Search clinical trials for: Placebo (semaglutide)

Total 53834 results

Rigmor Højland Jensen
Odense University Hospital; Rigshospitalet, Denmark; University of Copenhagen

Recruiting

The Effect of an Anti-obesity Drug, Semaglutide, as Treatment in New-onset Idiopathic Intracranial Hypertension (IIH) Compared to Standard Weight Management (Dietician) With Regards to Change in Weight and Intracranial Pressure (IIH:DUAL)

Obesity | Weight Loss | Idiopathic Intracranial Hypertension | Papilledema | Intracranial Pressure | Pseudotumor Cerebri Syndrome

Denmark
University of Colorado, Denver
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Active, not recruiting

Treating PCOS With Semaglutide vs Active Lifestyle Intervention (TEAL)

PCOS | NAFLD | Adolescent Obesity

United States
Novo Nordisk A/S

Completed

A Research Study Looking at New Protein-based Tablets in Healthy Men - Oral Formulation III

Healthy Participants

Canada
Novo Nordisk A/S

Active, not recruiting

DOORS: A Research Study to Understand How Oral Semaglutide Works in People With Type 2 Diabetes Who Change From Dipeptidyl Peptidase-4 Inhibitor (DPP4i) Treatment to Oral Semaglutide in Italy (DOORS)

Diabetes Mellitus, Type 2

Italy
Merck Sharp & Dohme LLC

Completed

A Study of Efinopegdutide (MK-6024) in Participants With Nonalcoholic Fatty Liver Disease (NAFLD) (MK-6024-001)

Nonalcoholic Fatty Liver Disease | Nonalcoholic Steatohepatitis

United States, Argentina, Australia, Canada, France, Israel, Italy, Korea, Republic of, Mexico, New Zealand, Poland, Russian Federation, Spain, Taiwan, Turkey, Ukraine
Novo Nordisk A/S

Completed

Investigating the Influence of Oral Semaglutide on Pharmacokinetics of Metformin and Digoxin in Healthy Subjects

Healthy | Diabetes

Germany
Second Affiliated Hospital, School of Medicine,...

Recruiting

Retrospective Analysis for Patients With Metabolic Syndrome

Metabolic Syndrome

China
Dasman Diabetes Institute

Completed

Obesity Treatment to Improve Diabetes (OTID)

Type 1 Diabetes

Kuwait
Steno Diabetes Center Copenhagen
Novo Nordisk A/S

Unknown

Renal Effects of Treatment With Empagliflozin Alone or in Combination With Semaglutide in Patients With Type 2 Diabetes and Albuminuria (EmpaSema)

Type 2 Diabetes With Renal Manifestations

Denmark
Novo Nordisk A/S

Completed

A Thorough QTc Evaluation of the Effect of Semaglutide on Cardiac Repolarisation in Healthy Subjects

Healthy | Diabetes

Germany
Gilead Sciences
Novo Nordisk A/S

Completed

Safety, Tolerability, and Efficacy of Monotherapy and Combination Regimens in Participants With Nonalcoholic Steatohepatitis (NASH)

Nonalcoholic Steatohepatitis

United States
Novo Nordisk A/S

Completed

Research Study Comparing a New Medicine Semaglutide to Liraglutide in People With Type 2 Diabetes (SUSTAIN 10)

Diabetes Mellitus, Type 2 | Diabetes

Italy, Spain, United Kingdom, France, Sweden, Finland, Poland, Slovenia, Hungary, Germany, Bulgaria, Czechia
Methodist Health System

Not yet recruiting

Semaglutide and Polycystic Ovarian Syndrome: an Emerging Treatment Strategy

Polycystic Ovary Syndrome

United States
Eli Lilly and Company

Recruiting

A Study of Orforglipron (LY3502970) Compared With Semaglutide in Participants With Type 2 Diabetes Inadequately Controlled With Metformin (ACHIEVE-3)

Type 2 Diabetes

United States, China, Japan, Argentina, Puerto Rico, Mexico
Pfizer

Terminated

A Study to Evaluate the Effect of the Experimental GLP-1 Drug PF-07081532 on Blood Levels of Common Birth Control Pills, and Drugs Omeprazole and Midazolam, and Effect of GLP-1 Drug Semaglutide on Midazolam Blood Levels in Healthy Adults With Weight in the Obesity Range

