Search clinical trials for: Somatic mutation

Total 3527 results

GlaxoSmithKline

Completed

Japan PhI/II of GSK2118436 and GSK1120212 Combination in Subjects With BRAF V600E/K Mutation Positive Advanced Solid Tumors (Phase I Part) or Cutaneous Melanoma (Phase II Part)

Solid Tumours

Japan
University Hospital, Caen

Completed

Prediction of Femoral Revascularization Quality Using the Somatic NIRS Signal (TEA-NIRS)

Lower Limb Vascular Surgery - Femoral Artery Endarteriectomy

France
Taipei Veterans General Hospital, Taiwan
Sanofi

Unknown

Natural History in Fabry Patients With IVS4+919G>A Mutation

Fabry Disease, Cardiac Variant
University of British Columbia
Rare Disease Foundation, Vancouver, Canada

Completed

Energy Requirements in Mitochondrial Disease

Mitochondrial Disease | Chronic Metabolic Disorder

Canada
Pfizer

Completed

A Study Of Dacomitinib (PF-00299804) In Patients With Advanced Non-Small Cell Lung Cancer

Non-small Cell Lung Cancer

Korea, Republic of, United States
Rabin Medical Center

Unknown

The Link Between BRCA Mutation and Endothelial Function

BRCA1 Gene Mutation | BRCA2 Gene Mutation

Israel
Centre Francois Baclesse
Hoffmann-La Roche; Groupe Français de Pneumo-Cancérologie

Terminated

A Multicenter Randomized Phase III Study Comparing Second-line Treatment With Chemotherapy Associated or Not to Erlotinib in NSCLC Patients With Secondary Resistance to TKI-EGFR (FLARE)

NSCLC Patients With EGFR Activating Mutation

France
University of Aarhus

Completed

Detection of BRAF Mutation on FNAB From Papillary Thyroid Carcinoma

Papillary Thyroid Carcinoma

Denmark
Gynecologic Oncology Group
National Cancer Institute (NCI)

Withdrawn

Breast Cancer Risk in Women Who Are BRCA1/BRCA2 Mutation Carriers

Breast Carcinoma | BRCA1 Mutation Carrier | BRCA2 Mutation Carrier

United States
Astellas Pharma Global Development, Inc.

Withdrawn

A Study for Subjects Who Are Participating in an Astellas-sponsored ASP8273 Study

Subjects With NSCLC With an EGFR Activating Mutation
National Institute of Allergy and Infectious Diseases...

Completed

Collection of Blood From Persons With Hemoglobin and Erythrocyte Polymorphisms for Laboratory Malaria Research

Hemoglobin Mutations | Erythrocyte Variants

United States
National Institute of Neurological Disorders and...

Completed

Study of Abnormal Blood Clotting in Children With Stroke

Cerebrovascular Accident | Blood Coagulation Disorder | Abnormalities | Vascular Disease | Brain Disease

United States
National Institute of Neurological Disorders and...

Completed

Timing of Voluntary Movement in Patients With Schizophrenia

Schizophrenia

United States
National Human Genome Research Institute (NHGRI)

Completed

Molecular Analysis of Microphthalmia/Anophthalmia

Anophthalmos

United States
National Institute of Environmental Health Sciences...

Completed

Estrogen Receptor Gene Mutations

Hormones | Mutations

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Identification of Genes Associated With Lung Disease in Patients With Rheumatoid Arthritis

Healthy | Rheumatoid Arthritis | Pulmonary Fibrosis

United States
National Institute of Environmental Health Sciences...

Completed

Prevalence of a Non-Expressing 11B Mutation in Aka Peoples of the Central African Republic

Zinc Fingers Proteins

United States, Central African Republic
National Human Genome Research Institute (NHGRI)

Completed

Gene Analysis of Parkinson's Disease

Parkinson's Disease

United States
National Cancer Institute (NCI)

Completed

Safety Study of ABT-888 Plus Topotecan Hydrochloride to Treat Patients With Solid Tumors and Lymphomas

Solid Tumors | Lymphomas

United States
National Human Genome Research Institute (NHGRI)

Completed

Genetic Analysis of Oculocerebrorenal Syndrome of Lowe

Lowe Syndrome

United States
Hospital General de Mexico

Unknown

IDH1/IDH2 Mutation Frequency in Acute Myeloblastic Patients

Acute Myeloid Leukemia (AML)

Mexico
National Eye Institute (NEI)

Completed

Investigating Age-Related Macular Degeneration

Age-Related Macular Degeneration

United States
National Institute of Dental and Craniofacial Research...

Completed

Studies on Abnormal Bone From Patients With Polyostotic Fibrous Dysplasia and McCune Albright Syndrome

Polyostotic Fibrous Dysplasia

United States
Mansoura University

Completed

A Randomized Controlled Trial Evaluating Sildenafil Citrate in Relieving Ureteral Stent Related Symptoms

Quality of Life

Egypt
Sheba Medical Center

Unknown

The Effect of ß-cell Specific Glucokinase Mutation on Glucose Homeostasis and Insulin Secretion in a MODY-2 Family

MODY-2 Diabetes

Israel
Vertex Pharmaceuticals Incorporated

Completed

Study of Lumacaftor in Combination With Ivacaftor in Subjects 6 Through 11 Years of Age With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation

Cystic Fibrosis

United States, Canada
Weill Medical College of Cornell University
Muscular Dystrophy Association

Completed

SOD1 Inhibition by Pyrimethamine in Familial Amyotrophic Lateral Sclerosis (ALS)

