Search clinical trials for: Hepatic Impairment,

Total 10209 results

HK inno.N Corporation

Recruiting

A Study to Evaluate Pharmacokinetics and Safety of Tegoprazan in Subjects With Hepatic Impairment and Healthy Controls

Healthy | Hepatic Impairment

Korea, Republic of
Reata, a wholly owned subsidiary of Biogen

Completed

Single-Dose, Open-Label Pharmacokinetic Study of Bardoxolone Methyl in Subjects With Mild, Moderate, and Severe Hepatic Impairment and Normal Hepatic Function

Healthy | Hepatic Impairment

United States
Janssen Infectious Diseases BVBA

Completed

A Study to Assess Safety and Pharmacokinetics of Telaprevir in Patients With Hepatic Impairment

Hepatic Impairment

Germany, Czech Republic
NewAmsterdam Pharma
Veranex

Recruiting

PK and Safety in Participants Taking Obicetrapib With Moderate Hepatic Impairment Relative to Normal Hepatic Function

Healthy | Hepatic Impairment

United States
Lykos Therapeutics

Not yet recruiting

MDMA in Subjects With Moderate Hepatic Impairment and Subjects With Normal Hepatic Function

Pharmacokinetics | Hepatic Impairment

United States
Guangdong Raynovent Biotech Co., Ltd

Completed

Pharmacokinetics of ZSP1273 in Participants With Hepatic Impairment

Pharmacokinetics | Hepatic Impairment

China
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Effect of Hepatic Impairment on Lazertinib (JNJ-73841937)

Healthy | Hepatic Impairment

Germany
zr Pharma & GmbH

Completed

Rucaparib Hepatic Impairment Study in Patients With a Solid Tumor

Neoplasms

United Kingdom, Poland, Slovakia
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Effect of Hepatic Impairment on JNJ-42847922 in Adult Participants

Healthy | Hepatic Impairment

Germany
Shire

Completed

Study of SSP-004184 (SPD602) in Healthy Adults and Subjects With Impaired Liver Function

Healthy | Hepatic Impairment

United States
Lexicon Pharmaceuticals

Completed

PK Study of Sotagliflozin in Subjects With Hepatic Impairment

Healthy | Hepatic Impairment

United States
Exelixis

Completed

Study to Assess the Pharmacokinetics of Cabozantinib (XL184) in Hepatic Impaired Adult Subjects

Healthy | Hepatic Impairment

United States
National Taiwan University Hospital

Completed

Mirror Feedback, Augmented Task-Specific, Impairment-Oriented Therapy, Home Practice, Stroke Rehabilitation

Stroke Rehabilitation

Taiwan
Sagimet Biosciences Inc.

Completed

A Phase I Pharmacokinetic Study of TVB-2640 (Denifanstat) in Subjects With Mild, Moderate, or Severe Hepatic Impairment Compared to Subjects With Normal Hepatic Function

Cirrhosis | Hepatic Impairment | Non-alcoholic Steatohepatitis

United States, Hungary
AstraZeneca

Completed

Phase 1 PK Study to Evaluate the PK of CIN-107 in Subjects With Hepatic Impairment

Hypertension

United States
Novartis Pharmaceuticals

Completed

Pharmacokinetics of LCQ908 in Patients With Hepatic Impairment

Hepatic Impairment

United States
Trevi Therapeutics
Syneos Health

Unknown

Nalbuphine ER Effects of Liver Disease on Pharmacokinetics and Itch

Hepatic Impairment | Nalbuphine

United States
Conatus Pharmaceuticals Inc.

Completed

PK and PD Study of IDN-6556 in Subjects With Hepatic Impairment and Matched Healthy Volunteers

Liver Diseases | Digestive System Diseases | Hepatic Impairment

United States
Eisai Inc.

Completed

A Pharmacokinetic and Safety Study of E7080 in Subjects With Mild (10 mg), Moderate (10 mg), and Severe Hepatic Impairment (5 mg) and Normal Hepatic Function (10 mg)

Hepatic Impairment | Hepatic Function

United States
Pfizer

Recruiting

A Study to Learn About How Loss of Liver Function Affects the Blood Levels of the Study Medicine Called PF-07817883.

COVID-19

United States
Pfizer

Completed

A Study to Understand How the Study Medicine (PF-07081532) is Processed in People With Liver Dysfunction

Healthy Volunteers | Hepatic Impairment

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Single-Dose Pharmacokinetics and Safety of Oral Lofexidine in Hepatically-Impaired Subjects

Liver Failure

United States
GlaxoSmithKline

Completed

A Study To Compare The Effects Of The Infusion Of A Sepsis Drug Between Healthy Adults And Adults With Damaged Livers

Sepsis

Slovakia
Tobira Therapeutics, Inc.

Completed

Phase 1 Study of Multiple-Dose Pharmacokinetics of Cenicriviroc in Subjects With Mild and Moderate Hepatic Impairment

Liver Insufficiency

United States
Idorsia Pharmaceuticals Ltd.

