Search clinical trials for: renal impairment

Total 21113 results

Sahlgrenska University Hospital, Sweden

Completed

Renal Perfusion, Filtration and Oxygenation During Cardiopulmonary Bypass (CPB) (ECCSTUD)

Renal Impairment | Complication of Extracorporeal Circulation

Sweden
GE Healthcare

Withdrawn

Renal Effects of Three Iodinated Contrast Media (CM) in Patients at Risk Undergoing Coronary Angiography

Diabetes Mellitus | Renal Impairment | Coronary Artery Disease (CAD)

United States, Germany
Astellas Pharma Inc

Completed

A Study to Assess Efficacy and Safety of ASP1941 in Diabetic Patients With Renal Impairment

Type 2 Diabetes Mellitus

Japan
Merck Sharp & Dohme LLC

Completed

Pharmacokinetics (PK) and Safety of a Single Intravenous (IV) Dose of MK-3866 in Participants With Impaired Renal Function and in Healthy Controls (MK-3866-005)

Renal Impairment

United States
Janssen Research & Development, LLC

Completed

A Study to Assess the Effects of Renal Impairment on the Pharmacokinetics, Safety, and Tolerability of Intranasally Administered Esketamine

Healthy | Renal Impairment

United States
University of Kansas Medical Center

Terminated

Impact of Exercise on Cognitive Impairment in End-Stage Renal Disease

Cognitive Impairment | End-Stage Renal Disease

United States
Novartis Pharmaceuticals

Terminated

Effect of Serelaxin Versus Standard of Care in Acute Heart Failure (AHF) Patients (RELAX-AHF-EU)

Acute Heart Failure (AHF)

Germany, Belgium, Croatia, Estonia, Hungary, Lithuania, Russian Federation, Austria, Switzerland, Spain, France, Greece, Slovenia, Bulgaria, Czechia, Italy, Serbia, Finland, United Kingdom, Poland, Portugal, Romania, Latvia, Slovakia, I...
Assiut University

Unknown

Cystatin c and Beta 2 Microglobulin in Thalassemic Children.

Blood Disease
Novo Nordisk A/S

Completed

Efficacy and Safety of Liraglutide Versus Placebo as add-on to Existing Diabetes Medication in Subjects With Type 2 Diabetes and Moderate Renal Impairment

Diabetes Mellitus, Type 2 | Diabetes

United States, Poland, Russian Federation, United Kingdom, France, Ukraine
Maastricht University Medical Center
ZonMw: The Netherlands Organisation for Health Research and Development; Envida...

Terminated

Neurotoxic Adverse Effects of Morphine and Oxycodone for Pain in Terminal Patients With Diminished Renal Function (MOSART)

Pain | Renal Impairment | Terminal Illness

Netherlands
Guerbet

Terminated

Effects of Contrast Media on Subjects With Stable Reduced Renal Function Undergoing Contrast-Enhanced Computed Tomography (CINOPSIS CT)

Renal Impairment

United States
Daiichi Sankyo Co., Ltd.

Completed

Safety and Pharmacokinetics Study of DU-176b Administered to Non-valvular Atrial Fibrillation With Severe Renal Impairment

Non-valvular Atrial Fibrillation

Japan
Daiichi Sankyo Co., Ltd.

Completed

Safety and Pharmacokinetics Study of DU-176b Administered to Patients With Severe Renal Impairment Undergoing Orthopedic Surgery of The Lower Limbs

Venous Thromboembolism

Japan
AbbVie

Completed

A Study to Evaluate the Efficacy and Safety of Glecaprevir/Pibrentasvir in Adults With Chronic Hepatitis C Virus Genotype 1 - 6 Infection and Renal Impairment (EXPEDITION-5)

Hepatitis C Virus (HCV)

United States, Canada, Germany, Greece, Italy, Korea, Republic of, Poland, Puerto Rico, Spain, Sweden
Lexicon Pharmaceuticals

Completed

Study to Evaluate Sotagliflozin in Subjects With Varying Degrees of Renal Function

