Clinical Trials Sponsored by Spark Therapeutics, Inc.

Total 3069 results

Vyne Therapeutics Inc.

Completed

VPD-737 for Treatment of Chronic Pruritus

Chronic Pruritus

United States
Solace Therapeutics, Inc.

Terminated

Vesair Clinical Trial (VAPOR)

Stress Urinary Incontinence

United States
AnHeart Therapeutics Inc.

Completed

A Study on the Effect of AB-106 on the Pharmacokinetics of Digoxin

Solid Tumor

China
Carmot Therapeutics, Inc.

Completed

A Study to Assess CT-868 and the Relationship Between Insulin Secretory Response and Ambient Blood Glucose.

Diabetes

United States
Cara Therapeutics, Inc.

Completed

A Study to Evaluate the Safety and Efficacy of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus (KALM-1)

Uremic Pruritus

United States
Eirion Therapeutics Inc.

Completed

ET-01 in Subjects With Lateral Canthal Lines

Lateral Canthal Lines | Crow's Feet

United States
Cara Therapeutics, Inc.

Completed

Study to Evaluate the Efficacy and Safety of Oral Difelikefalin (CR845) for Moderate to Severe Pruritus in Subjects With Atopic Dermatitis (KARE)

Pruritus | Atopic Dermatitis

United States, Canada
Esperion Therapeutics, Inc.

Completed

A Study of the Efficacy and Safety of ETC-1002 in Participants With Statin Intolerance

Hypercholesterolemia

United States
Sorrento Therapeutics, Inc.

Withdrawn

Study of Anti-CEA CAR-T + Chemotherapy VS Chemotherapy Alone in Patients With CEA+Pancreatic Cancer & Liver Metastases

Malignant Tumor of Pancreas Metastatic to Liver
Aldeyra Therapeutics, Inc.

Completed

The TRANQUILITY Trial: Clinical Trial to Assess the Efficacy and Safety in Subjects With Dry Eye Disease

Dry Eye | Dry Eye Syndromes

United States
Galectin Therapeutics Inc.

Completed

A Single-dose, Open-label, Pharmacokinetic Study of Belapectin (GR-MD-02) in Subjects With Normal Hepatic Function and Subjects With Varying Degrees of Hepatic Impairment

Hepatic Impairment

United States
Anika Therapeutics, Inc.

Completed

Repeat Injection of Cingal® for Osteoarthritis of the Knee

Osteoarthritis of the Knee

Czechia, Hungary, Poland
Xalud Therapeutics, Inc.

Withdrawn

Preliminary Safety and Efficacy of XT-150 in Facet Joint Osteoarthritis

Osteoarthritis, Spine

Australia
Aimmune Therapeutics, Inc.

Terminated

Oral Immunotherapy for Desensitization in Children, Adolescents, and Young Adults With Hen Egg Allergy

Hen Egg Allergy

United States
Denali Therapeutics Inc.

Completed

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL151 in Healthy Volunteers

Healthy Volunteers

Netherlands
Affect Therapeutics, Inc.

Completed

Field Study of a Digital Therapeutic Platform to Facilitate Treatment for Methamphetamine-Primary Stimulant Use Disorder

Methamphetamine Abuse

United States
Biosplice Therapeutics, Inc.

Completed

A Study Utilizing Patient-Reported Outcomes to Evaluate the Safety and Efficacy of Lorecivivint (SM04690) for the Treatment of Moderately to Severely Symptomatic Knee Osteoarthritis (STRIDES-1)

Knee Osteoarthritis

United States
Sorrento Therapeutics, Inc.

Withdrawn

Study to Evaluate the Safety and Efficacy of a Single Dose of STI-2020 (COVI-AMG™) to Treat COVID-19

Covid19
Actuate Therapeutics Inc.

Withdrawn

9-ING-41 Plus Carboplatin in Patients With Advanced, Metastatic Salivary Gland Carcinoma

Adenoid Cystic Carcinoma | Salivary Gland Neoplasms | Salivary Gland Cancer | Salivary Gland Carcinoma

United States
Protagonist Therapeutics, Inc.

