Search clinical trials for: Multiple ascending dose study

Total 138009 results

MedImmune LLC

Completed

A Multiple-ascending-dose Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of MEDI0382 in Overweight and Obese Participants With Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus

Germany
Merck Sharp & Dohme LLC

Completed

Multiple Ascending Dose Study of MK-5160 in Participants With Type 1 and Type 2 Diabetes Mellitus (MK-5160-002)

Type 2 Diabetes Mellitus | Type 1 Diabetes Mellitus

United States
Esperion Therapeutics, Inc.

Completed

A Multiple Ascending Dose Study of ETC-1002 in Subjects With Mild Dyslipidemia

Mild Dyslipidemia

United States
Esperion Therapeutics, Inc.

Completed

A Multiple Ascending Dose Study of ETC-1002 in Healthy Subjects

Safety Evaluation of Escalating Doses

United States
AstraZeneca

Completed

A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD5718 After Single and Multiple Ascending Dose Administration to Healthy Male Subjects

Cardiovascular Disease | Healthy Male Subjects

United Kingdom
Astellas Pharma Global Development, Inc.

Completed

A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MA-0211 in Healthy Adult Subjects Including a Food Effect Cohort

Healthy Volunteers

United States
Janssen Research & Development, LLC

Completed

A Single Ascending Dose Study in Healthy Participants and Multiple Dose Study of JNJ-55920839 in Participants With Mild to Moderate Systemic Lupus Erythematosus

Healthy | Systemic Lupus Erythematosus

United States, Spain, Romania, Taiwan, Belgium, Poland, Moldova, Republic of
Vitae Pharmaceuticals, Inc.

Completed

An Ascending Multiple Dose Study of VTP-38543 in Adult Participants With Mild to Moderate Atopic Dermatitis

Dermatitis, Atopic

United States, Canada
Daiichi Sankyo, Inc.

Completed

A Open-Label, Multiple Ascending Dose Study of DS-3078a, an Oral TORC1/2 Kinase Inhibitor, in Subjects With Advanced Solid Tumors or Lymphomas

Lymphoma | Advanced Solid Tumor

United States
Janssen Research & Development, LLC

Completed

A Study of Single and Multiple Ascending Doses of JNJ-61393215 in Healthy Participants

Healthy

Netherlands
Daiichi Sankyo, Inc.

Completed

Multiple Ascending Dose Study of DS-1093 in Healthy Subjects

Anaemia

United Kingdom
Regeneron Pharmaceuticals
Sanofi

Completed

Study of Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of REGN3500 in Adults With Moderate Asthma

Asthma | Moderate Asthma

United Kingdom
AstraZeneca

Completed

Single + Multiple Ascending Dose and Food Effect Study of AZD7986 in Healthy Volunteers, PK, PD and Safety Study

Safety, Pharmacokinetics, Pharmacodynamics, Food Effect

United Kingdom
Pfizer

Completed

Study To Evaluate Safety And Tolerability Of Single And Multiple Ascending Doses Of PF- 06260414 In Healthy Western And Japanese Male Subjects

Healthy

United States
Cortexyme Inc.

Completed

A Multiple Ascending Dose Study of COR388

Alzheimer Disease

United States
Amgen

Completed

Ascending Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Evolocumab (AMG 145) in Adults With Hyperlipidemia on Stable Doses of a Statin

Hyperlipidemia
Pfizer

Completed

First-In-Human Study Of Single And Multiple Ascending Doses Of PF-06751979

Healthy Subjects

United States
Pfizer

Completed

PF-06291874 Multiple Ascending Dose Study In Type 2 Diabetes Mellitus Patients

Diabetes Mellitus, Type 2

United States
Vitae Pharmaceuticals Inc., an Allergan affiliate

Completed

An Ascending Multiple Dose Study With VTP-43742 in Healthy Volunteers and Psoriatic Patients

Psoriasis

United States
Vitae Pharmaceuticals Inc., an Allergan affiliate

Completed

An Ascending Multiple Dose Study With VTP-43742 in Healthy Volunteers

Psoriasis

United States
Indivior Inc.

Completed

Multiple Ascending Dose Study of the Safety, Tolerability, Pharmacokinetic/Efficacy

Schizophrenia

United States
Enanta Pharmaceuticals, Inc
Pharmaceutical Research Associates

Completed

A Study of EDP-938 in Healthy Subjects

RSV Infection

United States
Tianjin Hemay Bio-Tech Co., Ltd

Unknown

Multiple Ascending Dose Study to Assess Safety and Pharmacokinetics of Hemay005 In Healthy Subjects

Psoriasis

China
Amgen

Completed

An Ascending Multiple Dose Study Evaluating AMG 167 in Healthy Men and Postmenopausal Women With Low Bone Mineral Density

Osteopenia
Pfizer

Completed

A Study To Understand Safety And Plasma Concentrations Of PF-06669571 During And Following The Oral Administration Of Single And Multiple Doses Of PF-06669571 In Healthy Volunteers Under Fasted And Fed Conditions

Healthy

United States
Biogen

Completed

Multiple Ascending Dose Study of Intravenously Administered BMS-986168 (BIIB092) in Patients With Progressive Supranuclear Palsy (CN002-003)

Progressive Supranuclear Palsy

United States
Crinetics Pharmaceuticals Inc.

