Search clinical trials for: Failed at least one line of standard therapy

Total 482849 results

Emory University
University of California, Davis

Recruiting

Caregiving While Black

Caregiver Burden

United States
Hellenic Cooperative Oncology Group

Recruiting

Durvalumab in Combination With Standard Chemotherapy of Patients With Extensive Stage Small Cell Lung Cancer (DRIVE)

Small-cell Lung Cancer | Extensive-stage Small-cell Lung Cancer

Greece
SeaStar Medical
ICON plc

Recruiting

Neutrophil and Monocyte Deactivation Via the SeLective CytopheretIc Device - A Randomized Clinical Trial in Acute Kidney Injury (NEUTRALIZE-AKI)

Acute Kidney Injury

United States
Xiangya Hospital of Central South University
Suzhou Suncadia Biopharmaceuticals Co., Ltd.

Recruiting

Apatinib Mesylate Versus Standard Second-line TKI in the Treatment of Advanced GIST

Gastrointestinal Stromal Tumors

China
University Hospital Ostrava
University of Ostrava

Recruiting

Improving the Quality of Life of Stroke Patients Using the Armeo Spring Device

Ischemic Stroke

Czechia
Xijing Hospital of Digestive Diseases

Recruiting

Effects of High-dose Dual Therapy and Bismuth Quadruple Therapy for Helicobacter Pylori Eradication on Intestinal Microecology

Gastritis | Dyspepsia | Gastric Cancer | Peptic Ulcer | Helicobacter Pylori Infection

China
Insel Gruppe AG, University Hospital Bern

Recruiting

Algorithm-based Tailoring of Dual Antiplatelet Therapy to Improve Outcomes Following Percutaneous Coronary Interventions (TAILOR-DAPT)

Coronary Artery Disease | Percutaneous Coronary Intervention | Platelet Aggregation Inhibitors

Switzerland
Peking Union Medical College Hospital

Not yet recruiting

Surufatinib and Envafolimab as Second or More-line Therapy in Advanced Soft Tissue Sarcoma Patients

Efficacy and Safety of Surufatinib Combined With Envafolimab as Second or More-line Therapy in Advanced Soft Tissue Sarcoma Patients
Lisata Therapeutics, Inc.

Recruiting

A Study of LSTA1 When Added to Standard of Care Versus Standard of Care Alone in Patients With Advanced Solid Tumors (BOLSTER)

Cholangiocarcinoma | Bile Duct Cancer | Intrahepatic Cholangiocarcinoma | Gallbladder Carcinoma | Gallbladder Cancer | Gall Bladder Cancer | Extrahepatic Cholangiocarcinoma | Gall Bladder Carcinoma

United States, Spain
Mercy Health Ohio
Northeast Ohio Medical University

Recruiting

Single Dose Aminoglycosides for Acute Uncomplicated Cystitis in the Emergency Department Setting

Urinary Tract Infections

United States
Nir Peled

Not yet recruiting

A Pilot Study to Understand the Impact of Therapy With Tumour Treating Fields (TTFields) in NSCLC

Non Small Cell Lung Cancer | EGFR Gene Mutation | Immune Checkpoint Inhibitor

Israel
Assistance Publique - Hôpitaux de Paris

Recruiting

Efficacy of Cotrimoxazole as a De-escalation Treatment of Ventilator-Associated Pneumonia in Intensive Care Unit (COTRIVAP)

Ventilator Associated Pneumonia

France
Poitiers University Hospital

Recruiting

Early High-flow Oxygen Therapy With nebuLized Beta-2-agonist Using a Vibrating Mesh for the Management of Moderate to Severe Asthma Exacerbation in the Emergency Department (EOLE)

Moderate Asthma Exacerbation | Severe Asthma Exacerbation

France
TVAX Biomedical
FDA Office of Orphan Products Development

Recruiting

Study of Neoantigen-specific Adoptive T Cell Therapy for Newly Diagnosed MGMT Negative Glioblastoma Multiforme (GBM)

Glioblastoma Multiforme of Brain

United States
University Hospital, Basel, Switzerland
Swiss Agency for Development and Cooperation (SDC); World Diabetes Foundation...

Recruiting

"Community-based, eHealth Supported Management of Cardiovascular Risk Factors by Lay Village Health Workers (ComBaCaL aHT TwiC 1 & ComBaCaL aHT TwiC 2)

Arterial Hypertension

Lesotho, Switzerland
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Recruiting

mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma

Clinical Stage III Gastric Cancer AJCC v8 | Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 | Clinical Stage IV Gastric Cancer AJCC v8 | Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8 | Metastatic Gastric Adenocarcinoma | Metastatic Gastroesophageal Junction... and other conditions

United States, Puerto Rico
Medical College of Wisconsin

Recruiting

Investigation of Profile-related Evidence Determining Individualized Cancer Therapy for Patients With Aggressive Malignancies and Poor Prognoses (MCW I-PREDICT)

Cancer

United States
Duk-Woo Park, MD
CardioVascular Research Foundation, Korea; Daewoong Pharmaceutical Co. LTD.

