Search clinical trials for: First line subjects

Total 38946 results

Bristol-Myers Squibb

Recruiting

A Study to Assess Health-Related Quality of Life in Patients With Hypertrophic Cardiomyopathy in Japan

Hypertrophic Cardiomyopathy

Japan
Bristol-Myers Squibb

Not yet recruiting

A Lactation Study in Women Receiving Treatment With Ozanimod

Lactating Women | Breastfed Infants
Centre Hospitalier Universitaire de Saint Etienne
Takeda France

Not yet recruiting

Comparison of Vedolizumab Treatment to Adalimumab Dose Intensification in Crohn's Disease Patients With Loss of Response or Biomarker Activity to Adalimumab on First Line With Therapeutic Drug Concentration. (VEDIAN)

Crohn's Disease

France
FutureGen Biopharmaceutical (Beijing) Co., Ltd

Recruiting

M108 Plus CAPOX Versus Placebo Plus CAPOX as First-line Treatment for Claudin (CLDN) 18.2-Positive, HER2-Negative, PD-L1 CPS<5, Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma.

Locally Advanced Unresectable or Metastatic Gastric Cancer | Locally Advanced Unresectable or Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma

China
yue junhan

Recruiting

Efficacy and Safety of Combined With Immunotherapy After Induction Therapy With Chemotherapy and Targeted Therapy in the First-line Treatment of Microsatellite Stable (MSS) Initially Unresectable Metastatic Colorectal Cancer (FOBECAMS)

Colorectal Cancer

China
Peking University People's Hospital
Peking University First Hospital; Beijing Friendship Hospital; Chinese PLA General... and other collaborators

Recruiting

Teriflunomide Plus High-dose Dexamethasone as First-line Treatment in Newly Diagnosed Primary Immune Thrombocytopenia

Immune Thrombocytopenia

China
Novatim Immune Therapeutics (Zhejiang) Co., Ltd.

Recruiting

Phase I Study of KY-0118 in Subjects With Locally Advanced or Metastatic Solid Tumors

Neoplasms | Neoplasms by Histologic Type

China
Soonchunhyang University Hospital

Not yet recruiting

A Single-center Clinical Study to Evaluate the Safety and Efficacy of Autologous Bone Marrow-derived DCs(CellgramDC-WT1) and Immune Checkpoint Inhibitors in Patients With Metastatic Pancreatic Cancer Who Have Failed First-line or More Standard Chemotherapy (DICI_PC)

Pancreas Cancer
Xencor, Inc.

Recruiting

Study of Vudalimab or Pembrolizumab in Combination With Chemotherapy as First-line Treatment in Patients With Advanced NSCLC

Nonsquamous Non-small Cell Lung Cancer

United States
Celgene

Recruiting

A Study to Assess the Effects of Itraconazole, Food, and pH on the Drug Levels of BMS-986368 in Healthy Participants

Healthy Participants

United States
Cancer Institute and Hospital, Chinese Academy...

Recruiting

Advanced First-line Treatment of Short-term Postoperative Progression of Head and Neck Squamous Cell Carcinoma

Head and Neck Squamous Cell Carcinoma

China
Bristol-Myers Squibb

Recruiting

An Observational Study to Evaluate Neoadjuvant Nivolumab (OPDIVO®) in Combination With Platinum-Based Chemotherapy in Non-Metastatic Non-Small Cell Lung Cancer Participants in Germany (NENI)

Resectable Non-small Cell Lung Cancer

Germany
China Medical University, China

Recruiting

A Study of Fruquintinib in Combination With Irinotecan and Capecitabine for the Second-line Treatment of Patients

Capecitabine | Fruquintinib | Gastrointestinal Tumours | Irinotecan

China
Future Cardia, Inc
Meditrial Europe Ltd.

Recruiting

Future Cardia™ Insertable Cardiac Monitor in Subjects With Paroxysmal Atrial Fibrillation (First-in-Human Study)

Atrial Fibrillation | Arrhythmias, Cardiac | Bradycardia | Ventricular Tachycardia | Asystole

Croatia
Bristol-Myers Squibb

Recruiting

A Study to Evaluate the Safety of Empliciti® (Elotuzumab) When Treating Patients With Multiple Myeloma in Taiwan

Relapsed or Refractory Multiple Myeloma

Taiwan
Zai Lab (Hong Kong), Ltd.