Completed

Pharmacokinetics of PN-235 in Healthy Volunteers

Healthy Volunteers

Australia
SynerGene Therapeutics, Inc.

Suspended

A Study of SGT-53 in Children With Refractory or Recurrent Solid Tumors

Neoplasm

United States
Ovid Therapeutics Inc.

Terminated

An Open-Label Study to Evaluate the Long-Term Safety, Tolerability, and Efficacy of OV101 in Individuals With Angelman Syndrome (ELARA)

Angelman Syndrome

United States, Israel
Antios Therapeutics, Inc

Completed

A Drug-Drug Interaction Study Between ATI-2173 and Tenofovir Disoproxil Fumarate in Healthy Subjects

Drug Interaction

Canada
Tobira Therapeutics, Inc.

Terminated

Rollover Study of Cenicriviroc for the Treatment of Liver Fibrosis in Participants With Nonalcoholic Steatohepatitis

Liver Cirrhosis | Non-alcoholic Fatty Liver Disease | Nonalcoholic Steatohepatitis

United States, Australia, France, Germany, Spain, Poland, United Kingdom, Italy, Puerto Rico, Belgium, Hong Kong
Stemline Therapeutics, Inc.

Terminated

SL-401 as Consolidation Therapy in Patients With Adverse Risk Acute Myeloid Leukemia in First Complete Remission

Acute Myeloid Leukemia

United States
Vyne Therapeutics Inc.

Completed

A Study to Compare the Efficacy and Safety of Topical Administration of FMX-101 for Treatment of Moderate-to-Severe Acne

Acne Vulgaris

United States, Dominican Republic
Vyne Therapeutics Inc.

Completed

A Study to Compare the Efficacy and Safety of Topical Administration of FMX-101 for Treatment of Moderate-to-Severe Acne

Acne Vulgaris

United States, Dominican Republic
Osteal Therapeutics, Inc.

Completed

Safety and Efficacy in Patients Treated for Hip or Knee PJI With Vancomycin and Tobramycin Joint Irrigation

Prosthetic Joint Infection

United States
Aristea Therapeutics, Inc.

Completed

A Study of the ADME of [14C]RIST4721 in Healthy Male Subjects

Healthy | ADME

United Kingdom
Aldeyra Therapeutics, Inc.

Completed

The INVIGORATE Trial: A Clinical Trial to Assess the Efficacy and Safety of Subjects With Seasonal Allergic Conjunctivitis.

Allergic Conjunctivitis

Canada
Outlook Therapeutics, Inc.

Completed

A 3-month Study to Assess the Safety of ONS-5010 in Subjects With Visual Impairment Due to Retinal Disorders

Age-related Macular Degeneration | Diabetic Macular Edema | Wet Macular Degeneration | Neovascular Age-related Macular Degeneration | BRVO - Branch Retinal Vein Occlusion

United States
Sorrento Therapeutics, Inc.

Withdrawn

Phase 3 Study to Assess Resiniferatoxin vs Standard of Care for the Treatment of Intractable Cancer Pain

Pain, Intractable | Pain Cancer
Pipeline Therapeutics, Inc.

Completed

Phase I Study Evaluating Safety and Tolerability of Escalating Single and Multiple Doses of of PIPE-307 and Food Effect in Healthy Volunteers

Multiple Sclerosis

Australia
Aimmune Therapeutics, Inc.

Completed

Real-World AR101 Market-Supporting Experience Study in Peanut-Allergic Children (RAMSES) (RAMSES)

Peanut Allergy

United States, Canada
CuraSen Therapeutics, Inc.

Withdrawn

A Study of CST-2032 in Subjects With Cognitive Impairment

Mild Cognitive Impairment (MCI) | Parkinson Disease (PD)
Biosplice Therapeutics, Inc.

