Search clinical trials for: intermittent single doses (ISD)

Total 13220 results

Knopp Biosciences
Biogen

Completed

Dexpramipexole Japanese PK Study

Amyotrophic Lateral Sclerosis

United Kingdom
Inversago Pharma Inc.

Completed

Safety, Tolerability, and Pharmacokinetics of Single Ascending Oral Doses of INV-101 in Healthy Male and Female Subjects

Pharmacokinetic

Canada
Morphic Therapeutic, Inc

Completed

Study of MORF 057 to Evaluate Single and Multi Ascending Doses in Healthy Volunteers

Healthy Volunteers

United States
Galapagos NV

Completed

A Study to Evaluate the Effects of Single and Multiple Oral Doses of GLPG3970

Healthy | Psoriasis

Belgium, Moldova, Republic of, Ukraine
Suzhou Yabao Pharmaceutical R&D Co., Ltd.

Completed

Single-dose/Multiple-doses Incremental Intravenous Injection of SY-005 （Recombinant Human Annexin A5）in Healthy Subjects

Sepsis

China
XOMA (US) LLC

Completed

An Open-Label Study of XOMA 358 in Patients With Hypoglycemia After Gastric Bypass Surgery (XOMA 358)

Hypoglycemia

United States
Enterprise Therapeutics Ltd

Completed

A First in Human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses of Inhaled ETD002 in Healthy Subjects

Healthy

United Kingdom
Otsuka Pharmaceutical Co., Ltd.

Completed

A Clinical Pharmacology Trial of Brexpiprazole Once-weekly (QW) Formulation Administered as Single and Multiple Oral Doses

Schizophrenia

Japan
Kind Pharmaceuticals LLC

Completed

A Dose-escalation Study of AND017 in Healthy Subjects

Healthy Volunteers

Australia
Galapagos NV

Terminated

A Study in Healthy Male Volunteers Investigating the Safety, Absorption and Elimination of Single Doses of GLPG4059

Healthy

Netherlands
Kiniksa Pharmaceuticals, Ltd.

Completed

Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Ascending Doses of KPL-404 in Healthy Subjects

Healthy Volunteers

Australia, United States
Shanghai Zhimeng Biopharma, Inc.

Completed

A Study of Orally Administered ZM-H1505R to Evaluate Safety, Tolerability and Pharmacokinetics After Single and Multiple Ascending Doses in Healthy Participants

Healthy Volunteers

United States
Auzone Biological Technology Pty Ltd
TIGERMED AUSTRALIA PTY LIMITED; CMAX Clinical Research Pty Ltd

Completed

A Study of TTYP01 in Healthy Adult Subjects

Healthy Adult Subjects

Australia
Celgene

Completed

A Study to Evaluate the Pharmacokinetics of Single Oral Doses of Ozanimod in Healthy Adult Chinese Subjects

Healthy Volunteer

China
University of California, San Diego
Teleflex; Zyno Medical

Completed

Continuous TAP Blocks: Relative Effects of a Basal Infusion vs. Repeated Bolus Doses

Postoperative Pain

United States
Pfizer

Completed

Clinical Study to Evaluate Pharmacokinetics and Safety of PF-06700841 After Single and Multiple Oral Doses as Modified Release Formulations

Healthy Participants

United States
GlaxoSmithKline

Completed

Primary Vaccination With Either Synflorix™ or Prevenar 13™ or Both Vaccines and Booster Vaccination With Synflorix™

Streptococcus Pneumoniae Vaccines | Infections, Streptococcal

Mexico
Shire

Completed

A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Ascending, Subcutaneous, Single and Multiple Doses of SHP681 (Glucagon-like Peptide-2 [GLP-2] Analog-Fc Fusion) in Healthy Adult Participants

Healthy Volunteers

United States
Zambon SpA

Completed

A Study to Evaluate Pharmacokinetics, Safety and Tolerability of Single and Multiple Intravenous Doses of N-acetylcysteine (NAC) in Chinese Healthy Volunteers

Respiratory Tract Disorders

China
Clementia Pharmaceuticals Inc.
Ipsen

Completed

Study to Assess Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of Palovarotene Ophthalmic Solution in Healthy Adult Subjects

Dry Eye Disease

Canada
Biogen

Completed

Safety, Tolerability and Pharmacokinetics of BIIB118 (PF-05251749)

Healthy

United States
Hepanova Inc.

Unknown

A Study to Evaluate the Safety and Tolerability of Single and Multiple Ascending Doses of HPN-01 in Healthy Subjects

Non-Alcoholic Steatohepatitis (NASH)

United States
Sichuan Haisco Pharmaceutical Group Co., Ltd

Completed

Safety, Tolerability and Pharmacokinetics of FTP-198 in Healthy Australian Volunteers

Healthy

Australia
Jazz Pharmaceuticals

Terminated

A Randomised, Open-label, Three-way Crossover Study to Assess the Pharmacokinetics and Safety of Single Doses of Four Sprays of Sativex® in a Range of Oral pH Environments in Healthy Subjects

Healthy Volunteers
Ionis Pharmaceuticals, Inc.

Completed

A Phase 1/2a Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of IONIS-ENaCRx in Healthy Volunteers and Patients With Cystic Fibrosis

Cystic Fibrosis | Healthy Subjects

United Kingdom, Germany
Cosmo Technologies Ltd
Cross S.A.