Recruiting

A Phase 3b Randomized, Double-blind, Multi-center Study to Compare the Safety and Efficacy of Omadacycline to Moxifloxacin for Treating Adult Subjects With CABP (public)

Community-acquired Bacterial Pneumonia

China
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Recruiting

A Clinical Trial of TQ-A3334 Tablet After Multiple Administration in Adult Subjects

Hepatitis B

China
Fudan University

Recruiting

A Study of PD-1 Inhibitors Combined With Fruquintinib and Chemotherapy in First-line Treatment of HER2-negative Advanced G/GEJ Cancer (G/GEJ cancer)

Gastric Cancer/Adenocarcinoma of Esophagogastric Junction

China
Nanfang Hospital, Southern Medical University

Recruiting

Lenvatinib Plus Tislelizumab and CapeOX as First-Line Treatment for Advanced GC/GEJC With Positive PD-L1 and Low TMEscore

Gastric Cancer

China
Chia Tai Tianqing Pharmaceutical Group Nanjing...

Recruiting

A Clinical Study of TQH2929 in Healthy Adult Subjects

Psoriasis

China
Fu Jen Catholic University Hospital

Recruiting

Fourteen-Day Vonoprazan-Based Dual Therapy With Amoxicillin as First-Line Helicobacter Pylori Treatment in Comparison With Extended Sequential Therapy

Helicobacter Pylori Infection

Taiwan
GeneQuantum Healthcare (Suzhou) Co., Ltd.

Recruiting

A Study of GQ1005 in Subjects With HER2-Expressing Advanced Solid Tumors

HER2 Expressing or Mutated Advanced Malignant Solid Tumors

China
RemeGen Co., Ltd.

Recruiting

A Study of RC48-ADC Combination With Zimberelimab Injection Therapies at Least First-line Platinum-containing Standard Therapy Failed With Recurrent or Metastatic Cervical Cancer

Cervical Cancer

China
Juno Therapeutics, Inc., a Bristol-Myers Squibb...

Recruiting

A Study to Assess BMS-986453 in Participants With Relapsed and/or Refractory Multiple Myeloma

Relapsed and/or Refractory Multiple Myeloma

United States, France, Spain, Germany
Joint Academy
Lund University; The Swedish Osteoarthritis Registry

Recruiting

Can Digitally Delivered First-line Osteoarthritis Treatment Improve Equal Access to Care (Access)

Osteoarthritis | First-line Treatment | Health Services Accessibility

Sweden
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Recruiting

Fruquintinib Plus Camrelizumab and Capecitabine as Salvage Therapy After Progression on FOLFOXIRI-based First-line Treatment in Patients With Unresectable/Metastatic Colorectal Cancer

Unresectable/Metastatic Colorectal Cancer

China
Hangzhou Sumgen Biotech Co., Ltd.

Recruiting

SG301-SC Injection Safety Study in Subjects With Systemic Lupus Erythematosus

Systemic Lupus Erythematosus (SLE)

China
Bristol-Myers Squibb

Recruiting

A Study to Evaluate the Safety, Tolerability, Drug Levels, Food, Formulation, and pH Effects on Relative Absorption of BMS-986465 and Its Active Derivative BMS-986464 in Healthy Participants

Healthy Participants

United States
Chia Tai Tianqing Pharmaceutical Group Nanjing...

Recruiting

A Clinical Trial of AP026 (TQA2226) for Injection in Adult Subjects.

Diabetes Mellitus, Type 2

China
Zhejiang Cancer Hospital

Not yet recruiting

The Efficacy and Safety of Lenvatinib Combined With Sindilimab and Nab-paclitaxel in the First-line Treatment for Recurrent and Metastatic Triple Negative Breast Cancer: a Phase Ib/IIa Clinical Trial.

Breast Neoplasms

China
Bristol-Myers Squibb
Zai Lab (Shanghai) Co., Ltd.

Recruiting

A Study of Repotrectinib Versus Crizotinib in Participants With Locally Advanced or Metastatic Tyrosine Kinase Inhibitor (TKI)-naïve ROS1-positive Non-Small Cell Lung Cancer (NSCLC) (TRIDENT-3)

Carcinoma, Non-Small-Cell Lung

Japan, China, Canada, Spain, Germany, Korea, Republic of, Austria, Brazil, Greece, France, United States, Italy, Argentina, Chile, Hungary, India, Turkey, Romania, Netherlands, Poland, Switzerland
Lixia Sheng

Recruiting

Clinical Study of OR for Second-line Treatment of Refractory MZL

OR Regimen for Relapsed/Refractory Marginal Zone Lymphoma

China
Merck Sharp & Dohme LLC

Recruiting

A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)