Healthy | Renal Impairment

United States
Cubist Pharmaceuticals LLC

Completed

Study of Pharmacokinetics of a Single IV Dose of CB-238,618 in Subjects With Varying Degrees of Renal Impairment Compared to Healthy Subjects (MK-6183-001)

Renal Impairment | Healthy Volunteers
Merck Sharp & Dohme LLC
Pfizer

Completed

Effect of Renal Impairment on the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Ertugliflozin in Participants With Type 2 Diabetes Mellitus (MK-8835-009)

Type 2 Diabetes Mellitus | Renal Impairment
Merck Sharp & Dohme LLC

Completed

A Study Evaluating the Pharmacokinetics of Doravirine (MK-1439) in Participants With Severe Renal Impairment (MK-1439-051)

Renal Impairment
Venatorx Pharmaceuticals, Inc.
National Institutes of Health (NIH)

Completed

VNRX-5133 With VNRX-5022 in Subjects With Varying Degrees of Renal Impairment

Pharmacokinetics

United States
Astellas Pharma Inc

Completed

Post-marketing Study of Gabapentin Enacarbil to Evaluate the Effect in Restless Leg Syndrome (RLS) Patients With Moderate Renal Impairment

Restless Legs Syndrome (RLS)

Japan
Bayer
Orion Corporation, Orion Pharma

Completed

Effect of Hepatic and Renal Impairment on the Pharmacokinetics, Safety and Tolerability of BAY1841788 (ODM-201)

Hepatic Insufficiency | Renal Insufficiency | Pharmacokinetics

Germany
Daiichi Sankyo Co., Ltd.

Completed

Study of CS-3150 in Combination With ARB or ACE Inhibitor in Hypertensive Patients With Moderate Renal Impairment

Hypertension With Moderate Renal Impairment

Japan
Merck Sharp & Dohme LLC

Completed

A Study to Assess the Addition of Sitagliptin to Metformin Compared With the Addition of Dapagliflozin to Metformin in Participants With Type 2 Diabetes Mellitus (T2DM) and Mild Renal Impairment Who Have Inadequate Glycemic Control on Metformin With or Without a Sulfonylurea (MK-0431-838)

Type 2 Diabetes Mellitus
Akebia Therapeutics

Completed

Relative Bioavailability of Two Formulations of AKB-6548 and the Food Effect of a New Tablet in Healthy Adult Subjects

Healthy

United States
Akebia Therapeutics

Completed

Effect of AKB-6548 on Cardiac Repolarization Intervals in Healthy Volunteers

Healthy Volunteers

United States
Akebia Therapeutics

Completed

Effects of Ferrous Sulfate on the Pharmacokinetics of AKB-6548

Healthy Volunteers

United States
The Medicines Company

Completed

A Study of Inclisiran in Participants With Renal Impairment Compared to Participants With Normal Renal Function (ORION-7)

Renal Impairment

New Zealand
CTI BioPharma
SGS S.A.

Completed

PK of Pacritinib in Patients With Mild, Moderate, Severe Renal Impairment and ESRD Compared to Healthy Subjects

Myelofibrosis

Moldova, Republic of, Germany, Romania
Astellas Pharma Inc

Completed

A Study to Assess the Pharmacokinetics, Pharmacodynamics of ASP1941 in Diabetes Mellitus Patients With Renal Impairment

Type 2 Diabetes Mellitus

Japan
Eli Lilly and Company

Completed

A Study of Evacetrapib (LY2484595) in Participants With Severe Renal Impairment and in Healthy Participants

Cardiovascular Disease

United States
Merck Sharp & Dohme LLC

Completed

A Study to Assess Pharmacokinetics (PK) of Preladenant in Participants With Chronic Renal Impairment (CRI) (P06512)

Parkinson Disease
Merck Sharp & Dohme LLC

Completed

Pharmacokinetics of Sugammadex (MK-8616) in Participants With Moderate and Severe Renal Insufficiency (MK-8616-105)