Recruiting

A Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics of a Single Dose of Cenerimod

Healthy | Hepatic Impairment

Portugal, Hungary
Mitsubishi Tanabe Pharma America

Completed

Pharmacokinetics Study of MCI-186 in Subjects With Mild or Moderate Hepatic Impairment

Healthy | Hepatic Impairment

Japan
MDVI, LLC

Completed

Pharmacokinetics of Favipiravir in Volunteers With Hepatic Impairment

Healthy | Hepatic Impairment

United States
Newron Pharmaceuticals SPA

Completed

Safinamide Renal Impairment Trial

Renal Impairment

Germany
CTI BioPharma

Withdrawn

Pharmacokinetic and Safety Study of Pixantrone in Patients With Metastatic Cancer and Hepatic Impairment (Hepatic)

Metastatic Cancer

United States
SecuraBio

Completed

Duvelisib in Hepatically Impaired Subjects Compared to Healthy Subjects (IPI-145-14)

Hepatic Impairment

United States
Hutchison Medipharma Limited

Completed

Surufatinib Renal Impairment Study

Renal Impairment

United States
University of Hawaii

Recruiting

Natives Engaged in Alzheimers Research - 'Ike Kupuna (NEAR)

Mild Cognitive Impairment | Subjective Cognitive Impairment

United States
University of California, San Francisco
National Institute on Aging (NIA)

Active, not recruiting

Brain Health Together: A Live-Streaming Group-Based Digital Program

Mild Cognitive Impairment | Cognitive Decline | Cognitive Deterioration | Cognitive Impairment, Mild | Cognitive Deficits, Mild

United States
University of California, Irvine
National Institute on Aging (NIA)

Recruiting

Using Nicotine to Reverse Age-related Auditory Processing Deficits (Nicotine)

Aging | Auditory Perceptual Impairment

United States
University of Colorado, Denver

Completed

Identifying and Treating Physical Function Impairment in Elders

Physical Activity | Physical Impairment

United States
Université du Québec a Montréal

Completed

Protein Supplementation and Mixed Power Training on Muscle Function and Functional Capacities in Elderly Men (PROMU)

Aging | Dynapenia | Physical Impairment
University of Campania "Luigi Vanvitelli"

Recruiting

Nutraceuticals and Drug Treatment in Frail Older Adults

Frailty

Italy
University of California, Los Angeles
National Institute of Mental Health (NIMH)

Completed

Anti-Inflammatory Treatment for Age-Associated Memory Impairment: A Double-Blind Placebo-Controlled Trial

Memory Disorders

United States
Colorado School of Public Health

Recruiting

Novel Approaches to Assessing Cannabis Impaired Driving (NAACID) (NAACID)

Cannabis Use

United States
Chiesi Farmaceutici S.p.A.

Completed

PK of CHF6001 in Subjects With Mild, Moderate and Severe Renal Impairment vs. Healthy Volunteers

Chronic Obstructive Pulmonary Disease

Bulgaria
Uppsala University

Completed

Insomnia and Cognitive Performance in Chronic Pain

Chronic Pain | Insomnia

Sweden
Trius Therapeutics LLC

Completed

A Pharmacokinetics and Safety Study in Subjects With Renal Impairment

Renal Impairment

United States
LG Life Sciences

Completed

A Phase IIIb Study to Evaluate the Safety and Efficacy of Gemigliptin in Type 2 Diabetes Mellitus Patients With Moderate or Severe Renal Impairment(GUARD Study) (GUARD)

Type 2 DM Patients With Moderate or Severe Renal Impairment

Korea, Republic of
Gilead Sciences

Completed

Pharmacokinetics of Eleclazine in Adults With Normal and Impaired Renal Function

Long QT Syndrome

United States, Romania, Moldova, Republic of
Repros Therapeutics Inc.

Terminated

Evaluate PK and Safety of Proellex® in Females With Various Stages of Impaired Renal Function and Healthy Females

Renal Impairment

United States
Bristol-Myers Squibb

Not yet recruiting

Study to Assess Drug Levels and Safety of BMS-986278 in Healthy Participants and Participants With Different Degrees of Hepatic Impairment

Hepatic Impairment | Healthy Participants
Bristol-Myers Squibb

Recruiting

A Study to Assess the Drug Levels of Repotrectinib in Healthy Participants and Participants With Moderate and Severe Hepatic Impairment

Healthy Volunteers | Hepatic Impairment

United States
Astellas Pharma Global Development, Inc.

Completed

A Study to Investigate the Effect of Mild and Moderate Hepatic Impairment on the Safety and Tolerability of Fezolinetant Compared to Participants With Normal Hepatic Function

Healthy Volunteers | Hepatic Impairment

United States
Astellas Pharma Global Development, Inc.

Completed

A Study to Evaluate ASP0367 in Participants With Mild/Moderate Hepatic Impairment Compared to Participants With Normal Hepatic Function

Healthy Volunteers | Hepatic Impairment

United States
Celgene

Completed

Evaluate the Pharmacokinetics of CC-220 in Subjects With Mild, Moderate, or Severe Hepatic Impairment Compared With Healthy Subjects

Healthy Volunteers | Hepatic Impairment

United States

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