Completed

Single and Multiple-Ascending Dose Study of CRN00808 in Healthy Volunteers

Healthy Volunteers

Australia
Ablynx

Completed

ALX-0171 Phase I Study, Evaluating Single Ascending Dose and Multiple Dose in Healthy Male Volunteers

RSV Infection

Netherlands
Idorsia Pharmaceuticals Ltd.

Completed

A Study to Assess the Tolerability, Safety, Pharmacodynamics, and Pharmacokinetics of Ascending Single Doses (Including Food Interaction) and Ascending Multiple Doses of ACT-453859, and Multiple Doses of Setipiprant (ACT-129968)

Healthy
Idorsia Pharmaceuticals Ltd.

Completed

First-in-man Study of Single and Multiple Ascending Doses of a New Drug for Neurological Disorders

Healthy Subjects

Germany
AstraZeneca
Parexel

Completed

Multiple-ascending Dose Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD9977 in Healthy Male Subjects

Healthy Volunteers

United Kingdom
Aelis Farma
National Institute on Drug Abuse (NIDA)

Completed

Multiple Ascending Dose to Study the Safety, Tolerability, PK and PD Effects of AEF0117

Healthy Volunteers

United States
Sanofi

Completed

Multiple Ascending Dose Study in Healthy Male Subjects and Overweight to Obese Male and Female Type 2 Diabetes Mellitus (T2DM) Patients

Type 2 Diabetes Mellitus

Germany
AstraZeneca

Completed

A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD5718 After Single and Multiple Ascending Dose Administration to Healthy Japanese Men

Coronary Artery Disease

United States
Biota Pharmaceuticals, Inc.

Completed

Safety and Pharmacokinetics Study of Multiple Ascending Doses of BTA-C585 in Healthy Volunteers

Healthy Volunteers | Pharmacokinetics

United States
Eidos Therapeutics, a BridgeBio company
Celerion

Completed

Single and Multiple Ascending Dose Study Assessing the Safety, Tolerability, PK and PD of AG10

Amyloid Cardiomyopathy, Transthyretin-Related

United States
Prothena Biosciences Limited

Completed

Multiple Ascending Dose Study of PRX003 in Subjects With Psoriasis

Psoriasis

United States
AstraZeneca
Parexel

Terminated

A Phase I Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Food Effect of AZD9898

Asthma

United Kingdom
Cinclus Pharma AG

Completed

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of X842 in Human: A Single/Multiple Ascending Dose Study

Healthy Volunteers

Sweden
Hanmi Pharmaceutical Company Limited

Unknown

Multiple Ascending Dose Study of HM12470 in Type 1 and Type 2 Diabetes Mellitus

Type2 Diabetes Mellitus | Type1 Diabetes Mellitus

United States
Bristol-Myers Squibb

Terminated

Single Ascending Dose and Multiple Ascending Dose Study in Healthy Participants and Proof of Mechanism Study in Patients With Ulcerative Colitis

Healthy Volunteers | Ulcerative Colitis

Australia, Georgia, Moldova, Republic of
AstraZeneca

Completed

A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses of AZD9567.

Rheumatoid Arthritis

Germany, United Kingdom
Genmedica Therapeutics S.L.
Simbec Research

Terminated

Multiple Ascending Dose Study of GMC-252-L-Lys Salt in Healthy Subjects and Type 2 Diabetics

Healthy | Type 2 Diabetes Mellitus

United Kingdom
Bristol-Myers Squibb

Completed

Phase 1, Multiple Ascending Dose Study of Anti-HER2 FCAB FS102 in HER2 Positive Solid Tumors (Anti HER2 Fcab)

Solid Tumors That Overexpress HER2 (HER2 Positive)

United States, Canada
ContraVir Pharmaceuticals, Inc.

Completed

Phase 2, Multiple Ascending Dose Proof of Concept Study

Infectious Disease

Thailand
Hoffmann-La Roche

Completed

Placebo-Controlled, Single and Multiple Ascending Subcutaneous Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BMS-986089 in Healthy Adult Subjects

Healthy Adults

United States
Pfizer

Completed

Multiple Ascending Dose and DDI Study

Healthy Volunteers

Belgium
Trius Therapeutics LLC

Completed

Single and Multiple Ascending Dose Pharmacokinetic Study of TR701 in Healthy Adults (SAD/MAD)

Healthy Subjects

United States
Enanta Pharmaceuticals, Inc
Pharmaceutical Research Associates

Completed

A Study of EDP 305 in Healthy Subjects and Subjects With Presumptive NAFLD

Presumptive NAFLD

United States
Biosplice Therapeutics, Inc.

Completed

A Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of SM04755 Following Topical Administration to Healthy Subjects

Tendinopathy

United States

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