Renal Insufficiency | Renal Impairment

United States
Boehringer Ingelheim

Completed

Treatment of Patients Undergoing Primary Unilateral Elective Total Knee or Hip Replacement With Dabigatran Etexilate

Arthroplasty, Replacement | Prevention of Venous Thromboembolism | Moderate Renal Impairment (CrCl 30-50 mL/Min)

Austria, Canada, Czechia, Finland, Netherlands, Sweden
Merck Sharp & Dohme LLC

Terminated

A Study of MK-7145 in Participants With Renal Insufficiency (Part I) and Heart Failure With Renal Insufficiency (Part II) (MK-7145-011)

Heart Failure | Renal Impairment
Eisai Inc.

Completed

Phase 0 Study in Healthy, Hepatic and Renal Impaired Subjects to Obtain Plasma for Lenvatinib Protein Binding

Hepatic Impairment; Renal Impairment

United States
Cubist Pharmaceuticals LLC

Terminated

Study of Daptomycin Safety and Efficacy for Complicated Skin and Skin Structure Infections (cSSSI) and Bacteremia in Renal Impairment (RENSE)

Renal Impairment | Complicated Skin and Skin Structure Infections | S. Aureus Bacteremia

United States
University of Pisa
Istituto di Fisiologia Clinica CNR

Unknown

Association Between Phthalates Exposure and Renal Function Impairment in TYpe 2 Diabetes (PURITY-2)

Diabetes Mellitus, Type 2 | Albuminuria | Cardiovascular Risk Factor

Italy
Wockhardt
Clinartis

Completed

To Investigate The Pharmacokinetics Of Intravenous WCK 5222 (FEP-ZID) In Patients With Renal Impairment

Renal Impairment

United States
Eli Lilly and Company
AstraZeneca

Withdrawn

A Study of Lanabecestat in Participants With Severe Kidney Impairment Compared to Healthy Participants

Renal Insufficiency

United States
Entasis Therapeutics

Completed

Evaluation of the Pharmacokinetics, Safety, and Tolerability of Intravenous ETX2514 and Sulbactam Administered Concurrently to Subjects With Various Degrees of Renal Impairment and Healthy Matched Control Subjects

Acinetobacter Baumannii Infection

United States
ContraVir Pharmaceuticals, Inc.

Completed

Evaluation of Effect of Renal Impairment on the PK of Tenofovir Exalidex

Renal Impairment

United States
Assiut University

Completed

Evaluation of Treatment of Chronic HCV Patients in Chronic Kidney Disease Versus End Stage Renal Disease Patients

Hepatitis C

Egypt
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Effect of Severe Renal Impairment on the Single-dose Pharmacokinetics of Odalasvir

Renal Insufficiency

United States
MedImmune LLC

Completed

A Study to Evaluate Pharmacokinetics, Safety and Tolerability of MEDI0382 in Renal Impairment Subjects

Renal Insufficiency

New Zealand, Germany
Pfizer

Completed

Study Of Palbociclib (PD-0332991) In Renal Impairment

Renal Impairment

United States
Celgene

Completed

A Study to Assess the Pharmacokinetics of CC-122 in Subjects With Mild, Moderate, and Severe Renal Impairment

Renal Insufficiency

United States
Janssen Pharmaceutica N.V., Belgium

Completed

A Study to Evaluate the Effect of Renal Impairment on the Pharmacokinetics of JNJ-64041575 in Adult Participants With Various Degrees of Renal Function

Renal Insufficiency

Germany
Syndax Pharmaceuticals

Completed

A Study to Evaluate the Pharmacokinetics of Entinostat in Adult Subjects With Normal and Impaired Renal Function

Renal Impairment | Healthy Volunteer

United States
Pharmaceutical Project Solutions, Inc.
Cognitive Research Corporation

Completed

PK Study of Intranasal RX0041-002 in Subjects With Severe Renal Impairment and Normal Renal Function

Healthy

United States
AstraZeneca

Completed

Subanalyses of Elderly Type 2 Diabetes Patients or Type 2 Diabetes Patients With Renal Impairment

Type 2 Diabetes

United States

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