Search clinical trials for: Tumor Necrosis Factor

Total 67238 results

Janssen Research & Development, LLC

Completed

A Study Evaluating the Efficacy and Safety of Guselkumab Administered Subcutaneously in Participants With Active Psoriatic Arthritis Including Those Previously Treated With Biologic Anti -Tumor Necrosis Factor (TNF) Alpha Agent(s) (Discover-1)

Arthritis, Psoriatic

United States, Canada, Taiwan, Hungary, Malaysia, Germany, Czechia, Korea, Republic of, Russian Federation, Spain, Australia, Ukraine, Poland
Charite University, Berlin, Germany

Completed

NSAIDs Added to Anti-TNF Therapy Versus Anti-TNF Therapy Alone on Progression of Structural Damage in Ankylosing Spondylitis (CONSUL)

Ankylosing Spondylitis

Germany
Merck Sharp & Dohme LLC

Completed

Correlation of Soluble Suppression of Tumorigenicity 2 (ST2) With Golimumab (MK-8259) Response in Participants With Ulcerative Colitis (UC) (MK-8529-022). (EVOLUTION)

Colitis, Ulcerative
Albany Medical College

Completed

Ziconotide as First-Line IDT

Neuropathic Pain

United States
UCB Pharma SA

Completed

Noninterventional Examination of Subcutaneous (sc) Tumor Necrosis Factor (TNF) Inhibitors (NexT)

Rheumatoid Arthritis

Germany
Stanford University
University of California, San Diego; Takeda; University of Western Ontario, Canada

Terminated

Ulcerative Colitis - Vedolizumab- With/Without Prior Exposure to Anti-TNF（Tumor Necrosis Factor）Therapy

Ulcerative Colitis

United States, Canada
Bozok University

Completed

Effect of Preoperative Anxiety on Fetus in Pregnant Women

Preoperative Anxiety | Cytokines

Turkey
National University of Malaysia
COTRA ENTERPRISES SDN BHD, MALAYSIA

Completed

An Evaluation of Cultured Milk Drink on Immune Status of Patients With Irritable Bowel Syndrome: Constipation Predominant

Irritable Bowel Syndrome With Constipation

Malaysia
Medical University of Graz

Terminated

Ultrasound and Withdrawal of Biological DMARDs in Rheumatoid Arthritis (RA-BioStop)

Rheumatoid Arthritis

Austria
Columbia University
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Completed

RHYTHM (Formerly Escape II Myocardium) (RHYTHM)

Rheumatoid Arthritis

United States
Instituto de Medicina Molecular João Lobo Antunes
Merck Sharp & Dohme LLC

Completed

Efficacy of Golimumab in Combination With Methotrexate (MTX) Versus MTX Monotherapy, in Improving Dactylitis, in MTX naïve Psoriatic Arthritis Patients (GO-DACT)

Psoriatic Arthritis

Portugal
Universidade Nova de Lisboa

Completed

Biomarkers Identification of Anti-tumor Necrosis Factor (TNF) α Agent's Efficacy in Ankylosing Spondylitis Patients

Ankylosing Spondylitis

Portugal
Assiut University

Unknown

The Role of C1q Tumor Necrosis Factor-related Protein 6 in Breast Cancer

Breast Cancer
Dr. Larry W. Moreland
Bristol-Myers Squibb; Genentech, Inc.

Terminated

Mechanistic Studies of B- and T-Cell Function in RA Patients Treated With TNF Antagonists, Tocilizumab, or Abatacept (MAZERATI)

Rheumatoid Arthritis (RA)

United States
Sungkyunkwan University
Ministry of Food and Drug Safety, Korea

Unknown

A Retrospective Cohort Study on the Risk of Serious Infections in Rheumatoid Arthritis Patients Receiving Tocilizumab

Rheumatoid Arthritis | Infection

Korea, Republic of
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Cytokine Gene Polymorphisms in Bone Marrow Failure

Bone Marrow Diseases

United States
Shanghai Mental Health Center

Unknown

PKC as Serum Biomarkers for Depression

Major Depressive Disorder
University of Chicago
Abbott

Terminated

Trial of Adalimumab in Progressive Sarcoidosis

Sarcoidosis

United States
Professor Mikkel Østergaard
Merck Sharp & Dohme LLC

Completed

Novel MRI ANd Biomarkers in GOlimumab-treated Patients With Axial Spondyloarthritis (MANGO)

