Search clinical trials for: Metabolizing enzyme genotype

Total 49388 results

Fudan University

Unknown

Genotype-driven Phase I Study of Irinotecan Administered in Neoadjuvant Chemoradiotherapy in Patients With Stage II/III Rectal Cancer

Rectal Cancer

China
M.D. Anderson Cancer Center

Completed

Subcutaneous Olanzapine for Hyperactive or Mixed Delirium

Advanced Cancer

United States
National Institute of Allergy and Infectious Diseases...

Completed

Effectiveness of Anti-HIV Drugs in Patients Who Have Not Received Previous Anti-HIV Drugs During Different Stages of HIV Infection

HIV Infections

United States
Seoul National University Hospital
Ministry of Health, Welfare and Family Affairs; Korea National Enterprise for...

Completed

PET Imaging Study on Occupancy of Dopamine D2 Receptors and Genotypes After Bupropion Administration

Smoking

Korea, Republic of
Sheba Medical Center

Unknown

Clinical Trial to Assess Safety and Efficacy of Combination Therapy: Hydroxychloroquine, Pegylated Interferon Alpha-2a and Ribavirin in Chronic Hepatitis C Subjects Non-responders to the Standard of Care Therapy.

Chronic Hepatitis C
Seoul National University Hospital

Completed

Influence of Organic Anion Transporting Polypeptide1B1(OATP1B1) Genotype on Rosuvastatin PK, PD and Lipid Profiles (OATP)

Organic Anion Transporting Polypeptide1B1 (OATP1B1) | Rosuvastatin

Korea, Republic of
Sun Yat-sen University
First Affiliated Hospital, Sun Yat-Sen University

Unknown

Exploration of Genotype Based Personalized Prescription of Valproate Sodium in Anti-epileptic Treatment (EGBPPVPA)

Epilepsy | Adverse Effects

China
University of Southern Denmark
Odense University Hospital

Terminated

Development of Cocktail for Measuring the Activity of Important Cytochrome P450 Enzymes

Cytochrome P450 Phenotype and Genotype Metrics

Denmark
Centre Hospitalier Universitaire, Amiens
Roche Pharma AG; Astellas Pharma Inc

Completed

TACrolimus in Renal Transplantation: Individualization by Pharmacogenetic

Kidney Transplantation

France
Seoul National University Hospital

Completed

Influence of CYP2C19 Genotype on the Pharmacokinetics (PK) of Voriconazole

Healthy

Korea, Republic of
Government Medical College, Bhavnagar
Health and Family Welfare Department, Government of Gujarat, India; Arjuna...

Completed

Effect of Curcumin as Nutraceutical in Patients of Depression

Major Depressive Disorder

India
National Taiwan University Hospital
National Science Council, Taiwan

Completed

Relation of Metabolic Rate of Omeprazole and Eradication of Helicobacter Pylori Infection

Helicobacter Pylori Infection | Duodenal Ulcer

Taiwan
University of Southern Denmark
Odense University Hospital

Completed

Uptake of the Antifungal Miconazole and Effect on Estrogen Metabolizing Enzymes in Humans

Healthy

Denmark
National Institute of General Medical Sciences...

Completed

Antidepressant Treatment of Mexican-Americans: UCLA Pharmacogenetics and Pharmacogenomics Research Group

Major Depression | Major Depressive Disorder | Unipolar Depression

United States
University of Turku
KELA; Finnish State Grant

Completed

Fluoxetine vs. Brief Psychotherapy for Major Depression

Major Depressive Disorder
University of Oslo School of Pharmacy

Completed

Metabolic Pattern of Cyclosporine A and Acute Renal Failure

Heart Transplantation | Acute Renal Failure

Norway
Hamamatsu University
Yokoyama Foundation for Clinical Pharmacology

Unknown

Tailored Treatment of H. Pylori Infection Based Polymorphisms of CYP2C19 and 23S rRNA of H. Pylori

Gastritis | Helicobacter Infections | Gastric Ulcer | Duodenal Ulcer

Japan
Centers for Disease Control and Prevention
Malaria Research and Training Center, Bamako, Mali

Completed

Antimalarial Drug Resistance in Mali

Malaria

Mali
Bassett Healthcare
PriCara, Unit of Ortho-McNeil, Inc.

