Search clinical trials for: Rare Mutations

Total 143884 results

Seoul National University Hospital
National Research Foundation of Korea

Active, not recruiting

Pancreas Cancer Surveillance Using an Abbreviated MRI

Pancreas Cancer

Korea, Republic of
Vincerx Pharma, Inc.

Active, not recruiting

Phase I Dose Escalation Study for VIP152 in Patients With Advanced Cancer

Neoplasms

United States, Chile, Spain
Li Junmin

Withdrawn

Decitabine and Arsenic Trioxide for Myelodysplastic Syndrome(MDS)

Myelodysplastic Syndromes | P53 Mutation

China
MeiraGTx UK II Ltd

Completed

Natural History Study of Patients With Leber Congenital Amaurosis Associated With Mutations in RPE65

Leber Congenital Amaurosis

United Kingdom, United States
Mingge LLC
Fudan University; Huashan Hospital

Active, not recruiting

Radiomics-Based Visualization and Quantitative Validation of IDH1 Heterogeneity in Gliomas

Glioma, Malignant | Computer-Assisted

China
University Health Network, Toronto

Terminated

Capturing BRCA1/2 Mutational Status in Women With High Grade Serous Ovarian Cancer and Impact on Clinical Outcome.

Ovarian Cancer

Canada
Amsterdam UMC, location VUmc
University Hospital, Essen; Institut Curie; Ligue contre le cancer, France

Completed

New Strategies to Detect Cancers in Carriers of Mutations in RB1 (NIRBTEST)

Retinoblastoma | Secondary Primary Malignancies After Retinoblastoma

Netherlands, France, Germany
Pfizer

Completed

Transthyretin Amyloidosis Outcome Survey (THAOS) (THAOS)

Transthyretin Amyloidosis | Transthyretin Gene Mutations

United States, France, Spain, Taiwan, Israel, Korea, Republic of, Denmark, Canada, Netherlands, Japan, Sweden, Brazil, Mexico, Argentina, Portugal, Belgium, Bulgaria, Cyprus, Germany, Italy, Malaysia, Romania, Saudi Arabia, Turkey, United...
Lynkcell Europe

Enrolling by invitation

Phase I Clinical Trials Investigating the Potential Efficacy of Axitinib in Patients With a BRCA 1/2 Mutations

Breast Cancer | Breast Neoplasms | Ovarian Neoplasms | Ovarian Cancer | HER2-positive Breast Cancer | HER2-negative Breast Cancer | HER-2 Protein Overexpression | BRCA Mutation

Ukraine
Lynkcell Europe

Available

An Expanded Access Program to Axitinib is Available for Patients With Advanced Forms of Kidney Cancer (Ductal; Papillary; Chromophobic; Oncocytic) With Mutations in VHL, PBRM1 / BAP1, SETD2, VEGF)

Kidney Cancer | Clear Cell Kidney Cancer | Kidney Cancer With PBRM1/BAP1/VHL/SETD2 Mutations
Memorial Sloan Kettering Cancer Center
Eisai Inc.

Active, not recruiting

A Study of E7820 in People With Bone Marrow (Myeloid) Cancers

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Chronic Myelomonocytic Leukemia

United States
University of Pennsylvania
National Eye Institute (NEI)

Active, not recruiting

Phase I Trial of Gene Vector to Patients With Retinal Disease Due to RPE65 Mutations (LCA)

Retinal Diseases | Amaurosis of Leber

United States
Hoffmann-La Roche

Completed

Study to Analyze Mutations in V600 BRAF Oncogen in Participants With Metastatic Melanoma

Metastatic Cancers

Spain
Revolution Medicines, Inc.
Sanofi

Completed

Dose-Esc/Exp RMC4630 & Cobi in Relapsed/Refractory Solid Tumors & RMC4630& Osi in EGFR+ Locally Adv/Meta NSCLC

Solid Tumor

United States, Korea, Republic of
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Completed

Analysis of Tumor Tissue and Lymph Nodes Surgically Removed From Patients With Cancers of the Head and Neck

Head and Neck Cancer

United States
Stichting Hemato-Oncologie voor Volwassenen Nederland
Astellas Pharma Global Development, Inc.; Deutsch-Österreichische Studiengruppe...