Axial Spondyloarthritis

Denmark
Benha University

Unknown

Glucocorticoid-induced Tumour Necrosis Factor Receptor Related Protein (GITR) in Rheumatoid Arthritis (GITR)

Rheumatoid Arthritis

Egypt
Zagazig University

Completed

Complement Component 3c and Tumor Necrosis Factor-α in Patients With Human Papillomavirus-Induced Cutaneous Warts

Warts

Egypt
Novartis Pharmaceuticals

Completed

A Study of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis or Hereditary Periodic Fevers Who Participated in the CACZ885G2301E1, CACZ885G2306 or CACZ885N2301 Studies

Hereditary Periodic Fevers | Systemic Juvenile Idiopathic Arthritis

France
Janssen Scientific Affairs, LLC

Completed

Comparative and Pragmatic Study of Golimumab Intravenous (IV) (Simponi Aria) Versus Infliximab (Remicade) in Rheumatoid Arthritis (AWARE)

Arthritis, Rheumatoid

United States
David Drobne

Unknown

Comparison of Two Different Golimumab Dosing Regimens for Ulcerative Colitis

Ulcerative Colitis

Slovenia
Hikma Pharmaceuticals LLC
Syneos Health

Completed

Safety Study of Remsima® (Infliximab) in Rheumatoid Arthritis Patients in Jordan (PASSRRA)

Rheumatoid Arthritis

Jordan
Hoffmann-La Roche

Terminated

A Study of RO7123520 to Evaluate the Safety and Efficacy in Participants With Moderately To Severely Active Rheumatoid Arthritis (RA) Who Are Inadequately Responding to Anti-Tumor Necrosis Factor (TNF)-Alpha Therapy

Rheumatoid Arthritis

Spain, United Kingdom, United States, Italy, Peru, Argentina, Colombia, Mexico, Germany, Austria, Guatemala
Imperial College London

Completed

T Cells and TNF (Tumor Necrosis Factor): The Impact of TNF Blockade

Rheumatoid Arthritis | Psoriatic Arthritis | Ankylosing Spondylitis

United Kingdom
Pamukkale University

Completed

Effects of Tai Chi in Patients With Ankylosing Spondylitis Receiving Anti-tumor Necrosis Factor Alpha Therapy

Spondylitis, Ankylosing

Turkey
TcLand Expression S.A.
European Commission

Terminated

RABIOPRED - a Validation Study of Theranostic Test to PREDict Treatment Response of Anti-TNFα BIologicals in Rheumatoid Arthritis (RABIOPRED)

RheumatoId Arthritis

France, Netherlands, Turkey, Czechia, Israel
Sun Yat-sen University

Completed

Treatment of Axial Spondyloarthritis by Recombinant Human Tumor Necrosis Factor-α Receptor Ⅱ IgG Fc Fusion Protein

Spondyloarthritis

China
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Investigating Cytokine Genes of Stem Cell Donors

Stem Cell Transplantation

United States
Peking Union Medical College Hospital

Unknown

Effectiveness and Adherence of Golimumab in Rheumatoid Arthritis

Arthritis, Rheumatoid

China
Aydin Adnan Menderes University

Completed

Tumor Necrosis Factor-alpha and Interleukin-18 Levels in Children With Gingivitis and Type 1 Diabetes Mellitus

Periodontal Diseases

Turkey
Mahmut Can Koska

Completed

Cytokines in Blister Fluids of Bullous Pemphigoid (BP) (BP)

Pemphigoid, Bullous

Turkey
University of Erlangen-Nürnberg Medical School

Completed

Comparing the Efficacy of Periarticular Bone Structure in Patients Treated With Either Tocilizumab or Tumor Necrosis Factor Blockers (Re-Bone)

Rheumatoid Arthritis

Germany
Janssen Research & Development, LLC

Terminated

A Study to Evaluate the Efficacy and Safety of Ustekinumab in the Treatment of Anti-TNFα Naive Participants With Active Radiographic Axial Spondyloarthritis

