Search clinical trials for: Double blind randomised sham-controlled

Total 7968 results

Devintec Sagl
Meditrial SrL

Recruiting

Devintec OR-AT0222 Oral Gel for the Treatment of Canker Sores: A Double Blind, Randomized, Placebo Controlled Clinical Investigation

Recurrent Aphthous Ulcer

Italy
Shionogi

Recruiting

A Phase 2b, Randomized, Double-blind Study of Redasemtide (S-005151) in Adult Participants With Acute Ischemic Stroke (REvive)

Acute Ischemic Stroke

Japan, Israel, United States, Australia, Hong Kong
Sunstone Medical

Recruiting

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of up to Two Doses of Psilocybin for the Treatment of Major Depressive Disorder in Adults With Cancer

Cancer | Major Depressive Disorder

United States
Centre Hospitalier Universitaire Dijon

Not yet recruiting

Effectiveness of tDCS on Reducing Craving in Patients Practicing Chemsex: a Single-center, Double-blind, Randomized Controlled Pilot Trial (CHEMSTIM)

Chemsex

France
Taiho Oncology, Inc.

Recruiting

Phase 2 Futibatinib in Combination With PD-1 Antibody Based Standard of Care in Solid Tumors

Pancreatic Cancer | Esophageal Adenocarcinoma | Esophageal Squamous Cell Cancer | Locally Advanced Unresectable or Metastatic Solid Tumors Including Esophageal Cancer | Siewert Type 1 GEJ Cancer

United States, Spain, Germany, France
Massachusetts General Hospital

Not yet recruiting

Effect of Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity

Obesity
Cairo University

Not yet recruiting

Clinical And Radiographic Evaluation Of Premixed Bio-ceramic MTA In Indirect Pulp Capping Of Young Permanent Molars

Indirect Pulp Capping
Amgen

Recruiting

A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

Non-Small Cell Lung Cancer (NSCLC)

United States, Australia, Netherlands, Taiwan, Korea, Republic of, United Kingdom, Spain, Austria, Japan, Switzerland, Sweden, France, Czechia, Italy, Portugal, Hong Kong, Thailand, Singapore, Bulgaria, Turkey, Argentina, Belgium, G... and more
Tanta University

Recruiting

Comparison Between Ultrasound Guided Ozone, Platelet-Rich Plasma or Steroid Injection in the Treatment of Sacroiliitis; a Randomized Double Blinded Controlled Study

the Efficacy of Ultrasound Guided Sacroiliac Injection of Ozone, Platelet Rich Plasma (PRP) or Steroid for Treatment of Sacroiliitis

Egypt
Cassiopea SpA
ICON Clinical Research; Canfield Scientific Inc.; Ergomed PLC; Pharmapace Inc

Recruiting

A Study to Evaluate the Efficacy and Safety of Clascoterone Solution in Treatment of Male Pattern Hair Loss (SCALP2) (SCALP2)

Alopecia, Androgenetic

Germany, United States, Poland
Cassiopea SpA
ICON Clinical Research; Canfield Scientific Inc.; Ergomed PLC; Pharmapace Inc

Recruiting

A Study to Evaluate the Efficacy and Safety of Clascoterone Solution in Treatment of Male Pattern Hair Loss (SCALP1)

Alopecia, Androgenetic

United States, Georgia
Centre Hospitalier Universitaire de Nice

Recruiting

Contribution of an Antiviral Drug (Valaciclovir) in the Treatment of Generalized Periodontitis (Stage III or IV and Grade A, B or C): Prospective, Randomized and Double Blind Clinical Trial (HERPARO)

Periodontitis Chronic Generalized Severe

France
Sichuan Cancer Hospital and Research Institute
Sichuan Province, Department of Science and Technology

Not yet recruiting

3D-printed Reconstruction Automated Matching System Predicts Size of Double-lumen Tube: a Prospective Double-blinded Randomized Controlled Trial

Lung Diseases | Lung Cancer | Tracheal Intubation Morbidity | Throat Injury | Bronchus; Injury
Shanghai Pulmonary Hospital, Shanghai, China

Not yet recruiting

Neoadjuvant Therapy With Toripalimab and JS004 Combined With Platinum-based Doublet Chemotherapy for Resectable or Potentially Resectable Stage III Non-small Cell Lung Cancer: A Randomised Controlled, Open-label, Phase 2 Trial

Stage III Non-small Cell Lung Cancer
Xi'an Honghui Hospital
Chugai Pharma China Co., Ltd.

