Clinical Trials Sponsored by PranaScience Institute LLC

Total 954 results

Institut de Recherches Internationales Servier
Merck Sharp & Dohme LLC

Recruiting

Study of Vorasidenib and Pembrolizumab Combination in Recurrent or Progressive Enhancing IDH-1 Mutant Glioma

Astrocytoma

United States
Servier Bio-Innovation LLC
Institut de Recherches Internationales Servier

Recruiting

A Study of PRS-344/S095012 (PD-L1x4-1BB Bispecific Antibody-Anticalin Fusion) in Patients With Solid Tumors

Solid Tumor

Spain, Australia, Belgium, United States
Curonix LLC
Texas Institute for Pain and spine; Performance Pain and Sports Medicine PLLC; Holy Cross Hospital, Inc and other collaborators

Recruiting

Freedom-1 Study for Chronic Knee Pain

Osteoarthritic Knee Pain

United States
Autotune Me LLC
University of Pennsylvania; National Institute on Aging (NIA)

Recruiting

A Music-Based Mobile App for People Living With ADRD

Dementia | Depressive Symptoms | Agitation

United States
Johns Hopkins University
National Institute on Aging (NIA); Labyrinth Devices, LLC

Recruiting

Vestibular Implantation in Older Adults

Labyrinth Diseases | Vestibular Diseases | Sensation Disorders | Bilateral Vestibulopathy | Other Disorders of Vestibular Function, Bilateral | Bilateral Vestibular Deficiency (BVD) | Gentamicin Ototoxicity | Bilateral Vestibular Hypofunction | Aminoglycoside Ototoxicity | Presbyvestibulopathy

United States
University of Southern California
National Cancer Institute (NCI); Virtually Strong, LLC

Recruiting

Virtual Reality in Reducing Pain and Anxiety in Cancer Participants Undergoing Painful Procedures

Malignant Neoplasm

United States
University Ghent
Merck Sharp & Dohme LLC; the Flanders Institute for Biotechnology

Completed

Efficacy of Golimumab in Early Axial Spondyloarthritis in Relation to Gut Inflammation (GO-GUT)

Axial Spondyloarthritis

Belgium
Virginia Commonwealth University
National Cancer Institute (NCI); Merck Sharp & Dohme LLC

Active, not recruiting

Neoadjuvant Pembrolizumab + Decitabine Followed by Std Neoadj Chemo for Locally Advanced HER2- Breast Ca

Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Invasive Breast Carcinoma | Stage IIA Breast Cancer | Stage IIB Breast Cancer | HER2/Neu Negative | Progesterone Receptor Negative | Estrogen Receptor-positive Breast Cancer | Breast Adenocarcinoma | Progesterone Receptor Positive... and other conditions

United States
Baptist Health South Florida
Merck Sharp & Dohme LLC; Miami Cancer Institute

Completed

Pembrolizumab Activity in Patients With Homologous Recombination Competent and Deficient Tumors

Solid Tumor, Adult

United States
University of Southern California
National Cancer Institute (NCI); Brooklyn ImmunoTherapeutics, LLC

Active, not recruiting

IRX-2 Regimen in Treating Women With Cervical Squamous Intraepithelial Neoplasia 3 or Squamous Vulvar Intraepithelial Neoplasia 3

Cervical Squamous Cell Carcinoma In Situ | Vulvar High Grade Squamous Intraepithelial Lesion

United States
Beth Israel Deaconess Medical Center
Massachusetts Institute of Technology; TriNetX, LLC

Active, not recruiting

Prospective Validation of an EHR-based Pancreatic Cancer Risk Model

Pancreatic Adenocarcinoma | Predictive Cancer Model

United States
University of Pennsylvania
National Institute on Aging (NIA); iFIT Prosthetics, LLC

Completed

Immediate Fit Using Innovative Technology Transtibial & Transfemoral Prosthesis

Amputation

United States
Innova Smart Technologies (Pvt.) Ltd
Rehman Medical Institute - RMI; NOABIO LLC

Completed

Comparison of NoaScope to the Conventional Stethoscope for Auscultation of Heart and Lung Sounds

Chest Pathology

Pakistan
Adrienne G. Waks
Merck Sharp & Dohme LLC

Active, not recruiting

A Study Of Changes In PD-L1 Expression During Preoperative Treatment With Nab-Paclitaxel And Pembrolizumab In Hormone Receptor-Positive Breast Cancer

Breast Cancer

United States
University of Washington
National Cancer Institute (NCI); Merck Sharp & Dohme LLC

Completed

Pembrolizumab and Carboplatin in Treating Patients With Relapsed or Refractory Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Recurrent Fallopian Tube Carcinoma | Recurrent Ovarian Carcinoma | Recurrent Primary Peritoneal Carcinoma

United States
University of Washington
National Cancer Institute (NCI); Janssen Scientific Affairs, LLC

Completed

A Phase II Neoadjuvant Study of Apalutamide, Abiraterone Acetate, Prednisone, Degarelix and Indomethacin in Men With Localized Prostate Cancer Pre-prostatectomy

