Search clinical trials for: Aquired resistance to EGFR TKI

Total 476809 results

Vanderbilt-Ingram Cancer Center
National Cancer Institute (NCI)

Withdrawn

Pemetrexed Disodium and Carboplatin or Cisplatin With or Without Erlotinib Hydrochloride in Treating Patient With Stage IV Non-Small Cell Lung Cancer Resistant to First-Line Therapy With Erlotinib Hydrochloride or Gefitinib

Recurrent Non-small Cell Lung Cancer | Stage IV Non-small Cell Lung Cancer
Sun Yat-sen University

Unknown

Erlotinib 100mg qd Versus Gefitinib 250mg qd for EGFR Mutant Nsclc (NSCLC EGFR TKI)

Advanced Stage Non Small Cell Lung Cancer

China
Ping-Yen Liu

Unknown

Platelet Resistance With Ticagrelor or Standard-Dose Clopidogrel Among CKD and ACS Patients (APROVE-CKD)

Chronic Kidney Disease | Acute Coronary Syndrome | End-Stage Renal Disease

Taiwan
Memorial Sloan Kettering Cancer Center
Bristol-Myers Squibb

Completed

Cetuximab in Patients With Lung Adenocarcinoma Receiving Erlotinib That Have Developed "Acquired Resistance" to Erlotinib

Lung Adenocarcinoma

United States
Groupe Français de Pneumo-Cancérologie

Completed

Retrospective Study in Non Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR) (EGFR-RETRO)

NSCLC Non Small Cells Lung Cancer

France
Wuhan Union Hospital, China

Unknown

Study of EGFR-TKI to Asymptomatic Brain Metastases of NSCLC (EABM)

Asymptomatic Brain Metastases of Non Small Cell Lung Cancer
Tongji University
Sun Yat-sen University; Peking Union Medical College Hospital; RenJi Hospital; Guangdong... and other collaborators

Completed

Erlotinib Versus Gemcitabine/Carboplatin in Chemo-naive Stage IIIB/IV Non-Small Cell Lung Cancer Patients With Epidermal Growth Factor Receptor (EGFR) Exon 19 or 21 Mutation (ML20981)

Non-small Cell Lung Cancer

China
Betta Pharmaceuticals Co., Ltd.

Completed

Dose Escalation Of Icotinib In Previously Treated Patients With Routine Dose

Non-small Cell Lung Cancer

China
Betta Pharmaceuticals Co., Ltd.

Completed

Icotinib Combined With WBRT For NSCLC Patients With Brain Metastases and EGFR Mutation

Non-small Cell Lung Cancer | Brain Metastases

China
Betta Pharmaceuticals Co., Ltd.

Completed

Safety and Efficacy Study of Icotinb in Non-small Cell Lung Cancer (NSCLC) Patients (ICOGEN)

Non-small Cell Lung Cancer

China
Zhejiang University

Unknown

Continuation of TKI With or Without Chemotherapy Beyond Gradual Progression

Non Small Cell Lung Cancer

China
Ulsan University Hospital
AstraZeneca

Unknown

Efficacy of EGFR TKIs in Patients With Rare EGFR-mutated NSCLC

Lung Neoplasms

Korea, Republic of
Xinjiang Medical University

Unknown

Erlotinib Intercalated With Chemotherapy Versus Erlotinib as First Line Treatment in Stage IIIB/IV NSCLC Patients With EGFR Mutation

Non-Small Cell Lung Cancer

China
Sun Yat-sen University

Completed

Prophylactic EVOZAC® Calming Skin Spray for EGFR-TKIs Associated Rash Eruption in NSCLC

Non-small Cell Lung Cancer

China
Sheba Medical Center

Unknown

An Open Label Study of BIBW 2992/Afatinib in Advanced Non-Small Cell Lung Cancer Patients Pre-treated With Erlotinib or Gefitinib

NSCLC

Israel
Peking Union Medical College Hospital

Unknown

Study of Chemotherapy Sequenced by or Combined With EGFR-TKIs for NSCLC Patients Failed to EGFR-TKIs Therapy

