Search clinical trials for: AME (Absorption, Metabolism, and Excretion)

Total 474698 results

Global Blood Therapeutics

Completed

A Study of the Absorption, Metabolism, and Excretion of GBT440 in Healthy Male Subjects

Anemia, Sickle Cell

United States
Eli Lilly and Company

Completed

A Study of the Absorption, Distribution, Metabolism and Excretion of LY3039478 in Healthy Participants

Healthy

United States
Pfizer

Completed

Phase I Study to Determine the Absorption, Distribution, Metabolism and Excretion of Esreboxetine (ADME)

Healthy

United States
Carolina Cannillo

Completed

The Effect of High and Low Sodium Intake on Urinary Aquaporin-2 in Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney, Autosomal Dominant

Denmark
Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Study to Investigate the Absorption, Metabolism, and Excretion of Canagliflozin (JNJ-28431754) in Healthy Male Volunteers

Healthy

Belgium
Nordic Society of Gynaecological Oncology - Clinical...
European Organisation for Research and Treatment of Cancer - EORTC

Completed

Radiation Therapy With or Without Chemotherapy in Treating Patients With High-Risk Endometrial Cancer

Endometrial Cancer

France, Norway, Belgium, Spain, Netherlands, Italy, United Kingdom, Ireland, Poland, Portugal, South Africa
Regional Hospital Holstebro

Completed

Urinary Aquaporin 2 Excretion After NSAID in Fasting Healthy Human

Healthy

Denmark
Astellas Pharma Europe B.V.
Medivation, Inc.

Completed

A Study to Explore the Routes of Elimination of MDV3100

Healthy Subjects | Pharmacokinetics of MDV3100

Netherlands
Universidad Autonoma de Baja California

Completed

Education to Decrease in Sodium Intake Evaluated With 24 Hour Urinary Sodium Excretion (RCT) (RCT)

Hypertension | Diabetes Mellitus, Type 2 | Overweight or Obesity

Mexico
Novartis Pharmaceuticals

Completed

Absorption, Distribution, Metabolism and Excretion (ADME) Study of TKI258 in Patients With Advanced Solid Malignancies

Advanced Solid Malignancies

Netherlands
Tesaro, Inc.

Completed

Absorption, Metabolism, Excretion, and the Determination of Absolute Bioavailability of Niraparib in Subjects With Cancer

Cancer

Netherlands
BeiGene

Completed

Study to Investigate the Absorption, Metabolism, and Excretion of [14C]-BGB-3111 in Healthy Males

Healthy Volunteers

United States
Esperion Therapeutics, Inc.

Completed

Single Radiolabeled Dose Study to Investigate the Absorption, Metabolism and Excretion of [14C]-ETC-1002

Hyperlipidemia

United Kingdom
Supernus Pharmaceuticals, Inc.

Completed

Phase I Study to Assess the Absorption, Metabolism, and Excretion of [14C] Labeled SPN-810M

Impulsive Aggression Comorbid With ADHD

United Kingdom
Trevena Inc.

Completed

A Study to Investigate the Metabolism and Excretion of [14C]-TRV130 in Healthy Male Subjects

Healthy

United States
Reata, a wholly owned subsidiary of Biogen

Completed

A Phase I Study to Investigate the Absorption, Metabolism and Excretion in Healthy Male Subjects

Healthy

United States
Vanderbilt University Medical Center
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Dietary Sodium's Effect on Urinary Sodium and Dopamine Excretion in Patients With Postural Tachycardia Syndrome

Postural Orthostatic Tachycardia Syndrome

United States
Ann & Robert H Lurie Children's Hospital of Chicago

Completed

Prediction of Excretion and Toxicity of High Dose Methotrexate in Children and Adolescents With ALL

ALL

United States
Takeda

Completed

Study to Evaluate Absorption, Metabolism, and Excretion, of TAK-994 in 6 Healthy Male Adults

Healthy Volunteers

United States
Assiut University

Unknown

Fractional Excretion of Urea for the Differential Diagnosis of Acute Kidney Injury in Liver Cirrhosis

Liver Cirrhosis
GlaxoSmithKline

Completed

A Single Dose Study to Determine the Excretion, Balance and Metabolic Disposition of Radiolabelled GW642444.

Pulmonary Disease, Chronic Obstructive

Netherlands
AstraZeneca

Completed

Study Evaluating Absorption, Distribution, Metabolism and Excretion (ADME) of Single Dose [14C] Selumetinib in Volunteers

Solid Tumours

United Kingdom
National Taiwan University Hospital

Completed

Establishment of a Creatinine Clearance Estimation Equation and Daily Creatinine Excretion Reference Table for Taiwanese

Estimated Creatinine Clearance
University Hospital, Limoges

Completed

Epidemiology of Human Cytomegalovirus Excretion in the Saliva of Children Attending Nursery in France (CrèchMV)

Healthy Volunteers

France
Warner Chilcott

Terminated

A Study of Asacol Absorption, Metabolism and Excretion in Children and Adolescents With Ulcerative Colitis.