Not yet recruiting

ENAVOgliflozin Outcome Trial in Patients With Severe Aortic Stenosis After Transcatheter Aortic Valve Replacement (ENAVO-TAVR)

Aortic Valve Stenosis

Korea, Republic of
Affiliated Hospital of Jiangnan University

Recruiting

Organoids Predict Therapeutic Response in Patients With Multi-line Drug-resistant Lung Cancer

Lung Cancer | Organoid

China
Sun Yat-sen University

Not yet recruiting

Study on the Efficacy and Toxicity of Pamiparib Combined With Tamoxifen in the Treatment of Epithelial Ovarian Cancer Patients With Biochemical Recurrence During First-line PARPi Maintenance Therapy

Ovarian Cancer

China
Federation Francophone de Cancerologie Digestive

Not yet recruiting

Study Evaluating the Benefit of Adding Ipilimumab to the Combination of Atezolizumab and Bevacizumab in Patients With Hepatocellular Carcinoma Receiving First-line Systemic Therapy (TRIPLET)

Metastatic Cancer | Metastatic Tumor | HCC - Hepatocellular Carcinoma

France
Fudan University
Huazhong University of Science and Technology; LinkDoc Technology (Beijing)...

Not yet recruiting

Effect and Safety of Huaier Granules Combined With Targeted Drugs and Anti-PD-(L)1 Antibody Compared With Targeted Drugs Combined With Anti-PD-(L)1 Antibody in First Line Treatment of Unresectable Hepatocellular Carcinoma(uHCC)

Unresectable Hepatocellular Carcinoma
The University of Texas Health Science Center,...

Recruiting

CompARing Long terM Outcomes in Chronic Stroke Survivors Across Investigational Assessments Following a Prescribed Upper Extremity Exercise Program

Chronic Stroke

United States
Genmab
AbbVie

Recruiting

Subcutaneous Epcoritamab With or Without Lenalidomide as First Line Therapy for Diffuse Large B-Cell Lymphoma (EPCORE DLBCL-3)

Diffuse Large B-Cell Lymphoma

France, Korea, Republic of, Spain, Belgium, Japan, Germany, Czechia, United Kingdom, Italy, Austria, United States, Poland
Memorial Sloan Kettering Cancer Center

Recruiting

A Study of Targeted Radiation Therapy in People With Non-Small Cell Lung Cancer (NSCLC)

NSCLC | Non Small Cell Lung Cancer | Non Small Cell Lung Cancer Metastatic | NSCLC Stage IV | Non-small Cell Carcinoma

United States
Manchester University NHS Foundation Trust

Not yet recruiting

Interferon-gamma as Adjunctive Therapy in Chronic Pulmonary Aspergillosis: a Randomised Feasibility Study (INCAS)

Aspergillosis | Chronic Pulmonary Aspergillosis
Shen Lin
RemeGen Co., Ltd.

Not yet recruiting

Real-world Study of HER2-overexpressed Advanced Solid Tumors After Progression of First-line Standard Therapy

Advanced Solid Tumor | Advanced Gastric Cancer | Advanced Gastroesophageal Junction Adenocarcinoma | HER2

China
Tianjin Medical University Cancer Institute and...

Recruiting

A Study Evaluating Cadonilimab Injection in Combination With Regorafenib for the Advanced Hepatocellular Carcinoma

Advanced Hepatocellular Carcinoma That Has Failed at Least One Prior Systemic Therapy

China
Fudan University

Not yet recruiting

Camrelizumab Combined With Bevacizumab and HAIC in Patients With Metastatic Liver Cancer Who Failed Standard Therapy

Metastatic Liver Cancer

China
Fujian Cancer Hospital

Not yet recruiting

The First-line Treatment of RCLM With RAS Mutation Was Local Short-course Radiotherapy (SCRT) + PD-1+ Standard Therapy

Rectal Cancer
UNC Lineberger Comprehensive Cancer Center
University Cancer Research Fund at Lineberger Comprehensive Cancer Center

Recruiting

CD30 CAR for CD30+ NSGCT

Nonseminomatous Germ Cell Tumor | Germ Cell Tumor

United States
Novartis Pharmaceuticals

Recruiting

Phase 3 Study to Evaluate Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 2) (SIRIUS-SLE 2)

Systemic Lupus Erythematosus

United States, Germany, France, Taiwan, Italy, India, Argentina, Korea, Republic of, Mexico, Malaysia, Chile, Colombia, Romania, Australia, United Kingdom
UNC Lineberger Comprehensive Cancer Center
United States Department of Defense; Bellicum Pharmaceuticals