Completed

Colon Staining Efficacy of Single Oral Doses of Methylene Blue MMX (CRO-11-108)

Colon Staining in Preparation for Colonoscopy
Assiut University

Unknown

Immunologic Responses to Single and Double Doses of COVID-19 Vaccines in Egyptians

COVID-19 Vaccines
Youngene Therapeutics Inc., Ltd.

Completed

A Randomized, Double-blind, Placebo-controlled, Sequential Single and Multiple Ascending Doses of YG1699

Diabete Mellitus

United States
F2G Biotech GmbH
Covance

Completed

A Biopharmaceutics Study to Assess the Pharmacokinetics of Single Oral and IV Doses of Olorofim

Healthy

United Kingdom
Bristol-Myers Squibb

Completed

A Study to Evaluate Safety of Single Doses of BMS-986177 in Patients With End Stage Renal Disease (ESRD) Treated With Hemodialysis

Antithrombotic

United States
Novartis Pharmaceuticals

Completed

Effect of AQW051 on Cognitive Function in Patients With Chronic Stable Schizophrenia

Schizophrenia Disorders

United States
Pfizer

Completed

Investigation Of Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Of Single Doses Of Vupanorsen In Japanese Healthy Adult Participants With Elevated Triglycerides

Healthy

Japan
LB Pharmaceuticals Inc.

Completed

Safety and Tolerability of Single and Multiple Doses of LB-102 in Healthy Adults

Schizophrenia

United States
Novartis Pharmaceuticals

Completed

Clinical Study to Assess the Pharmacokinetics, Safety and Tolerability of Single and Multiple Oral Doses of AFQ056 in Children With Fragile X Syndrome (FXS)

Fragile X Syndrome

United States, Spain
GlaxoSmithKline

Terminated

First-time-in-Human (FTIH) Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single (in Both Fed and Fasted States) or Repeat Doses of GSK3358699

Arthritis, Rheumatoid

United Kingdom
University of Oxford

Unknown

A Study of a Candidate COVID-19 Vaccine (COV003)

Coronavirus

Brazil
Arthrosi Therapeutics

Completed

The Study is Designed to Evaluate Single Ascending Doses of AR882 in Healthy Adult Males

Healthy Volunteers

Australia
GeNeuro Australia PTY Ltd

Completed

Single Ascending Doses Study With GNbAC1 in Healthy Male Volunteers

Multiple Sclerosis

Australia
F-star Therapeutics, Inc.
PRA Health Sciences

Completed

A Fixed-Sequence, Drug-Drug Interaction Study Between Multiple Oral Doses of Inarigivir Soproxil and a Single Oral Dose of Midazolam in Healthy Subjects

Drug Interaction Potentiation

Netherlands
Iconic Therapeutics, Inc.

Completed

Study Evaluating Single and Repeated Intravitreal Doses of ICON-1 in Patients With Uveal Melanoma

Uveal Melanoma | Choroid Neoplasm

United States
Isofol Medical AB

Completed

Study Evaluating ECG Effects, Safety, Tolerability and Pharmacokinetics of Single Doses of Modufolin (Arfolitixorin) in Healthy Volunteers Tetrahydrofolate in Healthy Male Volunteers

Phase I Study in Healthy Volunteers to Evaluate ECG Effect

Sweden
Biocad

Completed

First-In-Human Study to Evaluate Safety And Pharmacokinetics of Single Escalating Doses of BCD-147 (Bispecific Anti-HER2/HER2 Antibody) in Healthy Subjects

Healthy

Russian Federation
Idorsia Pharmaceuticals Ltd.

Completed

A Study to Assess the Effect of Single Doses of Daridorexant on Electrocardiogram Parameters in Healthy Subjects

Healthy

Czechia
Boston VA Research Institute, Inc.
Millennium Pharmaceuticals, Inc.

Completed

Safety and Efficacy Study of Single Weekly Bortezomib in Newly Diagnosed Multiple Myeloma

Multiple Myeloma

United States
Future Medicine

Completed

A SAD, MAD, and FE Study to Evaluate the Safety, Tolerability, and Pharmacokinetic Profile of FM101 in Healthy Volunteers

Healthy Subjects

Netherlands
Abrexa Pharmaceuticals, Inc.
Iqvia Pty Ltd

Completed

Study to Assess the Safety, Tolerability and Pharmacokinetics of Single Ascending Oral Doses of J147

Alzheimer's Disease

United States
Processa Pharmaceuticals

Terminated

Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of HT-100 in Duchenne Muscular Dystrophy

Duchenne Muscular Dystrophy

United States
Otsuka Pharmaceutical Development & Commercialization...
H. Lundbeck A/S; PRA Health Sciences

Completed

A Trial of Single- and Multiple-doses of Aripiprazole in Adult Subjects With Schizophrenia or Bipolar I Disorder

Schizophrenia | Bipolar I Disorder

United States
MedImmune LLC

Terminated

A 6-Part Study In Healthy Volunteers To Evaluate Safety, Tolerability and Uptake Of MEDI7219 in the Body When Given as Single and Multiple Doses

Healthy Volunteers

United Kingdom
MedImmune LLC

Completed

Single and Multiple Ascending Doses of MEDI6570 in Subjects With Type 2 Diabetes Mellitus

Cardiovascular Disease | Atherosclerosis

United States

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