Clinical Trials Sponsored by ProFem GmbH

Total 4025 results

Novaliq GmbH

Completed

ESSENCE 2: CyclASol for the Treatment of Signs and Symptoms of Dry Eye Disease (DED)

Dry Eye Disease

United States
Bioeq GmbH

Completed

A Double-blind Study to Compare the Efficacy, Safety, and Immunogenicity of the Proposed Biosimilar Ustekinumab FYB202 to Stelara® in Patients With Moderate-to-Severe Plaque Psoriasis (VESPUCCI)

Plaque Psoriasis

Poland, Estonia, Ukraine, Georgia
Vertanical GmbH

Completed

Food Effect Study of VER-01 in Healthy Volunteers

Healthy

Austria
Pentracor GmbH

Completed

Study on CRP Apheresis After Coronary Bypass Surgery (CABY1)

Post-cardiac Surgery

Germany
InnoRa GmbH

Terminated

Safety and Tolerance of the Use of InnoCath AB® Hyper-compliant Balloon (HYPER)

Lesions in the Superficial Femoral Artery and/or Popliteal Artery Pars I/II

Germany
Doasense GmbH

Active, not recruiting

Pharmacokinetics and Point of Care Testing of Direct Oral Anticoagulants Subjects (PHAPOCU)

Anticoagulant Therapy

Germany
JOTEC GmbH

Terminated

E-tegra Stent Graft System in the Treatment of Infra-renal Abdominal Aortic Aneurysms (SECURE)

Abdominal Aortic Aneurysm | AAA

France, Germany, Spain, Poland, Switzerland
Novaliq GmbH

Completed

Perfluorohexyloctane (NOV03) for the Treatment of Signs and Symptoms of Dry Eye Disease (DED)

Dry Eye Disease (DED)

United States
InnoRa GmbH

Completed

Treatment of Coronary In-stent Restenosis (ISR) by a Sirolimus Coated or a Paclitaxel Coated Balloon

Coronary Restenosis

Switzerland, Germany
InnoRa GmbH

Completed

Treatment of Coronary In-Stent Restenosis by a Sirolimus (Rapamycin) Coated Balloon or a Paclitaxel Coated Balloon (FIMLIMUSDCB)

DES In-stent Stenosis

Malaysia
Grünenthal GmbH

Completed

Intra-articular Lopain (MTX-071) Phase I/IIa Study in Chronic Osteoarthritic Knee Joint Pain

Osteoarthritis, Knee

Belgium
Glycotope GmbH

Completed

Combination of Gatipotuzumab and Tomuzotuximab in Patients With Solid Tumors (GATTO)

Solid Tumor, Adult

Germany, Italy, Spain
Glycotope GmbH

Completed

CetuGEX™: Phase 1 Study in Cancer Patients

Solid Tumors

Germany, Italy, Switzerland
Oncoethix GmbH

Completed

A Dose-Finding Study of Birabresib (MK-8628), a Small Molecule Inhibitor of the Bromodomain and Extra-Terminal (BET) Proteins, in Adults With Selected Advanced Solid Tumors (MK-8628-003)

Triple Negative Breast Cancer | Pancreatic Ductal Adenocarcinoma | Castrate-resistant Prostate Cancer | CRPC | NUT Midline Carcinoma | Non-small Cell Lung Cancer With Rearranged ALK Gene/Fusion Protein or KRAS Mutation
Nutrin GmbH

Completed

To Check Effectiveness of Medistus Antivirus Lozenges for Cough

Pharyngitis | Sore Throat | Throat Infection

India
Grünenthal GmbH

Terminated

Efficacy and Safety of Intravenous Neridronic Acid in CRPS

Complex Regional Pain Syndrome (CRPS)

United States, Australia, France, Germany, Korea, Republic of, New Zealand, Spain
medac GmbH

Completed

Clinical Phase III Trial Treosulfan-based Conditioning Versus Reduced-intensity Conditioning (RIC)

Acute Myeloid Leukemia | Myelodysplastic Syndrome

Germany, Italy, Poland, France, Finland, Hungary
Grünenthal GmbH

Terminated

Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Pain Due to Osteoarthritis Taking WHO Step III Analgesics But Showing a Lack of Tolerability.

Osteoarthritis | Chronic Pain

Germany, United Kingdom, Spain, Australia, Denmark, Poland
Affimed GmbH

Terminated

Safety Study to Assess AFM11 in Patients With Relapsed or Refractory Adult B-precursor ALL

Leukemia, B-Cell

Austria, Israel, Russian Federation, Poland, Czechia
Affimed GmbH

Terminated

Safety Study to Assess AFM11 in Patients With Relapsed and/or Refractory CD19 Positive B-cell NHL

Refractory B-Cell Non-Hodgkin Lymphoma | Relapsed B-Cell Non-Hodgkin Lymphoma

United States, Czechia, Germany, Poland
Grünenthal GmbH

Completed

Pharmacokinetic Characterization of Two Novel CG5503 Tablet Formulations in Healthy Volunteers

Pharmacokinetics

Germany
Grünenthal GmbH

Completed

Investigation How CG5503 is Taken up and Excreted From the Body After 2 Minutes Intravenous Infusion With and Without Oral Co-administration of Charcoal

Pharmacokinetic

Germany
Grünenthal GmbH

Completed

Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Chronic Low Back Pain Taking Either WHO Step I or Step II Analgesics or no Regular Analgesics

Low Back Pain | Chronic Pain

Austria, Germany, United Kingdom, Croatia, France, Italy, Poland, Spain, Switzerland
Grünenthal GmbH

Completed

Efficacy and Safety of GRT9906 Tablets Compared to Placebo in Patients With Fibromyalgia