Stage III Prostate Adenocarcinoma AJCC v7 | Stage IV Prostate Adenocarcinoma AJCC v7 | Stage IV Prostate Cancer AJCC v7 | Stage III Prostate Cancer AJCC v7

United States
Kenya Medical Research Institute
Merck Sharp & Dohme LLC; University of Washington

Completed

Antibody Response to Prophylactic QHPV Vaccine at 48 Months Among HIV-infected Girls and Boys

HPV Infection | HPV Vaccine | HIV-1-infection

Kenya
AIDS Malignancy Consortium
National Cancer Institute (NCI); The Emmes Company, LLC

Completed

Detecting Anal and Genital Human Papillomavirus Infection and Squamous Intraepithelial Lesions in HIV-Positive Patients Enrolled in AIDS Cancer Clinical Trials

Sarcoma | Lymphoma | Precancerous Condition | Aids-related Malignancies

United States
AIDS Malignancy Consortium
National Cancer Institute (NCI); The Emmes Company, LLC

Completed

Bortezomib, Ifosfamide, Carboplatin, and Etoposide, With or Without Rituximab, in Treating Patients With Relapsed or Refractory AIDS-Related Non-Hodgkin Lymphoma

Lymphoma

United States
AIDS Malignancy Consortium
National Cancer Institute (NCI); The Emmes Company, LLC

Terminated

Biomarkers in Blood Samples From Patients With HIV Infection and Stage III or Stage IV Hodgkin Lymphoma Undergoing Chemotherapy

Lymphoma | Nonneoplastic Condition

United States
Janssen Research & Development, LLC
The George Institute for Global Health, Australia

Completed

A Study of the Effects of Canagliflozin (JNJ-28431754) on Renal Endpoints in Adult Participants With Type 2 Diabetes Mellitus (CANVAS-R)

Diabetes Mellitus, Type 2 | Albuminuria

Australia, France, Italy, Poland, Ukraine, United Kingdom, United States, China, Belgium, Germany, Taiwan, Spain, Argentina, Mexico, Malaysia, Canada, Netherlands, Korea, Republic of, New Zealand, Brazil, Russian Federation, Puerto... and more
AIDS Malignancy Consortium
National Cancer Institute (NCI); The Emmes Company, LLC

Completed

Combination Chemotherapy and Rituximab in Treating Patients With Newly Diagnosed AIDS-Related B-Cell Non-Hodgkin's Lymphoma

Lymphoma

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Pharmacokinetic & Pharmacodynamic Interaction of Lofexidine and Buprenorphine in Buprenorphine Maintained Patients

Opioid Dependence | Buprenorphine Withdrawal Syndrome

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Single-Dose Pharmacokinetics and Safety of Oral Lofexidine in Hepatically-Impaired Subjects

Liver Failure

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Single-dose Pharmacokinetics and Safety of Oral Lofexidine in Renally-Impaired Subjects

Renally Impaired Subjects

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Main Study of Lofexidine and Methadone Pharmacodynamic Interaction in Methadone Maintained Patients

Opioid Dependence | Methadone Withdrawal Syndrome

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Lofexidine ADME & Mass Balance in Volunteers

Normal Healthy Volunteers Will be Treated With Lofexidine to Understand the Absolute Bioavailability and Mass Balance Recovery of the Product

United States
AIDS Malignancy Consortium
National Cancer Institute (NCI); The Emmes Company, LLC

Completed

Human Papilloma Virus Infection in HIV-Positive Indian Men Who Have Sex With Men

Precancerous Condition | Nonneoplastic Condition

United States
AIDS Malignancy Consortium
National Cancer Institute (NCI); The Emmes Company, LLC

Completed

Sirolimus in Treating Patients With HIV-Related Kaposi's Sarcoma

Sarcoma

United States
AIDS Malignancy Consortium
National Cancer Institute (NCI); The Emmes Company, LLC

Completed

Valproic Acid in Treating Patients With Kaposi's Sarcoma

Sarcoma

United States
Koning Corporation
National Cancer Institute (NCI); Elizabeth Wende Breast Care, LLC

Completed

Cone Beam Computed Tomography for Breast Imaging

Breast Cancer

United States
New York State Psychiatric Institute
National Institute on Drug Abuse (NIDA); The Emmes Company, LLC

Completed

Surmounting Withdrawal to Initiate Fast Treatment With Naltrexone (SWIFT)

Opioid-use Disorder

United States
Anne Lindblad
National Institute of Neurological Disorders and Stroke (NINDS); Ortho-McNeil...

Completed

NINDS CRC Chronic Migraine Treatment Trial (CMTT)

Chronic Migraine

United States
Andrew Rezvani
National Institutes of Health (NIH); Pharmacyclics LLC.