Completed

Comparative Effects of Azithromycin, Telithromycin and Levofloxacin on Drug Metabolizing Enzymes

Healthy
National Institute of Mental Health (NIMH)
Icahn School of Medicine at Mount Sinai

Completed

Study of Fluoxetine in Patients With Depersonalization Disorder

Depersonalization Disorder

United States
Glaxo Wellcome

Completed

Safety and Effectiveness of Lamivudine When Given Once a Day Versus Twice a Day in Combination With Other Anti-HIV Drugs in HIV-Infected Adults Who Have Never Received Anti-HIV Drugs

HIV Infections

United States, Canada, Argentina, Brazil, Puerto Rico
Agouron Pharmaceuticals

Unknown

Treatment With Nelfinavir or Efavirenz of HIV-Infected Patients Who Have Never Received Anti-HIV Drugs

HIV Infections

United States
Glaxo Wellcome

Completed

A Phase III Randomized Double-Blind, Multicenter Study to Evaluate the Safety and Efficacy of 3TC/ZDV/1592U89 and 3TC/ZDV/IDV in HIV-1 Infected Antiretroviral Therapy-Naive Subjects.

HIV Infections

United States
Dupont Merck

Completed

A Study of Three Different Anti-HIV Drug Combinations in HIV-Infected Patients

HIV Infections

United States, Puerto Rico
Mayo Clinic

Not yet recruiting

Deucravacitinib (BMS-986165) for Pityriasis Rubra Pilaris

Pityriasis Rubra Pilaris

United States
Peking University

Recruiting

Real-world Study to Evaluate the Efficacy and Safety of Liposome Irinotecan

Colorectal Cancer | Solid Tumor

China
Columbia University
University of Southern California; Abdul Latif Jameel Poverty Action Lab; Bowdoin... and other collaborators

Not yet recruiting

E-mail Nudges for Prescribing Risky Drugs

Opioid Prescribing | Prescription Drug Misuse

United States
Regeneron Pharmaceuticals

Not yet recruiting

Assessment of Gastrointestinal Blood Loss After Receiving Aspirin or Aspirin Plus Rivaroxaban, or Aspirin Plus REGN9933, or Aspirin Plus REGN7508 in Healthy Adult Participants

Healthy Volunteers
Ain Shams University

Recruiting

Clinical Outcome of Vinpocetine in Diabetic Nephropathy

Diabetic Kidney Disease | Diabetic Nephropathies

Egypt
Applied Science & Performance Institute

Recruiting

Acute Effects of PLT Health Solutions zümXR Extended-Release Caffeine

Cognitive Change | Mood | Caffeine | Mood Change

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Vemurafenib and Cobimetinib for the Treatment of Patients With High Risk Differentiated Thyroid Carcinoma With BRAFV600E Mutation

Thyroid Gland Follicular Carcinoma | Thyroid Gland Papillary Carcinoma | Thyroid Gland Oncocytic Carcinoma

United States
University of California, San Francisco
Johns Hopkins University

Not yet recruiting

Program for Rifampicin-Resistant Disease With Stratified Medicine for Tuberculosis (PRISM-TB)

Tuberculosis, Pulmonary | Tuberculosis, Multidrug-Resistant | Tuberculosis, MDR

Peru, Vietnam, Moldova, Republic of, Mongolia, Pakistan, Philippines, South Africa
Nottingham University Hospitals NHS Trust

Not yet recruiting

Pneumocystis Jirovecii Genotyping

Pneumocystis Pneumonia
Incyte Corporation

Not yet recruiting

A Study to Evaluate the Effect of Povorcitinib on the QT/QTc Interval in Healthy Participants

Healthy Participants
Fondazione Italiana Linfomi - ETS

Not yet recruiting

Retrospective-prospective Study to Evaluate Treatment Management and Outcomes of Patients With Waldenström's Macroglobulinemia (WM) Treated in Italy According to the Zanubrutinib (Brukinsa®) Compassionate Use Program (CUP) and in Common Practice Following Commercial Approval.