Active, not recruiting

A Study of Gilteritinib Versus Midostaurin in Combination With Induction and Consolidation Therapy Followed by One-year Maintenance in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndromes With Excess Blasts-2 With FLT3 Mutations Eligible for Intensive Chemotherapy (HOVON 156 AML)

Acute Myeloid Leukemia | Myelodysplastic Syndrome With Excess Blasts-2

Netherlands, Belgium, Germany, Switzerland, Australia, Finland, Norway, Sweden, Austria, France, Ireland, Lithuania, Luxembourg, Spain
Yonsei University

Withdrawn

Efficacy of Triplet Combination With Pembrolizumab, Neratinib, and Paclitaxel as a Second Line Treatment in Recurrent/Advanced Gastric Cancer Having Somatic Human Epidermal Growth Factor Receptor Family (EGFR, HER2, HER3, HER4) Mutations or HER2 Amplification/Overexpression

Recurrent/Advanced Gastric Cancer

Korea, Republic of
Rennes University Hospital
QIAGEN Gaithersburg, Inc

Completed

cKIT, BRAF/NRAS Mutations in Advanced Melanoma : Clinical Outcome in Response to Tyrosine-kinase Inhibitors - KitMel Project (KitMel)

Melanoma

France
AnchorDx Medical Co., Ltd.
The First Affiliated Hospital with Nanjing Medical University; Peking University... and other collaborators

Completed

Diagnostic Evaluation of Urine DNA Methylation/Somatic Mutation Profiling for the Detection of Urothelial Carcinoma

Bladder Cancer | Urothelial Carcinoma

China
University of Alabama at Birmingham

Completed

Cabozantinib for Plexiform Neurofibromas (PN) in Subjects With NF1 in Children and Adults (NF105-CABO)

Neurofibromatosis | Plexiform Neurofibromas | NF1

United States
Centre Hospitalier Universitaire, Amiens

Completed

Mutations of the Pre-core Region of Hepatite B Virus (HBV) (HEPATITEB)

Hepatitis B Virus
Jinsong Wu

Completed

Molecular Pathology Research Project of Glioma

Glioma, Malignant

China
Cancer Trials Ireland

Completed

CLL-Irl Study. CTRIAL-IE (ICORG) 07-01, V7

Leukemia

Ireland
Calithera Biosciences, Inc

Terminated

Study of Mivavotinib (CB-659) in Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)

Non-GCB/ABC Diffuse Large B-Cell Lymphoma | With and Without MyD88 and/or CD79B Mutations

United States
University Hospital, Montpellier

Completed

Consequences of Mutations in the SPG7 Gene at the Heterozygous State (CONSP-HET7)

SPG7

France
Fondation Ophtalmologique Adolphe de Rothschild

Completed

Neuronal Excitability of HCN1 Channel Mutations in Dravet Syndrome (EXCIDRAH)

Dravet Syndrome

France
Pfizer

Completed

A Study Of Oral PF-02341066, A C-Met/Hepatocyte Growth Factor Tyrosine Kinase Inhibitor, In Patients With Advanced Cancer (PROFILE 1001)

Systemic Anaplastic Large-Cell Lymphoma | Non-Small Cell Lung Cancer ALK-positive | Non-Small Cell Lung Cancer c-Met Dependent | Non-Small Cell Lung Cancer ROS Marker Positive | Advanced Malignancies Except Leukemia

United States, Korea, Republic of, Australia, Japan
ProQR Therapeutics

Terminated

Study to Evaluate the Efficacy Safety and Tolerability of QR-421a in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene With Early to Moderate Vision Loss (Celeste)

Eye Diseases | Retinitis Pigmentosa | Eye Diseases, Hereditary | Vision Disorders | Retinal Disease | Eye Disorders Congenital | Usher Syndrome Type 2 | Deaf Blind

United States, United Kingdom
Institut de Recherches Internationales Servier

Completed

Study of AG-120 in Previously Treated Advanced Cholangiocarcinoma With IDH1 Mutations (ClarIDHy) (ClarIDHy)

Metastatic Cholangiocarcinoma | Advanced Cholangiocarcinoma

United States, Spain, Korea, Republic of, Italy, France, United Kingdom
Sidney Kimmel Cancer Center at Thomas Jefferson...
National Cancer Institute (NCI)

Completed

Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies

Follicular Lymphoma | Myeloid Leukemia | Polycythemia Vera | Hodgkin Lymphoma | Myelofibrosis | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Chronic Lymphocytic Leukemia | Secondary Acute Myeloid Leukemia | Non-Hodgkin Lymphoma | Myelodysplastic Syndrome | Plasma Cell Myeloma | Refractory... and other conditions

United States
Theresienkrankenhaus und St. Hedwig-Klinik GmbH
University Hospital Heidelberg

Completed

DNA-mutation Analysis in Cyst Fluid of Suspected Intraductal Papillary Mucinous Neoplasia of the Pancreas

Pancreas Cyst

Germany
Ohio State University Comprehensive Cancer Center

Active, not recruiting

Universal Endometrial Cancer DNA Sequencing for Detection of Lynch Syndrome and Personalized Care (OPTEC)

Lynch Syndrome | Relatives | Endometrial Carcinoma | Endometrial Adenocarcinoma

United States
Seoul National University Hospital

Completed

The Association Between Post-ERCP Acute Pancreatitis and Various Genetic Mutations

Acute Pancreatitis

Korea, Republic of
X4 Pharmaceuticals

Completed

A Study of Mavorixafor in Combination With Ibrutinib in Participants With Waldenstrom's Macroglobulinemia (WM) Whose Tumors Express Mutations in MYD88 and CXCR4

Waldenstrom's Macroglobulinemia

United States, Greece
Assistance Publique - Hôpitaux de Paris

Withdrawn

Acute Rhabdomyolysis and Muscle Pain Associated With Mutations in the LPIN1 Gene - A Retrospective Study Describing the Safety and Efficacy of Hydroxychloroquine Sulfate Given on a Compassionate Basis to Patients Suffering From Lipin-1 Deficiency (LIPIN-1-METAB)

LIPIN1 Deficiency

France
Instituto Nacional de Ciencias Medicas y Nutricion...

