Search clinical trials for: long-term safety

Total 44665 results

Nuritas Ltd

Recruiting

A Study to Determine the Safety and Tolerability of a Range of Doses of PeptiControl in Pre-diabetic Individuals

Overweight | Pre Diabetes

India
Onconic Therapeutics Inc.

Not yet recruiting

Study to Evaluate the Efficacy and Safety of JP-1366 in the Prevention of NSAIDs-Induced Peptic Ulcers

Peptic Ulcer

Korea, Republic of
Henan Cancer Hospital

Recruiting

An Exploratory Study of Efficacy and Safety of Iruplinalkib Tablets in Patients With ROS1 Positive Non-small Cell Lung Cancer

Non-Small Cell Lung Cancer

China
Hanmi Pharmaceutical Company Limited

Recruiting

A Study to Evaluate Efficacy and Safety of HCP1803 Compared to RLD2001-1 in Patients With Essential Hypertension (HM_APOLLO)

Hypertension

Korea, Republic of
Heart Rhythm Clinical and Research Solutions, LLC
Boston Scientific Corporation

Recruiting

Safety and Efficacy of Workflows of High Volume Single Operators in a LAAO Device Implant Procedural Day

Atrial Fibrillation

United States
Spot Biosystems Ltd.
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Not yet recruiting

Preliminary Evaluation of the Safety and Tolerability of SPOT-mRNA01 Subcutaneously Administered in Healthy Subjects

Skin Aging
Daewoong Pharmaceutical Co. LTD.

Not yet recruiting

to Evaluate the Safety/Tolerability and Pharmacokinetics, and Pharmacodynamics of DWP14012 Injection

Erosive Gastroesophageal Reflux Disease
Seoul National University Hospital

Not yet recruiting

Verification of the Efficacy/Safety of the Mixed Drug Injectable Delivery Vehicle for Treating Intractable Hearing Loss

Hearing Loss, Sensorineural | Hearing Loss, Sudden | Intratympanic Injection
argenx

Not yet recruiting

A Phase 1b Study to Investigate Safety and Tolerability of ARGX-119 in Adult Participants With DOK7-Congenital Myasthenic Syndromes (CMS)

Congenital Myasthenic Syndrome
Entos Pharmaceuticals Inc.
Q2 Solutions; Calian CRO; PCI Pharma Services

Not yet recruiting

To Evaluate Safety and Immunogenicity of a Prophylactic Plasmid DNA (VAX-002-01)

COVID-19

Canada
ENTire Medical Ltd.

Recruiting

Efficacy And Safety of An IRE System For Treatment of Inferior Turbinate Hypertrophy

Nasal Obstruction | Inferior Turbinate Hypertrophy | Turbinate; Hypertrophy Mucous Membrane

Israel, Lithuania
Wuhan Union Hospital, China

Recruiting

Efficacy and Safety of Ganciclovir Capsules in the Treatment of Refractory Moderate-to-severe Allergic Rhinitis

Rhinitis, Allergic

China
Beijing Tongren Hospital
The First Affiliated Hospital with Nanjing Medical University

Recruiting

Efficacy and Safety of Sugammadex in Thoracoscopy Thymectomy for Chinese Adults With Myasthenia Gravis

Reversal of Neuromuscular Blockade

China
Rallybio IPA, LLC

Not yet recruiting

Phase 2 Study on the Pharmacokinetics and Safety of RLYB212 in Pregnant Women at Higher Risk for HPA-1a Alloimmunization

Fetal and Neonatal Alloimmune Thrombocytopenia
Istituto Clinico Humanitas

Not yet recruiting

Efficacy, Safety and Recurrence After Cold-EMR Plus APC for Large Colonic Lesions (EMR+APC)

Colonic Disease

Italy
ID3 Medical
Abbott; Vascular Science LP GmbH

Not yet recruiting

Investigating Efficacy and Safety of JETi® in Arterial Occlusions in FEM-POP and Prox BTK-Lesions (JETART) (JETART)

Peripheral Arterial Disease
Opna Bio LLC

Recruiting

Study to Assess Safety and Tolerability of OPN-6602 in Subjects With Relapsed and/or Refractory Multiple Myeloma

Refractory Multiple Myeloma | Relapsed Multiple Myeloma

United States
LadeRx LLC
Duke Clinical Research Institute

Not yet recruiting

Evaluation of Ascorbate-Meglumine Therapeutic for SRS

Safety

United States
Hanlim Pharm. Co., Ltd.