Obesity

United States
Novo Nordisk A/S

Completed

Investigating the Influence of Omeprazole on the Pharmacokinetics of Oral Semaglutide in Healthy Subjects

Healthy | Diabetes

Germany
Novo Nordisk A/S

Not yet recruiting

Regulatory Post Marketing Surveillance (rPMS) Study of Rybelsus (Oral Semaglutide) to Evaluate Safety and Effectiveness in Patients With Type 2 Diabetes Mellitus in Routine Clinical Practice in Korea

Diabetes Mellitus, Type 2
Novo Nordisk A/S

Completed

Safety Study of Weekly Semaglutide in Chilean Participants With Type 2 Diabetes

Diabetes Mellitus, Type 2

Chile
Attikon Hospital

Recruiting

The Effect of Semaglutide on Cardiovascular Markers and Liver Function

Diabetes Type 2

Greece
Veru Inc.

Recruiting

Dose-Finding Study Evaluating Effect on Body Composition of Enobosarm in Patients Taking a GLP-1 for Chronic Weight Mgmt

Obesity | Muscle Loss

United States
Novo Nordisk A/S

Recruiting

A Research Study to See How a New Weekly Insulin, Insulin Icodec When Given Along With Semaglutide Helps in Reducing the Blood Sugar Level in Patients With Type 2 Diabetes

Diabetes Mellitus, Type 2

Thailand, Poland, Czechia, Malaysia, Serbia
Innovent Biologics (Suzhou) Co. Ltd.

Recruiting

A Study Comparing IBI362 vs Semaglutide in Chinese Adults With Early Type 2 Diabetes and Obesity

Obesity | Type 2 Diabetes

China
Novo Nordisk A/S

Enrolling by invitation

Real-world Study of CHina Ozempic cLinicAl pRactice in Patients With Type 2 Diabetes (SCHOLAR) (SCHOLAR)

Diabetes Mellitus, Type 2

China
Novo Nordisk A/S

Completed

Efficacy and Safety of Semaglutide Once-weekly Versus Sitagliptin Once-daily as add-on to Metformin and/or TZD in Subjects With Type 2 Diabetes (SUSTAIN™ 2)

Diabetes Mellitus, Type 2 | Diabetes

India, Japan, Russian Federation, Spain, Sweden, Argentina, Hungary, Norway, South Africa, Turkey, Bulgaria, Romania, Thailand, Portugal, Hong Kong, Mexico, Ukraine, Czechia
Massachusetts General Hospital

Not yet recruiting

Effect of Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity

Obesity
Capital Medical University

Not yet recruiting

Exploratory Study on the Efficacy and Safety of Semaglutide for Idiopathic Intracranial Hypertension Treatment

Idiopathic Intracranial Hypertension
Novo Nordisk A/S

Withdrawn

Research Study to Compare Semaglutide Tablets With Empagliflozin Tablets Taken Once Daily in People With Type 2 Diabetes and Obesity (PIONEER START)

Diabetes Mellitus, Type 2
Eli Lilly and Company

Recruiting

Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)

Diabetes Mellitus, Type 2

United States, Canada, Mexico, Argentina, Puerto Rico
Washington University School of Medicine
Novo Nordisk A/S

Not yet recruiting

Primary Prevention and Uterine Preservation in Premenopausal Women With Obesity and Endometrial Hyperplasia

Endometrial Hyperplasia

United States
Novo Nordisk A/S

Completed

Efficacy and Long-term Safety of Oral Semaglutide Versus Sitagliptin in Subjects With Type 2 Diabetes (PIONEER 3)

Diabetes Mellitus, Type 2 | Diabetes

United States, India, Israel, Japan, Russian Federation, United Kingdom, France, Mexico, South Africa, Turkey, Argentina, Germany, Romania, Brazil, Ukraine
Novo Nordisk A/S

Completed

A Trial Investigating the Influence of Oral Semaglutide on the Pharmacokinetics of Lisinopril and Warfarin in Healthy Subjects

Healthy | Diabetes

Germany
RenJi Hospital

Recruiting

Effects of GLP-1RA on Body Weight, Metabolism and Fat Distribution in Overweight/Obese Patients With Type 2 Diabetes Mellitus

Diabetes Mellitus, Type 2 | Obesity, Abdominal | Non-Alcoholic Fatty Liver Disease | Metabolism Disorder, Glucose | Metabolism Disorder, Lipid | Metformin | Abdominal Fat

China
Novo Nordisk A/S

Withdrawn

Research Study to Compare Semaglutide Tablets With Empagliflozin or Metformin Tablets in People With Type 2 Diabetes

Diabetes Mellitus, Type 2

Thailand, Malaysia, Poland, India, Hungary, Mexico, Brazil, United States, Croatia, Romania, Bulgaria, Greece, Serbia
Robin, Alan L., M.D.