Primary Fibromyalgia

United States
Grünenthal GmbH

Completed

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GRT9906 Prolonged Release Tablets After Dose Escalation in Healthy Subjects

Pharmacokinetics

Germany
Grünenthal GmbH

Completed

A Comparison of How Likely it is That Different Tablets of Oxycodone Will be Broken up and Snorted by Adults Who Sometimes Take Drugs for Pleasure

Substance Abuse

Canada
Grünenthal GmbH

Completed

A Clinical Study in Healthy Adults Who Sometimes Take Drugs for Pleasure to Investigate the Safety and Tolerability of GRT0151Y and to Find Out Which Single Dose of the Compound is Maximally Tolerated

Pain | Chronic Pain | Acute Pain

Canada
Grünenthal GmbH

Completed

A Clinical Study in Healthy Subjects Which Aims to Investigate the Safety, the Tolerability and the Effects of GRT0151Y and How the Compound is Taken up and Excreted From the Body

Acute Pain

France
Humedics GmbH

Completed

Fast-track LiveR: Study for the Early Identification of Low-risk Patients After Partial Liver Resection by the LiMAx-test

Liver Failure

Germany
Grünenthal GmbH

Completed

Efficacy and Safety of Intravenous Neridronic Acid in CRPS-I

Complex Regional Pain Syndrome, Type I

United States, Germany, United Kingdom
Phenox GmbH

Unknown

pCONUS2 Treatment of Wide Neck Intracranial Aneurysms 2 (pToWin2)

Intracranial Aneurysm
Ligartis GmbH

Withdrawn

Phase Ib/II Study Assessing the Neo-adjuvant Combination Therapy of Vinflunine With Cisplatin Followed by Radical Cystectomy in Patients With Muscle-invasive Bladder Cancer (JaNEO) (JaNEO)

Bladder Cancer

Germany
Joimax GmbH

Withdrawn

Trial to Show Non-inferiority / Superiority of an Endoscopic Transforaminal Discectomy to Standard Microdiscectomy (TESCORT)

Lumbar Disc Herniation

Austria, Germany
Novaliq GmbH

Completed

Influence of Perfluorohexyloctane (NovaTears) on Tear Film Thickness in Patients With Mild to Moderate Dry Eye Disease

Dry Eye Disease

Austria
Grünenthal GmbH

Completed

Efficacy and Tolerability of Lidocaine Plaster for Treatment of Long-term Local Nerve Pain

Pain | Chronic Pain | Postoperative Pain | Neuropathic Pain

Austria, Belgium, Brazil, Denmark, France, Italy, Spain, United Kingdom
Novaliq GmbH

Completed

NovaTears® Eye Drops Observational Study NT-002

Dry Eye Syndromes

Germany
Vasopharm GmbH

Completed

Phase 2 a Study to Assess Safety and Pharmacokinetics of VAS203 in Patients With Traumatic Brain Injury (NOSTRA)

Traumatic Brain Injury

Austria, France, Spain, Switzerland, United Kingdom
Ethicare GmbH

Unknown

Orodispersible Minitablets of Enalapril in Young Children With Heart Failure Due to Congenital Heart Disease (LENA-WP09)

Heart Failure | Congenital Heart Disease

Austria, United Kingdom, Hungary, Netherlands, Serbia
Grünenthal GmbH

Terminated

Multiple Dose Trial Comparing the Plasma Levels of Two Different Analgesic Transdermal Patch Formulations

Healthy

Germany
SportWelding GmbH

Unknown

Clinical Evaluation of the SportWelding FijiAnchor® in Hand and Hand Wrist Surgery

Lesion of Ligament of Wrist and/or Hand

Austria
Beneo GmbH

Completed

Effect of Consumption of Orafti® Inulin on Bowel Motor Function in Subjects With Constipation

Healthy | Constipation

Germany
Vaximm GmbH

Completed

VXM01 Phase I Dose Escalation Study in Patients With Locally Advanced, Inoperable and Stage IV Pancreatic Cancer

Stage IV Pancreatic Cancer

Germany
Abnoba Gmbh

Completed

Maximum Tolerable Concentration of abnobaVISCUM Fraxini Intravesically in Patients With Superficial Bladder Cancer

Superficial Bladder Cancer

Egypt, Germany
Synthes GmbH

Completed

Clinical Follow-up to Evaluate the Clinical Usefulness of Gentamicin-coated Titanium Nails in Tibia Fractures

Tibia Fractures

Germany
medac GmbH

Terminated

Urokinase Therapy in Patients With Diabetic Foot Syndrome

Ischemia | Diabetic Foot | Arterial Occlusive Disease

Germany
Synthes GmbH

Completed

chronOS Inject in Proximal Tibial Fractures

Closed Proximal Tibial Fracture Schatzker I - VI | Closed Proximal Tibial Fracture AO-OTA 41 | Closed Proximal Tibial Fracture AO-OTA 42

Korea, Republic of
Novaliq GmbH

Completed

CyclASol® Phase 1 Study

Healthy

Germany
Eurocor GmbH

Unknown

FREERIDE STUDY, Freeway Paclitaxel Coated Balloon Catheter to Treat Peripheral Artery Disease

Peripheral Artery Disease

Germany, Italy, Austria, Colombia, Hungary, Spain
Synthes GmbH

Withdrawn

Case Series to Evaluate Patient Specific Implants (PSI) in Polyether Ether Ketone (PEEK) Performance After 2 Years

Craniotomy | Craniectomy | E04.525.190

Spain, Switzerland, Finland, Germany, Colombia, Singapore, United Kingdom, Austria, Belgium, Chile, Costa Rica, Czech Republic, Denmark, France, Portugal
Provascular GmbH

Completed

Evaluation of Efficacy and Safety of the FlexStent Self-Expanding Stent System

Efficacy of the Study Device

Germany

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