Recruiting

Study to Evaluate Efficacy and Safety of Bronpass Tab. in Patients With Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

Korea, Republic of
Jazz Pharmaceuticals

Not yet recruiting

A Phase 3, Randomized, Open-label, Controlled Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer

Metastatic HER2-positive Breast Cancer
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Not yet recruiting

The Efficacy and Safety of Nelarabine Injection in Patients With T-lymphoblastic Leukemia and T-lymphoblastic Lymphoma

T-lymphoblastic Lymphoma | T-lymphoblastic Leukemia

China
SAb Biotherapeutics, Inc.

Recruiting

A Study to Assess the Safety of SAB-176 to Prevent the Flu, Given IM in Healthy Adults Compared With Placebo (SAB-176-103)

PHA1A

United States
Massachusetts General Hospital
Patient-Centered Outcomes Research Institute

Not yet recruiting

Sequential Multiple Assignment Randomized Trial for Bipolar Depression (SMART-BD)

Depression | Bipolar I Disorder

United States, Canada
Peking University Third Hospital
Bayer

Not yet recruiting

Efficacy and Safety of Darolutamide in Combination With Androgen-Deprivation Therapy in Prostate Cancer Patients With Lymph Node-positive After Radical Prostatectomy: A Prospective Observational Cohort Study

Prostate Cancer

China
Achieve Life Sciences

Not yet recruiting

Safety Study of Cytisinicline in Adult Combustible and/or E-cigarette Smokers (ORCA-OL)

Smoking Cessation | Vaping Cessation

United States
Priovant Therapeutics, Inc.

Not yet recruiting

A 12-Week Open-Label Study to Investigate the Efficacy and Safety of Brepocitinib in Adults With Skin-Predominant Dermatomyositis

Dermatomyositis | Dermatomyositis, Adult Type
Levita Magnetics

Recruiting

Safety and Feasibility of Liver Retraction With the Levita Magnetic Surgical System: Extended Magnetic Grasper Device

Hiatal Hernia | Bariatric Surgery Candidate

Chile
Shanghai Vitalgen BioPharma Co., Ltd.

Not yet recruiting

A Trial to Evaluate Safety and Efficacy of a Product Named VGN-R09b in Severe AADC Deficiency

Aromatic L-amino Acid Decarboxylase Deficiency
University of Alberta
University of Calgary

Not yet recruiting

PAUSE: Sick Day Medication Management Mobile App Study (PAUSE)

Adverse Event | Chronic Condition
Hospital San Carlos, Madrid

Recruiting

Efficacy and Safety of Atropine and DIMS Lenses in Controlling Myopia in Children (DIMS)

Myopia

Spain
Athira Pharma
Fortrea Holdings, Inc.

Recruiting

A SAD and MAD Study of the Safety, Tolerability, and Pharmacokinetics of ATH-1105

Healthy Volunteers

United States
Ascendis Pharma Growth Disorders A/S

Not yet recruiting

A Phase 2 Clinical Trial to Evaluate Efficacy, Safety, and Tolerability of Navepegritide in Combination With Lonapegsomatropin in Children With Achondroplasia (COACH)

Achondroplasia

Denmark, Ireland, United Kingdom
Octapharma

Not yet recruiting

Post Marketing Observational Study on Safety of BALFAXAR vs. KCENTRA for Reversal of Vitamin K Antagonist Induced Anticoagulation in Adults Undergoing Urgent Surgery or Invasive Procedure

Significant Bleeding Risk | Vitamin K-Dependent Coagulation Defect
Nanjing First Hospital, Nanjing Medical University

Recruiting

Safety and Efficacy of Recombinant Human Thyroid Stimulating Hormone for Adjuvant Diagnosis in Patients With Locally Advanced/Metastatic Differentiated Thyroid Cancer

Recombinant Human Thyroid Stimulating Hormone

China
Ionis Pharmaceuticals, Inc.