Axial Spondyloarthritis

United States, Ukraine, Taiwan, Poland, Korea, Republic of, Russian Federation, Czechia
Janssen Research & Development, LLC

Terminated

A Study to Evaluate the Efficacy and Safety of Ustekinumab in the Treatment of Anti-TNF(Alpha) Refractory Participants With Active Radiographic Axial Spondyloarthritis

Axial Spondyloarthritis

United States, Canada, France, Ukraine, United Kingdom, Belgium, Germany, Taiwan, Spain, Argentina, Mexico, Poland, Portugal, Bulgaria, Korea, Republic of, Brazil, Russian Federation, Hungary, Czechia
University Hospital, Ghent
UCB Pharma SA

Completed

Scintigraphic Detection of the Biodistribution of Tumor Necrosis Factor With a Radiolabeled Anti-TNFα in Patients With Active Rheumatoid Arthritis and Active Axial and Peripheral Spondyloarthritis (SCINTRA)

Rheumatoid Arthritis | Axial and Peripheral Spondyloarthritis

Belgium
Nanjing First Hospital, Nanjing Medical University

Completed

Epidural Intervention of Spinal Nerves With Tumor Necrosis Factor-Alpha Inhibitor

Spinal Stenosis
Amgen

Completed

Safety and Efficacy of Etanercept (Recombinant Human Tumor Necrosis Factor Receptor Fusion Protein [TNFR:Fc]) in Children With Juvenile Rheumatoid Arthritis (JRA)

Juvenile Rheumatoid Arthritis
Janssen Biotech, Inc.

Completed

Golimumab Safety and Surveillance Program Using the Ingenix NHI Database

Rheumatoid Arthritis | Arthritis, Psoriatic | Ankylosing Spondylitis
Menarini International Operations Luxembourg SA

Completed

Intensive Urate Lowering Therapy of Febuxostat Compared to Allopurinol on Cardiovascular Risk in Patients With Gout (FORWARD)

Gout

Poland, Serbia, Germany, Italy, Netherlands, Romania
University Hospital, Ghent
Janssen Biologics B.V.

Completed

Exploration of TNF-alpha Blockade With Golimumab in the Induction of Clinical Remission in Patients With Early Peripheral Spondyloarthritis (SpA) According to ASAS-criteria (CRESPA)

Peripheral Spondylarthritis

Belgium
Imperial College Healthcare NHS Trust
Merck Sharp & Dohme LLC; Imperial College London

Terminated

Thermography in Assessing Treatment Response to Golimumab in Psoriatic Arthritis (Go-Thermal)

Psoriatic Arthritis

United Kingdom
NICHD Neonatal Research Network
Centers for Disease Control and Prevention; National Center for Research Resources...

Completed

Inflammatory Cytokines Associated With Perinatal Brain Injury (Cytokines)

Cerebral Palsy | Infant, Small for Gestational Age | Infant, Premature | Infant, Low Birth Weight | Infant, Newborn

United States
University of Wisconsin, Madison
Immunex Corporation

Completed

A Pilot Study to Examine the Feasibility and Effect of Tumor Necrosis Factor (TNF) Inhibition on HIV Disease

HIV Infections

United States
Novartis Pharmaceuticals

Completed

Secukinumab in Tumor Necrosis Factor (TNF) - Inadequate Response (IR) Psoriasis Participants. (SIGNATURE)

Psoriasis

United Kingdom, Ireland
Merck Sharp & Dohme LLC

Completed

Preference for a Prefilled Syringe or Smartject™ Device for Delivering Golimumab in Participants Suffering From Moderate-to-severe Ulcerative Colitis (MK-8259-027) (SMART)

Ulcerative Colitis
Merck Sharp & Dohme LLC

Completed

Golimumab Utilization and Impact on Ulcerative Colitis (MK-8259-032) (GO-COLITIS)

Ulcerative Colitis

United Kingdom
Innovent Biologics (Suzhou) Co. Ltd.

Completed

Comparative Clinical Trial to Evaluate Bioequivalency and Safety of Monoclonal Antibody Injection and Adalimumab in Chinese Healthy Volunteers

Healthy

3

Subscribe