Recruiting

Autologous CAR T-Cells Targeting the GD2 Antigen for Lung Cancer

Small Cell Lung Carcinoma | Lung Cancer | Non Small Cell Lung Cancer

United States
University of Pennsylvania

Not yet recruiting

Inhaled Nitric Oxide for Microvascular Dysfunction in Traumatic Brain Injury

Traumatic Brain Injury

United States
UNICANCER
Cancer Research UK; National Cancer Institute, France; Servier; Pierre Fabre Medicament and other collaborators

Recruiting

Personalized Medicine for Advanced Biliary Cancer Patients (SAFIR-ABC10)

Biliary Tract Neoplasms

France, Belgium, United Kingdom
Bristol-Myers Squibb
Eisai Inc.

Recruiting

A Study of MORAb-202 Versus Investigator's Choice Chemotherapy in Female Participants With Platinum-resistant High-grade Serous (HGS) Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Neoplasms, Ovarian

Australia, United States, Korea, Republic of, Chile, Belgium, Italy, Spain, Israel, Japan
UNC Lineberger Comprehensive Cancer Center

Recruiting

Physical Function During ARSI Treatment

Advanced Prostate Carcinoma

United States
M.D. Anderson Cancer Center

Recruiting

Feasibility, Safety, and Efficacy of Stereotactic MRI-Guided Adaptive Radiation Therapy (SMART) for Central Lung Tumors

Lung Cancer

United States
Kyunghee Burkitt, DO, PhD

Not yet recruiting

Vorinostat in Combination With Chemoradiation in Locally Advanced HPV Negative HNSCC (HPV)

Squamous Cell Carcinoma of the Larynx | Squamous Cell Carcinoma of the Oral Cavity | HPV-Related Squamous Cell Carcinoma | Squamous Cell Carcinoma of the Oropharynx | Squamous Cell Carcinoma of the Hypopharynx

United States
Regeneron Pharmaceuticals

Recruiting

A Trial to See if the Combination of Fianlimab With Cemiplimab Works Better Than Pembrolizumab for Preventing or Delaying Melanoma From Coming Back After it Has Been Removed With Surgery

Melanoma

United States, Australia, Spain, United Kingdom, Canada, Brazil, Mexico, Germany, Ireland, South Africa, France, Israel, Georgia, Turkey, Italy, Poland, Chile, Argentina, Belgium, Czechia, Romania, Greece
Northwestern University
3M

Recruiting

NPWTi on Closure of Chronic Pressure Sores

Pressure Sore

United States
NYU Langone Health
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Pulmonary Embolism - Thrombus Removal With Catheter-Directed Therapy (PE-TRACT)

Pulmonary Embolism

United States
Vitruvian Medical Devices, Inc.

Recruiting

Study to Assess the Safety of DERMASEAL for Diabetic Foot Ulcers

Foot Ulcer, Diabetic

United States
Boston Children's Hospital
Baylor College of Medicine

Recruiting

Hydrogen's Feasibility and Safety as a Therapy in ECPR (HydrogenFAST)

Extracorporeal Membrane Oxygenation | Reperfusion Injury | Cardiac Arrest

United States
SWOG Cancer Research Network
National Cancer Institute (NCI)

Recruiting

Monitoring Symptoms to Help Young Women Take Hormone Therapy for Stage I-III Breast Cancer, ASPEN Study

Anatomic Stage I Breast Cancer AJCC v8 | Anatomic Stage II Breast Cancer AJCC v8 | Anatomic Stage III Breast Cancer AJCC v8 | Hormone Receptor-Positive Breast Carcinoma

United States, Peru
Regeneron Pharmaceuticals

Recruiting

A Trial That Evaluates Disease Characteristics in Hemophilia B Adult Male Participants Receiving Prophylaxis With Standard of Care Factor IX Protein (FIX) Replacement Therapy (Honey-B)

Hemophilia B

United States, Germany, United Kingdom, Canada
University of Zurich

Recruiting

Response Assessment During MR-guided Radiation Therapy for Glioblastoma (MARGA)

Glioblastoma Multiforme

Switzerland
Menoufia University

Recruiting

A Study Evaluating Maintenance Therapy After First Line Chemotherapy in Metastatic Cancer Pancreas

Cancer of Pancreas

Egypt
National Cancer Institute (NCI)

Recruiting

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

Acute Myeloid Leukemia | Myelodysplastic Syndrome

United States, Puerto Rico
University of Cambridge
University of Oxford; University of Edinburgh

Recruiting

Closed-loop for People Living With Cystic Fibrosis Related Diabetes (CL4P-CF)

Cystic Fibrosis-related Diabetes

United Kingdom

Search clinical trials for: Failed at least one line of standard therapy

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