean Section | Spinal Anesthetics Causing Adverse Effects in Therapeutic Use

United States
Galapagos NV
MorphoSys AG

Completed

First in Human of Single and Multiple Doses of MOR106

Healthy | Dermatitis, Atopic

Belgium, Hungary, Moldova, Republic of, Romania
Avalo Therapeutics, Inc.

Completed

A Study of Intermittent Doses of CERC-301 in MDD

Major Depressive Disorder

United States
Hasan Kalyoncu University

Completed

The Purpose of This Study Was to Determine Whether or Not Functional Training Has Similar Effects on Muscular Strength, Flexibility, Agility, Speed and Anthropometric Measures in Basketball Players as Traditional Resistance Training

Exercise | Basketball
Laboratoire de la Mer

Completed

RESPIMER® Netiflow® vs. Saline Solutions During Nasal Irrigation Following Bilateral Ethmoidectomy (Nasal Polyposis) (NETIFLOW)

Surgery | Polyp of Ethmoidal Sinus

France
EMD Serono

Withdrawn

Determine if Either of 2 Doses of Study Drug Given With a Low-dose of Cyclophosphamide After a Complete or Partial Response to a Platinum-based Second-line Therapy in Women With Recurrent Ovarian Carcinoma Results in a Longer Time to Progression When Compared to the First Time to Progression.

Ovarian Cancer
Merck KGaA, Darmstadt, Germany

Completed

A Study to Determine the Safety, Tolerability, Pharmacokinetics and Dynamic Effects of Different Doses of the Study Drug EMD 525797 in Prostate Cancer

Prostate Cancer | Bone Metastases

Belgium, Germany
CHU de Reims

Completed

Children Toxine Botulinum Detrusor Injection in Neurogenic Vesical Hyperactivity Syndrom: Non Inferiority Multicenter Controlled Therapeutic Study Between Two Reported Weight's Doses (TBIDE)

Neurogenic Vesical Hyperactivity Syndrom

France
GlaxoSmithKline

Completed

Study to Determine the Effect of Repeated Administration of Diltiazem on the Pharmacokinetics of Darapladib (Sb-480848).

Atherosclerosis

United States
GlaxoSmithKline

Terminated

A First Time in Human Study to Assess the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of Single and Repeat Doses of GSK2485852 in Chronically Infected Hepatitis C Subjects

Hepatitis C

United States
Yale University
National Institute on Drug Abuse (NIDA); National Alliance for Research on...

Completed

Yale Pink and Blue Kids: Effects of Exposure During Pregnancy to Nicotine or Antidepressants in 4-8 Year Old Children (PABKids)

Behavioral Problems | Cognitive Problems | Motor Development

United States
Gynecologic Oncology Group
National Cancer Institute (NCI)

Unknown

Lymphedema After Surgery in Patients With Endometrial Cancer, Cervical Cancer, or Vulvar Cancer (LEG)

Lymphedema | Stage II Uterine Corpus Cancer | Stage IVB Vulvar Cancer | Stage IA Uterine Corpus Cancer | Stage IB Uterine Corpus Cancer | Stage IA Cervical Cancer | Stage IB Cervical Cancer | Stage II Vulvar Cancer | Stage IIA Cervical Cancer | Stage IA Vulvar Cancer | Stage IB Vulvar Cancer | Stage IIIA Vulvar... and other conditions

United States
GlaxoSmithKline

Completed

To Test 2 Doses of GSK Biologicals' Oral Live Attenuated Human Rotavirus (HRV) Vaccine in Healthy Infants in Co-administration With Specific Childhood Vaccines

Infections, Rotavirus

Finland, Germany, Spain, Italy, France, Czech Republic
Johnson & Johnson Consumer Inc. (J&JCI)

Completed

Trial to Determine the Therapeutic Benefit of an OTC Cream on Dry, Itchy Skin of Adults and Children With Eczema

Atopic Dermatitis

United States
Allergy Therapeutics
Inflamax Research Incorporated; Metronomia Clinical Research GMBH

Completed

A Study of Tolerability and Safety of Two New Doses of Grass MATA MPL

Allergic Rhinitis

United States
GlaxoSmithKline
PATH

Completed

A Study to Investigate the Safety and Pharmacodynamics of Repeat Intranasal Administration of the TLR7 Agonist GSK2245035 in Subjects With Respiratory Allergies