Recruiting

Comparison of Efficacy of Denosumab With Eldecalcitol or Native Vitamin D in Postmenopausal Women With Osteoporosis.

Osteoporosis in Postmenopausal Women

China
National Cancer Institute (NCI)

Recruiting

Testing Immunotherapy (Atezolizumab) With or Without Chemotherapy in Locoregional MSI-H/dMMR Gastric and Gastroesophageal Junction (GEJ) Cancer

Gastric Adenocarcinoma | Clinical Stage III Gastric Cancer AJCC v8 | Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 | Gastroesophageal Junction Adenocarcinoma | Clinical Stage I Gastric Cancer AJCC v8 | Clinical Stage II Gastric Cancer AJCC v8 | Clinical Stage IVA Gastric... and other conditions

United States
Chinook Therapeutics, Inc.

Recruiting

Randomized, Double-blind, Placebo-controlled, Crossover Study of Atrasentan in Subjects With IgA Nephropathy (ASSIST)

Immunoglobulin A Nephropathy | IgA Nephropathy

Spain, United States, Australia, Korea, Republic of, Brazil, Malaysia
Maimonides Medical Center

Recruiting

Vaginal Cuff Infiltration With Liposomal Bupivacaine for Pain Relief: A Double Blind, Randomized Controlled Trial

Postoperative Pain

United States
Salim S. Hayek

Recruiting

A Randomized, Double-Blind, Placebo-Controlled Phase 2/3 Study to Determine the Safety and Effectiveness of Azeliragon in the Treatment of Patients Hospitalized for Coronavirus Disease 2019 (COVID-19) or Pneumonia

COVID-19

United States
Eva Pharma
MARC-CRO

Recruiting

Phase IV Trial to Evaluate Efficacy of Alpha-Lipoic Acid in Treating Symptomatic Diabetic Polyneuropathy in Egypt (MIRACLE-ALA)

Polyneuropathy, Diabetic

Egypt
Mayo Clinic

Recruiting

Aldesleukin With Nivolumab and Standard Chemotherapy for Treatment of Gastric Cancer With Peritoneal Metastasis

Gastric Adenocarcinoma | Clinical Stage IV Gastric Cancer AJCC v8 | Gastroesophageal Junction Adenocarcinoma | Metastatic Gastric Carcinoma | Metastatic Malignant Neoplasm in the Peritoneum

United States
Qilu Pharmaceutical Co., Ltd.

Not yet recruiting

A Multicenter, Randomized, Double-blind Phase II Trial to Evaluate GM1 Prevention of Peripheral Neuropathy in Patients With Breast Cancer

To Evaluate the Effectiveness of GM1 in the Prevention of Albumin-paclitaxel Therapy Induced Peripheral Neuropathy in Breast Cancer Patients
Sun Yat-sen University
JIANGSU JIBEIER PHARMACEUTICAL CO.,LTD

Not yet recruiting

A Multi-center, Randomized, Double-blind, Phase III Clinical Trial of Leucogen Versus Placebo on Leukocyte and Platelet Whole-course Management Assisted by PFLL Chemotherapy in the Treatment of Stage IV, Recurrent or Metastatic NPC

Nasopharyngeal Carcinoma | Chemotherapy | Myelosuppression | Leucogen

China
University of Alberta

Recruiting

Comparison of MI Paste Plus and Resin Infiltration in White Spot Lesions Following Orthodontic Treatment

Orthodontic Appliance Complication | Caries Arrested | White Spot Lesions | Smooth Surface Caries

Canada
Chang Gung Memorial Hospital

Recruiting

Improvement of Fertilization Rate and Embryo Quality by Treating Calcium Ionophore in IVF Patients: a Sibling Oocyte Control Study (GM508 in IVF)

Infertility | IVF | Artificial Oocyte Activation

Taiwan
Anthos Therapeutics, Inc.