Completed

An Evaluation of Use of Topical Ocular Hypotensive Medication by Compliance

Ocular Hypertension | Glaucoma
Region Skane
Göteborg University

Active, not recruiting

Semaglutide and Dapagliflozin in Diabetic Patients With Different Pathophysiology

Type2 Diabetes

Sweden
Boehringer Ingelheim

Not yet recruiting

A Study in People With Obesity to Test the Effects of BI 456906 Compared With Semaglutide on Glucagon Receptor Activity in the Liver

Obesity
Novo Nordisk A/S

Completed

Efficacy and Safety of Oral Semaglutide Versus Empagliflozin in Subjects With Type 2 Diabetes Mellitus (PIONEER 2)

Diabetes Mellitus, Type 2 | Diabetes

United States, Croatia, Italy, Poland, Russian Federation, Spain, Greece, Serbia, Thailand, Brazil, Hungary, Argentina
Eli Lilly and Company

Completed

A Study of Tirzepatide (LY3298176) Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes (SURPASS-2)

Type 2 Diabetes

United States, Puerto Rico, Australia, United Kingdom, Mexico, Argentina, Brazil, Israel, Canada
Ege University

Completed

Care to Caregiver: The Effect of Reflexology on Sleep and Anxiety of Cancer Caregiver

Sleep | Anxiety

Turkey
Western University, Canada
Unity Health Toronto; Lawson Health Research Institute; Queen Elizabeth II Health...

Not yet recruiting

Obesity Management for Kidney TRANSPLANTation: OK-TRANSPLANT 2

Obesity | Chronic Kidney Disease

Canada
Nanjing First Hospital, Nanjing Medical University

Recruiting

Therapeutic Effects and Effects on Body Fat of GLP-1 Receptor Agonists in Patients With Type 2 Diabetes for 1-4 Years

Diabetes

China
Assistance Publique - Hôpitaux de Paris
Iltoo Pharma

Completed

Low Dose IL-2 Therapy in Patients With a Depressive Episode in the Course of a Bipolar Disorder (DEPIL-2)

Bipolar Depression

France
Washington University School of Medicine

Completed

Alirocumab and Reverse Cholesterol Transport

Atherosclerosis | Coronary Heart Disease

United States
Orphan Australia

Completed

VSL#3 Versus Placebo in Maintenance of Remission in Crohn's Disease

Crohn's Disease

Australia
Alcon Research

Completed

Safety and Intraocular Pressure (IOP) Lowering Efficacy of Low Dose Travoprost

Ocular Hypertension | Open-angle Glaucoma

United States
The Cleveland Clinic
Novo Nordisk A/S

Completed

Transition From Basal/Bolus to Once-weekly Subcutaneous Semaglutide and Basal Insulin in Patients With Type-2 Diabetes Mellitus (TRANSITION-T2D)

Type 2 Diabetes

United States
Nowarta Biopharma Inc

Completed

A Phase I/II Double-blind Safety and Efficacy Evaluation of Nowarta110 in Patients With Plantar Warts

Plantar Warts

United States
Novo Nordisk A/S

Completed

A Research Study to Compare Semaglutide to Insulin Aspart, When Taken Together With Metformin and Insulin Glargine, in People With Type 2 Diabetes (SUSTAIN 11)

Diabetes Mellitus, Type 2

Croatia, India, Poland, Spain, Serbia, Germany, Slovakia, Slovenia, Turkey, Hungary, Greece, Czechia, Bulgaria, South Africa, Romania, Bosnia and Herzegovina, Estonia, Portugal, Latvia, Lithuania, North Macedonia
Novo Nordisk A/S

Completed

A Research Study Looking Into the Effect of Semaglutide and NNC0480 0389 on Blood Levels of a Birth Control Pill in Woman After Menopause

Diabetes Mellitus, Type 2

Germany
Novo Nordisk A/S

Recruiting

A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor

Type 2 Diabetes

United States, Taiwan, Australia, Hungary, Germany, India, Canada, Spain, Czechia, Argentina, Poland, Colombia, South Africa, France, Greece, Romania

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