Completed

A Study Utilizing Patient-Reported and Radiographic Outcomes and Evaluating the Safety and Efficacy of Lorecivivint (SM04690) for the Treatment of Moderately to Severely Symptomatic Knee Osteoarthritis (STRIDES-X-ray)

Knee Osteoarthritis

United States
RAPT Therapeutics, Inc.

Completed

A First-in-Human Study of RPT193 in Healthy Volunteers and Patients With Atopic Dermatitis

Atopic Dermatitis

United States, Netherlands
Sorrento Therapeutics, Inc.

Withdrawn

Study of Intravenous Administration of Allogeneic Adipose-Derived Mesenchymal Stem Cells for COVID-19-Induced Acute Respiratory Distress

Covid19 | ARDS

United States
Kartos Therapeutics, Inc.

Completed

A Phase 1 Study Evaluating AMG 232 in Advanced Solid Tumors or Multiple Myeloma

Cancer | Glioblastoma | Multiple Myeloma | Advanced Solid Tumors | Oncology | Tumors | Advanced Malignancy | Oncology Patients

United States, France, Netherlands
Aptabio Therapeutics, Inc.

Completed

Safety, Tolerability and Renal Effects of APX-115 in Subjects With Type 2 Diabetes and Nephropathy

Diabetes Mellitus, Type 2 | Diabetic Nephropathies | Nephropathy, Diabetic

Bulgaria, Czechia, Hungary, Serbia
Cognito Therapeutics, Inc.

Active, not recruiting

Study of Tolerability, Safety and Efficacy of Sensory Stimulation at Multiple Dose Levels to Improve Brain Function (Etude Study)

Cognitive Impairment | Alzheimer Disease | Mild Cognitive Impairment | Cognitive Decline | Alzheimer Disease, Early Onset | Alzheimer Disease, Late Onset | Dementia, Alzheimer Type | Memory Disorders | Memory Impairment | Alzheimer Dementia | Memory Loss | Dementia, Mild | Memory Disorders, Age Related

United States
Impact Therapeutics, Inc.

Completed

BA Study of IMP4297 (20mg vs 10mg) in Healthy Male Subjects

Solid Tumor

Australia
Antios Therapeutics, Inc

Completed

A Phase 1 Double-Blinded Study for Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of ATI-2173 in Healthy Subjects and Subjects With Chronic Hepatitis B Virus Infection

Hepatitis B, Chronic

Canada, Moldova, Republic of, Ukraine
Gala Therapeutics, Inc.

Completed

Gala Treatment for Chronic Bronchitis in Canada

COPD | Chronic Bronchitis

Canada
Soleno Therapeutics, Inc.

Withdrawn

An Open-Label Study of DCCR Tablet in Patients With PWS

Prader-Willi Syndrome
Odonate Therapeutics, Inc.

Terminated

The Effect of Tesetaxel on the QTc Interval and the Effect of Food, Itraconazole, and Rifampin on Tesetaxel Pharmacokinetics in Patients With Advanced Solid Tumors

Advanced Solid Tumors

United States
Click Therapeutics, Inc.

Completed

Feasibility and Acceptability of Click's EMA and Text Message Intervention for STRESS Management (FACE Stress)

Covid19 | Stress | Stress, Psychological | Loneliness

United States
Axsome Therapeutics, Inc.

Enrolling by invitation

An Evaluation of AXS-05 for the Treatment of TRD in Treatment-Adherent Patients (TARGET)

Major Depressive Disorder | Treatment Resistant Depression

United States
Protagonist Therapeutics, Inc.

Completed

Study of PTG-300 in Non-Transfusion Dependent and Transfusion-Dependent Beta-Thalassemia Subjects With Chronic Anemia (TRANSCEND)

Chronic Anemia | β-thalassemia | Ineffective Erythropoiesis

United States, Malaysia, Turkey, Thailand, United Kingdom, Italy, Lebanon, Tunisia, Greece
TG Therapeutics, Inc.

Completed

Phase IIa Study of Ublituximab in Participants With Relapsing Forms of Multiple Sclerosis

Multiple Sclerosis

United States

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