Recruiting

Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76) (LILAC-TIMI 76)

Atrial Fibrillation (AF)

United States, Canada, Israel, Japan, China, Brazil, Chile, United Kingdom, Bulgaria, Germany, Hungary, Italy, Poland, Romania, Spain, Czechia, Latvia, Mexico, India, Estonia
West Virginia University
University of Florida; Tourette Association of America

Recruiting

Strengthening Tourette Treatment OPtions Using TMS to Improve CBIT, a Double-blind, Randomized, Controlled Study (STOP-TIC)

Tourette Syndrome

United States
Assiut University

Not yet recruiting

Effect of IV Nalbuphine on Nausea and Vomiting Following Intrathecal Morphine

Inguinal Hernia
Guangdong Raynovent Biotech Co., Ltd

Recruiting

A Randomized, Double-blind, Placebo-controlled Study of ZSP1601 in Adult Subjects With Nonalcoholic Steatohepatitis (NASH)

Nonalcoholic Steatohepatitis (NASH)

China
Hospital Universitario Pedro Ernesto
Conselho Nacional de Desenvolvimento Científico e Tecnológico; Rio de Janeiro...

Recruiting

Vitamins D and K Effects on Vascular Function in Obese Adults.

Obesity | Vitamin D3 Deficiency

Brazil
Peking Union Medical College Hospital

Not yet recruiting

Multicenter Randomized Double-blind Placebo-controlled Study to Investigate Azvudine in Symptomatic Adults With COVID-19 at Increased Risk of Progressing to Severe Illness

COVID-19 Respiratory Infection
Queen Mary Hospital, Hong Kong

Not yet recruiting

An Randomized Double Blind Controlled Trial of niPGT-A in Women With RPL (niPGTA)

Infertility

Hong Kong
Novartis Pharmaceuticals

Recruiting

24 Weeks Double-blind Randomized Placebo-controlled Trial to Evaluate Efficacy, PK, Safety of LOU064 in Adolescents (12 - <18) With CSU and Inadequate Response to H1-antihistamine Followed by Optional 3 Years Open-label Extension and an Optional 3 Years Safety Long-term Treatment-free Follow-up

Chronic Spontaneous Urticaria

United States, Singapore, Spain, Germany, Turkey, Italy, Hong Kong, China, Argentina, Malaysia, Thailand, Poland, Japan, Netherlands, South Africa, Chile, Canada
Laboratorio Elea Phoenix S.A.
Syneos Health

Recruiting

Double-blind Study to Evaluate the PK, Efficacy, Safety and Immunogenicity of MB12 Versus Keytruda® in Stage IV NSCLC

Non Small Cell Lung Cancer Metastatic

Argentina
Geropharm

Recruiting

Double-blind, Randomized Comparative Cross-sectional Study of Pharmacodynamics and Pharmacokinetics of Drugs GP40141

Pharmacokinetics | Pharmacodynamics | Bioequivalence

Russian Federation
RedDress Ltd.

Recruiting

A Double Blind, Randomized Controlled Study, Evaluating the Safety and Efficacy of RD2 Ver.02 For the Management of Anal Fistulas

Anal Fistula

United States, Israel
University of Minnesota

Recruiting

Brivaracetam to Reduce Neuropathic Pain in Chronic SCI: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Neuropathic Pain | Spinal Cord Injuries

United States
Massachusetts General Hospital
Pfizer

Recruiting

Double Blind, Placebo-controlled Trial to Establish Safety and Efficacy of Ritlecitinib in Celiac Disease Patients in Remission

Celiac Disease

United States
Women's Hospital School Of Medicine Zhejiang University
ORGANON (SHANGHAI) PHARMACEUTICAL TECHNOLOGY CO., LTD.