Non Small Cell Lung Cancer

China
Severance Hospital
AstraZeneca

Unknown

De Novo Resistance to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors

NSCLC
AstraZeneca

Completed

Comparing Efficacy Between Anti-microtubule and Non-anti-microtubule as 3th Therapy After 2nd Line EGFR-TKI Therapy

Cancer

Taiwan
AstraZeneca

Completed

Multicentre Study to Explore the Correlation Between Smoking Pattern and Clinical Efficacy of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor (TKI) in Male Patients

Non Small Cell Lung Cancer

Taiwan
Istituto Clinico Humanitas

Completed

Molecular Features Predicting Response/Resistance to Trastuzumab in Metastatic Breast Cancer Patients

Breast Cancer

Italy
Zhejiang Cancer Hospital

Unknown

Prophylactic Cranial Irradiation in Erlotinib/Gefitinib-responders With Non-small Cell Lung Cancer (NSCLC) (RT1001)

Non-small Cell Lung Cancer

China
Chinese PLA General Hospital

Unknown

A Chinese Randomized Crossover Study of Erlotinib Versus Docetaxel/Cisplatin in Previously Untreated Stage IIIB/IV Lung Adenocarcinoma With EGFR Mutations

Neoplasms, Lung | Carcinoma, Non-Small Cell Lung | Drug Therapy | Genes, EGFR

China
Zhejiang Cancer Hospital

Unknown

Erlotinib Combined With Radiotherapy in Patients With Non-resectable Locally Advanced Non-small Cell Lung Cancer (LA-NSCLC) (RT0901)

Non-small Cell Lung Cancer

China
City of Hope Medical Center
National Cancer Institute (NCI)

Not yet recruiting

Regorafenib in Combination With Venetoclax and Azacitidine for the Treatment of Patients With Relapsed or Refractory Acute Myeloid Leukemia

Recurrent Acute Myeloid Leukemia | Recurrent Myelodysplastic Syndrome | Refractory Acute Myeloid Leukemia | Refractory Myelodysplastic Syndrome | Myelodysplastic Syndrome/Acute Myeloid Leukemia

United States
Guangdong Provincial People's Hospital

Not yet recruiting

Randomized Study of ABC-14 Regimen Compared With "3+7" Standard Induction Therapy or AB-14 for ND AML

Acute Myeloid Leukemia

China
Hong Kong Baptist University

Not yet recruiting

CHM for T2DM & MetS

Type 2 Diabetes Mellitus With Metabolic Syndrome
The Swedish School of Sport and Health Sciences
Karolinska Institutet; Sahlgrenska University Hospital, Sweden; Prostate Cancer... and other collaborators

Recruiting

Training for Men Undergoing Androgen Deprivation Therapy. (ADT-train)

Prostate Cancer

Sweden
Pfizer

Recruiting

A Study in Advanced/Metastatic Solid Tumors With the Study Medicine (PF-07329640) When Given Alone or In Combination (LTbR)

Melanoma | Colorectal Cancer | Non-Small Cell Lung Cancer | Urothelial Cancer | Advanced or Metastatic Solid Tumors

United States, Puerto Rico
Pfizer

Not yet recruiting

A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation.

Carcinoma, Non-Small-Cell Lung | Colorectal Neoplasms | Carcinoma, Pancreatic Ductal
Aga Khan University

Recruiting

Mobile Health (M-health) Intervention to Reduce the Epigenetic Signature in Metabolic Syndrome (MetS)

Obesity | Metabolic Syndrome

Pakistan
M.D. Anderson Cancer Center
Regeneron Pharmaceuticals

Not yet recruiting

A Phase 2 Study to Evaluate the Efficacy of the Combination of Cemiplimab and Cetuximab Prior to Salvage Surgery in Patients With Locally Recurrent (Stage 3-5) OCSCC

Locally Recurrent OCSCC

United States
Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical...

Recruiting

Ultrasound to Assess Sarcopenia in Prader Willi Syndrome (PWS)

Metabolic Syndrome | Sarcopenia | Prader-Willi Syndrome

Taiwan
Revolution Medicines, Inc.