Chronic Lymphocytic Leukemia | Small Lymphocytic Lymphoma

United States, Israel, Taiwan, United Kingdom, Chile, Canada, Japan, Brazil, China, Colombia
Yi Yang

Not yet recruiting

Safety and Efficacy of Urinary Kallidinogenase for Large Artery Atherosclerosis Acute Ischemic Stroke

Acute Ischemic Stroke

China
Nanfang Hospital, Southern Medical University

Not yet recruiting

First-In-Human Study of Bispecific Antibody MR001 In Subjects With Advanced Solid Tumors

Advanced Solid Tumors

China
Central Hospital, Nancy, France

Not yet recruiting

Steroids Versus ECP and Steroids as First-line Treatment of Grade II Acute GVHD (COPAVEHDI)

Graft Vs Host Disease

France
Bristol-Myers Squibb

Not yet recruiting

A Study to Evaluate the Safety of Ozanimod Exposure During Pregnancy in Women With Ulcerative Colitis and Their Infants

Ulcerative Colitis

United States
Protox Inc.

Not yet recruiting

The Efficacy and Safety of Protoxin in Subjects With Moderate to Severe Glabellar Lines

Glabellar Frown Lines
Bristol-Myers Squibb

Recruiting

Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF) (AURORA-HFpEF)

Heart Failure

United States, Spain, Canada, Italy, Poland
Juno Therapeutics, Inc., a Bristol-Myers Squibb...

Recruiting

A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of BMS-986393 in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma

Multiple Myeloma

United States, Canada
Janssen Research & Development, LLC

Recruiting

Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib (COCOON)

Carcinoma, Non-Small-Cell Lung

United States, Taiwan, Korea, Republic of, Malaysia, Turkey, France, Spain, China, Germany, Argentina, Brazil
Mario Negri Institute for Pharmacological Research
AstraZeneca

Recruiting

First Line Treatment With Olaparib in Combination With Bevacizumab in HRD Positive Patients (IOLANTHE)

Carcinoma, Ovarian Epithelial

Italy
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Recruiting

The PLATINUM Trial: Optimizing Chemotherapy for the Second-Line Treatment of Metastatic BRCA1/2 or PALB2-Associated Metastatic Pancreatic Cancer

Pancreatic Adenocarcinoma | Pancreatic Ductal Adenocarcinoma | Stage IV Pancreatic Cancer AJCC v8 | Pancreatic Carcinoma | Pancreatic Acinar Cell Carcinoma | Pancreatic Adenosquamous Carcinoma | Pancreatic Squamous Cell Carcinoma

United States
Shanghai General Hospital, Shanghai Jiao Tong University...

Not yet recruiting

Study of Fuquinitinib Combined With Capecitabine First-line Maintenance in the Treatment of Metastatic Colorectal Cancer

Colorectal Carcinoma
Bristol-Myers Squibb

Recruiting

A Study to Evaluate Mavacamten Impact on Myocardial Structure in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy (MEMENTO)

Cardiomyopathy, Hypertrophic

United States, Argentina, Australia, Belgium, Canada, Czechia, Hungary, Poland, Switzerland, France, Austria, Finland, Germany, Greece, Italy, Spain, United Kingdom
Fujian Akeylink Biotechnology Co., Ltd.

Recruiting

Pharmacokinetics and Safety of GST-HG171 Tablets in Subjects With Impaired and Normal Renal Function

COVID-19 Pneumonia

China
Cardiff Oncology
Pfizer

Recruiting

Study of Onvansertib in Combination With FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab Versus FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer in Adult Participants With a KRAS or NRAS Mutation

Metastatic Colorectal Cancer | CRC | KRAS/NRAS Mutation

United States
Chia Tai Tianqing Pharmaceutical Group Nanjing...

Recruiting

TQB3909 Tablets in Subjects With Relapsed or Refractory Mantle Cell Lymphoma (MCL)

Mantle Cell Lymphoma

China
COUR Pharmaceutical Development Company, Inc.

Recruiting

Evaluate the Safety, Tolerability, Pharmacodynamics and Efficacy of CNP-106 in Subjects With Myasthenia Gravis

Myasthenia Gravis | Generalized Myasthenia | AChR Myasthenia Gravis | MuSK MG

United States
Bristol-Myers Squibb

Recruiting

A Study to Evaluate Deucravacitinib in Participants With Moderate-to-Severe Plaque Psoriasis in Germany (DELPHIN) (DELPHIN)

Plaque Psoriasis

Germany

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