Not yet recruiting

ATTUNE: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intrathecally-Administered ION440 in Participants With Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome (MDS)

Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome
Chong Kun Dang Pharmaceutical

Recruiting

Efficacy and Safety of Telmisartan Compared With Losartan

Hypertension | Diabetic Nephropathies

Korea, Republic of
Erzincan Military Hospital

Not yet recruiting

Evaluating the Efficacy and Safety of Preoperative Administration of Duloxetine for Pain Management in Women Undergoing Vaginal Hysterectomy.

Postoperative Pain | Vaginal Hysterectomy
Hookipa Biotech GmbH

Recruiting

Safety, Reactogenicity and Immunogenicity of HB-502 and HB-501 Versus Placebo in People With HIV on Suppressive ART

Human Immunodeficiency Virus (HIV) Infection

United States
Sichuan University

Recruiting

Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung Cancer

NSCLC | PD-1 Inhibitor | Leptomeningeal Metastasis | Low Dose Radiotherapy

China
Quan Jiang

Not yet recruiting

Efficacy and Safety of Saussurea Involucrata Liquid Tonic in Patient With Postpartum Rheumatism

Postpartum Rheumatism
AstraZeneca

Not yet recruiting

A PROSPECTIVE, MULTI-CENTER, PHASE 4 STUDY TO ASSESS THE SAFETY OF TRASTUZUMAB DERUXTECAN, AN ANTI-HER2-ANTIBODY DRUG CONJUGATE IN INDIAN PATIENTS WITH UNRESECTABLE OR METASTATIC HER2-POSITIVE BREAST CANCER WHO HAVE RECEIVED A PRIOR ANTI-HER2-BASED REGIMEN (STRIDE)

BREAST CANCER
Ironshore Pharmaceuticals and Development, Inc

Not yet recruiting

Ph3 Multicenter, 3wk RDBPC Efficacy, Safety & PK Study of Evening Dosed MPH HCl ER Capsules (HLD200) in Children 4-5 Yr With ADHD

Attention Deficit Hyperactivity Disorder
First Affiliated Hospital, Sun Yat-Sen University

Not yet recruiting

The Correlation Between Ripretinib Exposure and the Efficacy and Safety in Patients With Advanced GISTs

Gastrointestinal Stromal Tumors
GlaxoSmithKline

Not yet recruiting

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Clinical Activity of GSK5733584 for Injection in Participants With Advanced Solid Tumors

Solid Tumors

United States, Finland, Canada, Netherlands, Australia
Pharmosa Biopharm Inc.
Novotech (New Zealand) Limited

Not yet recruiting

Safety, Tolerability and Pharmacokinetics Study of L608 in Healthy Adults

Pulmonary Arterial Hypertension

New Zealand
Jeil Pharmaceutical Co., Ltd.

Recruiting

To Evaluate the Safety, Pharmacokinetic Characteristics and the Effect of Food After Administration of JLP-2004

Healthy

Korea, Republic of
Wuxi People's Hospital

Recruiting

The Clinical Efficacy and Safety of Intratumoral Injection of Chemotherapy for Advanced Solid Tumors

Cancer | Intratumoral Injection

China
Beijing Geekgene Technology Co., LTD

Recruiting

a Single-arm, Single-center, Open Clinical Study (GK-01)

Cervical Cancer | Gastric Cancer | Esophageal Cancer | Non-Small Cell Lung Cancer NSCLC | Triple Negative Breast Cancer TNBC

China
Chong Kun Dang Pharmaceutical

Recruiting

Efficacy and Safety of EsoDuo®

Gastro Esophageal Reflux

Korea, Republic of
Atara Biotherapeutics

Not yet recruiting

A Study to Evaluate the Safety and Preliminary Efficacy of ATA3219 in Participants With Lupus Nephritis

Systemic Lupus Erythematosus | Lupus Nephritis

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