Not yet recruiting

Comparison of Clinical Outcomes in Fresh Cycle With Single Blastocyst Stage and Double Cleavage-stage Embryos: a Single-center, Non-blind, Randomized Controlled Study

Infertility, Female
Dong-A ST Co., Ltd.

Recruiting

Efficacy and Safety of Actonel® After Denosumab Discontinuation in Postmenopausal Osteoporosis Women

Postmenopausal Osteoporosis

Korea, Republic of
Ain Shams University

Recruiting

Effects of Curcumin on Inflammation and Oxidative Stress in Pediatric Patients on Regular Hemodialysis: A Randomized, Double-Blind, Placebo-Controlled Pilot Study

Pediatric Patients Having Renal Failure and on Regular Hemodialysis

Egypt
Indonesia University

Not yet recruiting

The Effectiveness of Transcranial Direct Current Stimulation as Adjunctive Treatment for Chronic Daily Headache in Systemic Lupus Erythematosus (SHADE)

Systemic Lupus Erythematosus | Chronic Headache
Aurigene Discovery Technologies Limited

Recruiting

A First in Human Study of AUR 103 Calcium to Evaluate Safety, Pharmacokinetics and Pharmacodynamics (BHARAT-1)

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Non Hodgkin Lymphoma | Solid Tumor, Adult

India
Xeolas Pharmaceuticals Limited

Recruiting

A Randomized Control Trial Phase (IIIa) Unicentric, Placebo Controlled, Double-Blinded Efficacy and Safety of Topical Alendronic Acid on Alveolar Bone Remodeling After Tooth Extraction (XEOLAS)

Bone Loss, Alveolar

Spain
University Hospital, Tours

Recruiting

Evaluation of Efficacy and Safety of Rituximab in Patients With Progressive Interstitial Lung Disease (ILD) With Inflammatory Component: a Multicentre Double-blind Placebo-controlled Randomized Trial (EvER-ILD2)

Lung Diseases

France
Beijing Tiantan Hospital
CSPC Ouyi Pharmaceutical Co., Ltd.

Not yet recruiting

Efficacy of Pentoxifylline on Cerebrovascular Function in Patients With Cerebral Small Vessel Disease(PERFORM) (PERFORM)

Cerebral Small Vessel Diseases

China
Centre Hospitalier Universitaire de Saint Etienne
Ministry of Health, France

Recruiting

Study of the Impact of Mother-of-pearl Nutritional Supplementation on the Prevention of Post-menopausal Osteoporosis (NUTRANACRE)

Post Menopausal Osteoporosis

France
National Nutrition and Food Technology Institute

Not yet recruiting

Relationship Between Serum Vitamin D and Outcomes of Liver Transplantation in Cirrhotic Patients Undergoing Liver Transplantation and Effects of Vitamin D Supplementation in Post-transplant Period

Vitamin D Deficiency | Liver Transplant; Complications
National Cancer Institute (NCI)

Recruiting

Study of Chemotherapy, With or Without Binimetinib in Advanced Biliary Tract Cancers in 2nd Line Setting (A ComboMATCH Treatment Trial)

Stage III Intrahepatic Cholangiocarcinoma AJCC v8 | Recurrent Gallbladder Carcinoma | Unresectable Gallbladder Carcinoma | Stage III Hilar Cholangiocarcinoma AJCC v8 | Stage IV Hilar Cholangiocarcinoma AJCC v8 | Stage IV Intrahepatic Cholangiocarcinoma AJCC v8 | Stage IV Distal Bile Duct Cancer... and other conditions

United States
Sun Yat-sen University

Recruiting

A Randomized, Double-blind,Phase Ⅲ Study of Liposome Doxorubicin in Desmoid Tumor

Desmoid Tumor

China

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