Search clinical trials for: Pharmacodynamics (PD)

Total 7691 results

Merck Sharp & Dohme LLC

Recruiting

A Study of Pembrolizumab (MK-3475) in Pediatric Participants With an Advanced Solid Tumor or Lymphoma (MK-3475-051/KEYNOTE-051)

Melanoma | Lymphoma | Solid Tumor | Classical Hodgkin Lymphoma | Microsatellite-instability-high Solid Tumor

France, Germany, Italy, Netherlands, Sweden, United Kingdom, Brazil, Israel, Korea, Republic of, United States
University Hospital Heidelberg
Department of Dermatology, Heidelberg University Hospital

Completed

Exercise as a Supportive Measure for Patients Undergoing Checkpoint-inhibitor Treatment (Sportivumab)

Melanoma | Exercise | PD-1 Antibodies

Germany
NYU Langone Health
Merck Sharp & Dohme LLC

Terminated

Study of Pembrolizumab and Chemotherapy With or Without Radiation in Small Cell Lung Cancer (SCLC)

Small Cell Lung Cancer (SCLC)

United States
Jason J. Luke, MD

Recruiting

Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors

Melanoma | Cervical Cancer | Hepatocellular Carcinoma | Gastric Cancer | Colorectal Cancer | NSCLC | Advanced Solid Tumors | Cholangiocarcinoma | Bladder Cancer | Renal Cancer | Anal Cancer | Merkel Cell Carcinoma | HNSCC

United States
Roswell Park Cancer Institute

Withdrawn

Binimetinib and Palbociclib Before Surgery for the Treatment of Operable KRAS-Positive Lung, Colorectal, or Pancreatic Cancer

Malignant Solid Neoplasm | Lung Adenocarcinoma | Colorectal Carcinoma | Pancreatic Carcinoma

United States
Emory University
National Cancer Institute (NCI)

Withdrawn

Stereotactic Radiosurgery With Abemaciclib, Ribociclib, or Palbociclib in Treating Patients With Hormone Receptor Positive Breast Cancer With Brain Metastases

Prognostic Stage IV Breast Cancer AJCC v8 | Metastatic Malignant Neoplasm in the Brain | Metastatic Breast Carcinoma | Anatomic Stage IV Breast Cancer American Joint Committee on Cancer (AJCC) v8
Shanghai Huaota Biopharmaceutical Co., Ltd.

Recruiting

A Study Evaluating the Safety and Efficacy of HB0036 in Subjects With Advanced Solid Tumors

NSCLC | Advanced Solid Tumor

United States, China
Agenus Inc.

Completed

Study of AGEN2034 in Advanced Tumors and Cervical Cancer

Cervical Cancer | Advanced Cancer

France, United States, Belgium, Australia, Spain, Estonia, Brazil, Chile, Poland
Lene Meldgaard Knudsen
IO Biotech

Terminated

PD-L1 Peptide Vaccination in High Risk Smoldering Multiple Myeloma

Smoldering Multiple Myeloma

Denmark
VA Puget Sound Health Care System
Dr. Gregory Merrick; Theragenics Corporation

Unknown

I-125 Versus Pd-103 for Medium Risk Prostate Cancer

Prostate Cancer

United States
Hoffmann-La Roche

Completed

A Study of Atezolizumab in Participants With Locally Advanced or Metastatic Urothelial Bladder Cancer (Cohort 2)

Bladder Cancer

United States, Spain, United Kingdom, Canada, France, Germany, Italy, Netherlands
Jiangsu HengRui Medicine Co., Ltd.

Completed

A Study of SHR-1210 in Combination With Pemetrexed and Carboplatin in Subjects With Non-squamous NSCLC

Lung Diseases | Neoplasms by Site | Carcinoma, Non-Small-Cell Lung | Lung Neoplasms | Respiratory Tract Neoplasms | Thoracic Neoplasms | Carcinoma, Bronchogenic | Respiratory Tract Disease | Neoplasm, Bronchial

China
Molecular Templates, Inc.

