Clinical Trials Sponsored by Aspire Foundation

Total 16735 results

Shire

Completed

Study of Safety and Efficacy of a rhPTH[1-84] of Fixed Doses of 25 and 50 mcg in Adults With Hypoparathyroidism (RELAY)

Hypoparathyroidism

United States
Shire

Completed

Evaluation of Safety and Activity of Celaderm in Healing Venous Leg Ulcers

Leg Ulcer | Varicose Ulcer

United States
Shire

Completed

A Study Of PF-00547659 In Patients With Moderate To Severe Ulcerative Colitis (TURANDOT)

Ulcerative Colitis

United States, France, Spain, Canada, Korea, Republic of, Australia, Germany, New Zealand, Serbia, Belgium, Czechia, Poland, Hungary, Austria, Bulgaria, Israel, Italy, Netherlands, South Africa, Russian Federation, Slovakia
Shire

Completed

A Study for Patients With Neurogenic Orthostatic Hypotension

Hypotension, Orthostatic

United States
Shire

Completed

A Pilot Study to Evaluate the Use of C1 Esterase Inhibitor (Human) in Patients With Acute Antibody-Mediated Rejection

Graft Rejection

United States, Germany
Shire

Terminated

Evaluation of Ecallantide for Treatment of Angiotensin Converting Enzyme (ACE) Inhibitor Induced Angioedema

ACE Inhibitor Induced Angioedema

United States
Shire

Completed

Efficacy and Safety of Two Doses of SPD476 (Mesalazine) 2.4g and 4.8g Once Daily, With Reference to Asacol 0.8g Three Times Daily in Subjects With Acute, Mild to Moderate Ulcerative Colitis

Ulcerative Colitis

Belgium
Shire

Terminated

Prucalopride Effects on Subjects With Chronic Non-cancer Pain Suffering From Opioid Induced Constipation (OIC)

Opioid Induced Constipation | Non-cancer Pain

Belgium
Shire

Completed

Safety and Efficacy of SPD503 in Treating Attention-Deficit/Hyperactivity Disorder (ADHD) in Children Aged 6-17

Attention Deficit Disorder With Hyperactivity
Shire

Completed

Absorption, Metabolism and Excretion (AME) of Single Dose Radiolabeled Prucalopride Succinate in Volunteers

Healthy

United States
Shire

Completed

Safety and Efficacy Study of VP20621 for Prevention of Recurrent Clostridium Difficile Infection

Clostridium Difficile Infection

United States, Belgium, Canada, Germany, Switzerland, Spain
Shire

Completed

Troxacitabine in Treating Patients With Chronic Myelogenous Leukemia

Leukemia

United States, Canada
Shire

Completed

Study of SSP-004184 (FBS0701) in Healthy Adults and Elderly Subjects and in Subjects With Impaired Renal Function

Impaired Renal Function

United States
Shire

Completed

Safety and Efficacy of MMX Mesalamine/Mesalazine in Pediatric Subjects With Mild to Moderate Ulcerative Colitis (PACE)

Ulcerative Colitis

United States, United Kingdom, Israel, Canada, Hungary, Poland, Slovakia
Shire

Completed

SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder

Major Depressive Disorder

United States, Chile, Australia, Argentina, United Kingdom
Shire

Completed

Safety and Pregnancy Outcomes in Thrombocythemia Patients Exposed to XAGRID® (Anagrelide Hydrochloride) Compared to Other Treatments

Thrombocythemia, Essential

Spain, United Kingdom, Greece, Denmark, Italy, France, Finland, Norway, Sweden, Germany, Cyprus, Ireland, Netherlands, Portugal
Shire

Completed

Double-blind, Placebo-controlled, Randomised Withdrawal, Extension, Safety and Efficacy Study of LDX in Children and Adolescents Aged 6-17

ADHD

Germany, Hungary, Italy, Poland, Sweden, United States, United Kingdom, Belgium, France
Shire

Completed

Effect of SPD422 on Platelet Lowering and Safety in Japanese Adults With At Risk Essential Thrombocythaemia

Essential Thrombocythemia (ET)

Japan
Shire

Completed

Safety and Efficacy Study of Teduglutide in Subjects With Short Bowel Syndrome

Short Bowel Syndrome

United States, France, Germany, Canada, Netherlands, Poland, Denmark, Belgium, United Kingdom
Shire

Completed

Treatment of Bacterial Conjunctivitis With SHP640 Compared to PVP-Iodine and Placebo

Bacterial Conjunctivitis

United States, Australia, Austria, Israel, Poland, Hungary, South Africa, Canada, Estonia, France, Italy, Spain, Puerto Rico
Shire

Completed

Ciprofloxacin XR Drug Interaction Study With MMX® Mesalazine/Mesalamine

Healthy

United States
Shire

Completed

A Study in Adolescents and Adults With Eosinophilic Esophagitis (EoE) Measuring Histologic Response and Determine if Reduction in Dysphagia is Achieved

Eosinophilic Esophagitis (EoE)

United States
Shire

Completed

SPD489 in Adults Aged 18-55 Years With Moderate to Severe Binge Eating Disorder

Binge Eating Disorder

United States, Spain, Germany, Sweden
Shire

Terminated

An Efficacy and Safety Study of SRM003 in the Treatment of Subjects Undergoing Placement of an Arteriovenous Graft to Facilitate Hemodialysis Access

Arteriovenous Graft

United States
Shire

Completed

Efficacy Study of DX-88 (Ecallantide) to Treat Acute Attacks of Hereditary Angioedema (HAE)

Hereditary Angioedema (HAE)

United States, Jordan, Canada
Shire

Terminated

Open-Label Extension Study of Recombinant Human Arylsulfatase A (HGT-1111) in Late Infantile MLD

