Search clinical trials for: Moderate to Severe Parkinson's Disease

Total 477745 results

Q32 Bio Inc.

Recruiting

Evaluating Safety and Efficacy of ADX-914 in Patients With Moderate to Severe Atopic Dermatitis (SIGNAL-AD)

Atopic Dermatitis

United States
Pan Xiangbin

Not yet recruiting

To Evaluate the Efficacy and Safety of the Transfemoral Mitral Valve Repair System in the Treatment of Patients With Moderately Severe and Severe Functional Mitral Regurgitation(FMR) Who Remained Clinically Symptomatic After Guideline-directed Medical Treatment

Mitral Valve Insufficiency

China
The Hospital for Sick Children

Recruiting

A Mindfulness-Based Intervention to Improve CPAP

Obstructive Sleep Apnea | Obstructive Sleep Apnea (Moderate to Severe)

Canada
Teva Branded Pharmaceutical Products R&D, Inc.

Recruiting

A Study to Test the Effect of TEV-48574 in Moderate to Severe Ulcerative Colitis or Crohn's Disease (RELIEVE UCCD)

Crohn Disease | Colitis, Ulcerative

United States, Bulgaria, Czechia, Hungary, Poland, Spain, Belgium, France, Italy, Japan, Norway, Slovakia, Germany, Canada, Ukraine, United Kingdom, Israel, Serbia
Celltrion

Recruiting

To Compare Pharmacokinetics, Efficacy, and Safety of CT-P17 With Humira in Patients With Moderate to Severe Chronic Plaque Psoriasis

Moderate to Severe Chronic Plaque Psoriasis

Estonia
AbbVie

Recruiting

An Observational Study to Assess Change in Disease Activity and Adverse Events of Upadacitinib in Adult Participants With Moderate to Severe Ulcerative Colitis (UC) in Real-World Practice (PROFUNDUS)

Ulcerative Colitis

Germany, Russian Federation, United Arab Emirates, United Kingdom, Australia, Ireland, Argentina, Canada, Kuwait, Israel, Portugal, Czechia, France, Greece, Italy, Spain
Sanofi

Recruiting

Long-Term Safety and Efficacy Evaluation of Amlitelimab in Participants of Previous Amlitelimab Moderate to Severe Atopic Dermatitis Clinical Trials (RIVER-AD)

Dermatitis Atopic

Canada, United States, Australia, Bulgaria, Czechia, Germany, Hungary, Japan, Poland, Spain, Taiwan, United Kingdom
Ganzhou Hemay Pharmaceutical Co., Ltd

Recruiting

Phase II Study of Hemay005 in Patients With Active Ulcerative Colitis

Moderate to Severe Ulcerative Colitis

China
Bristol-Myers Squibb

Recruiting

A Study to Evaluate the Efficacy, Safety, and Drug Levels of Oral Ozanimod in Pediatric Participants With Moderately to Severely Active Crohn's Disease With an Inadequate Response to Conventional Therapy

Crohn Disease

United States, Belgium, Hungary, France, Canada, Spain, Australia, Germany, Poland, United Kingdom
Changhai Hospital
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University and other collaborators

Not yet recruiting

Magnetically Controlled Capsule Endoscope System in Stomach Examination of Moderately and Severely Obese Patients

Obesity

China
Janssen Research & Development, LLC

Recruiting

A Study of Aticaprant as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy (VENTURA-1)

Anhedonia | Depressive Disorder, Major

United States, Spain, Bulgaria, Italy, Poland, Belgium, Argentina, Czechia, Hungary, Sweden, Brazil, Australia, Portugal
Central Hospital, Nancy, France

Recruiting

A Study to Evaluate Biomarkers in Moderate to Severe Ulcerative Colitis (UC) Patients Treated With Different Targeted Therapies (ImmUniverse)

Inflammatory Bowel Diseases | Ulcerative Colitis

France
AbbVie

Recruiting

A Study to Assess Change in Disease Activity in Adolescents and Adults With Moderate to Severe Prurigo-type Atopic Dermatitis in Japan Who Are Treated With Oral Upadacitinib (ADMIRE)

Atopic Dermatitis

Japan
Frontier Biotechnologies Inc.

Recruiting

Evaluate the Efficacy and Safety of FB2001 in Hospitalized Patients With Moderate to Severe COVID-19 (BRIGHT Study)

COVID-19

China
PhytoHealth Corporation

Recruiting

PG2 Injection for the Treatment of moderate-to Severe Fatigue in Breast Cancer Patients

Cancer-related Fatigue

Taiwan
First Affiliated Hospital Xi'an Jiaotong University

Not yet recruiting

Efficacy and Safety of Memantine and Sodium Oligomannate in Patients With Moderate to Severe Alzheimer's Disease

Alzheimer Disease | Efficacy | Treatment | Safety
Takeda

Recruiting

A Study of Vedolizumab SC Given to Adults With Moderate to Severe Ulcerative Colitis or Crohn's Disease in South Korea

Crohn's Disease | Ulcerative Colitis | Inflammatory Bowel Disease (IBD)

Korea, Republic of
Suzhou Alphamab Co., Ltd.