Ulcerative Colitis

United States
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating The Excretion Of Moxidectin Into The Breast Milk Of Lactating, Non-Breastfeeding Women

Infection

United Kingdom
Orion Corporation, Orion Pharma

Completed

Excretion Balance and Metabolism After a Single Oral Dose of 14C-Labelled ORM-12741 (ALMAS)

Healthy Male Volunteers

Netherlands
University Hospital, Basel, Switzerland
Toppharm Apotheke Hersberger, Spalenberg 41, CH-4051 Basel

Recruiting

Pharmacogenetic Testing of Patients With Unwanted Adverse Drug Reactions or Therapy Failure

Adverse Drug Reaction | Therapy Failure

Switzerland
Universidade do Porto
Fundação para a Ciência e a Tecnologia; Centro Hospitalar De São João, E.P.E.; Instituto Nacional de Saúde Doutor Ricardo Jorge

Unknown

Study With an Innovative Equipment to Monitor and Control SALT During Cooking (iMC_SALT)

Hypertension | Salt; Excess

Portugal
Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Study to Evaluate of the Absorption, Metabolism, and Excretion of 14C-JNJ-39823277 in Healthy Male Participants

Healthy

Belgium
University of Alabama at Birmingham
University of Texas Southwestern Medical Center

Recruiting

Effect of Weight Loss on Urinary Oxalate Excretion in Obese Calcium Oxalate Kidney Stone Formers

Kidney Stone

United States
Kyowa Kirin, Inc.

Completed

Phase 1, Open-label Study of the Absorption, Metabolism, and Excretion of [14C]-KW-6356

Healthy Male Subjects

United States
Corcept Therapeutics

Completed

Single Dose Absorption, Distribution, Metabolism, and Excretion Study of [14C]-CORT113176 in Healthy Male Participants

Healthy

United Kingdom
LTN PHARMACEUTICALS, INC.

Completed

Single-Dose Study to Assess the Absorption, Metabolism, Excretion, and Mass Balance of Radiolabeled Galeterone

Healthy

United States
Pfizer

Completed

Single-dose Study of [14C]PF-05221304 Metabolism and Excretion in Healthy Adult Male Subjects

Healthy

United States
Kowa Research Institute, Inc.

Completed

Evaluation of Absorption, Metabolism, and Excretion and Estimation of the Absolute Bioavailability of K-312

Dyslipidemia

United States
Weill Medical College of Cornell University

Unknown

The Effect of Vitamin D Supplementation on Calcium Excretion in Thalassemia: a Dose Response Study

Thalassemia Major

United States
Bristol-Myers Squibb

Completed

A Study to Evaluate the Drug Levels of [14C]CC-99677 in Healthy Male Participants

Healthy Volunteers

United States
Universitair Ziekenhuis Brussel

Recruiting

Lanthanum Carbonate (Fosrenol®) to Reduce Oxalate Excretion in Patients With Secondary Hyperoxaluria and Nephrolithiasis (LaCa)

Nephrolithiasis | Secondary Hyperoxaluria

Belgium
AstraZeneca
Quotient Sciences

Completed

A Study to Investigate the Absolute Bioavailability, Absorption, Metabolism, Distribution and Excretion of [14C]AZD5363 (Capivasertib)

Healthy Volunteer

United Kingdom
Celgene

Completed

A Study to Evaluate the Metabolism and Excretion of [14C]-CC-92480 in Healthy Male Participants

Healthy Volunteers

United States
Cyclerion Therapeutics

Completed

A Trial to Study the Absorption, Metabolism, and Excretion of [14C]-Praliciguat in Healthy Male Volunteers

Healthy Volunteers

United States
Regional Hospital Holstebro
Aarhus University Hospital

Unknown

Effect of Renal Denervation on NO-mediated Sodium Excretion and Plasma Levels of Vasoactive Hormones (RENO)

Essential Hypertension

Denmark
Alizyme

Completed

Study of the Blood Levels and Effects of ATL-962 on Fat Excretion in Obese Subjects

Obesity

United States
The First Affiliated Hospital of Soochow University

Recruiting

The Effect of Precise Aerosol Inhalation Nursing on Sputum Excretion in Elderly Patients With Lung Surgery

Inhalation

China
Seoul National University Hospital

Unknown

To Investigate the Absorption, Metabolism, Excretion, Absolute Bioavailability, and Immunogenicity of GX-I7 in Healthy Volunteers

Leukopenia

Korea, Republic of
Hangzhou ACEA Pharmaceutical Research Co., Ltd.

Completed

Study to Investigate the Absorption, Metabolism and Excretion of [14C] AC0010 in Patients With Advanced NSCLC

Carcinoma, Non-Small-Cell Lung

China
Pfizer

Completed

Radiolabeled [14C]PF-02341066 Study To Investigate The Absorption, Metabolism And Excretion In Healthy Male Volunteers

Healthy Volunteer

United States
AstraZeneca

Completed

Study to Assess the Metabolism, Excretion and Pharmacokinetics of [14C]AZD1981 in Healthy Male Volunteers (ADME)

Healthy
Pfizer

Completed

Study to Investigate the Mass Balance, Metabolism, and Excretion of [14C]-PF-07304814 in Healthy Participants

Healthy

United States

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