Recruiting

Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

Colorectal Cancer | Pancreatic Ductal Adenocarcinoma | Gastrointestinal Cancer | CRC | Metastatic Pancreatic Ductal Adenocarcinoma | PDAC

United States
Hunan Province Tumor Hospital
Hunan Cancer Hospital

Recruiting

Efficacy and Resistance Mechanisms of IP in NSCLC With Leptomeningeal Metastases (EPIC)

Non-Small Cell Lung Cancer

China
Clinical Hospital Centre Zagreb

Not yet recruiting

Therapeutic Options for CRAB (TheraCRAB)

Infections, Bacterial | Sepsis Bacterial
University of Regina

Recruiting

Strategic Ingestion of Creatine Supplementation and Resistance Training in Trained Young Adults

Muscle | Strength

Canada
Arizona State University

Recruiting

Resistance Exercise Plus Vinegar Ingestion on Biomarkers in Healthy Adults

Mood Disorders | Cognitive Change | LPS

United States
Penn State University

Not yet recruiting

Optimizing Antibiotics Prescription: A Stepped-Wedge Randomized Trial

Antimicrobial Resistance
University of Illinois at Urbana-Champaign

Not yet recruiting

Nutritional Intervention for Sustaining Health (NURISH) Trial

Cognitive Change | Diet, Healthy | Metabolic Syndrome, Protection Against
Riphah International University

Recruiting

Effects of Theraband Resistance Training on Muscle Strength in Coronary Artery Diseases

Coronary Artery Disease

Pakistan
Maastricht University Medical Center

Not yet recruiting

Effects of Ingesting Multiple Boluses of Collagen on Muscle & Skin Connective Protein Synthesis in Vivo in Humans (CODIAK)

Muscle Protein Synthesis

Netherlands
Kent State University

Recruiting

Solarplast (R) Supplementation Effects Following High-intensity Resistance Exercise

Muscle Damage

United States
EMD Serono Research & Development Institute, Inc.
Merck KGaA, Darmstadt, Germany

Not yet recruiting

Tuvusertib Combined With Niraparib or Lartesertib in Participants With Epithelial Ovarian Cancer (DDRiver EOC 302)

Ovarian Cancer

United States, Germany
University Hospital, Brest

Not yet recruiting

Droplet Digital PCR and PCR-free BIOSensors for the Detection of Resistance-associated SNPs in Pneumocystis Jirovecii (DDBIOS)

Pneumocystis Pneumonia

France
Central South University

Not yet recruiting

Investigating the Insulin Resistance in Individuals With Type 2 Diabetes

Type 2 Diabetes

China
Merck Sharp & Dohme LLC

Not yet recruiting

Study of Belzutifan (MK-6482) Plus Fulvestrant for ER+/HER2- Metastatic Breast Cancer (MK-6482-029/LITESPARK-029)

Metastatic Breast Cancer
Novartis Pharmaceuticals

Not yet recruiting

Clinical Study of Asciminib in Previously Treated Indian Patients With Ph+ CML-CP Without T315I Mutation and in Patients With Ph+ CML-CP With T315I Mutation (ASC4INDIA)

Philadelphia Chromosome-Positive Chronic Myeloid Leukemia in Chronic Phase
University of Sao Paulo General Hospital
Conselho Nacional de Desenvolvimento Científico e Tecnológico

Not yet recruiting

Effect of Resistance Training in Patients on the Waiting List for Heart Transplant

Heart Failure | Heart Transplant

Brazil
Tongji Hospital

Not yet recruiting

A Study of Cadonilimab（AK104）Combined With Standard Treatment for Function Preservation in Urinary System Tumors

Urinary System Tumor
Khyber Medical University Peshawar

Recruiting

Impact of FTO Gene Variation on Body Composition, Lipid Profile, Insulin Resistance, Advanced Glycation End-Products and Ghrelin Levels in Response to Hypocaloric, Protein Rich-Diet

Inflammation | Obesity | Insulin Resistance | Dyslipidemias | Advance Glycation

Pakistan

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