Recruiting

Study of MT-6402 in Subjects With Advanced Solid Cancer That Expresses PD-L1

Squamous Cell Carcinoma of Head and Neck | Advanced Solid Tumor | Non-small Cell Lung Cancer

United States
PD Dr. Andreas Strauß
Bayer

Recruiting

Osteoporosis and Haemophilia

Osteoporosis | Haemophilia | Bone Mass

Germany
PD Dr. Jan Kottner

Completed

Enhancing SKIN Health and Safety in Aged CARE (SKINCARE)

Pruritus | Intertrigo | Skin Care | Pressure Ulcer | Xerosis Cutis | Dry Skin | Incontinence-associated Dermatitis | Skin Tear

Germany
Patrick Schoettker,MD PD

Unknown

Comparison of iLTS-D® and ILMA® for Intubation With Fiberoptic Control

Intubation; Difficult

Switzerland
PD Dr. Jan Kottner

Completed

Skin Health and Effectiveness of Standardized Skin Care Regimens in Nursing Home Residents

Xerosis Cutis

Germany
University of Pennsylvania

Completed

GEnetic Counseling Through Virtual Visits in Parkinson's Disease (GET-VIRTUAL)

Parkinson Disease

United States
Baylor College of Medicine

Completed

MER Versus MRI Guidance DBS in Parkinson's Disease

Idiopathic Parkinson's Disease (PD)

United States
Sheba Medical Center

Unknown

The Effect of Electrode Implantation for Deep Brain Stimulation (DBS) on Brain Function Using Single Photon Emission Computed Tomography (SPECT) With Technetium-99m-ethyl Cysteinatedimer (Tc-ECD)

Parkinson's Disease | Deep Brain Stimulation

Israel
Vestre Viken Hospital Trust
Oslo University Hospital; University Hospital of North Norway; Helse Stavanger... and other collaborators

Recruiting

Efficacy and Safety of Anti-PD-1/PD-L1 Treatment +/- UV1 Vaccination in Patients With Non-small Cell Lung Cancer (LUNGVAC)

Oncology | NSCLC Stage IV | NSCLC, Stage III

Norway
Lars Møller Pedersen
IO Biotech

Completed

Peptide Vaccination With PD-L1 and PD-L2 Peptides in Untreated Chronic Lymphatic Leukemia.

Chronic Lymphocytic Leukemia

Denmark
Merck Sharp & Dohme LLC
Array BioPharma

Completed

Safety and Efficacy of Pembrolizumab (MK-3475) Plus Binimetinib Alone or Pembrolizumab Plus Chemotherapy With or Without Binimetinib in Metastatic Colorectal Cancer (mCRC) Participants (MK-3475-651)

Metastatic Colorectal Cancer

United States, Canada
Georgetown University
National Cancer Institute (NCI); Mayo Clinic; Emory University; Indiana University and other collaborators

Terminated

Durvalumab Plus CV301 With Maintenance Chemotherapy in Metastatic Colorectal or Pancreatic Adenocarcinoma

Metastatic Colorectal Cancer | Pancreatic Adenocarcinoma | Colorectal Adenocarcinoma | Metastatic Pancreatic Cancer

United States
UNC Lineberger Comprehensive Cancer Center
Syndax Pharmaceuticals

Completed

An Exploratory Study of Pembrolizumab Plus Entinostat in Non-Inflamed Stage III/IV Melanoma

Melanoma

United States
Dana-Farber Cancer Institute
Merck Sharp & Dohme LLC; Gilead Sciences

Recruiting

Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

Breast Cancer | Triple Negative Breast Cancer | PD-L1 Negative

United States
Region Skane
Lund University; Cambridge University Hospitals NHS Foundation Trust; University...

Recruiting

A Trial to Determine the Safety and Tolerability of Transplanted Stem Cell Derived Dopamine Neurons to the Brains of Individuals With Parkinson's Disease (STEM-PD)

Parkinson Disease

Sweden, United Kingdom
Medical University of South Carolina

Completed

Atomoxetine for Freezing of Gait in Parkinson's Disease (ATMFOG)

Parkinson's Disease | Freezing of Gait

United States
Shandong New Time Pharmaceutical Co., LTD

Recruiting

Efficacy and Safety Study of F520 Combined With Lenvatinib in the Treatment of Patients With Advanced Solid Tumors

Solid Tumors

China
The First Affiliated Hospital of Zhengzhou University

Active, not recruiting

Tislelizumab in Addition to BACE in Patients With NSCLC

NSCLC

China
Shirish M Gadgeel
AstraZeneca; Henry Ford Health System

Withdrawn

Study of Durvalumab or Durvalumab Plus Chemotherapy in Kras Mutation Positive and PD-L1 High (≥ 50%) NSCLC Patients

Lung Cancer | Non-small Cell Lung Cancer | PD-L1 Gene Mutation | KRAS Activating Mutation

United States
Melissa Marchand

Completed

Evaluate the Safety and Feasibility of Injecting PMD-MSC Into the Penis to Treat the Symptoms of PD (PMD-MSC-PD-01)