Completed

Germline Mutations Associated With Hereditary Pancreatic Cancer in Unselected Patients With Pancreatic Cancer in Mexico

Pancreatic Cancer | Pancreatic Adenocarcinoma

Mexico
Blueprint Medicines Corporation

Completed

(VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST

GIST

United States, Korea, Republic of, Netherlands, China, France, Spain, Italy, Belgium, United Kingdom, Singapore, Australia, Canada, Germany, Sweden, Hungary, Austria, Czechia, Poland
H. Lee Moffitt Cancer Center and Research Institute
Karyopharm Therapeutics Inc

Completed

A Study of Selinexor in Combination With Daunorubicin and Cytarabine for Untreated AML

Acute Myeloid Leukemia | Leukemia | AML

United States
National Cancer Center, Korea

Active, not recruiting

Verification of Predictive Biomarkers for Pancreatic Cancer Treatment Using Multicenter Liquid Biopsy

Pancreas Adenocarcinoma

Korea, Republic of
ProQR Therapeutics

Active, not recruiting

Study to Evaluate the Efficacy Safety and Tolerability of Ultevursen in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene (Sirius)

Eye Diseases | Retinitis Pigmentosa | Eye Diseases, Hereditary | Vision Disorders | Retinal Disease | Eye Disorders Congenital | Usher Syndrome Type 2 | Deaf Blind

United States, Netherlands, United Kingdom, Germany
Virginia Commonwealth University
Cystic Fibrosis Foundation

Withdrawn

The Relationship Between CFTR Gene Mutations and Exercise Capacity

Cystic Fibrosis

United States
Ambrx, Inc.

Withdrawn

ARX788 in Selected HER2-mutated or HER2-amplified/Overexpressed Solid Tumors (ACE-Pan Tumor-02)

HER2 Mutation-Related Tumors | HER2 Amplified Solid Tumors

United States
Venthera, Inc., a BridgeBio company

Terminated

First in Human Trial of Topical VT30 in Pts With Venous/Lymphatic Malformations Assoc With PIK3CA or TEK Gene Mutations

Lymphatic Malformation | Venous Malformation | Venolymphatic Malformation

United States
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Study of Biomarkers in Blood and Bone Marrow Samples From Patients With Previously Untreated Chronic Lymphocytic Leukemia

Leukemia

United States
Hellenic Cooperative Oncology Group

Completed

Molecular Characterization of Gliomas Using a Broad Next Generation Sequencing (NGS)Panel

Malignant Glioma
Calithera Biosciences, Inc

Completed

Study of the Glutaminase Inhibitor CB-839 in Solid Tumors

Renal Cell Carcinoma | Non Small Cell Lung Cancer | Mesothelioma | Solid Tumors | Triple-Negative Breast Cancer | Fumarate Hydratase (FH)-Deficient Tumors | Succinate Dehydrogenase (SDH)-Deficient Gastrointestinal Stromal Tumors (GIST) | Succinate Dehydrogenase (SDH)-Deficient Non-gastrointestinal... and other conditions

United States
Noah Hahn, M.D.
Novartis Pharmaceuticals; Hoosier Cancer Research Network

Terminated

Dovitinib in BCG Refractory Urothelial Carcinoma With FGFR3 Mutations or Over-expression

Bladder Cancer

United States
University Hospital, Clermont-Ferrand

Enrolling by invitation

Phenotypic Description of Patients With Atypical Clinical Forms of PLA2G6 Mutations (ATYPICPLA2G6)

Neuroaxonal Dystrophy, Atypical

France
University of Washington
National Cancer Institute (NCI)

Completed

High Throughput Drug Sensitivity Assay and Genomics- Guided Treatment of Patients With Relapsed or Refractory Acute Leukemia

Recurrent Acute Myeloid Leukemia | Refractory Acute Myeloid Leukemia | Recurrent Acute Lymphoblastic Leukemia | Refractory Acute Lymphoblastic Leukemia | Refractory Acute Leukemia of Ambiguous Lineage | Recurrent Acute Leukemia of Ambiguous Lineage

United States
Brenda Cooper, MD
National Cancer Institute (NCI)

Completed

Midostaurin and Azacitidine in Treating Elderly Patients With Acute Myelogenous Leukemia

Untreated Adult Acute Myeloid Leukemia

United States

Search clinical trials for: Rare Mutations

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Luxembourg

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations