Clinical Trials Sponsored by Aspire Foundation

Total 16669 results

Shire

Terminated

Treatment of Adenoviral Conjunctivitis With SHP640 Compared to Povidone-iodine (PVP-I) and Placebo

Adenoviral Conjunctivitis

United States, Israel, France, India, Australia, Austria, Spain, Estonia, Hungary, Poland, South Africa, Canada, Germany, Italy, Peru, United Kingdom
Shire

Terminated

Efficacy and Safety Study of SHP647 as Induction Therapy in Participants With Moderate to Severe Ulcerative Colitis (FIGARO UC 301)

Ulcerative Colitis

United States, Australia, Russian Federation, Romania, Brazil, Israel, Germany, Italy, Croatia, Netherlands, Poland, United Kingdom, Austria, Japan, Lithuania, Serbia, South Africa, Czechia
Shire

Completed

Screening Study to Identify Pediatric Patients With Hunter Syndrome Who Demonstrate Evidence of Central Nervous System (CNS) Involvement and Who Are Currently Receiving Treatment With Elaprase®

Hunter Syndrome

United States, United Kingdom
Shire

Completed

Guanfacine Immediate-release Electrocardiogram Results (QTc) Study

Healthy Volunteers

United States
Shire

Completed

Study to Assess the Benefit of Midodrine in the Treatment of Patients With Neurogenic Orthostatic Hypotension

Hypotension, Orthostatic

United States
Shire

Completed

Efficacy and Safety of SPD503 in Combination With Psychostimulants

ADHD

United States
Shire

Completed

Pharmacodynamic Profile of SPD489 in Healthy Adult Males Undergoing a Nocturnal Period of Acute Sleep Loss

Sleep Deprivation

United States
Shire

Completed

Prevention of Recurrence of Diverticulitis (PREVENT2)

Diverticulitis

United States, Italy, Germany, Canada, Brazil, Romania, Netherlands, Finland, South Africa, Hungary
Shire

Completed

Efficacy and Safety Study of Velaglucerase Alfa in Children and Adolescents With Type 3 Gaucher Disease

Gaucher Disease, Type 3

Egypt, India, Tunisia
Shire

Completed

Head to Head Study Against Sevelamer Hydrochloride

Chronic Kidney Disease, Stage 5

United States, Germany, Puerto Rico, United Kingdom
Shire

Completed

Efficacy Study to Evaluate the Effectiveness of 3 Concentrations of SAR 1118 in Allergic Conjunctivitis

Allergic Conjunctivitis

United States
Shire

Completed

Phase II Dose-Ranging Study in Subjects With Mild to Moderate Ulcerative Colitis Treated With SPD476

Colitis, Ulcerative

Belgium
Shire

Completed

Study of Intrathecal Idursulfase-IT Administered in Conjunction With Elaprase® in Pediatric Patients With Hunter Syndrome and Early Cognitive Impairment (AIM-IT)

Hunter Syndrome

Spain, United States, Canada, United Kingdom, France, Australia, Mexico
Shire

Completed

Prophylactic Use of Maribavir for the Prevention of Cytomegalovirus (CMV) Disease in Stem Cell Transplant Recipients

Cytomegalovirus Infections

United States, Canada, United Kingdom, Germany, France, Belgium, Italy, Spain, Sweden
Shire

Completed

Maribavir Versus Oral Ganciclovir For The Prevention of Cytomegalovirus (CMV) Disease in Liver Transplant Recipients

Cytomegalovirus Infections

United States
Shire

Completed

Safety Study of Lifitegrast to Treat Dry Eye (SONATA)

Dry Eye Disease

United States
Shire

Terminated

An Extension Study to Determine Safety and Efficacy for Pediatric Patients With MPS Type IIIA Disease Who Participated in Study HGT-SAN-093.

Sanfilippo Syndrome | Mucopolysaccharidosis (MPS)

United States, United Kingdom, Spain, Germany, France, Italy, Netherlands
Shire

Completed

Dose-Ranging Study of Oral Viscous Budesonide in Pediatrics With Eosinophilic Esophagitis

Eosinophilic Esophagitis (EoE)

United States
Shire

Completed

A Study to Evaluate Efficacy and Safety of Lifitegrast in Subjects With Dry Eye (OPUS-3) (OPUS-3)

Dry Eye Disease

United States
Shire

Completed

Efficacy and Safety Study of DX-88 to Treat Acute Attacks of Hereditary Angioedema (HAE)

Hereditary Angioedema (HAE)

United States
Shire

Completed

Safety and Efficacy of SPD503 in Treating ADHD in Children and Adolescents Aged 6-17

Attention Deficit Disorder With Hyperactivity
Shire

Terminated

An Explorative Trial to Evaluate the Pharmacodynamic Effect of SPD557 on Reflux Parameters in Refractory GERD Patients

Gastroesophageal Reflux Disease

United Kingdom, Switzerland, Netherlands, Belgium, France, Germany
Shire

Completed

Evaluation of Prucalopride in Male Subjects With Chronic Constipation.

Male Subjects With Chronic Constipation

Belgium, Romania, Poland, Netherlands, Germany, United Kingdom, Bulgaria, Czechia, Denmark, France
Shire

Completed

Safety and Pharmacodynamic Study of an Oral Iron Chelator Given for 6 Months to Patients With Iron Overload

Beta-thalassemia | Transfusional Iron Overload

United States, United Kingdom, Italy, Thailand, Turkey
Shire

Completed

Safety and Tolerability of SPD503 and Psychostimulants in Children and Adolescents Aged 6-17 With Attention-Deficit/Hyperactivity Disorder (ADHD)

Attention Deficit Disorder With Hyperactivity
Shire

Completed

Adsorption, Metabolism and Excretion (AME) of Single Dose Radiolabeled SPD557 in Volunteers

Healthy Volunteers

United States
Shire

Completed

Study to Evaluate the Safety, Efficacy and Pharmacokinetics of Teduglutide in Japanese Subjects With PN-dependent Short Bowel Syndrome (SBS)

Short Bowel Syndrome

Japan
Shire

Completed

Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension

Symptomatic Orthostatic Hypotension

United States, Poland, Czechia, Slovakia
Shire

Completed

Ability to Maintain or Achieve Clinical and Endoscopic Remission With MMX Mesalamine Once Daily in Adults With Ulcerative Colitis

Ulcerative Colitis

United States, France, Spain, Ireland, Czechia, Poland, Colombia, Canada, Romania, India, United Kingdom, South Africa, Belgium, Germany, Hungary
Shire

Completed

Efficacy and Safety Study of SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder

Major Depressive Disorder

United States, Spain, Canada, Puerto Rico, Croatia, Mexico
Shire

Completed

Effects of Lanthanum Carbonate on FGF-23 in Subjects With Stage 3 CKD

Chronic Kidney Disease

France
Shire

Completed

Selective 5-HT4 Receptor Agonist and Proton Pump Inhibitor (PPI) in Subjects With Gastroesophageal Reflux Disease (GERD)

Gastroesophageal Reflux Disease

United States, Czechia, Germany, Latvia, Poland, Romania
Shire

Completed

Effect of Anagrelide Hydrochloride on Any Changes in Heart Function in Healthy Volunteers

Healthy

France
Shire

Completed

Safety and Efficacy of SPD489 on Executive Function Behaviors in Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)

ADHD Specifically With Executive Function Impairment

United States
Shire

Completed

Subcutaneous Treatment With Icatibant for Acute Attacks of Hereditary Angioedema

Angioedema

United States
Shire

Completed

Metronidazole Drug Interaction Study With MMX® Mesalazine/Mesalamine

Healthy

United States
Shire

Completed

A Pharmacokinetic, Safety, and Pharmacodynamic Study of Teduglutide in Pediatric Subjects With Short Bowel Syndrome

Short Bowel Syndrome

United States, United Kingdom
Shire

Completed

SPD544 High Strength Bioequivalence Study

ADHD

United Kingdom
Shire

Completed

Efficacy, Safety, and Tolerability of SPD489 in Adults With Schizophrenia and Predominant Negative Symptoms

Schizophrenia and Predominant Negative Symptoms

United States
Shire

Completed

Open-Label C1 Esterase Inhibitor (C1INH-nf) for the Treatment of Acute Hereditary Angioedema (HAE) Attacks (CHANGE 2)

Hereditary Angioedema

United States
Shire

Completed

Long-term Safety and Efficacy Study of DX-2930 (SHP643) to Prevent Acute Angioedema Attacks in Patients With Type I and Type II HAE

Hereditary Angioedema (HAE)

United States, United Kingdom, Germany, Canada, Italy, Jordan, Puerto Rico
Shire

Completed

Efficacy and Tolerability of Treatment With Lanthanum Carbonate in Patients With End Stage Renal Disease Receiving Dialysis

Kidney Failure, Chronic
Shire

Completed

Efficacy and Safety of Lanthanum Carbonate in Reducing Serum Phosphorus Levels in Subjects With Stage 3 and 4 Chronic Kidney Disease

Kidney Diseases

United States
Shire

Completed

An Observational Study Evaluating Anti-Idursulfase Serum Antibody Response in Hunter Syndrome Patients

Hunter Syndrome

United Kingdom, United States, Brazil
Shire

Completed

Safety and Efficacy Study in Preschool Children Aged 4-5 Years With Attention-deficit/Hyperactivity Disorder (ADHD)

Attention Deficit Hyperactivity Disorder (ADHD)

United States
Shire

Completed

Study of rhPTH(1-84) in Japanese Healthy Subjects Compared With Matched Caucasian Healthy Adult Subjects

Hypoparathyroidism

United States
Shire

Completed

Analog Classroom Study Comparison of ADDERALL XR With STRATTERA in Children Aged 6-12 With ADHD

ADHD

United States
Shire

Completed

Extension Study of TKT028 Evaluating Safety and Clinical Outcomes of Replagal® in Adult Patients With Fabry Disease

Fabry Disease

United States, Slovenia, Australia, Finland, Poland, Czechia, United Kingdom
Shire

Completed

Safety and Efficacy of ADDERALL XR in the Treatment of Adolescents Aged 13-17 With Attention Deficit Hyperactivity Disorder (ADHD)

ADHD

United States
Shire

Completed

Efficacy and Safety of Lanthanum in Controlling Serum Phosphate Levels in Subjects With End Stage Renal Disease Who Require Treatment for High Levels of Phosphate in Their Blood

Kidney Failure, Chronic

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