Familial Amyotrophic Lateral Sclerosis

United States, Germany, Italy, Sweden
Institute of Cancer Research, United Kingdom
Royal Marsden NHS Foundation Trust

Completed

A Trial Looking at Nilotinib to Treat Acral and Mucosal Melanoma Skin Cancer That Has Spread (NICAM)

Mucosal Lentiginous Melanoma | Acral Lentiginous Malignant Melanoma

United Kingdom
Tanta University

Unknown

Pharmacogentic Screening of Coumarine Based Oral Anticoagulant Using Next Generation Seguencer

Thrombosis

Egypt
VA Connecticut Healthcare System

Completed

Carbamazapine for Inherited Erythromelalgia Patients With NaV1.7 Mutations

Erythromelalgia

United States
University Health Network, Toronto

Completed

Role of Cerebral Oximetry In Reducing Delirium After Complex Cardiac Surgery

Cardiac Disease

Canada
Assiut University

Unknown

Gene Study for Infantile Onset Diabetes

Study Genetic Basis of Infantile Onset Diabetes Mellitus
Sebastian Bauer
Hannover Medical School; University Hospital Tuebingen; Universitätsmedizin Mannheim and other collaborators

Unknown

POETIG Trial - POnatinib After rEsisTance to Imatinib in GIST (POETIG)

GIST, Malignant | KIT Gene Mutation | KIT Exon 13 Mutation

Germany
ViiV Healthcare

Completed

Observational Study Of A Protease Inhibitor (PI) Containing Regimen In Subjects With PI Mutations Selected During Prior Treatment With GW433908 (Fosamprenavir)

HIV Infection | Infection, Human Immunodeficiency Virus I

United States, Italy
Genentech, Inc.

Terminated

Study Of Zelboraf (Vemurafenib) in Patients With Locally-Advanced, Unresectable, Stage IIIc Or Metastatic Melanoma and Activating Exon 15 BRAF Mutations Other Than V600E

Malignant Melanoma

United States
University of Utah

Withdrawn

Radiation Use During Vemurafenib Treatment

Stage IV Melanoma | BRAFV600 Mutation

United States
National Cancer Institute (NCI)
University of Chicago; City of Hope Medical Center; University of Southern California and other collaborators

Completed

Randomized Phase II Study of AZD6244 (Mitogen-activated Protein Kinase Inhibitor) MEK-Inhibitor With Erlotinib in KRAS Wild Type Advanced Non-Small Cell Lung Cancer (NSCLC) and a Randomized Phase II Study of AZD6244 With Erlotinib in Mutant KRAS Adva...

Non Small Cell Lung Carcinoma

United States
Eastern Cooperative Oncology Group
National Cancer Institute (NCI)

Completed

Biomarkers in Blood Samples From Patients With Acute Myeloid Leukemia

Leukemia
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Completed

Biomarkers in Patients With Head and Neck Cancer

Head and Neck Cancer
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Completed

HER-2 Mutations in Tumor Samples From Patients With Advanced Non-Small Cell Lung Cancer Treated on Clinical Trial ECOG-2598

Lung Cancer
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Completed

Biomarkers in Bone Marrow Samples From Patients With Acute Myeloid Leukemia

Leukemia
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Completed

Study of Tissue and Blood Samples From Patients With Recurrent Prostate Cancer Who Received Lapatinib on Clinical Trial ECOG-E5803

Prostate Cancer
Eastern Cooperative Oncology Group
National Cancer Institute (NCI)

Completed

Study of Bone Marrow Samples From Patients With Acute Leukemia

Leukemia
Eastern Cooperative Oncology Group
National Cancer Institute (NCI)

Completed

Biomarkers in Tumor Tissue Samples From Patients With Peripheral T-cell Lymphoma or Natural Killer Cell Neoplasms

Lymphoma
Eastern Cooperative Oncology Group
National Cancer Institute (NCI)

Completed

Studying Biomarkers in Samples From Patients With Recurrent or Metastatic Head and Neck Cancer Treated on E1302 Trial

Head and Neck Cancer
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Completed

Biomarkers in Blood Samples From Patients With Refractory Non-Small Cell Lung Cancer Previously Treated With Sorafenib Tosylate

Lung Cancer
AstraZeneca

Completed

Asia Pacific and Russia Diagnostic Study for EGFR Testing (IGNITE)

EGFR Mutation Status in aNSCLC Patients

Korea, Republic of, Russian Federation, Malaysia, China, Australia, Taiwan, Thailand, Indonesia, Singapore
Sichuan Cancer Hospital and Research Institute

Unknown

Icotinib Combined With SBRT for Patients With Metastatic Non-squamous NSCLC With EGFR Mutation

Lung Cancer Stage IV
Vertex Pharmaceuticals Incorporated

Completed

A Phase 3 Rollover Study of Lumacaftor in Combination With Ivacaftor in Subjects 12 Years and Older With Cystic Fibrosis

Cystic Fibrosis, Homozygous or Heterozygous for the F508del-CFTR Mutation

United States, France, United Kingdom, Germany, Spain, Belgium, Canada, Australia, Netherlands, Denmark, Czech Republic, Italy, Austria, Ireland, Sweden
Vertex Pharmaceuticals Incorporated
Cystic Fibrosis Foundation

Completed

Rollover Study of Ivacaftor in Subjects With Cystic Fibrosis and a Non G551D CFTR Mutation (KONTINUE)

Cystic Fibrosis

United States, France, Belgium, United Kingdom

Search clinical trials for: Somatic mutation

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