Recruiting

KN057 Multiple Dose Study in Moderately Severe to Severe Hemophilia

Hemophilia

China
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Up-front Matched Unrelated Donor Transplantation in Pediatric Patients With Idiopathic Aplastic Anemia (UPFRONT-MUD)

Severe Aplastic Anemia | Idiopathic Aplastic Anemia | Moderate Aplastic Anemia Requiring Transfusions
Nadja Naenni

Recruiting

The Adjunctive Effect of Soft Tissue Augmentation Procedures of Moderate-severe Peri-implantitis

Peri-Implantitis

Germany, Singapore, Switzerland
Amgen

Recruiting

A Study Evaluating Rocatinlimab in Moderate-to-severe Atopic Dermatitis (ROCKET-IGNITE) (ROCKET-Ignite)

Atopic Dermatitis

Japan, Korea, Republic of, United States, Taiwan, Spain, Germany, Croatia, China, Greece, Italy, Czechia, Brazil, Poland, Portugal, Slovakia, Argentina, Canada, Puerto Rico, Hungary, Latvia, Netherlands
Suzhou Suncadia Biopharmaceuticals Co., Ltd.

Not yet recruiting

Efficacy and Safety of SHR-1314 by Subcutaneous Injection in Active Moderate to Severe Graves' Orbitopathy Patients

Active Moderate to Severe Graves' Orbitopathy
AbbVie

Recruiting

An Observational Study of Upadacitinib to Assess Change in Disease Activity in Canadian Adult Participants With Moderate-to-Severe Atopic Dermatitis Who Are Inadequate Responders To or Discontinuing Dupilumab (CAN UpTIMISE)

Atopic Dermatitis

Canada
Vitti Labs, LLC

Recruiting

Safety and Effectiveness of Placental Derived Exosomes and Umbilical Cord Mesenchymal Stem Cells in Moderate to Severe Acute Respiratory Distress Syndrome (ARDS) Associated With the Novel Corona Virus Infection (COVID-19)

Respiratory Distress Syndrome | COVID-19 Acute Respiratory Distress Syndrome

United States
Innovent Biologics (Suzhou) Co. Ltd.

Recruiting

A Study to Evaluate IBI112 in the Treatment of Moderate to Severe Active Ulcerative Colitis

Ulcerative Colitis (UC)

China
Bristol-Myers Squibb

Recruiting

An Open-label Study of Ozanimod in Moderate to Severe Ulcerative Colitis in Clinical Practice

Colitis, Ulcerative

United States, United Kingdom
MicuRx

Recruiting

Safety and Efficacy Study of Contezolid Acefosamil and Contezolid Compared to Linezolid Administered Intravenously and Orally to Adults With Moderate or Severe Diabetic Foot Infections (DFI)

Diabetic Foot Infection

Spain, China, United States, Estonia, Latvia, Portugal, Bulgaria, Greece, Italy, Lithuania, Puerto Rico
LEO Pharma

Recruiting

Efficacy and Safety of Delgocitinib Cream in Adolescents 12-17 Years of Age With Moderate to Severe Chronic Hand Eczema (DELTA TEEN)

Chronic Hand Eczema

Spain, France, Belgium, Australia, Canada, Poland, United Kingdom
Charite University, Berlin, Germany

Recruiting

Atopy Network - Comprehensive Allergy Centers: Medical Care of Patients With Moderate to Severe Allergic Diseases (ATAC)

Atopic Disorders

Germany
NEMA Research, Inc.

Recruiting

Ketorolac Applied by Continuous IV Infusion for Treatment of Moderately Severe Postoperative Pain Following Bunionectomy

Pain, Postoperative

United States
RemeGen Co., Ltd.

Recruiting

A Study of Telitacicept for the Treatment of Moderately to Severely Active Systemic Lupus Erythematosus (REMESLE-1)

Systemic Lupus Erythematosus

United States, Colombia, Bulgaria, Poland, Puerto Rico, Argentina, Australia, Chile, Hungary, Spain, Germany, Philippines
Natalie Kreitzer
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Recruiting

Caregiver Wellness After Traumatic Brain Injury (CG-WELL): An Intervention Designed to Promote Well-being in Caregivers of Acute Moderate to Severe Traumatic Brain Injuries (CG-Well)

Trauma, Brain

United States
Samsung Pharmaceutical Co., Ltd.

Not yet recruiting

GV1001 Subcutaneous for the Treatment of Moderate to Severe Alzheimer's Disease(AD)

Moderate to Severe Alzheimer's Disease
Fundación Pública Andaluza para la gestión de la...

Recruiting

Pupillometry Techniques Usage to Quantify the Programming Parameters Effect in the Auditory Effort in Zti Opticon Cochlear Implant Adult Users

Bilateral Sensorineural Hearing Loss | Unilateral Sensorineural Hearing Loss

Spain
Genmab
AbbVie

Recruiting

A Study to Evaluate Adverse Events and Change in Disease Activity of Subcutaneous (SC) Epcoritamab in Combination With Oral and Intravenous Anti-Neoplastic Agents in Adult Participants With Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma

United States, France, Israel, Korea, Republic of, Spain, Taiwan, Netherlands, Czechia, Japan, Hungary, Germany, Denmark
McMaster University

Recruiting

Tezepelumab on Airway Structure and Function in Patients With Uncontrolled Moderate-to-severe Asthma

Asthma

Canada
UCB Biopharma SRL

Recruiting

A Single-ascending Dose (Part A) and Repeat-dose (Part B) Study to Investigate the Safety, Pharmacokinetics and Efficacy (Part B Only) of UCB1381 in Healthy Study Participants (Part A) and in Study Participants With Moderate to Severe Atopic Dermatitis (Part B)

Atopic Dermatitis

United States
Keymed Biosciences Co.Ltd

Recruiting

A Study of CM310 in Patients With Moderate-to-Severe Atopic Dermatitis

Atopic Dermatitis

China
3D Medicines

Not yet recruiting

3D1002 in Combination With Oxycodone Hydrochloride Sustained-release Tablets in Patients With Moderate to Severe Cancer Pain

Cancer Pain
Shanghai East Hospital

Recruiting

Clinical Study of Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Moderate and Severe Crohn's Disease

Crohn Disease

China
GC Cell Corporation

Recruiting

Clinical Trial to Evaluate the Safety, Tolerability and Efficacy of CT303 in Patients With Psoriasis

Moderate to Severe Plaque Psoriasis

Korea, Republic of
Pfizer

Recruiting

A Study to Learn About the Study Medicine (Called Abrocitinib) in Adult Patients With Moderate to Severe Atopic Dermatitis

Dermatitis, Atopic

Germany
AstraZeneca

Recruiting

Study to Assess the Efficacy and Safety of Atuliflapon in Moderate-to-Severe Uncontrolled Asthma (FLASH)

Asthma

United States, Argentina, Italy, Mexico, Germany, Hungary, Netherlands, Poland, Spain, Korea, Republic of, Bulgaria, Ukraine, Serbia, Turkey, Slovakia, United Kingdom, Chile, Australia, Croatia, Japan, Romania, South Africa, France, S...
Taejoon Pharmaceutical Co., Ltd.

Recruiting

Evaluating the Efficacy and Safety of TJO-087 in Moderate to Severe Dry Eye Disease Patients

Dry Eye Syndrome

Korea, Republic of
Shanghai Dermatology Hospital

Recruiting

Efficacy and Safety of STBF Photodynamic Therapy for Moderate and Severe Acne Vulgaris

Acne

China
Janssen Research & Development, LLC

Recruiting

A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Crohn's Disease (DUET-CD)

Crohn's Disease

United States, Denmark, Belgium, Taiwan, Italy, Korea, Republic of, Germany, United Kingdom, Israel, Malaysia, Poland, Japan, New Zealand, Netherlands, China, Canada, France, Spain, Norway, Singapore, Croatia, Brazil, Switzerland, Aus... and more
Janssen Research & Development, LLC

Recruiting

A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Ulcerative Colitis (DUET-UC)

Colitis, Ulcerative

United States, Denmark, Belgium, Austria, Greece, Korea, Republic of, United Kingdom, Israel, Poland, Japan, Hungary, Italy, Germany, Australia, Taiwan, New Zealand, Spain, Norway, China, Switzerland, India, Brazil, Croatia, Netherlands, Eston... and more
BiomX, Inc.
Maruho Co., Ltd.

Not yet recruiting

A Study of Topical BX005-A in Subjects With Moderate to Severe Atopic Dermatitis

Atopic Dermatitis
Assistance Publique - Hôpitaux de Paris

Recruiting

Levosimendan Versus Placebo Before Tricuspid Valve Surgery in Patients With Right Ventricular Dysfunction (LEONARD)

Patients Referred for an Isolated or a Combined Surgical Correction of Functional Moderate to Severe Tricuspid

France
Pfizer

Recruiting

A Study to Learn About the Study Medicine (Called Lorlatinib) in People With Liver Dysfunction

Healthy Volunteers | Moderate Hepatic Impairment | Severe Hepatic Impairment

United States

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