Late Infantile Metachromatic Leukodystrophy

Denmark
Shire

Completed

A Multicenter Open-Label Treatment Protocol to Observe the Safety of Replagal (Agalsidase Alfa) Enzyme Replacement Therapy in Canadian Patients With Fabry Disease

Fabry Disease

Canada
Shire

Completed

Study of SHP639 Eye Drops in Adults With High Eye Pressure or Primary Open-angle Glaucoma

Ocular Hypertension | Primary Open-angle Glaucoma (POAG)

United States
Shire

Completed

Safety, Tolerability, Pharmacokinetic, and Efficacy Study of SPD489 in Preschool Children With Attention-deficit/Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder (ADHD)

United States
Shire

Completed

SPD489 in Adults With Persistent Executive Function Impairments (EFI) and Partial or Full Remission of Recurrent Major Depressive Disorder

Major Depressive Disorder

United States
Shire

Completed

Study of Gene-Activated® Human Glucocerebrosidase (GA-GCB) ERT Compared With Imiglucerase in Type I Gaucher Disease

Gaucher Disease, Type 1

Spain, Israel, United States, India, Paraguay, United Kingdom, Russian Federation, Tunisia, Argentina
Shire

Completed

Tolerability and Efficacy of AM and PM Once Daily Dosing With Extended-release Guanfacine Hydrochloride in Children 6-12 With Attention-Deficit/Hyperactivity Disorder (ADHD) (The ADHD Tempo Study)

Attention-Deficit/Hyperactivity Disorder

United States, Canada
Shire

Completed

Study of SHP620 (Maribavir) in Healthy Adults

Cytomegalovirus (CMV)

United States
Shire

Completed

Safety and Efficacy Study of SHP465 in Children and Adolescents Aged 6-17 Years With Attention-Deficit Hyperactivity Disorder (ADHD)

Attention Deficit Hyperactivity Disorder (ADHD)

United States
Shire

Completed

Long-Term Safety Of PF-00547659 In Ulcerative Colitis (TURANDOT II)

Ulcerative Colitis

Korea, Republic of, United States, Spain, Australia, Canada, Israel, Serbia, Netherlands, Belgium, Italy, New Zealand, Austria, Bulgaria, Czechia, France, Germany, Hungary, Poland, Russian Federation, Slovakia, South Africa
Shire

Completed

Study To Test Whether PF-00547659 Is Safe And Improves Disease Symptoms In Patients With Crohn's Disease (OPERA)

Crohn's Disease

Korea, Republic of, United States, Spain, Japan, Serbia, Germany, Belgium, Netherlands, Poland, Austria, Bulgaria, Canada, France, Norway, Slovakia, South Africa
Shire

Completed

Study of Lanadelumab in Healthy Japanese and Matched Caucasian Adult Subjects

Healthy Volunteers

United States
Shire

Completed

Assess the Safety and Pharmacokinetics of Ascending, Multiple Oral Doses of SPD489 in Adults With Schizophrenia

Schizophrenia

United States
Shire

Completed

THIN Database Study: Resource Use and Outcomes in Patients With Adrenal Insufficiency Prescribed Hydrocortisone: Immediate, or Modified Release, or Prednisolone

Adrenal Insufficiency
Shire

Completed

Use of NPSP558 in the Treatment of Hypoparathyroidism (REPLACE)

Hypoparathyroidism

United States, Denmark, Canada, Hungary, United Kingdom, Belgium, France, Italy
Shire

Completed

Safety and Efficacy of NPS 1776 in the Acute Treatment of Migraine Headaches

Migraine Headache

United States
Shire

Completed

Safety and Efficacy Study of Teduglutide in Subjects With Short Bowel Syndrome Who Completed Protocol CL0600-004 (NCT00081458)

Short Bowel Syndrome

United States, Denmark, France, Canada, Belgium, Netherlands, Poland, United Kingdom
Shire

Completed

A Study of Anagrelide and Hydroxyurea in High-Risk Essential Thrombocythemia Patients

Thrombocythemia, Hemorrhagic

Bulgaria, France, Hungary, Poland, Portugal, Serbia
Shire

Completed

A Open-label Study Investigating the Safety and Tolerability of NPSP558, a Recombinant Human Parathyroid Hormone (rhPTH [1-84]), for the Treatment of Adults With Hypoparathyroidism - A Clinical Extension Study (RACE)

Hypoparathyroidism

United States
Shire

Completed

Study to Assess the Blood Concentrations and Actions of Recombinant Human Parathyroid Hormone (rhPTH [1-84]) When Given Once and Twice Daily to Participants With Hypoparathyroidism (PARALLAX)

Hypoparathyroidism

United States, Hungary, Canada, Denmark
Shire

Completed

A Double-Blind Multi-Dose Tolerability and Pharmacokinetic Study of Teduglutide

Pharmacokinetics and Safety of Elevated Doses

United States
Shire

Completed

ADDERALL XR (Mixed Salts of a Single-entity Amphetamine) and STRATTERA ( Atomoxetine Hydrochloride) Compared to Placebo on Simulated Driving Safety and Performance and Cognitive Functioning in Adults With ADHD

Attention Deficit Disorder With Hyperactivity

United States
Shire

Terminated

Conversion From Standard Phosphate Binder Therapy to Fosrenol® (Lanthanum Carbonate) in Chronic Kidney Disease Stage 5

Kidney Diseases

Netherlands, Germany, Austria, Belgium, Denmark, Italy
Shire

No longer available

Treatment Protocol of Replagal for Patients With Fabry Disease

Fabry Disease

United States
DePuy Spine

Completed

An ACDF Multi-Center Study Using ViviGen Cellular Bone Matrix

Herniated Disc | Cervical Spondylosis | Degenerative Intervertebral Discs

3

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