Completed

Ibrutinib in Preventing Acute Leukemia in Patients After Reduced-Intensity Conditioning and Stem Cell Transplant

Acute Myeloid Leukemia | Acute Lymphoblastic Leukemia | Hematopoietic Cell Transplantation Recipient | Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Acute Biphenotypic Leukemia

United States
Instituto de Medicina Molecular João Lobo Antunes
Merck Sharp & Dohme LLC

Completed

Efficacy of Golimumab in Combination With Methotrexate (MTX) Versus MTX Monotherapy, in Improving Dactylitis, in MTX naïve Psoriatic Arthritis Patients (GO-DACT)

Psoriatic Arthritis

Portugal
Pear Therapeutics, Inc.
National Institute on Drug Abuse (NIDA); Kaiser Foundation Research Institute; Whitman-Walker Institute, Inc... and other collaborators

Completed

Feasibility Study of Novel Prescription Digital Therapeutic Supporting Unobserved Buprenorphine Initiation & Adherence

Opioid Use Disorder

United States
Fundación Santiago Dexeus Font
Merck Sharp & Dohme LLC

Completed

Double Stimulation Followed by a Fresh Embryo Transfer (DUO_STIM_FRESH)

Infertility

Spain
M.D. Anderson Cancer Center
National Cancer Institute (NCI); GlaxoSmithKline; Merck Sharp & Dohme LLC; National...

Active, not recruiting

Study of the Selective PI3K-Beta Inhibitor GSK2636771 in Combination With Pembrolizumab in Patients With Metastatic Melanoma and PTEN Loss

Metastatic Melanoma | Melanoma and Other Malignant Neoplasms of Skin

United States
National Institute of Allergy and Infectious Diseases...
Auro Vaccines LLC

Completed

Therapeutic Vaccine for HIV

HIV | Therapeutic Vaccine

United States
H. Lee Moffitt Cancer Center and Research Institute
Merck Sharp & Dohme LLC

Recruiting

Olaparib in Combination With Pembrolizumab for Advanced Uveal Melanoma

Ocular Melanoma | Uveal Melanoma

United States
H. Lee Moffitt Cancer Center and Research Institute
Merck Sharp & Dohme LLC

Recruiting

Neoadjuvant Lenvatinib Plus Pembrolizumab in Merkel Cell Carcinoma

Merkel Cell Carcinoma | Neuroendocrine Carcinoma of the Skin | Trabecular Carcinoma of the Skin

United States
Dana-Farber Cancer Institute
Merck Sharp & Dohme LLC; BioNTech SE; Oncovir, Inc.

Recruiting

A Personalized Neoantigen Cancer Vaccine in Treatment Naïve, Asymptomatic Patients With IGHV Unmutated CLL.

Lymphocytic Leukemia

United States
The Emmes Company, LLC
National Eye Institute (NEI); University of California, Davis

Completed

Treatment of Central Retinal Vein Occlusion Using Stem Cells Study (TRUST)

Central Retinal Vein Occlusion

United States
Flint Rehabilitation Devices, LLC
University of California, Irvine; Rancho Research Institute, Inc.

Completed

FitMi Plus Home Therapy for Stroke Patients

Cerebral Stroke

United States
Kirby Institute
Merck Sharp & Dohme LLC; The University of New South Wales

Completed

Surveillance for Antiviral Resistant Variants in Chronic Hepatitis C Patients (SEARCH-C)

Chronic Hepatitis C Infection

Australia
Kaiser Permanente
National Institute on Drug Abuse (NIDA); The Emmes Company, LLC

Completed

PRimary Care Opioid Use Disorders Treatment (PROUD) Trial (PROUD)

Opioid-use Disorder

United States
Yale University
National Institute on Drug Abuse (NIDA); The Emmes Company, LLC

Completed

Opioid Use Disorder in the Emergency Department: CTN 0069

Opioid Use Disorder

United States
Northwestern University
National Cancer Institute (NCI); Merck Sharp & Dohme LLC; Seagen Inc.

Withdrawn

Brentuximab Vedotin and Pembrolizumab in Treating Patients With Recurrent Peripheral T-Cell Lymphoma

Recurrent Angioimmunoblastic T-Cell Lymphoma | Refractory Angioimmunoblastic T-Cell Lymphoma | Refractory Peripheral T-Cell Lymphoma, Not Otherwise Specified | Recurrent Enteropathy-Associated T-Cell Lymphoma | Recurrent Follicular T-Cell Lymphoma | Recurrent Hepatosplenic T-Cell Lymphoma | Recurrent... and other conditions

United States
Northwestern University
National Cancer Institute (NCI); MedImmune LLC; Avon Breast Cancer Foundation

Completed

MEDI4736 and Tremelimumab in Treating Patients With Metastatic HER2 Negative Breast Cancer

Stage IV Breast Cancer | Recurrent Breast Carcinoma | Estrogen Receptor Negative | Estrogen Receptor Positive | HER2/Neu Negative

United States
Amy C. Sherman, MD
Merck Sharp & Dohme LLC

Completed

Letermovir Treatment for Refractory or Resistant Cytomegalovirus Infection

Cytomegalovirus Infections

United States

Clinical Trials Sponsored by PranaScience Institute LLC

Sponsors and Collaborators

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CROs in Burkina Faso

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