Asthma and Rhinitis

Canada
BioMarin Pharmaceutical

Terminated

A Phase I/II, Open Label, Escalating Dose, Pilot Study to Assess Effect, Safety, Tolerability and PK of Multiple SC Doses of Drisapersen in Patients With Duchenne Muscular Dystrophy and to Assess the Potential for IV Dosing as an Alternative Route of Administration

Muscular Dystrophies
Hoffmann-La Roche

Completed

A Two-part, Single-dose, Randomized Study to Evaluate the Safety of Supra-therapeutic Doses of RO7033877 and to Investigate the Effect of RO7033877 on the QTc Interval

Healthy Volunteer

United States
Mast Therapeutics, Inc.

Completed

Evaluation of Repeat Administration of Purified Poloxamer 188 (EPIC-E)

Sickle Cell Disease

United States
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

Measure Liver Fat Content After ISIS 301012 (Mipomersen) Administration

Metabolic Diseases | Congenital Abnormalities | Infant, Newborn, Diseases | Genetic Diseases, Inborn | Dyslipidemias | Metabolism, Inborn Errors | Lipid Metabolism Disorders | Hypercholesterolemia | Hyperlipidemias | Lipid Metabolism, Inborn Errors | Hypobetalipoproteinemias | Hypolipoproteinemias | Hypolipopro... and other conditions

Netherlands
Atopix Therapeutics, Ltd.
Simbec Research

Completed

First in Man Evaluation of Single and Multiple Doses of Oral ATX2417

Allergy

United Kingdom
Ohio State University

Completed

Study to Determine Whether There Are Any Cognitive or Motor Effects From Taking the Medicine Risperidone.

Bipolar Disorder | Conduct Disorder | Oppositional Defiant Disorder | Adjustment Disorder | Pervasive Developmental Disorder | Attention Deficit/Hyperactivity Disorder (ADHD) | Intermittent Explosive Disorder | Impulse-Control Disorders

United States
BIND Therapeutics

Completed

A Phase 2 Study to Determine the Safety and Efficacy of BIND-014 (Docetaxel Nanoparticles for Injectable Suspension) as Second-line Therapy to Patients With Non-Small Cell Lung Cancer

Non-small Cell Lung Cancer

United States, Russian Federation
Baylor College of Medicine

Terminated

Intraoperative Methadone vs Morphine for Postoperative Pain Control in Patients Undergoing Surgery of the Tibia

Pain, Postoperative

United States
The Facial Surgery Research Foundation

Unknown

Neck Surgery in Treating Patients With Early-Stage Oral Cancer

Head and Neck Cancer

United Kingdom
Merck Sharp & Dohme LLC

Completed

A Study to Determine the Efficacy and Safety of 2 Doses of Org 34517 as Adjunctive Therapy in Subjects With Psychotic Major Depression (28130)(P05845) (Hermes)

Depression | Psychotic Disorders | Depressive Disorders
Memorial Sloan Kettering Cancer Center
Ascenta Therapeutics

Terminated

Erlotinib and AT-101 in Advanced Non-Small Cell Lung Cancer (NSCLC) Patients With Epidermal Growth Factor Receptor (EGFR) Activating Mutations

Lung Cancer

United States
Merck Sharp & Dohme LLC

Completed

A Study of MK-0893 on Glucagon-Induced Glycemic Excursion in Healthy Male Participants Following Intravenous Administration of Glucagon, Sandostatine® and Insulin (MK-0893-002)

Type 2 Diabetes Mellitus
Attikon Hospital

Completed

The Effect of Administration of Small Doses of Thyroxine on Glucose and Lipid Metabolism, in Type 2 Diabetes Mellitus.

Diabetes Mellitus
Immunomic Therapeutics, Inc.

Completed

A Safety and Immunogenicity Phase IC Study of CryJ2 -DNA-LAMP Plasmid Vaccine for Assessment of Intradermal (ID) Route of Administration Using the Biojector 2000 Device

Allergic Rhinitis

United States

Search clinical trials for: To determine whether lixivaptan administration at supratherapeutic or therapeutic doses results in t

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