Waldenström's Macroglobulinemia (WM)

Italy
Fudan University

Not yet recruiting

Efficacy and Safety of HAIC in Combination With TQB2868 and Ramucirumab for Second-line Treatment of Advanced Hepatocellular Carcinoma

Hepatocellular Carcinoma，Bispecific Antibodies, HAIC, Ramucirumab

China
Ruijin Hospital

Not yet recruiting

Efficacy of Pola-RCHP-X vs Pola-RCHP in Untreated DLBCL

Diffuse Large B-Cell Lymphoma
Fujian Cancer Hospital

Not yet recruiting

Double Dose of Third-generation EGFR-TKI Plus Intrathecal Pemetrexed Versus Double Dose of Third-generation EGFR-TKI in Patients With LM Progression Following the Treatment of Routine Dose of Third-generation EGFR-TKI

Leptomeningeal Metastasis

China
Medical University of Vienna

Recruiting

Comparing Anticoagulation Strategies Using UFH, Argatroban and LMWH for ECMO Support (CASUAL-ECMO)

Respiratory Insufficiency | Bleeding | Thromboembolism | Circulatory Failure

Austria
Astellas Pharma Global Development, Inc.

Not yet recruiting

A Study to Confirm if Fezolinetant Helps Reduce Hot Flashes in Women With Breast Cancer Who Are Having Hormone Therapy

Hot Flashes
Regina Elena Cancer Institute

Recruiting

Low Intensity Shock Wave Therapy in the Rehabilitation Treatment of Erectile Dysfunction After Robotic Radical Prostatectomy.

Erectile Dysfunction

Italy
Australasian Gastro-Intestinal Trials Group
AstraZeneca; Wayne Elphinstone Research Fund

Not yet recruiting

Phase II Study of the Combination of Durvalumab (MEDI4736) (PDL1 Inhibitor) and Olaparib (PARP Inhibitor) in Advanced Cholangiocarcinoma After Initial Chemotherapy and Durvalumab (BIL-PPP)

Cholangiocarcinoma

Australia
International Bio service

Not yet recruiting

Bioequivalence Study of Dabigatran Etexilate Capsules 150 mg in Healthy Thai Volunteers Under Fasting Conditions

Healthy Volunteer | Bioequivalence Study | Dabigatran
Yinyi(Liaoning) Biotech Co., Ltd.

Not yet recruiting

Bingo Drug-eluting Balloon Versus a Drug-eluting Stent for Coronary Bifurcation Lesions

Coronary Artery Disease
Hunan Province Tumor Hospital
Hunan Cancer Hospital

Recruiting

Efficacy and Resistance Mechanisms of IP in NSCLC With Leptomeningeal Metastases (EPIC)

Non-Small Cell Lung Cancer

China
Anhui Provincial Hospital

Recruiting

Effect of Letermovir Prophylaxis on CMV-specific Immune Reconstitution Post UCBT

Cytomegalovirus Infection Reactivation

China
XIANG YANQUN

Not yet recruiting

Efficacy and Safety of TPC+Apatinib+Camrelizumab vs GP+ Camrelizumab for High-Risk Nasopharyngeal Carcinoma: A Phase 3 Trial

Nasopharyngeal Carcinoma
West China Hospital

Not yet recruiting

Cadonilimab Combined With Liposomal Irinotecan Plus Leucovorin and Fluorouracil for Advanced Cholangiocarcinoma

Cholangiocarcinoma
Tang-Du Hospital

Not yet recruiting

Baricitinib for the Lung Injury Following Spontaneous SAH (BLISS)

Spontaneous Subarachnoid Hemorrhage
Dana-Farber Cancer Institute
Johns Hopkins University; Translational Breast Cancer Research Consortium

Not yet recruiting

The SAPPHO Study: A Single-Arm, Phase II Study of Sequential Therapy With Curative Intent in de Novo HER2+ Metastatic Breast Cancer

Breast Cancer | HER2-positive Breast Cancer | Stage IV Breast Cancer | Breast Cancer Female | Breast Cancer Metastatic | Estrogen Receptor-positive Breast Cancer

United States

Search clinical trials for: Metabolizing enzyme genotype

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