Peyronie's Disease

United States
Cancer Hospital of Guangxi Medical University

Recruiting

Sintilimab in Combination With Chemoradiotherapy in High-risk Locoregionally-advanced Nasopharyngeal Carcinoma

Nasopharyngeal Carcinoma | Sintilimab

China
Shanghai Cell Therapy Research Institute

Unknown

CTLA-4 and PD-1 Antibodies Expressing EGFR-CAR-T Cells for EGFR Positive Advanced Solid Tumor

Advanced Solid Tumor

China
National Cancer Institute (NCI)

Not yet recruiting

A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing

Metastatic Melanoma | Locally Advanced Melanoma | Metastatic Alveolar Soft Part Sarcoma | Metastatic Non Small Cell Lung Cancer | Metastatic Hepatocellular Carcinoma | Locally Advanced Hepatocellular Carcinoma | Metastatic Small Cell Lung Cancer | Locally Advanced Non Small Cell Lung Cancer | Locally... and other conditions

United States
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
First Affiliated Hospital, Sun Yat-Sen University; Affiliated Cancer Hospital... and other collaborators

Recruiting

PD-1 Inhibitor Therapy Versus Radiotherapy in pCR Patients With Locally Advanced HNSCC After Neoadjuvant Immunochemotherapy (HNC-SYSU-003)

Radiotherapy | HNSCC | PD-1

China
Curis, Inc.

Completed

A Study of CA-170 (Oral PD-L1, PD-L2 and VISTA Checkpoint Antagonist) in Patients With Advanced Tumors and Lymphomas

Advanced Solid Tumors or Lymphomas

United States, Spain, Korea, Republic of, United Kingdom
Fudan University

Recruiting

Camrelizumab Combined With Apatinib in the Treatment of Advanced Sarcomatoid Carcinoma or Carcinosarcoma

Carcinosarcoma | Sarcomatoid Carcinoma | PD-1 Immunotherapy | VEGFR-TKI

China
Chinese PLA General Hospital

Recruiting

The Clinical Trial of Chidamide+Decitabine+Camrelizumab Versus Decitabine+Camrelizumab in Anti-PD-1 Antibody Resistant Patients With Classical Hodgkin Lymphoma.

Hodgkin Lymphoma | Anti-PD-1 Antibody Resistant

China
Korea Health Industry Development Institute

Recruiting

Meridian Activation Remedy System for Parkinson's Disease (MARS-PD)

Parkinson Disease

Korea, Republic of
Hunan Province Tumor Hospital

Completed

The Prediction Biomarkers of Survival Outcome for Severe Immune-related Hepatitis

Lung Cancer

China
Uppsala University
Swedish Society for Medical Research; Swedish Parkinson's Disease Foundation

Completed

Different Dyskinesias in Parkinson's Disease and Their Relation to Levodopa Pharmacokinetics (DYSK-PD-2007)

Parkinson Disease | Dyskinesias

Sweden
University of Bern
ITI International Team for Implantology, Switzerland

Recruiting

Immediate Loading in Single Tooth Implants

Partial Edentulism Class 3

Switzerland
Actelion

Terminated

Iloprost Power Disc-15 in Pulmonary Arterial Hypertension (INHALE-15)

Pulmonary Arterial Hypertension

United States
Guangdong Provincial People's Hospital

Unknown

Standardization and Optimization of TMS Protocols for the Treatment of PD With Depression or Cognitive Impairment

TMS Protocols in the Treatment of PD

China
Shanghai Henlius Biotech

Recruiting

A Phase I Study to Evaluate the Safety, Tolerability, and PK of HLX43 in Advanced/Metastatic Solid Tumors

Advanced Solid Tumor

China
Sahlgrenska University Hospital, Sweden
Odense University Hospital; Karolinska Institutet; Rigshospitalet, Denmark; Sheffield... and other collaborators

Completed

Prevention of Peritonitis in Peritoneal Dialysis (PEPS)

Kidney Failure, Chronic | Peritoneal Dialysis-associated Peritonitis | Dialysis Capd Infection

Sweden
University of Leipzig

Recruiting

Cabozantinib Treatment in a Phase II Study for Patients With Hepatocellular Carcinoma (HCC) Refractory to PD-1 Inhibitors (CaPture)

Hepatocellular Carcinoma

Germany
Tel-Aviv Sourasky Medical Center

Unknown

Biofeedback-based Motor Learning to Ameliorate Freezing of Gait

Parkinson Disease | Gait

Israel
Georgiamune Inc

Recruiting

Safety and Tolerability Study of GIM-531 in Advanced Solid Tumors

Solid Tumor | Melanoma Stage IV

United States

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